IN2014CN04470A - - Google Patents

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Publication number
IN2014CN04470A
IN2014CN04470A IN4470CHN2014A IN2014CN04470A IN 2014CN04470 A IN2014CN04470 A IN 2014CN04470A IN 4470CHN2014 A IN4470CHN2014 A IN 4470CHN2014A IN 2014CN04470 A IN2014CN04470 A IN 2014CN04470A
Authority
IN
India
Prior art keywords
ketoreductase polypeptides
preparation
present disclosure
making
methods
Prior art date
Application number
Other languages
English (en)
Inventor
Fabien Cabirol
Haibin Chen
Anupam Gohel
Steven J Collier
Derek Smith
Birgit Kosjek
Jacob Janey
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of IN2014CN04470A publication Critical patent/IN2014CN04470A/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/001Amines; Imines
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/02Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184Carbonyl reductase (NADPH) (1.1.1.184)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IN4470CHN2014 2011-11-18 2012-11-14 IN2014CN04470A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161561665P 2011-11-18 2011-11-18
PCT/US2012/065046 WO2013074650A1 (en) 2011-11-18 2012-11-14 Biocatalysts for the preparation of hydroxy substituted carbamates

Publications (1)

Publication Number Publication Date
IN2014CN04470A true IN2014CN04470A (es) 2015-09-04

Family

ID=47295185

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4470CHN2014 IN2014CN04470A (es) 2011-11-18 2012-11-14

Country Status (8)

Country Link
US (8) US9139819B2 (es)
EP (1) EP2780448B1 (es)
CN (2) CN106479990B (es)
HU (1) HUE046089T2 (es)
IL (1) IL232621B (es)
IN (1) IN2014CN04470A (es)
SG (1) SG11201402401TA (es)
WO (1) WO2013074650A1 (es)

Families Citing this family (10)

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US7977078B2 (en) 2007-08-24 2011-07-12 Codexis, Inc. Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
EP2771006B1 (en) 2011-10-27 2016-05-25 Merck Sharp & Dohme Corp. Process for making beta 3 angonists and intermediates
US20150087832A1 (en) 2011-10-27 2015-03-26 Merck Sharp & Dohme, Corp. Process for making beta 3 agonists and intermediates
WO2013074650A1 (en) 2011-11-18 2013-05-23 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
WO2014150633A1 (en) * 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
SI2968269T1 (sl) 2013-03-15 2019-12-31 Merck Sharp & Dohme Corp. Postopek priprave antagonistov beta 3 in vmesnih spojin
EP3256577B1 (en) * 2015-02-10 2020-08-26 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CN106011095B (zh) * 2016-07-27 2021-02-26 苏州汉酶生物技术有限公司 工程化酮还原酶多肽及使用其制备依替米贝中间体的方法
CN109943543B (zh) * 2019-03-28 2020-12-11 上海健康医学院 醇脱氢酶突变体及其制备方法和应用
CN114410599B (zh) * 2022-01-29 2023-08-18 浙江工业大学 羰基还原酶突变体及其制备瑞舒伐他汀手性中间体的应用

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Also Published As

Publication number Publication date
IL232621A0 (en) 2014-06-30
US20160319247A1 (en) 2016-11-03
US11713451B2 (en) 2023-08-01
CN106479990B (zh) 2020-09-18
US9139819B2 (en) 2015-09-22
US10100287B2 (en) 2018-10-16
US20210071151A1 (en) 2021-03-11
US10253303B2 (en) 2019-04-09
US10851351B2 (en) 2020-12-01
SG11201402401TA (en) 2014-06-27
WO2013074650A1 (en) 2013-05-23
EP2780448B1 (en) 2019-09-11
IL232621B (en) 2019-10-31
HUE046089T2 (hu) 2020-01-28
US9422531B2 (en) 2016-08-23
CN104053771A (zh) 2014-09-17
US20240018489A1 (en) 2024-01-18
US20150344850A1 (en) 2015-12-03
CN104053771B (zh) 2016-11-09
US20180371427A1 (en) 2018-12-27
US20140322769A1 (en) 2014-10-30
EP2780448A1 (en) 2014-09-24
US20180010100A1 (en) 2018-01-11
US9803178B2 (en) 2017-10-31
CN106479990A (zh) 2017-03-08
US20190177702A1 (en) 2019-06-13

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