SG48098A1 - N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives - Google Patents

N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives

Info

Publication number
SG48098A1
SG48098A1 SG1996007025A SG1996007025A SG48098A1 SG 48098 A1 SG48098 A1 SG 48098A1 SG 1996007025 A SG1996007025 A SG 1996007025A SG 1996007025 A SG1996007025 A SG 1996007025A SG 48098 A1 SG48098 A1 SG 48098A1
Authority
SG
Singapore
Prior art keywords
ylacyl
pyrrolo
pyrimidin
glutamic acid
acid derivatives
Prior art date
Application number
SG1996007025A
Other languages
English (en)
Inventor
Gerald B Grindey
Dietmar G Kuhnt
Chuan Shih
Original Assignee
Lilly Co Eli
Univ Princeton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27503964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG48098(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/528,155 external-priority patent/US5028608A/en
Application filed by Lilly Co Eli, Univ Princeton filed Critical Lilly Co Eli
Publication of SG48098A1 publication Critical patent/SG48098A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
SG1996007025A 1989-12-11 1990-12-10 N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives SG48098A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44874289A 1989-12-11 1989-12-11
US47965590A 1990-02-08 1990-02-08
US07/528,155 US5028608A (en) 1989-12-11 1990-05-24 N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
US07/528,805 US4996206A (en) 1989-12-11 1990-05-24 N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives

Publications (1)

Publication Number Publication Date
SG48098A1 true SG48098A1 (en) 1998-04-17

Family

ID=27503964

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996007025A SG48098A1 (en) 1989-12-11 1990-12-10 N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives

Country Status (22)

Country Link
EP (1) EP0432677B1 (fr)
JP (1) JP3016876B2 (fr)
CN (1) CN1030608C (fr)
AR (1) AR245129A1 (fr)
AT (1) ATE135007T1 (fr)
AU (1) AU640182B2 (fr)
CA (1) CA2031890C (fr)
CY (1) CY2076B1 (fr)
DE (2) DE122005000012I2 (fr)
DK (1) DK0432677T3 (fr)
ES (1) ES2084639T4 (fr)
GR (1) GR3019784T3 (fr)
HK (1) HK1000920A1 (fr)
HU (1) HU218483B (fr)
IE (1) IE904445A1 (fr)
IL (1) IL96531A (fr)
LU (1) LU91147I2 (fr)
NL (1) NL300181I2 (fr)
NZ (1) NZ236385A (fr)
PT (1) PT96140B (fr)
RU (1) RU2057131C9 (fr)
SG (1) SG48098A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254687A (en) 1991-12-04 1993-10-19 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
US5235053A (en) * 1992-06-22 1993-08-10 Eli Lilly And Company Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
EP2316468A1 (fr) 2002-02-22 2011-05-04 Shire LLC Système de distribution et méthodes de protection et d'administration de dextroamphetamine
CN100344615C (zh) * 2004-11-25 2007-10-24 重庆医药工业研究院有限责任公司 制备N－(吡咯并[2,3－d]嘧啶－5－基)酰基谷氨酸衍生物的方法及中间体
US20080161251A1 (en) 2005-01-21 2008-07-03 Astex Therapeutics Limited Pharmaceutical Compounds
JP2008543976A (ja) 2006-08-14 2008-12-04 シコール インコーポレイティド ペメトレキセド二酸の医薬上許容される凍結乾燥塩の調製方法
TWI377063B (en) 2006-08-14 2012-11-21 Sicor Inc Crystalline forms of pemetrexed diacid and processes for the preparation thereof
JP2008543973A (ja) 2006-08-14 2008-12-04 シコール インコーポレイティド ペメトレキセドの中間体の調製方法
EP1934226A2 (fr) 2006-08-14 2008-06-25 Sicor, Inc. Diacide de pemetrexed de haute pureté et ses procédés de préparation
WO2008044041A1 (fr) 2006-10-12 2008-04-17 Astex Therapeutics Limited Combinaisons pharmaceutiques
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
CN101417998B (zh) 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
LT2985025T (lt) * 2008-06-06 2018-04-10 Boehringer Ingelheim International Gmbh Farmacinis derinys
AU2015210337B2 (en) * 2008-06-06 2017-02-02 Boehringer Ingelheim International Gmbh Pharmaceutical combination
CN101684121B (zh) 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
WO2011064256A1 (fr) 2009-11-24 2011-06-03 Azad Pharmaceutical Ingredients Ag Nouvelle forme cristalline du pemetrexed disodique
EP2854768B1 (fr) 2012-05-30 2017-03-22 Fresenius Kabi Oncology Limited Compositions pharmaceutiques de pemetrexed
ITRM20120398A1 (it) 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
WO2014167585A1 (fr) 2013-04-12 2014-10-16 Actavis Group Ptc Ehf. Formulation de pemetrexed
EP2997031A1 (fr) 2013-05-17 2016-03-23 Instytut Farmaceutyczny Procédé pour la préparation de pemetrexed disodique amorphe de haute pureté et formes cristallines de l'acide n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)éthyl]benzoyl]-l-glutamique
WO2014198338A1 (fr) 2013-06-14 2014-12-18 Synthon B.V. Sel d'arginine du pémétrexed stable et compositions le comprenant
US9688682B2 (en) 2013-07-16 2017-06-27 Dr. Reddy's Laboratories Limited Crystalline forms of pemetrexed tromethamine salts
NZ630292A (en) 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
PT3206666T (pt) 2014-10-16 2020-03-11 Synthon Bv Composição farmacêutica líquida compreendendo pemetrexedo
CN104672241B (zh) * 2015-01-29 2018-04-24 王磊 吡咯并[2,3-d]嘧啶类化合物及其用途
FR3037956B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2017157825A1 (fr) 2016-03-15 2017-09-21 F. Hoffmann-La Roche Ag Combinaisons d'inhibiteurs de lsd1 pour leur utilisation dans le traitement des tumeurs solides
EP3675864A4 (fr) * 2017-08-31 2022-02-16 Duquesne University of The Holy Spirit Inhibiteurs de shmt2 et de mthfd2 de première catégorie utilisés comme agents antitumoraux
CN110305137A (zh) * 2018-03-20 2019-10-08 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法
CN110305134B (zh) * 2018-03-20 2022-02-22 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法
CN110305136A (zh) * 2018-03-20 2019-10-08 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法
CN110305135B (zh) * 2018-03-20 2022-02-22 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
DK172753B1 (da) * 1988-05-25 1999-06-28 Lilly Co Eli N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
US4883799A (en) * 1988-06-29 1989-11-28 The Trustees Of Princeton University N-(4-(1-hydroxy-3-(5,6,7,8-tetrahydropyrido(2,3,-d)-pyrimidin-6-yl)prop-2-yl)benzoyl)glutamic acid derivatives

Also Published As

Publication number Publication date
ES2084639T4 (es) 2013-06-11
ATE135007T1 (de) 1996-03-15
CA2031890A1 (fr) 1991-06-12
PT96140A (pt) 1991-09-30
RU2057131C1 (ru) 1996-03-27
JPH083166A (ja) 1996-01-09
JP3016876B2 (ja) 2000-03-06
EP0432677B1 (fr) 1996-03-06
CN1055182A (zh) 1991-10-09
CA2031890C (fr) 2000-07-25
CY2076B1 (en) 1998-09-11
HUT58335A (en) 1992-02-28
GR3019784T3 (en) 1996-07-31
HU218483B (hu) 2000-09-28
CN1030608C (zh) 1996-01-03
LU91147I2 (fr) 2005-05-17
DE69025723T2 (de) 1996-10-31
IL96531A (en) 1995-08-31
IE904445A1 (en) 1991-06-19
DE122005000012I2 (de) 2006-02-09
NL300181I2 (nl) 2005-06-01
HU908147D0 (en) 1991-06-28
DE122005000012I1 (de) 2005-06-23
AR245129A1 (es) 1993-12-30
DK0432677T3 (da) 1996-04-09
NZ236385A (en) 1992-05-26
PT96140B (pt) 1997-06-30
RU2057131C9 (ru) 2006-04-10
IL96531A0 (en) 1991-09-16
NL300181I1 (nl) 2005-05-02
DE69025723D1 (de) 1996-04-11
ES2084639T3 (es) 1996-05-16
AU640182B2 (en) 1993-08-19
EP0432677A1 (fr) 1991-06-19
AU6779190A (en) 1991-06-13
HK1000920A1 (en) 1998-05-08

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