SG149880A1 - Novel inhibitors of chymase - Google Patents

Novel inhibitors of chymase

Info

Publication number
SG149880A1
SG149880A1 SG200900530-7A SG2009005307A SG149880A1 SG 149880 A1 SG149880 A1 SG 149880A1 SG 2009005307 A SG2009005307 A SG 2009005307A SG 149880 A1 SG149880 A1 SG 149880A1
Authority
SG
Singapore
Prior art keywords
chymase
novel inhibitors
methods
intermediates
derivatives
Prior art date
Application number
SG200900530-7A
Other languages
English (en)
Inventor
Michael J Hawkins
Michael N Greco
Eugene Powell
Bruce E Maryanoff
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of SG149880A1 publication Critical patent/SG149880A1/en

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
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SG200900530-7A 2004-01-23 2005-01-18 Novel inhibitors of chymase SG149880A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53866304P 2004-01-23 2004-01-23

Publications (1)

Publication Number Publication Date
SG149880A1 true SG149880A1 (en) 2009-02-27

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SG200900530-7A SG149880A1 (en) 2004-01-23 2005-01-18 Novel inhibitors of chymase

Country Status (24)

Country Link
US (2) US7459444B2 (fr)
EP (1) EP1716160B1 (fr)
JP (1) JP5022711B2 (fr)
KR (1) KR101182143B1 (fr)
CN (2) CN1934120B (fr)
AR (1) AR047448A1 (fr)
AT (1) ATE493421T1 (fr)
AU (1) AU2005207856B2 (fr)
BR (1) BRPI0507052A (fr)
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EP2463268B1 (fr) 2004-12-02 2013-08-28 Daiichi Sankyo Company, Limited Acides 4-(aminométhyl)benzoïques comme intermédiaires pour la préparation de composés 1,4-diazépan-2,5-dione inhibant la chymase
KR20080085093A (ko) * 2006-01-12 2008-09-22 얀센 파마슈티카 엔.브이. 키마아제에 의한 ｓｌｐｉ의 프로세싱
US7897781B2 (en) * 2006-05-10 2011-03-01 Janssen Pharmaceutica Nv Cold menthol receptor-1 antagonists
US8629281B2 (en) 2011-01-14 2014-01-14 Janssen Pharmaceutica, Nv Cold menthol receptor-1 antagonists
MX2008015196A (es) 2006-05-31 2008-12-15 Asubio Pharma Co Ltd Compuesto de anillo de 7 miembros, proceso para producir el mismo, y su uso medico.
CA2666658C (fr) 2006-10-06 2015-01-20 Boehringer Ingelheim International Gmbh Inhibiteurs de chymase
EP2097399A4 (fr) * 2006-10-18 2011-02-09 Janssen Pharmaceutica Nv Nouveaux inhibiteurs de chymase
UY30648A1 (es) * 2006-10-20 2008-05-02 Janssen Pharmaceutica Nv Formas salinas de compuestos de benzotienilo sustituido
US20080287398A1 (en) * 2007-05-02 2008-11-20 Colburn Raymond W Cold menthol receptor-1 antagonists
CN101827599B (zh) * 2007-10-16 2013-08-28 詹森药业有限公司 用于合成膦酸和次膦酸化合物的方法
WO2009102384A2 (fr) * 2007-12-21 2009-08-20 Molecular Insight Pharmaceuticals, Inc. Dérivés d’inhibiteurs de la chymase marqués radioactivement
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
WO2010051372A1 (fr) * 2008-10-29 2010-05-06 Janssen Pharmaceutica Nv Procédé de préparation de modulateurs de chymase
WO2010088195A1 (fr) 2009-01-30 2010-08-05 Boehringer Ingelheim International Gmbh Azaquinazolinediones inhibiteurs de chymase
US8193372B2 (en) * 2009-03-04 2012-06-05 Idenix Pharmaceuticals, Inc. Phosphothiophene and phosphothiazole HCV polymerase inhibitors
CA2784180C (fr) * 2009-12-25 2014-03-11 Daiichi Sankyo Company, Limited Compose de type cycle a sept chainons et utilisation pharmaceutique associee
US8558011B2 (en) 2010-08-31 2013-10-15 Janssen Pharmaceutica, Nv Cold menthol receptor-1 antagonists
CN106467515B (zh) * 2015-08-18 2019-09-24 宁波洞密生物科技有限公司 一类6-吡啶苯并咪唑吲哚衍生物及其制备方法与医药领域的应用
CN107573263B (zh) * 2017-08-14 2020-04-07 大连理工大学 一种ω-取代缩二脲类化合物的合成方法
CN108383875B (zh) * 2018-03-22 2020-04-28 昆明学院 一种银催化的3-膦酰甲基吲哚啉及制备方法
CN115873037A (zh) * 2022-11-30 2023-03-31 南通大学 一种膦化氮杂吲哚啉的合成方法

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BRPI0507052A (pt) 2007-06-12
IL177037A (en) 2013-05-30
IL177037A0 (en) 2006-12-10
ES2357013T3 (es) 2011-04-15
ECSP066721A (es) 2006-10-31
ZA200607024B (en) 2010-02-24
CN101863923B (zh) 2013-04-24
US7459444B2 (en) 2008-12-02
HK1148753A1 (en) 2011-09-16
CR8563A (es) 2009-01-14
CN1934120B (zh) 2010-05-26
AU2005207856A1 (en) 2005-08-11
CN101863923A (zh) 2010-10-20
AU2005207856B2 (en) 2011-07-14
EA200601358A1 (ru) 2007-02-27
CA2554205A1 (fr) 2005-08-11
MXPA06008375A (es) 2007-03-21
US20050176769A1 (en) 2005-08-11
EA011745B1 (ru) 2009-06-30
JP2007518807A (ja) 2007-07-12
KR20060129401A (ko) 2006-12-15
NO20063647L (no) 2006-10-19
DE602005025600D1 (de) 2011-02-10
CN1934120A (zh) 2007-03-21
WO2005073214A2 (fr) 2005-08-11
AR047448A1 (es) 2006-01-18
ATE493421T1 (de) 2011-01-15
KR101182143B1 (ko) 2012-09-13
CA2554205C (fr) 2013-08-27
WO2005073214A3 (fr) 2005-10-20
TW200539881A (en) 2005-12-16
EP1716160A2 (fr) 2006-11-02
JP5022711B2 (ja) 2012-09-12
NZ548684A (en) 2009-04-30
EP1716160B1 (fr) 2010-12-29

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