WO2006126081A3 - Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors - Google Patents
Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors Download PDFInfo
- Publication number
- WO2006126081A3 WO2006126081A3 PCT/IB2006/001386 IB2006001386W WO2006126081A3 WO 2006126081 A3 WO2006126081 A3 WO 2006126081A3 IB 2006001386 W IB2006001386 W IB 2006001386W WO 2006126081 A3 WO2006126081 A3 WO 2006126081A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pyrazinones
- pyridino
- pde
- inhibitors
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of Formula (I), wherein R2, Y6, R6A, R6, and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002603830A CA2603830A1 (en) | 2005-05-24 | 2006-05-17 | Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68413005P | 2005-05-24 | 2005-05-24 | |
US60/684,130 | 2005-05-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006126081A2 WO2006126081A2 (en) | 2006-11-30 |
WO2006126081A3 true WO2006126081A3 (en) | 2007-01-18 |
Family
ID=37046762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2006/001386 WO2006126081A2 (en) | 2005-05-24 | 2006-05-17 | Pyridino [2 , 3-b] pyrazinones as pde-5 inhibitors |
Country Status (2)
Country | Link |
---|---|
CA (1) | CA2603830A1 (en) |
WO (1) | WO2006126081A2 (en) |
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AU2009221213B2 (en) | 2008-03-05 | 2014-02-27 | Merck Patent Gmbh | Pyridopyrazinones derivatives insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
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CA2872154C (en) | 2012-05-04 | 2016-08-23 | Pfizer Inc. | Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of app, bace1 and bace2 |
CA2882389A1 (en) | 2012-09-20 | 2014-03-27 | Pfizer Inc. | Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
UA110688C2 (en) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Bicyclic pirydynony |
JP2016502978A (en) | 2012-12-11 | 2016-02-01 | ファイザー・インク | Hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of BACE1 |
JP6162820B2 (en) | 2012-12-19 | 2017-07-12 | ファイザー・インク | Carbocyclic and heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds |
WO2014125394A1 (en) | 2013-02-13 | 2014-08-21 | Pfizer Inc. | HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS |
US9233981B1 (en) | 2013-02-15 | 2016-01-12 | Pfizer Inc. | Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds |
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WO2015049616A1 (en) | 2013-10-04 | 2015-04-09 | Pfizer Inc. | Novel bicyclic pyridinones as gamma-secretase modulators |
AU2015242330B2 (en) | 2014-04-01 | 2017-08-17 | Pfizer Inc. | Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators |
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WO2016012896A1 (en) | 2014-07-24 | 2016-01-28 | Pfizer Inc. | Pyrazolopyrimidine compounds |
EP3177624B1 (en) | 2014-08-06 | 2019-05-01 | Pfizer Inc | Imidazopyridazine compounds |
WO2016125048A1 (en) | 2015-02-03 | 2016-08-11 | Pfizer Inc. | Novel cyclopropabenzofuranyl pyridopyrazinediones |
CA2989456C (en) | 2015-06-17 | 2022-01-04 | Pfizer Inc. | Tricyclic compounds and their use as phosphodiesterase inhibitors |
JP2018531924A (en) | 2015-09-24 | 2018-11-01 | ファイザー・インク | Tetrahydropyrano [3,4-D] [1,3] oxazine derivatives and their use as BACE inhibitors |
WO2017051294A1 (en) | 2015-09-24 | 2017-03-30 | Pfizer Inc. | N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors |
JP2018531923A (en) | 2015-09-24 | 2018-11-01 | ファイザー・インク | N- [2- (2-Amino-6,6-disubstituted-4,4a, 5,6-tetrahydropyrano [3,4-d] [1,3] thiazin-8a (8H) -yl)- 1,3-thiazol-4-yl] amide |
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JP7046018B2 (en) | 2016-07-01 | 2022-04-01 | ファイザー・インク | 5,7-Dihydropyrrolopyridine derivative for treating neurological and neurodegenerative diseases |
US11198692B2 (en) | 2017-06-22 | 2021-12-14 | Pfizer Inc. | Dihydro-pyrrolo-pyridine derivatives |
CN109400463B (en) * | 2017-08-16 | 2021-10-22 | 北京颖泰嘉和生物科技股份有限公司 | Preparation method of 2-n-propoxyacetyl chloride |
FI3768669T3 (en) | 2018-03-23 | 2023-04-26 | Pfizer | Piperazine azaspiro derivaves |
BR112021013924A2 (en) | 2019-01-18 | 2021-09-21 | Astrazeneca Ab | PCSK9 INHIBITORS AND METHODS OF USING THEM |
WO2024118524A1 (en) | 2022-11-28 | 2024-06-06 | Cerevel Therapeutics, Llc | Azaindole compounds and their use as phosphodiesterase inhibitors |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996001825A1 (en) * | 1994-07-11 | 1996-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Heterobicyclic derivatives |
WO1997024355A1 (en) * | 1995-12-27 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Pyrido (2,3-b) pyrazine derivatives |
US20020147199A1 (en) * | 2000-03-14 | 2002-10-10 | Degenhard Marx | Process for the treatment of erectile dysfunction and product therefor |
EP1364950A1 (en) * | 2001-02-26 | 2003-11-26 | Tanabe Seiyaku Co., Ltd. | Pyridopyrimidine or naphthyridine derivative |
-
2006
- 2006-05-17 CA CA002603830A patent/CA2603830A1/en active Pending
- 2006-05-17 WO PCT/IB2006/001386 patent/WO2006126081A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996001825A1 (en) * | 1994-07-11 | 1996-01-25 | Fujisawa Pharmaceutical Co., Ltd. | Heterobicyclic derivatives |
WO1997024355A1 (en) * | 1995-12-27 | 1997-07-10 | Fujisawa Pharmaceutical Co., Ltd. | Pyrido (2,3-b) pyrazine derivatives |
US20020147199A1 (en) * | 2000-03-14 | 2002-10-10 | Degenhard Marx | Process for the treatment of erectile dysfunction and product therefor |
EP1364950A1 (en) * | 2001-02-26 | 2003-11-26 | Tanabe Seiyaku Co., Ltd. | Pyridopyrimidine or naphthyridine derivative |
Also Published As
Publication number | Publication date |
---|---|
CA2603830A1 (en) | 2006-11-30 |
WO2006126081A2 (en) | 2006-11-30 |
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