SG187175A1 - Compounds with antibacterial activity against clostridium - Google Patents
Compounds with antibacterial activity against clostridium Download PDFInfo
- Publication number
- SG187175A1 SG187175A1 SG2013005202A SG2013005202A SG187175A1 SG 187175 A1 SG187175 A1 SG 187175A1 SG 2013005202 A SG2013005202 A SG 2013005202A SG 2013005202 A SG2013005202 A SG 2013005202A SG 187175 A1 SG187175 A1 SG 187175A1
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- Singapore
- Prior art keywords
- compound
- formula
- compounds
- hydroxy
- pharmaceutically acceptable
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- 238000004090 dissolution Methods 0.000 description 1
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- 239000004495 emulsifiable concentrate Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 229940032049 enterococcus faecalis Drugs 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- PGZDKLQEQZFHHR-UHFFFAOYSA-N ethyl n-(1h-pyrazol-5-ylcarbamothioyl)carbamate Chemical compound CCOC(=O)NC(=S)NC1=CC=NN1 PGZDKLQEQZFHHR-UHFFFAOYSA-N 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 244000144992 flock Species 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
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- 238000001640 fractional crystallisation Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
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- 238000010438 heat treatment Methods 0.000 description 1
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- 238000004128 high performance liquid chromatography Methods 0.000 description 1
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- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
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- 125000002346 iodo group Chemical group I* 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
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- 230000014759 maintenance of location Effects 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- UOPFIWYXBIHPIP-SFTDATJTSA-N n-[(1s,2s)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N[C@@H](C=1C=CC=CC=1)[C@@H](N)C1=CC=CC=C1 UOPFIWYXBIHPIP-SFTDATJTSA-N 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000002638 palliative care Methods 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 description 1
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 1
- 229960005235 piperonyl butoxide Drugs 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- JADFCQKRKICRKI-UHFFFAOYSA-N quinoline;sulfane Chemical compound S.N1=CC=CC2=CC=CC=C21 JADFCQKRKICRKI-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 238000010956 selective crystallization Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
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- 239000002689 soil Substances 0.000 description 1
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- 239000003381 stabilizer Substances 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10171842 | 2010-08-04 | ||
| PCT/EP2011/063434 WO2012017030A1 (en) | 2010-08-04 | 2011-08-04 | Compounds with antibacterial activity against clostridium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG187175A1 true SG187175A1 (en) | 2013-02-28 |
Family
ID=43125618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013005202A SG187175A1 (en) | 2010-08-04 | 2011-08-04 | Compounds with antibacterial activity against clostridium |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8618100B2 (enExample) |
| EP (1) | EP2601193B1 (enExample) |
| JP (1) | JP5886285B2 (enExample) |
| KR (1) | KR101499368B1 (enExample) |
| CN (1) | CN103038234B (enExample) |
| AR (1) | AR082472A1 (enExample) |
| AU (1) | AU2011287584B2 (enExample) |
| BR (1) | BR112013003675A8 (enExample) |
| CA (1) | CA2805358C (enExample) |
| CL (1) | CL2013000331A1 (enExample) |
| CO (1) | CO6680629A2 (enExample) |
| CY (1) | CY1116238T1 (enExample) |
| DK (1) | DK2601193T3 (enExample) |
| EA (1) | EA021567B1 (enExample) |
| ES (1) | ES2538998T3 (enExample) |
| HR (1) | HRP20150467T1 (enExample) |
| ME (1) | ME02061B (enExample) |
| MX (1) | MX2013001246A (enExample) |
| NZ (1) | NZ605850A (enExample) |
| PH (1) | PH12013500219A1 (enExample) |
| PL (1) | PL2601193T3 (enExample) |
| PT (1) | PT2601193E (enExample) |
| RS (1) | RS53990B1 (enExample) |
| SG (1) | SG187175A1 (enExample) |
| SI (1) | SI2601193T1 (enExample) |
| TW (1) | TWI498330B (enExample) |
| WO (1) | WO2012017030A1 (enExample) |
| ZA (1) | ZA201300432B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
| WO2016127102A2 (en) | 2015-02-06 | 2016-08-11 | Ernesto Abel-Santos | Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis |
| GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
| KR101769204B1 (ko) * | 2015-08-04 | 2017-08-17 | 씨제이헬스케어 주식회사 | 크로마놀 유도체의 신규한 제조방법 |
| WO2023039159A2 (en) | 2021-09-09 | 2023-03-16 | Abel Santos Ernesto | Inhibitors of c. difficile spore germination |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2094714B1 (en) * | 2006-09-26 | 2012-08-15 | Crestone, Inc. | Substituted thienopyridone compounds with antibacterial activity |
| EP2091536B1 (en) * | 2006-09-26 | 2013-07-31 | Crestone, Inc. | Enantiomeric compounds with antibacterial activity |
| US8658670B2 (en) * | 2006-09-26 | 2014-02-25 | Crestone, Inc. | Methods and compounds for treatment of clostridium based infection |
-
2011
- 2011-08-03 TW TW100127482A patent/TWI498330B/zh not_active IP Right Cessation
- 2011-08-03 AR ARP110102808A patent/AR082472A1/es unknown
- 2011-08-04 PH PH1/2013/500219A patent/PH12013500219A1/en unknown
- 2011-08-04 SG SG2013005202A patent/SG187175A1/en unknown
- 2011-08-04 PT PT117409219T patent/PT2601193E/pt unknown
- 2011-08-04 BR BR112013003675A patent/BR112013003675A8/pt not_active IP Right Cessation
- 2011-08-04 HR HRP20150467TT patent/HRP20150467T1/hr unknown
- 2011-08-04 US US13/809,238 patent/US8618100B2/en not_active Expired - Fee Related
- 2011-08-04 RS RS20150318A patent/RS53990B1/sr unknown
- 2011-08-04 JP JP2013522249A patent/JP5886285B2/ja not_active Expired - Fee Related
- 2011-08-04 SI SI201130439T patent/SI2601193T1/sl unknown
- 2011-08-04 ES ES11740921.9T patent/ES2538998T3/es active Active
- 2011-08-04 AU AU2011287584A patent/AU2011287584B2/en not_active Ceased
- 2011-08-04 DK DK11740921.9T patent/DK2601193T3/en active
- 2011-08-04 MX MX2013001246A patent/MX2013001246A/es not_active Application Discontinuation
- 2011-08-04 KR KR1020137002738A patent/KR101499368B1/ko not_active Expired - Fee Related
- 2011-08-04 CA CA2805358A patent/CA2805358C/en not_active Expired - Fee Related
- 2011-08-04 PL PL11740921T patent/PL2601193T3/pl unknown
- 2011-08-04 NZ NZ605850A patent/NZ605850A/en not_active IP Right Cessation
- 2011-08-04 EA EA201270817A patent/EA021567B1/ru not_active IP Right Cessation
- 2011-08-04 EP EP11740921.9A patent/EP2601193B1/en active Active
- 2011-08-04 ME MEP-2015-40A patent/ME02061B/me unknown
- 2011-08-04 WO PCT/EP2011/063434 patent/WO2012017030A1/en not_active Ceased
- 2011-08-04 CN CN201180037487.5A patent/CN103038234B/zh not_active Expired - Fee Related
-
2013
- 2013-01-16 ZA ZA2013/00432A patent/ZA201300432B/en unknown
- 2013-02-01 CO CO13019560A patent/CO6680629A2/es active IP Right Grant
- 2013-02-01 CL CL2013000331A patent/CL2013000331A1/es unknown
-
2015
- 2015-04-30 CY CY20151100392T patent/CY1116238T1/el unknown
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