SG148180A1 - Improved halohydrin dehalogenases and related polynucleotides - Google Patents
Improved halohydrin dehalogenases and related polynucleotidesInfo
- Publication number
- SG148180A1 SG148180A1 SG200808477-4A SG2008084774A SG148180A1 SG 148180 A1 SG148180 A1 SG 148180A1 SG 2008084774 A SG2008084774 A SG 2008084774A SG 148180 A1 SG148180 A1 SG 148180A1
- Authority
- SG
- Singapore
- Prior art keywords
- related polynucleotides
- polynucleotides
- improved halohydrin
- polypeptides
- halohydrin dehalogenases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49438203P | 2003-08-11 | 2003-08-11 | |
US54603304P | 2004-02-18 | 2004-02-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG148180A1 true SG148180A1 (en) | 2008-12-31 |
Family
ID=34197997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200808477-4A SG148180A1 (en) | 2003-08-11 | 2004-08-11 | Improved halohydrin dehalogenases and related polynucleotides |
Country Status (12)
Country | Link |
---|---|
US (3) | US7824898B2 (es) |
EP (1) | EP1654356A1 (es) |
JP (1) | JP2007502123A (es) |
KR (1) | KR20060064617A (es) |
AU (1) | AU2004265693A1 (es) |
BR (1) | BRPI0413501A (es) |
CA (1) | CA2535255A1 (es) |
IL (1) | IL173261A0 (es) |
MX (1) | MXPA06001725A (es) |
NO (1) | NO20060405L (es) |
SG (1) | SG148180A1 (es) |
WO (1) | WO2005017141A1 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE501264T1 (de) | 2002-08-09 | 2011-03-15 | Codexis Inc | Enzymatische verfahren zur herstellung 4- substituierter 3-hydroxybuttersäure-derivate |
US7588928B2 (en) * | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
US7541171B2 (en) | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
JP2007502111A (ja) * | 2003-08-11 | 2007-02-08 | コデクシス, インコーポレイテッド | 4−置換3−ヒドロキシ酪酸誘導体およびビシナルなシアノ,ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス |
BRPI0413501A (pt) | 2003-08-11 | 2006-10-10 | Codexis Inc | polipetìdeo, polinucleotìdeo isolado ou recombinante, vetor de expressão, célula hospedeira, e, método de preparar um polipetìdeo de hhdh |
ATE556141T1 (de) | 2005-12-21 | 2012-05-15 | Basf Se | Verfahren zur herstellung eines optisch angereicherten tertiären alkohols |
ATE437954T1 (de) | 2006-03-03 | 2009-08-15 | Basf Se | Verfahren zur herstellung optisch aktiver 5- substituierter 2-oxazolidinone aus racemischen epoxiden und cyanat unter einsatz einer halohydrin-dehalogenase |
EP2066788B1 (en) | 2006-10-02 | 2014-07-23 | Codexis, Inc. | Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor |
WO2008108466A1 (ja) | 2007-03-07 | 2008-09-12 | Mitsubishi Rayon Co., Ltd. | 改良型ハロヒドリンエポキシダーゼ |
US7977078B2 (en) | 2007-08-24 | 2011-07-12 | Codexis, Inc. | Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane |
US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
EP2285958B1 (en) | 2008-06-13 | 2016-03-09 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
US8288131B2 (en) | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
US8426178B2 (en) | 2008-08-27 | 2013-04-23 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
US8187856B2 (en) | 2008-12-18 | 2012-05-29 | Codexis, Inc. | Recombinant halohydrin dehalogenase polypeptides |
EP2401366B1 (en) | 2009-02-26 | 2013-12-18 | Codexis, Inc. | Transaminase biocatalysts |
HUE055413T2 (hu) | 2009-06-22 | 2021-11-29 | Codexis Inc | Ketoreduktáz-közvetített sztereoszelektív útvonal alfa-klóralkoholokhoz |
CN102597226B (zh) | 2009-06-22 | 2015-08-19 | 科德克希思公司 | 转氨酶反应 |
US20110082055A1 (en) * | 2009-09-18 | 2011-04-07 | Codexis, Inc. | Reduced codon mutagenesis |
DK3301208T3 (da) | 2009-09-18 | 2020-12-14 | Codexis Inc | Reduceret codon-mutagenese |
SI2510089T1 (sl) | 2009-12-08 | 2015-12-31 | Codexis, Inc. | Sinteza prazolnih spojin |
US9040262B2 (en) | 2010-05-04 | 2015-05-26 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
WO2012024104A2 (en) | 2010-08-16 | 2012-02-23 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine |
DK2649187T3 (da) | 2010-12-08 | 2018-01-29 | Codexis Inc | Biokatalysatorer og fremgangsmåder til syntesen af armodafinil |
EP2697662B1 (en) | 2011-04-13 | 2018-06-06 | Codexis, Inc. | Biocatalytic process for preparing eslicarbazepine and analogs thereof |
IN2014CN04470A (es) | 2011-11-18 | 2015-09-04 | Codexis Inc | |
CN104428313B (zh) | 2012-05-11 | 2017-11-17 | 科德克希思公司 | 工程化亚胺还原酶以及用于酮和胺化合物的还原胺化的方法 |
CN104372038A (zh) * | 2013-08-12 | 2015-02-25 | 南京朗恩生物科技有限公司 | 两步催化制备(r)-4-氰基-3-羟基丁酸乙酯的方法 |
JP6643987B2 (ja) | 2013-11-13 | 2020-02-12 | コデクシス, インコーポレイテッド | ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法 |
EP3224354B1 (en) | 2014-11-25 | 2021-01-13 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
DK3256577T3 (da) | 2015-02-10 | 2020-09-14 | Codexis Inc | Ketoreduktase polypeptider til syntesen af chirale forbindelser |
CN104745557B (zh) * | 2015-03-05 | 2017-09-22 | 浙江工业大学 | 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用 |
CN106139887A (zh) | 2015-05-13 | 2016-11-23 | 三星电子株式会社 | 包含编码具有羟化酶活性的蛋白质的基因的微生物和使用其降低样品中氟化甲烷浓度的方法 |
US10358632B2 (en) | 2015-12-07 | 2019-07-23 | Samsung Electronics Co., Ltd. | Bacterial cytochrome P450 protein variant and method of reducing concentration of fluorinated methane in sample using the same |
EP3587393B1 (en) | 2018-06-21 | 2024-01-17 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Enzymatic process for the preparation of droxidopa |
CN109295044A (zh) * | 2018-10-26 | 2019-02-01 | 浙江大学 | 一种卤醇脱卤酶突变体及其应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5210031A (en) | 1989-07-20 | 1993-05-11 | Nitto Chemical Industry Co., Ltd. | Process for the production of R(-)-4-halo-3-hydroxybutyronitrile |
JP2840722B2 (ja) | 1989-07-20 | 1998-12-24 | 日東化学工業株式会社 | 4‐ハロ‐3‐ヒドロキシブチロニトリルの製造法 |
JP3073037B2 (ja) | 1991-03-04 | 2000-08-07 | 三菱レイヨン株式会社 | ハロヒドリンエポキシダ−ゼ遺伝子を有する組換え体プラスミドおよび該プラスミドにより形質転換された微生物 |
JP3171931B2 (ja) | 1992-06-02 | 2001-06-04 | 高砂香料工業株式会社 | (R)−(−)−4−シアノ−3−ヒドロキシ酪酸t−ブチルエステル及びその製造方法 |
GB9512837D0 (en) | 1995-06-23 | 1995-08-23 | Zeneca Ltd | reduction of ketone groups |
US5908953A (en) | 1996-12-18 | 1999-06-01 | Mitsubishi Chemical Corporation | Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester |
JP3728045B2 (ja) | 1997-01-31 | 2005-12-21 | 三菱レイヨン株式会社 | ハロヒドリンより光学活性ジオールへの変換を触媒する新規なタンパク質 |
EP0879890A1 (en) | 1997-05-21 | 1998-11-25 | Rijksuniversiteit te Groningen | Enantioselective epoxide hydrolases and genes encoding these |
WO1999032434A1 (en) | 1997-12-19 | 1999-07-01 | Warner-Lambert Export Limited | Process for the synthesis of 1,3-diols |
CA2329893A1 (en) | 1998-04-30 | 1999-11-11 | Kaneka Corporation | Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives |
EP1619191B1 (en) | 1998-08-05 | 2010-10-27 | Kaneka Corporation | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl] acetic acid derivatives |
WO2001004336A1 (de) | 1999-07-09 | 2001-01-18 | Forschungszentrum Jülich GmbH | Verfahren zur reduktion von keto-carbonsäuren und deren estern |
CA2360376C (en) | 1999-12-03 | 2005-04-26 | Noriyuki Kizaki | Novel carbonyl reductase, gene thereof and method of using the same |
EP1158054A1 (en) | 2000-05-25 | 2001-11-28 | Rijksuniversiteit te Groningen | Enzymatic conversion of epoxides |
ATE501264T1 (de) | 2002-08-09 | 2011-03-15 | Codexis Inc | Enzymatische verfahren zur herstellung 4- substituierter 3-hydroxybuttersäure-derivate |
BRPI0413501A (pt) | 2003-08-11 | 2006-10-10 | Codexis Inc | polipetìdeo, polinucleotìdeo isolado ou recombinante, vetor de expressão, célula hospedeira, e, método de preparar um polipetìdeo de hhdh |
US7541171B2 (en) | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
US7588928B2 (en) | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
JP2007502111A (ja) | 2003-08-11 | 2007-02-08 | コデクシス, インコーポレイテッド | 4−置換3−ヒドロキシ酪酸誘導体およびビシナルなシアノ,ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス |
-
2004
- 2004-08-11 BR BRPI0413501-6A patent/BRPI0413501A/pt not_active IP Right Cessation
- 2004-08-11 MX MXPA06001725A patent/MXPA06001725A/es unknown
- 2004-08-11 AU AU2004265693A patent/AU2004265693A1/en not_active Abandoned
- 2004-08-11 CA CA002535255A patent/CA2535255A1/en not_active Abandoned
- 2004-08-11 WO PCT/US2004/026654 patent/WO2005017141A1/en active Application Filing
- 2004-08-11 EP EP04781364A patent/EP1654356A1/en not_active Withdrawn
- 2004-08-11 KR KR1020067002876A patent/KR20060064617A/ko not_active Application Discontinuation
- 2004-08-11 SG SG200808477-4A patent/SG148180A1/en unknown
- 2004-08-11 US US10/917,179 patent/US7824898B2/en active Active
- 2004-08-11 JP JP2006523447A patent/JP2007502123A/ja active Pending
-
2006
- 2006-01-19 IL IL173261A patent/IL173261A0/en unknown
- 2006-01-25 NO NO20060405A patent/NO20060405L/no not_active Application Discontinuation
-
2009
- 2009-10-05 US US12/573,824 patent/US8101395B2/en active Active
-
2012
- 2012-01-12 US US13/349,514 patent/US8535910B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20060064617A (ko) | 2006-06-13 |
NO20060405L (no) | 2006-03-10 |
MXPA06001725A (es) | 2006-04-27 |
AU2004265693A1 (en) | 2005-02-24 |
US8535910B2 (en) | 2013-09-17 |
US7824898B2 (en) | 2010-11-02 |
JP2007502123A (ja) | 2007-02-08 |
US20100167345A1 (en) | 2010-07-01 |
BRPI0413501A (pt) | 2006-10-10 |
US20120208259A1 (en) | 2012-08-16 |
US20050153417A1 (en) | 2005-07-14 |
EP1654356A1 (en) | 2006-05-10 |
WO2005017141A1 (en) | 2005-02-24 |
CA2535255A1 (en) | 2005-02-24 |
IL173261A0 (en) | 2006-06-11 |
US8101395B2 (en) | 2012-01-24 |
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