ES2084639T3 - Derivados de acido n-(pirrolo(2,3-d)pirimidin-3-ilacetil)-glutamico. - Google Patents

Derivados de acido n-(pirrolo(2,3-d)pirimidin-3-ilacetil)-glutamico.

Info

Publication number
ES2084639T3
ES2084639T3 ES90123671T ES90123671T ES2084639T3 ES 2084639 T3 ES2084639 T3 ES 2084639T3 ES 90123671 T ES90123671 T ES 90123671T ES 90123671 T ES90123671 T ES 90123671T ES 2084639 T3 ES2084639 T3 ES 2084639T3
Authority
ES
Spain
Prior art keywords
pirimidin
acid derivatives
ilacetil
glutamico
pyrrollo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90123671T
Other languages
English (en)
Other versions
ES2084639T4 (es
Inventor
Edward C Taylor
Dietmar G Kuhnt
Chuan Shih
Gerald B Grindey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Princeton University
Original Assignee
Eli Lilly and Co
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27503964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2084639(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/528,155 external-priority patent/US5028608A/en
Application filed by Eli Lilly and Co, Princeton University filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2084639T3 publication Critical patent/ES2084639T3/es
Anticipated expiration legal-status Critical
Publication of ES2084639T4 publication Critical patent/ES2084639T4/es
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LOS DERIVADOS DE ACIDO N-(ACIL)GLUTAMICO EN LOS QUE EL GRUPO ACIDO SE SUSTITUYE CON UN GRUPO 4-HIDROXIPIRROLO[2, 3-D]-PIRIMIDIN-3-IL SON AGENTES ANTINEOPLASTICOS. UNA TIPICA PERSONIFICACION ES ACIDO N-[ 4-(2-{ 4-HIDROXI-6-AMINOPIRROLO[ 2, 3-D]PIRIMIDIN-3-IL}-ETIL) BENZOILO]-L-GLUTAMICO.
ES90123671T 1989-12-11 1990-12-10 Derivados de N-(pirrolo[2,3-d]pirimidin-3-ilacetil)-glutámico Expired - Lifetime ES2084639T4 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US528805 1983-09-02
US44874289A 1989-12-11 1989-12-11
US448742 1989-12-11
US47965590A 1990-02-08 1990-02-08
US479655 1990-02-08
US07/528,155 US5028608A (en) 1989-12-11 1990-05-24 N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
US07/528,805 US4996206A (en) 1989-12-11 1990-05-24 N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives
US528155 1990-05-24

Publications (2)

Publication Number Publication Date
ES2084639T3 true ES2084639T3 (es) 1996-05-16
ES2084639T4 ES2084639T4 (es) 2013-06-11

Family

ID=27503964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90123671T Expired - Lifetime ES2084639T4 (es) 1989-12-11 1990-12-10 Derivados de N-(pirrolo[2,3-d]pirimidin-3-ilacetil)-glutámico

Country Status (22)

Country Link
EP (1) EP0432677B1 (es)
JP (1) JP3016876B2 (es)
CN (1) CN1030608C (es)
AR (1) AR245129A1 (es)
AT (1) ATE135007T1 (es)
AU (1) AU640182B2 (es)
CA (1) CA2031890C (es)
CY (1) CY2076B1 (es)
DE (2) DE69025723T2 (es)
DK (1) DK0432677T3 (es)
ES (1) ES2084639T4 (es)
GR (1) GR3019784T3 (es)
HK (1) HK1000920A1 (es)
HU (1) HU218483B (es)
IE (1) IE904445A1 (es)
IL (1) IL96531A (es)
LU (1) LU91147I2 (es)
NL (1) NL300181I2 (es)
NZ (1) NZ236385A (es)
PT (1) PT96140B (es)
RU (1) RU2057131C9 (es)
SG (1) SG48098A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254687A (en) 1991-12-04 1993-10-19 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
US5235053A (en) * 1992-06-22 1993-08-10 Eli Lilly And Company Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
CN100344615C (zh) * 2004-11-25 2007-10-24 重庆医药工业研究院有限责任公司 制备N－(吡咯并[2,3－d]嘧啶－5－基)酰基谷氨酸衍生物的方法及中间体
US20080161251A1 (en) 2005-01-21 2008-07-03 Astex Therapeutics Limited Pharmaceutical Compounds
KR101101443B1 (ko) 2006-08-14 2012-01-03 시코르, 인크. 페메트렉세드의 중간체의 제조 방법
EP1934226A2 (en) 2006-08-14 2008-06-25 Sicor, Inc. Highly pure pemetrexed diacid and processes for the preparation thereof
DE602007010894D1 (de) 2006-08-14 2011-01-13 Sicor Inc Tellungsverfahren dafür
EP1943252B1 (en) 2006-08-14 2010-12-22 Sicor, Inc. Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
CN101417998B (zh) 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
ME02273B (me) * 2008-06-06 2016-02-20 Boehringer Ingelheim Int Farmaceutska kombinacija
AU2015210337B2 (en) * 2008-06-06 2017-02-02 Boehringer Ingelheim International Gmbh Pharmaceutical combination
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
US9174991B2 (en) 2009-11-24 2015-11-03 Azad Pharmaceutical Ingredients Ag Crystalline form of pemetrexed disodium
EP2854768B1 (en) 2012-05-30 2017-03-22 Fresenius Kabi Oncology Limited Pharmaceutical compositions of pemetrexed
ITRM20120398A1 (it) 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
US20160051679A1 (en) 2013-04-12 2016-02-25 Actavis Group Ptc Ehf. Pemetrexed Formulation
WO2014185797A1 (en) 2013-05-17 2014-11-20 Instytut Farmaceutyczny Process for the preparation of high purity amorphous pemetrexed disodium and crystalline forms of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3- d] pyrimidin-5-yl)ethyl] benzoyl]-l-glutamic acid
US20160145260A1 (en) 2013-06-14 2016-05-26 Synthon B.V. Stable pemetrexed arginine salt and compositions comprising it
WO2015008221A1 (en) 2013-07-16 2015-01-22 Dr. Reddy’S Laboratories Limited Novel crystalline forms of pemetrexed tromethamine salts
NZ630292A (en) 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
SI3206666T1 (sl) 2014-10-16 2020-04-30 Synthon B.V. Tekoč farmacevtski sestavek, ki obsega pemetreksed
CN104672241B (zh) * 2015-01-29 2018-04-24 王磊 吡咯并[2,3-d]嘧啶类化合物及其用途
FR3037956B1 (fr) * 2015-06-23 2017-08-04 Servier Lab Nouveaux derives d'acide amine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BR112018068565A2 (pt) 2016-03-15 2019-02-12 Oryzon Genomics, S.A. combinações de inibidores de lsd1 para uso no tratamento de tumores sólidos
EP3675864A4 (en) * 2017-08-31 2022-02-16 Duquesne University of The Holy Spirit FIRST REPRESENTATIVES OF SHMT2 AND MTHFD2 INHIBITORS AS ANTITUMORS
CN110305135B (zh) * 2018-03-20 2022-02-22 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法
CN110305137A (zh) * 2018-03-20 2019-10-08 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法
CN110305136A (zh) * 2018-03-20 2019-10-08 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法
CN110305134B (zh) * 2018-03-20 2022-02-22 鲁南制药集团股份有限公司 一种培美曲塞二钠中间体及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818819A (en) * 1986-10-20 1989-04-04 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
DK172753B1 (da) * 1988-05-25 1999-06-28 Lilly Co Eli N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
US4883799A (en) * 1988-06-29 1989-11-28 The Trustees Of Princeton University N-(4-(1-hydroxy-3-(5,6,7,8-tetrahydropyrido(2,3,-d)-pyrimidin-6-yl)prop-2-yl)benzoyl)glutamic acid derivatives

Also Published As

Publication number Publication date
RU2057131C1 (ru) 1996-03-27
AU640182B2 (en) 1993-08-19
PT96140A (pt) 1991-09-30
EP0432677B1 (en) 1996-03-06
NL300181I1 (nl) 2005-05-02
LU91147I2 (fr) 2005-05-17
CA2031890A1 (en) 1991-06-12
ES2084639T4 (es) 2013-06-11
HU218483B (hu) 2000-09-28
JP3016876B2 (ja) 2000-03-06
PT96140B (pt) 1997-06-30
HU908147D0 (en) 1991-06-28
HUT58335A (en) 1992-02-28
DE122005000012I1 (de) 2005-06-23
CN1055182A (zh) 1991-10-09
RU2057131C9 (ru) 2006-04-10
SG48098A1 (en) 1998-04-17
EP0432677A1 (en) 1991-06-19
IE904445A1 (en) 1991-06-19
AR245129A1 (es) 1993-12-30
DK0432677T3 (da) 1996-04-09
NZ236385A (en) 1992-05-26
JPH083166A (ja) 1996-01-09
DE122005000012I2 (de) 2006-02-09
NL300181I2 (nl) 2005-06-01
IL96531A (en) 1995-08-31
GR3019784T3 (en) 1996-07-31
AU6779190A (en) 1991-06-13
ATE135007T1 (de) 1996-03-15
HK1000920A1 (en) 1998-05-08
DE69025723T2 (de) 1996-10-31
CA2031890C (en) 2000-07-25
CN1030608C (zh) 1996-01-03
CY2076B1 (en) 1998-09-11
DE69025723D1 (de) 1996-04-11
IL96531A0 (en) 1991-09-16

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