SG45503A1 - Substituted quinoline-2-carboxyamides their preparation and their use as pharmaceuticals and intermediates - Google Patents
Substituted quinoline-2-carboxyamides their preparation and their use as pharmaceuticals and intermediatesInfo
- Publication number
- SG45503A1 SG45503A1 SG1996010735A SG1996010735A SG45503A1 SG 45503 A1 SG45503 A1 SG 45503A1 SG 1996010735 A SG1996010735 A SG 1996010735A SG 1996010735 A SG1996010735 A SG 1996010735A SG 45503 A1 SG45503 A1 SG 45503A1
- Authority
- SG
- Singapore
- Prior art keywords
- alkyl
- opt
- alkoxy
- substd
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Electroluminescent Light Sources (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19536263A DE19536263A1 (de) | 1995-09-28 | 1995-09-28 | Substituierte Chinolin-2-carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE19605170 | 1996-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG45503A1 true SG45503A1 (en) | 1998-01-16 |
Family
ID=26019051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1996010735A SG45503A1 (en) | 1995-09-28 | 1996-09-27 | Substituted quinoline-2-carboxyamides their preparation and their use as pharmaceuticals and intermediates |
Country Status (20)
Country | Link |
---|---|
US (2) | US5719164A (fr) |
EP (1) | EP0765871B1 (fr) |
JP (1) | JPH09124606A (fr) |
KR (1) | KR970061869A (fr) |
CN (2) | CN1120157C (fr) |
AT (1) | ATE263155T1 (fr) |
AU (1) | AU728208B2 (fr) |
CA (1) | CA2186717A1 (fr) |
CZ (1) | CZ283396A3 (fr) |
DE (1) | DE59610950D1 (fr) |
ES (1) | ES2215184T3 (fr) |
HU (1) | HUP9602685A3 (fr) |
IL (2) | IL135495A (fr) |
MX (1) | MX9604378A (fr) |
MY (1) | MY133647A (fr) |
NO (1) | NO308600B1 (fr) |
NZ (1) | NZ299455A (fr) |
PL (1) | PL316321A1 (fr) |
SG (1) | SG45503A1 (fr) |
SI (1) | SI9600287A (fr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19650215A1 (de) * | 1996-12-04 | 1998-06-10 | Hoechst Ag | 3-Hydroxypyridin-2-carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE19746287A1 (de) * | 1997-10-20 | 1999-04-22 | Hoechst Marion Roussel De Gmbh | Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
US20020198145A1 (en) * | 1999-06-10 | 2002-12-26 | Cognetix, Inc. | MuO-conopeptides and their use as local anesthetics |
US6706724B2 (en) | 2000-12-21 | 2004-03-16 | Nitromed, Inc. | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
AU2002241154A1 (en) * | 2001-03-21 | 2002-10-03 | Isis Innovation Ltd. | Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase |
EP2295060B1 (fr) | 2001-12-06 | 2018-10-31 | Fibrogen, Inc. | Traitement de conditions ischémiques ou hypoxiques |
CN102526044A (zh) * | 2001-12-06 | 2012-07-04 | 法布罗根股份有限公司 | 提高内源性红细胞生成素(epo)的方法 |
US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
US7618940B2 (en) * | 2002-12-06 | 2009-11-17 | Fibrogen, Inc. | Fat regulation |
US8614204B2 (en) | 2003-06-06 | 2013-12-24 | Fibrogen, Inc. | Enhanced erythropoiesis and iron metabolism |
EP1644336B1 (fr) * | 2003-06-06 | 2011-01-19 | Fibrogen, Inc. | Composes heteroaryliques contenant de l'azote et leur utilisation dans l'augmentation de l'erythropoietine endogene |
WO2005034929A2 (fr) * | 2003-10-10 | 2005-04-21 | Fibrogen, Inc. | Remodelage et vascularisation de tissus |
AU2006254897A1 (en) * | 2005-06-06 | 2006-12-14 | Fibrogen, Inc. | Improved treatment for anemia using a HIF-alpha stabilising agent |
MX2007016160A (es) | 2005-06-15 | 2008-03-07 | Fibrogen Inc | Uso de moduladoers de hif-1 alfa para el tratamiento contra el cancer. |
EP1910296B1 (fr) | 2005-07-27 | 2010-04-21 | F.Hoffmann-La Roche Ag | 4-ARYLOXY QUINOLINES ET LEUR UTILISATION EN TANT QUE modulateurs de 5-HT6 |
ES2446416T3 (es) * | 2005-12-09 | 2014-03-07 | Amgen, Inc. | Compuestos basados en quinolona que presentan actividad inhibidora de prolil hidroxilasa, composiciones y usos de los mismos |
ZA200806752B (en) * | 2006-01-27 | 2009-10-28 | Fibrogen Inc | Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (HIF) |
WO2007101204A1 (fr) * | 2006-02-27 | 2007-09-07 | Alcon Research, Ltd. | Méthode de traitement du glaucome |
US7745461B1 (en) | 2006-02-27 | 2010-06-29 | Alcon Research, Ltd. | Method of treating dry eye disorders |
AU2007232607B2 (en) * | 2006-03-30 | 2010-09-16 | Lg Electronics Inc. | A method and apparatus for decoding/encoding a video signal |
AU2007234408B2 (en) * | 2006-04-04 | 2011-05-19 | Fibrogen, Inc. | Pyrrolo- and thiazolo-pyridine compounds as HIF modulators |
EP2044005B8 (fr) | 2006-06-26 | 2012-12-05 | Warner Chilcott Company, LLC | Inhibiteurs de la prolyl hydroxylase et procédés d'utilisation |
CA2672656C (fr) * | 2006-12-18 | 2012-03-20 | Amgen Inc. | Composes de naphtalenone presentant une activite inhibititrice de prolyle hydroxylase, compositions et utilisations de ceux-ci |
US8048892B2 (en) * | 2006-12-18 | 2011-11-01 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
US7569726B2 (en) * | 2007-04-18 | 2009-08-04 | Amgen Inc. | Indanone derivatives that inhibit prolyl hydroxylase |
CA2683956C (fr) * | 2007-04-18 | 2012-12-18 | Amgen Inc. | Quinolones et azaquinolones inhibant la prolyl hydroxylase |
CA2685216C (fr) * | 2007-05-04 | 2014-07-08 | Amgen Inc. | Derives de la thienopyridine et de la thiazolopyridine qui inhibent l'activite prolyle hydroxylase |
CA2685219C (fr) * | 2007-05-04 | 2012-06-19 | Amgen Inc. | Diazaquinolones inhibant l'activite de la prolyl hydroxylase |
WO2009002533A1 (fr) * | 2007-06-27 | 2008-12-31 | The Brigham And Women's Hospital, Inc. | Thérapies d'affection abdominale inflammatoire |
US8927591B2 (en) | 2008-11-14 | 2015-01-06 | Fibrogen, Inc. | Thiochromene derivatives as HIF hydroxylase inhibitors |
UA107360C2 (en) | 2009-08-05 | 2014-12-25 | Biogen Idec Inc | Bicyclic aryl sphingosine 1-phosphate analogs |
MX336774B (es) * | 2009-12-17 | 2016-01-28 | Merck Sharp & Dohme | Moduladores alostericos positivos de receptores m1 de la quinolina amida. |
CN106278999B (zh) | 2011-02-07 | 2019-10-25 | 比奥根Ma公司 | S1p调节剂 |
NO2686520T3 (fr) | 2011-06-06 | 2018-03-17 | ||
NZ700760A (en) | 2012-03-09 | 2016-08-26 | Fibrogen Inc | 4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors |
US8883823B2 (en) | 2012-07-16 | 2014-11-11 | Fibrogen, Inc. | Crystalline forms of a prolyl hydroxylase inhibitor |
EP2872487B1 (fr) | 2012-07-16 | 2017-04-26 | Fibrogen, Inc. | Procédé de fabrication de composés isoquinoléine |
PT3470397T (pt) | 2012-07-16 | 2022-02-18 | Fibrogen Inc | Formas cristalinas de um inibidor da prolil-hidroxilase |
ES2668694T3 (es) * | 2012-07-27 | 2018-05-21 | Biogen Ma Inc. | Derivados de ácido 1-[7-(cis-4-metil-ciclohexiloxi)-8-trifluorometil-naftalen-2-ilmetil]-piperidin-4-carboxílico como moduladores de autotaxina (ATX) para tratar inflamaciones y trastornos autoinmunitarios |
ES2694297T3 (es) | 2013-01-24 | 2018-12-19 | Fibrogen, Inc. | Formas cristalinas de ácido {[1-ciano-5-(4-clorofenoxi)-4-hidroxi-isoquinolina-3-carbonilo]-amino}-acético |
EP3007695B1 (fr) | 2013-06-13 | 2024-02-07 | Akebia Therapeutics, Inc. | Compositions et méthodes de traitement de l'anémie |
MA39033A1 (fr) | 2013-11-15 | 2017-11-30 | Akebia Therapeutics Inc | Formes solides d'acide {[5-(3-chlorophényl)-3-hydroxypyridine-2-carbonyl] amino}acétique, compositions et leurs utilisations |
BR112017015852A2 (pt) | 2015-01-23 | 2018-03-27 | Akebia Therapeutics Inc | forma de cristal, sal hemicálcico, sal hemicálcico di-hidratado, sal monossódico hidratado, sal bissódico monoidratado, sal monossódico anidro e método para preparar o composto 1 |
DK3277270T3 (da) | 2015-04-01 | 2021-12-06 | Akebia Therapeutics Inc | Sammensætninger og fremgangsmåder til behandling af anæmi |
US11713298B2 (en) | 2018-05-09 | 2023-08-01 | Akebia Therapeutics, Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
WO2020097389A1 (fr) | 2018-11-09 | 2020-05-14 | Vivace Therapeutics, Inc. | Composés bicycliques |
AU2020257207A1 (en) | 2019-04-16 | 2021-11-25 | Vivace Therapeutics, Inc. | Bicyclic compounds |
US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4015255A1 (de) * | 1990-05-12 | 1991-11-14 | Hoechst Ag | Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase |
US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
EP0541042A1 (fr) * | 1991-11-05 | 1993-05-12 | Hoechst Aktiengesellschaft | Dérivés d'acide pyridine 2,4- et 2,5-dicarboxyliques, leur procédé de préparation et leur utilisation comme médicaments |
TW352384B (en) * | 1992-03-24 | 1999-02-11 | Hoechst Ag | Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals |
DE4233124A1 (de) * | 1992-10-02 | 1994-04-07 | Hoechst Ag | Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DK122693D0 (da) * | 1993-10-29 | 1993-10-29 | Hempels Skibsfarve Fab J C | Marin struktur |
DE59401923D1 (de) * | 1993-11-02 | 1997-04-10 | Hoechst Ag | Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel |
EP0650961B1 (fr) * | 1993-11-02 | 1997-03-05 | Hoechst Aktiengesellschaft | Amides d'acide carboxylique hétérocycliques substitués, leur preparation et leur utilisation comme médicaments |
CA2138929A1 (fr) * | 1993-12-30 | 1995-07-01 | Klaus Weidmann | Carboxamides heterocycliques substitues, leur preparation et leur utilisation comme composes pharmaceutiques |
-
1996
- 1996-06-29 IL IL13549596A patent/IL135495A/en not_active IP Right Cessation
- 1996-07-03 US US08/675,208 patent/US5719164A/en not_active Expired - Lifetime
- 1996-07-03 US US08/675,155 patent/US5726305A/en not_active Expired - Lifetime
- 1996-09-20 DE DE59610950T patent/DE59610950D1/de not_active Expired - Lifetime
- 1996-09-20 EP EP96115110A patent/EP0765871B1/fr not_active Expired - Lifetime
- 1996-09-20 AT AT96115110T patent/ATE263155T1/de not_active IP Right Cessation
- 1996-09-20 ES ES96115110T patent/ES2215184T3/es not_active Expired - Lifetime
- 1996-09-25 KR KR1019960042606A patent/KR970061869A/ko not_active Application Discontinuation
- 1996-09-26 IL IL11930296A patent/IL119302A0/xx unknown
- 1996-09-26 AU AU65838/96A patent/AU728208B2/en not_active Ceased
- 1996-09-26 CZ CZ962833A patent/CZ283396A3/cs unknown
- 1996-09-26 CN CN96122806A patent/CN1120157C/zh not_active Expired - Lifetime
- 1996-09-26 NZ NZ299455A patent/NZ299455A/en unknown
- 1996-09-27 NO NO964093A patent/NO308600B1/no not_active IP Right Cessation
- 1996-09-27 CA CA002186717A patent/CA2186717A1/fr not_active Abandoned
- 1996-09-27 SI SI9600287A patent/SI9600287A/sl unknown
- 1996-09-27 MX MX9604378A patent/MX9604378A/es unknown
- 1996-09-27 MY MYPI96004023A patent/MY133647A/en unknown
- 1996-09-27 PL PL96316321A patent/PL316321A1/xx unknown
- 1996-09-27 SG SG1996010735A patent/SG45503A1/en unknown
- 1996-09-27 HU HU9602685A patent/HUP9602685A3/hu unknown
- 1996-09-30 JP JP8276901A patent/JPH09124606A/ja active Pending
-
2000
- 2000-06-14 CN CN00118801A patent/CN1282737A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
SI9600287A (en) | 1997-04-30 |
CN1154365A (zh) | 1997-07-16 |
JPH09124606A (ja) | 1997-05-13 |
DE59610950D1 (de) | 2004-05-06 |
CZ283396A3 (en) | 1997-04-16 |
HUP9602685A2 (hu) | 1998-09-28 |
HU9602685D0 (en) | 1996-11-28 |
NO308600B1 (no) | 2000-10-02 |
IL135495A (en) | 2002-12-01 |
PL316321A1 (en) | 1997-04-01 |
US5719164A (en) | 1998-02-17 |
HUP9602685A3 (en) | 2001-04-28 |
CN1120157C (zh) | 2003-09-03 |
US5726305A (en) | 1998-03-10 |
IL119302A0 (en) | 1996-12-05 |
CN1282737A (zh) | 2001-02-07 |
EP0765871B1 (fr) | 2004-03-31 |
NO964093D0 (no) | 1996-09-27 |
AU728208B2 (en) | 2001-01-04 |
ATE263155T1 (de) | 2004-04-15 |
CA2186717A1 (fr) | 1997-03-29 |
EP0765871A1 (fr) | 1997-04-02 |
NZ299455A (en) | 1997-06-24 |
MX9604378A (es) | 1997-03-29 |
AU6583896A (en) | 1997-04-10 |
NO964093L (no) | 1997-04-01 |
KR970061869A (ko) | 1997-09-12 |
ES2215184T3 (es) | 2004-10-01 |
MY133647A (en) | 2007-11-30 |
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