SG153822A1 - Novel oxabispidine compounds and their use in the treatment of cardiac arrhythmias - Google Patents

Novel oxabispidine compounds and their use in the treatment of cardiac arrhythmias

Info

Publication number
SG153822A1
SG153822A1 SG200904004-9A SG2009040049A SG153822A1 SG 153822 A1 SG153822 A1 SG 153822A1 SG 2009040049 A SG2009040049 A SG 2009040049A SG 153822 A1 SG153822 A1 SG 153822A1
Authority
SG
Singapore
Prior art keywords
treatment
cardiac arrhythmias
oxabispidine compounds
novel
novel oxabispidine
Prior art date
Application number
SG200904004-9A
Other languages
English (en)
Inventor
Annika Bjoere
Peter Bonn
Ulrik Gran
Johan Kajanus
Christina Olsson
Fritiof Ponten
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32710059&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG153822(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SG153822A1 publication Critical patent/SG153822A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG200904004-9A 2004-06-15 2005-06-13 Novel oxabispidine compounds and their use in the treatment of cardiac arrhythmias SG153822A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0401539A SE0401539D0 (sv) 2004-06-15 2004-06-15 New compounds

Publications (1)

Publication Number Publication Date
SG153822A1 true SG153822A1 (en) 2009-07-29

Family

ID=32710059

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200904004-9A SG153822A1 (en) 2004-06-15 2005-06-13 Novel oxabispidine compounds and their use in the treatment of cardiac arrhythmias

Country Status (22)

Country Link
US (2) US7648985B2 (zh)
EP (1) EP1765832B8 (zh)
JP (1) JP2008502678A (zh)
KR (1) KR20070039045A (zh)
CN (2) CN101525339A (zh)
AR (1) AR049823A1 (zh)
AU (2) AU2005254924B2 (zh)
BR (1) BRPI0512012A (zh)
CA (1) CA2568895A1 (zh)
DK (1) DK1765832T3 (zh)
ES (1) ES2434043T3 (zh)
IL (1) IL179560A0 (zh)
MX (1) MXPA06014692A (zh)
NO (1) NO20070148L (zh)
RU (1) RU2379311C9 (zh)
SE (1) SE0401539D0 (zh)
SG (1) SG153822A1 (zh)
TW (1) TW200612907A (zh)
UA (1) UA85877C2 (zh)
UY (1) UY28959A1 (zh)
WO (1) WO2005123748A1 (zh)
ZA (2) ZA200610418B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
AR057064A1 (es) * 2005-06-13 2007-11-14 Astrazeneca Ab Compuestos para el tratamiento de arritmias cardiacas, formulacion farmaceutica y preparacion del compuesto
TW200734342A (en) * 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
AU2009259494A1 (en) 2008-06-16 2009-12-23 F. Hoffmann-La Roche Ag Heteroaromatic monoamides as orexinin receptor antagonists
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
WO2010059119A1 (en) * 2008-11-21 2010-05-27 Astrazeneca Ab A combination of tert -butyl (2-{7- [2- (4-cyano-2- f luorophenoxy) ethyl] -9-oxa-3, 7-diazabicyclo [3.3.1] non-3- yl } ethyl) carbamate and certain antiarrhythmic benzofurans
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
CN117384037B (zh) * 2023-12-13 2024-03-08 山东国邦药业有限公司 一种二氟乙酸乙酯的制备方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196154A (en) * 1962-05-17 1965-07-20 Sterling Drug Inc 3-substituted-9-methyl-3, 9-diazabicyclo [3.3.1] nonanes
US3503939A (en) * 1967-03-29 1970-03-31 Du Pont Polyamides from heterocyclic diamines
CH488048A (de) 1969-06-12 1970-03-31 Inventa Ag Verfahren zur Herstellung von Polyesterfasern mit verbesserter Gummihaftung
DE2428792A1 (de) 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
JPS5772977A (en) 1980-10-23 1982-05-07 Dainippon Ink & Chem Inc Fluorine-containing diepoxy compound and its preparation
DE3112055A1 (de) 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
US4533713A (en) * 1983-05-06 1985-08-06 Minnesota Mining And Manufacturing Company Fluoroaliphaticsulfonamides containing oxirane groups and/or N-β-hydroxyalkylene groups
PT88381B (pt) 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5140033A (en) * 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
FI100151B (fi) 1992-09-04 1997-09-30 Nokia Mobile Phones Ltd Tehonsäästö matkaviestimessä
US5294621A (en) * 1992-10-07 1994-03-15 Ortho Pharmaceutical Corporation Thieno tetrahydropyridines useful as class III antiarrhythmic agents
JPH06284071A (ja) 1993-01-27 1994-10-07 Casio Comput Co Ltd 無線受信機
US5468858A (en) 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
FR2713081B1 (fr) 1993-11-29 1996-01-12 Celsa Lg Filtre sanguin perfectionné à deux séries de pattes en pétales.
US5831099A (en) * 1995-03-10 1998-11-03 The United States Of America As Represented By The Secretary Of The Army Compounds of 1,5-disubstituted-3,7 diaza bicyclo 3.3.0! octanes and products containing the same
SE9704709D0 (sv) 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
NZ514477A (en) 1999-04-09 2003-04-29 Astrazeneca Ab Adamantane derivatives
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
AR030756A1 (es) * 2000-10-02 2003-09-03 Astrazeneca Ab Compuesto de oxabispidina util en el tratamiento de arritmias cardiacas
SE0101327D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
SE0101323D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0101324D0 (sv) * 2001-04-12 2001-04-12 Astrazeneca Ab New process
SE0201662D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Pharmaceutical combination
GB0223712D0 (en) 2002-10-14 2002-11-20 Astrazeneca Ab Chemical intermediate
SE0401539D0 (sv) 2004-06-15 2004-06-15 Astrazeneca Ab New compounds
SE0401540D0 (sv) * 2004-06-15 2004-06-15 Astrazeneca Ab New compounds

Also Published As

Publication number Publication date
RU2379311C9 (ru) 2010-05-27
JP2008502678A (ja) 2008-01-31
RU2379311C2 (ru) 2010-01-20
KR20070039045A (ko) 2007-04-11
ZA200610418B (en) 2008-07-30
AU2005254924B2 (en) 2009-08-27
TW200612907A (en) 2006-05-01
WO2005123748A1 (en) 2005-12-29
IL179560A0 (en) 2007-05-15
US20090270383A1 (en) 2009-10-29
AR049823A1 (es) 2006-09-06
UA85877C2 (uk) 2009-03-10
MXPA06014692A (es) 2007-02-12
ES2434043T3 (es) 2013-12-13
AU2005254924A1 (en) 2005-12-29
AU2009222548A1 (en) 2009-10-22
SE0401539D0 (sv) 2004-06-15
UY28959A1 (es) 2006-01-31
US20090005558A1 (en) 2009-01-01
EP1765832A1 (en) 2007-03-28
EP1765832B8 (en) 2013-09-25
US7648985B2 (en) 2010-01-19
CA2568895A1 (en) 2005-12-29
NO20070148L (no) 2007-01-09
RU2006145202A (ru) 2008-07-20
BRPI0512012A (pt) 2008-02-06
CN1968956A (zh) 2007-05-23
CN101525339A (zh) 2009-09-09
DK1765832T3 (da) 2013-10-21
EP1765832B1 (en) 2013-08-14
ZA200710111B (en) 2009-08-26

Similar Documents

Publication Publication Date Title
SG153822A1 (en) Novel oxabispidine compounds and their use in the treatment of cardiac arrhythmias
WO2004101528A3 (en) Isoquinoline derivatives and their use as gfat inhibitors
MX2009006742A (es) Inhibidores acilaminopirazoles como fgfr.
WO2008123469A1 (ja) ６員環アミド化合物およびその用途
HK1167607A1 (en) Quinoline derivative-containing pharmaceutical composition
EE05556B1 (et) 3-hüdroksü-3-metüülglutarüüli koensüümi kasutamine reduktaasi inhibiitorina ravimi valmistamiseks diabeetilise neuropaatia raviks
IL179634A0 (en) 5-substituted-2-phenylamino-benzamides as mek inhibitor
IL181281A0 (en) Extended release pellet formulation containing pramipexole of a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
WO2006126082A3 (en) Pyridine [3,4-b] pyrazinones as pde-5 inhibitors
WO2005103037A3 (de) Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
WO2002094203A3 (en) Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
WO2004074218A3 (en) Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
HK1104974A1 (en) Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof
IL164302A (en) Substituted benzazoles, compositions and use thereof in the manufacture of a medicament for the inhibition of raf kinase activity
EP1505068A4 (en) PYRAZOLO (1,5-a) PYRIMIDINE DERIVATIVE AND INHIBITOR OF NAD (P) H OXIDASE CONTAINING SAID DERIVATIVE
WO2006126081A3 (en) Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors
NZ544009A (en) Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
WO2005092304A3 (en) Antifungal agents
NZ545506A (en) Therapeutic agents useful for treating pain
GEP20104878B (en) Inhibitors of microsomal triglyceride transfer protein and apo-b secretion
WO2006043149A3 (en) Novel dicarboxylic acid derivatives
EG25619A (en) New process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds and application in the synthesis of iv abradine and addition saltsthereof wwith a pharmaceutically acceptable acid
WO2007017695A3 (en) Dihydroxyanthraquinones and their use
UA96969C2 (en) Acylaminopyrazoles as fgfr inhibitors
EP2005954A4 (en) KIT FOR CANCER THERAPY AND PHARMACEUTICAL COMPOSITION FOR CANCER THERAPY