SG2389G - Gamma-butyrolactone derivatives with myocardium protecting and antiarrhytmic activity,process for their preparation and medicines containing them - Google Patents
Gamma-butyrolactone derivatives with myocardium protecting and antiarrhytmic activity,process for their preparation and medicines containing themInfo
- Publication number
- SG2389G SG2389G SG23/89A SG2389A SG2389G SG 2389 G SG2389 G SG 2389G SG 23/89 A SG23/89 A SG 23/89A SG 2389 A SG2389 A SG 2389A SG 2389 G SG2389 G SG 2389G
- Authority
- SG
- Singapore
- Prior art keywords
- group
- products
- antiarrhytmic
- gamma
- activity
- Prior art date
Links
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical class O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003416 antiarrhythmic agent Substances 0.000 title 1
- 210000004165 myocardium Anatomy 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229930188620 butyrolactone Natural products 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8218705A FR2535722B1 (fr) | 1982-11-08 | 1982-11-08 | Derives de la g-butyrolactone protecteurs du myocarde presentant une activite antiarythmique, procede pour leur preparation et medicaments en contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG2389G true SG2389G (en) | 1991-01-04 |
Family
ID=9278999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG23/89A SG2389G (en) | 1982-11-08 | 1989-01-11 | Gamma-butyrolactone derivatives with myocardium protecting and antiarrhytmic activity,process for their preparation and medicines containing them |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4542134A (no) |
| EP (1) | EP0113600B1 (no) |
| JP (1) | JPS59161379A (no) |
| KR (1) | KR900006723B1 (no) |
| AT (1) | ATE28644T1 (no) |
| AU (1) | AU560032B2 (no) |
| CA (1) | CA1224467A (no) |
| CS (1) | CS244680B2 (no) |
| DD (2) | DD231567A5 (no) |
| DE (1) | DE3372767D1 (no) |
| DK (1) | DK503683A (no) |
| ES (1) | ES8406071A1 (no) |
| FI (1) | FI79538C (no) |
| FR (1) | FR2535722B1 (no) |
| GR (1) | GR78746B (no) |
| HU (1) | HU192825B (no) |
| IE (1) | IE56208B1 (no) |
| IL (1) | IL70062A (no) |
| MA (1) | MA19947A1 (no) |
| NO (1) | NO159853C (no) |
| NZ (1) | NZ206176A (no) |
| OA (1) | OA07581A (no) |
| PH (1) | PH19547A (no) |
| PL (2) | PL139945B1 (no) |
| PT (1) | PT77606B (no) |
| SG (1) | SG2389G (no) |
| SU (1) | SU1279529A1 (no) |
| YU (2) | YU220483A (no) |
| ZA (1) | ZA837935B (no) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3714173A (en) * | 1971-07-06 | 1973-01-30 | Smith Kline French Lab | Pyridyl ketipate lactones and derivatives |
| FR2467200A1 (fr) * | 1979-10-11 | 1981-04-17 | Clin Midy | Derives du pyrrole actifs sur les troubles du rythme cardiovasculaire |
-
1982
- 1982-11-08 FR FR8218705A patent/FR2535722B1/fr not_active Expired
-
1983
- 1983-10-20 US US06/543,898 patent/US4542134A/en not_active Expired - Fee Related
- 1983-10-25 ZA ZA837935A patent/ZA837935B/xx unknown
- 1983-10-26 IL IL70062A patent/IL70062A/xx unknown
- 1983-10-27 AU AU20639/83A patent/AU560032B2/en not_active Ceased
- 1983-11-03 DK DK503683A patent/DK503683A/da not_active Application Discontinuation
- 1983-11-04 AT AT83402141T patent/ATE28644T1/de not_active IP Right Cessation
- 1983-11-04 DE DE8383402141T patent/DE3372767D1/de not_active Expired
- 1983-11-04 PT PT77606A patent/PT77606B/pt not_active IP Right Cessation
- 1983-11-04 GR GR72873A patent/GR78746B/el unknown
- 1983-11-04 IE IE2580/83A patent/IE56208B1/xx unknown
- 1983-11-04 EP EP83402141A patent/EP0113600B1/fr not_active Expired
- 1983-11-05 SU SU833661802A patent/SU1279529A1/ru active
- 1983-11-07 FI FI834069A patent/FI79538C/fi not_active IP Right Cessation
- 1983-11-07 KR KR1019830005270A patent/KR900006723B1/ko active IP Right Grant
- 1983-11-07 YU YU02204/83A patent/YU220483A/xx unknown
- 1983-11-07 CA CA000440588A patent/CA1224467A/en not_active Expired
- 1983-11-07 NO NO834053A patent/NO159853C/no unknown
- 1983-11-07 MA MA20167A patent/MA19947A1/fr unknown
- 1983-11-07 DD DD83270122A patent/DD231567A5/de not_active IP Right Cessation
- 1983-11-07 NZ NZ206176A patent/NZ206176A/en unknown
- 1983-11-07 DD DD83256412A patent/DD220313A5/de not_active IP Right Cessation
- 1983-11-08 PL PL1983244461A patent/PL139945B1/pl unknown
- 1983-11-08 JP JP58209771A patent/JPS59161379A/ja active Pending
- 1983-11-08 ES ES527092A patent/ES8406071A1/es not_active Expired
- 1983-11-08 PL PL1983249775A patent/PL142949B1/pl unknown
- 1983-11-08 CS CS838219A patent/CS244680B2/cs unknown
- 1983-11-08 HU HU833826A patent/HU192825B/hu not_active IP Right Cessation
- 1983-11-08 PH PH29801A patent/PH19547A/en unknown
- 1983-11-08 OA OA58152A patent/OA07581A/xx unknown
-
1985
- 1985-09-12 YU YU01435/85A patent/YU143585A/xx unknown
-
1989
- 1989-01-11 SG SG23/89A patent/SG2389G/en unknown
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