HK1148753A1 - Novel inhibitors of chymase - Google Patents

Novel inhibitors of chymase

Info

Publication number
HK1148753A1
HK1148753A1 HK11102953.8A HK11102953A HK1148753A1 HK 1148753 A1 HK1148753 A1 HK 1148753A1 HK 11102953 A HK11102953 A HK 11102953A HK 1148753 A1 HK1148753 A1 HK 1148753A1
Authority
HK
Hong Kong
Prior art keywords
chymase
novel inhibitors
methods
intermediates
derivatives
Prior art date
Application number
HK11102953.8A
Other languages
English (en)
Inventor
Michael J Hawkins
Michael N Greco
Eugene Powell
Lawrence De Garavilla
Bruce E Maryanoff
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1148753A1 publication Critical patent/HK1148753A1/xx

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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
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HK11102953.8A 2004-01-23 2011-03-23 Novel inhibitors of chymase HK1148753A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53866304P 2004-01-23 2004-01-23

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HK1148753A1 true HK1148753A1 (en) 2011-09-16

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Country Status (24)

Country Link
US (2) US7459444B2 (fr)
EP (1) EP1716160B1 (fr)
JP (1) JP5022711B2 (fr)
KR (1) KR101182143B1 (fr)
CN (2) CN1934120B (fr)
AR (1) AR047448A1 (fr)
AT (1) ATE493421T1 (fr)
AU (1) AU2005207856B2 (fr)
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KR20080085093A (ko) * 2006-01-12 2008-09-22 얀센 파마슈티카 엔.브이. 키마아제에 의한 ｓｌｐｉ의 프로세싱
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CA2666658C (fr) 2006-10-06 2015-01-20 Boehringer Ingelheim International Gmbh Inhibiteurs de chymase
EP2097399A4 (fr) * 2006-10-18 2011-02-09 Janssen Pharmaceutica Nv Nouveaux inhibiteurs de chymase
UY30648A1 (es) * 2006-10-20 2008-05-02 Janssen Pharmaceutica Nv Formas salinas de compuestos de benzotienilo sustituido
US20080287398A1 (en) * 2007-05-02 2008-11-20 Colburn Raymond W Cold menthol receptor-1 antagonists
CN101827599B (zh) * 2007-10-16 2013-08-28 詹森药业有限公司 用于合成膦酸和次膦酸化合物的方法
WO2009102384A2 (fr) * 2007-12-21 2009-08-20 Molecular Insight Pharmaceuticals, Inc. Dérivés d’inhibiteurs de la chymase marqués radioactivement
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
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WO2010088195A1 (fr) 2009-01-30 2010-08-05 Boehringer Ingelheim International Gmbh Azaquinazolinediones inhibiteurs de chymase
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CA2784180C (fr) * 2009-12-25 2014-03-11 Daiichi Sankyo Company, Limited Compose de type cycle a sept chainons et utilisation pharmaceutique associee
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CN106467515B (zh) * 2015-08-18 2019-09-24 宁波洞密生物科技有限公司 一类6-吡啶苯并咪唑吲哚衍生物及其制备方法与医药领域的应用
CN107573263B (zh) * 2017-08-14 2020-04-07 大连理工大学 一种ω-取代缩二脲类化合物的合成方法
CN108383875B (zh) * 2018-03-22 2020-04-28 昆明学院 一种银催化的3-膦酰甲基吲哚啉及制备方法
CN115873037A (zh) * 2022-11-30 2023-03-31 南通大学 一种膦化氮杂吲哚啉的合成方法

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BRPI0507052A (pt) 2007-06-12
IL177037A (en) 2013-05-30
IL177037A0 (en) 2006-12-10
ES2357013T3 (es) 2011-04-15
ECSP066721A (es) 2006-10-31
ZA200607024B (en) 2010-02-24
CN101863923B (zh) 2013-04-24
US7459444B2 (en) 2008-12-02
CR8563A (es) 2009-01-14
CN1934120B (zh) 2010-05-26
AU2005207856A1 (en) 2005-08-11
CN101863923A (zh) 2010-10-20
AU2005207856B2 (en) 2011-07-14
EA200601358A1 (ru) 2007-02-27
CA2554205A1 (fr) 2005-08-11
MXPA06008375A (es) 2007-03-21
US20050176769A1 (en) 2005-08-11
EA011745B1 (ru) 2009-06-30
JP2007518807A (ja) 2007-07-12
KR20060129401A (ko) 2006-12-15
NO20063647L (no) 2006-10-19
DE602005025600D1 (de) 2011-02-10
CN1934120A (zh) 2007-03-21
SG149880A1 (en) 2009-02-27
WO2005073214A2 (fr) 2005-08-11
AR047448A1 (es) 2006-01-18
ATE493421T1 (de) 2011-01-15
KR101182143B1 (ko) 2012-09-13
CA2554205C (fr) 2013-08-27
WO2005073214A3 (fr) 2005-10-20
TW200539881A (en) 2005-12-16
EP1716160A2 (fr) 2006-11-02
JP5022711B2 (ja) 2012-09-12
NZ548684A (en) 2009-04-30
EP1716160B1 (fr) 2010-12-29

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