CN103038234B - 针对梭状芽胞杆菌具有抗菌活性的化合物 - Google Patents

针对梭状芽胞杆菌具有抗菌活性的化合物 Download PDF

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Publication number
CN103038234B
CN103038234B CN201180037487.5A CN201180037487A CN103038234B CN 103038234 B CN103038234 B CN 103038234B CN 201180037487 A CN201180037487 A CN 201180037487A CN 103038234 B CN103038234 B CN 103038234B
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China
Prior art keywords
compound
compounds
formula
pharmaceutically acceptable
acid addition
Prior art date
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Expired - Fee Related
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CN201180037487.5A
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English (en)
Chinese (zh)
Other versions
CN103038234A (zh
Inventor
J.E.G.圭勒蒙
P.J-M.B.拉伯瓦森
N.罗尼斯
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Elanco Animal Health Ireland Ltd
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Elanco Animal Health Ireland Ltd
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Publication of CN103038234A publication Critical patent/CN103038234A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201180037487.5A 2010-08-04 2011-08-04 针对梭状芽胞杆菌具有抗菌活性的化合物 Expired - Fee Related CN103038234B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10171842 2010-08-04
EP10171842.7 2010-08-04
PCT/EP2011/063434 WO2012017030A1 (en) 2010-08-04 2011-08-04 Compounds with antibacterial activity against clostridium

Publications (2)

Publication Number Publication Date
CN103038234A CN103038234A (zh) 2013-04-10
CN103038234B true CN103038234B (zh) 2016-02-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180037487.5A Expired - Fee Related CN103038234B (zh) 2010-08-04 2011-08-04 针对梭状芽胞杆菌具有抗菌活性的化合物

Country Status (28)

Country Link
US (1) US8618100B2 (enExample)
EP (1) EP2601193B1 (enExample)
JP (1) JP5886285B2 (enExample)
KR (1) KR101499368B1 (enExample)
CN (1) CN103038234B (enExample)
AR (1) AR082472A1 (enExample)
AU (1) AU2011287584B2 (enExample)
BR (1) BR112013003675A8 (enExample)
CA (1) CA2805358C (enExample)
CL (1) CL2013000331A1 (enExample)
CO (1) CO6680629A2 (enExample)
CY (1) CY1116238T1 (enExample)
DK (1) DK2601193T3 (enExample)
EA (1) EA021567B1 (enExample)
ES (1) ES2538998T3 (enExample)
HR (1) HRP20150467T1 (enExample)
ME (1) ME02061B (enExample)
MX (1) MX2013001246A (enExample)
NZ (1) NZ605850A (enExample)
PH (1) PH12013500219A1 (enExample)
PL (1) PL2601193T3 (enExample)
PT (1) PT2601193E (enExample)
RS (1) RS53990B1 (enExample)
SG (1) SG187175A1 (enExample)
SI (1) SI2601193T1 (enExample)
TW (1) TWI498330B (enExample)
WO (1) WO2012017030A1 (enExample)
ZA (1) ZA201300432B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9079935B2 (en) 2012-08-13 2015-07-14 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas Reducing risk of contracting Clostridium-difficile associated disease
WO2016127102A2 (en) 2015-02-06 2016-08-11 Ernesto Abel-Santos Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis
GB201509326D0 (en) 2015-05-29 2015-07-15 Antibio Tx Aps Novel use
KR101769204B1 (ko) * 2015-08-04 2017-08-17 씨제이헬스케어 주식회사 크로마놀 유도체의 신규한 제조방법
WO2023039159A2 (en) 2021-09-09 2023-03-16 Abel Santos Ernesto Inhibitors of c. difficile spore germination

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008039642A2 (en) * 2006-09-26 2008-04-03 Replidyne, Inc. Methods and compounds for treatment of clostridium based infection
WO2008039639A2 (en) * 2006-09-26 2008-04-03 Crestone, Inc. Substituted thienopyridone compounds with antibacterial activity
CN101652140A (zh) * 2006-09-26 2010-02-17 克莱斯通公司 具有抗菌活性的对映体化合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008039642A2 (en) * 2006-09-26 2008-04-03 Replidyne, Inc. Methods and compounds for treatment of clostridium based infection
WO2008039639A2 (en) * 2006-09-26 2008-04-03 Crestone, Inc. Substituted thienopyridone compounds with antibacterial activity
CN101652140A (zh) * 2006-09-26 2010-02-17 克莱斯通公司 具有抗菌活性的对映体化合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues;Richard L. Jarvest，等;《Bioorganic & Medicinal Chemistry Letters》;20040619;第14卷(第15期);第3937-3941页 *
Design, Synthesis, and Structure±Activity Relationship Studies of ATP Analogues as DNA Gyrase Inhibitors;Thomas Lubbers，等;《Bioorganic & Medicinal Chemistry Letters》;20000430;第10卷(第8期);第821-826页 *

Also Published As

Publication number Publication date
PL2601193T3 (pl) 2015-08-31
EP2601193B1 (en) 2015-03-11
HRP20150467T1 (hr) 2015-06-05
NZ605850A (en) 2014-07-25
US20130109694A1 (en) 2013-05-02
TWI498330B (zh) 2015-09-01
WO2012017030A1 (en) 2012-02-09
PT2601193E (pt) 2015-05-18
CO6680629A2 (es) 2013-05-31
CL2013000331A1 (es) 2013-06-28
PH12013500219A1 (en) 2013-02-25
DK2601193T3 (en) 2015-03-23
ES2538998T3 (es) 2015-06-25
SG187175A1 (en) 2013-02-28
ME02061B (me) 2015-05-20
AU2011287584A1 (en) 2013-02-07
ZA201300432B (en) 2014-08-27
BR112013003675A2 (pt) 2016-09-06
RS53990B1 (sr) 2015-10-30
AR082472A1 (es) 2012-12-12
CY1116238T1 (el) 2017-02-08
SI2601193T1 (sl) 2015-05-29
JP5886285B2 (ja) 2016-03-16
EA201270817A1 (ru) 2013-05-30
EA021567B1 (ru) 2015-07-30
EP2601193A1 (en) 2013-06-12
JP2013532714A (ja) 2013-08-19
CA2805358A1 (en) 2012-02-09
US8618100B2 (en) 2013-12-31
TW201211048A (en) 2012-03-16
KR20130033440A (ko) 2013-04-03
AU2011287584B2 (en) 2014-05-01
CN103038234A (zh) 2013-04-10
MX2013001246A (es) 2013-03-21
HK1180690A1 (en) 2013-10-25
BR112013003675A8 (pt) 2017-12-26
KR101499368B1 (ko) 2015-03-05
CA2805358C (en) 2016-02-16

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Granted publication date: 20160224

Termination date: 20170804