SI2968269T1 - Postopek priprave antagonistov beta 3 in vmesnih spojin - Google Patents
Postopek priprave antagonistov beta 3 in vmesnih spojinInfo
- Publication number
- SI2968269T1 SI2968269T1 SI201431333T SI201431333T SI2968269T1 SI 2968269 T1 SI2968269 T1 SI 2968269T1 SI 201431333 T SI201431333 T SI 201431333T SI 201431333 T SI201431333 T SI 201431333T SI 2968269 T1 SI2968269 T1 SI 2968269T1
- Authority
- SI
- Slovenia
- Prior art keywords
- agonists
- intermediates
- preparing beta
- beta
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791247P | 2013-03-15 | 2013-03-15 | |
| EP14768236.3A EP2968269B1 (en) | 2013-03-15 | 2014-03-12 | Process for preparing beta 3 agonists and intermediates |
| PCT/US2014/023858 WO2014150639A1 (en) | 2013-03-15 | 2014-03-12 | Process for preparing beta 3 agonists and intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2968269T1 true SI2968269T1 (sl) | 2019-12-31 |
Family
ID=51580798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201431333T SI2968269T1 (sl) | 2013-03-15 | 2014-03-12 | Postopek priprave antagonistov beta 3 in vmesnih spojin |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10287289B2 (sl) |
| EP (2) | EP2968269B1 (sl) |
| JP (1) | JP6383403B2 (sl) |
| CY (1) | CY1122690T1 (sl) |
| DK (1) | DK2968269T3 (sl) |
| ES (1) | ES2746801T3 (sl) |
| HR (1) | HRP20191546T1 (sl) |
| HU (1) | HUE045260T2 (sl) |
| LT (1) | LT2968269T (sl) |
| ME (1) | ME03506B (sl) |
| PL (1) | PL2968269T3 (sl) |
| PT (1) | PT2968269T (sl) |
| RS (1) | RS59402B1 (sl) |
| SI (1) | SI2968269T1 (sl) |
| WO (1) | WO2014150639A1 (sl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2770996B1 (en) | 2011-10-27 | 2016-09-28 | Merck Sharp & Dohme Corp. | Process for making beta 3 agonists and intermediates |
| US9809536B2 (en) | 2011-10-27 | 2017-11-07 | Merck Sharp & Dohme Corp. | Process for making beta 3 agonists and intermediates |
| RS59402B1 (sr) | 2013-03-15 | 2019-11-29 | Merck Sharp & Dohme | Postupak za pripremu beta 3 agonista i međuproizvoda |
| CN104496875B (zh) * | 2014-12-12 | 2017-09-08 | 常州大学 | 2‑烯丙基‑2‑甲醛基‑n‑苯基吡咯碄的合成方法 |
| JP2020522560A (ja) | 2017-06-06 | 2020-07-30 | ウロバント サイエンシズ ゲゼルシャフト ミット ベシュレンクター ハフトゥングＵｒｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ | 過活動膀胱を治療するためのビベグロンの使用 |
| WO2018224990A1 (en) | 2017-06-06 | 2018-12-13 | Urovant Sciences Gmbh | Dosing of vibegron for treatment of overactive bladder |
| TW202015692A (zh) | 2018-05-23 | 2020-05-01 | 瑞士商優洛凡特科學公司 | 維貝格龍（ｖｉｂｅｇｒｏｎ）於治療與腸躁症候群相關之疼痛之用途 |
| CA3115190A1 (en) | 2018-12-05 | 2020-06-11 | Urovant Sciences Gmbh | Vibegron for the treatment of overactive bladder symptoms |
| KR20210142004A (ko) | 2019-03-18 | 2021-11-23 | 유로반트 사이언시즈 게엠베하 | 과민성 방광을 치료하기 위한 비베그론의 용도 |
| CA3202926A1 (en) | 2020-12-22 | 2022-06-30 | Paul N. Mudd Jr. | Methods of monitoring digoxin with concomitant use of vibegron to treat overactive bladder |
| WO2022175848A1 (en) | 2021-02-16 | 2022-08-25 | Urovant Sciences Gmbh | Methods of treating heart failure with vibegron |
| CN113816917B (zh) * | 2021-11-19 | 2022-02-18 | 奥锐特药业(天津)有限公司 | 一种维贝格龙中间体的制备方法 |
| CN115850286B (zh) * | 2022-12-05 | 2023-08-22 | 奥锐特药业(天津)有限公司 | 一种维贝格龙中间体及其制备方法 |
| CN117467628B (zh) * | 2023-09-18 | 2024-04-16 | 长兴制药股份有限公司 | 一种酮还原酶及其制备高光学纯度β-3肾上腺素能激动剂中间体的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6525202B2 (en) | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
| DOP2003000587A (es) | 2002-02-27 | 2003-08-30 | Pfizer Prod Inc | AGONISTAS DEL RECEPTOR ß3-ADRENERGICO |
| FR2874011B1 (fr) | 2004-08-03 | 2007-06-15 | Sanofi Synthelabo | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| JP5973131B2 (ja) | 2007-09-13 | 2016-08-23 | コデクシス， インコーポレイテッド | アセトフェノンの還元のためのケトレダクターゼポリペプチド |
| PE20091825A1 (es) | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
| CN102186972B (zh) | 2008-08-29 | 2014-08-20 | 科德克希思公司 | 用于立体选择性生产(4s)-3-[(5s)-5-(4-氟苯基)-5-羟基戊酰基]-4-苯基-1，3-噁唑烷-2-酮的酮还原酶多肽 |
| CN102638987A (zh) * | 2009-10-07 | 2012-08-15 | 默沙东公司 | 使用β3肾上腺素能受体激动剂和抗毒蕈碱药剂的组合疗法 |
| EP2563123B1 (en) | 2010-04-30 | 2018-04-25 | Merck Sharp & Dohme Corp. | Novel beta 3 adrenergic receptor agonists |
| US9809536B2 (en) | 2011-10-27 | 2017-11-07 | Merck Sharp & Dohme Corp. | Process for making beta 3 agonists and intermediates |
| EP2770996B1 (en) | 2011-10-27 | 2016-09-28 | Merck Sharp & Dohme Corp. | Process for making beta 3 agonists and intermediates |
| SG11201402401TA (en) | 2011-11-18 | 2014-06-27 | Codexis Inc | Biocatalysts for the preparation of hydroxy substituted carbamates |
| RS59402B1 (sr) | 2013-03-15 | 2019-11-29 | Merck Sharp & Dohme | Postupak za pripremu beta 3 agonista i međuproizvoda |
-
2014
- 2014-03-12 RS RSP20191136 patent/RS59402B1/sr unknown
- 2014-03-12 US US14/776,366 patent/US10287289B2/en active Active
- 2014-03-12 WO PCT/US2014/023858 patent/WO2014150639A1/en active Application Filing
- 2014-03-12 PL PL14768236T patent/PL2968269T3/pl unknown
- 2014-03-12 PT PT147682363T patent/PT2968269T/pt unknown
- 2014-03-12 SI SI201431333T patent/SI2968269T1/sl unknown
- 2014-03-12 EP EP14768236.3A patent/EP2968269B1/en active Active
- 2014-03-12 ES ES14768236T patent/ES2746801T3/es active Active
- 2014-03-12 DK DK14768236.3T patent/DK2968269T3/da active
- 2014-03-12 LT LT14768236T patent/LT2968269T/lt unknown
- 2014-03-12 ME MEP-2019-255A patent/ME03506B/me unknown
- 2014-03-12 HU HUE14768236A patent/HUE045260T2/hu unknown
- 2014-03-12 JP JP2016501364A patent/JP6383403B2/ja active Active
- 2014-03-12 EP EP19184972.8A patent/EP3597737A1/en active Pending
-
2019
- 2019-03-11 US US16/298,467 patent/US10696681B2/en active Active
- 2019-08-28 HR HRP20191546 patent/HRP20191546T1/hr unknown
- 2019-10-09 CY CY20191101059T patent/CY1122690T1/el unknown
-
2020
- 2020-06-26 US US16/914,138 patent/US11091493B2/en active Active
-
2021
- 2021-08-11 US US17/399,274 patent/US11649243B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2746801T3 (es) | 2020-03-06 |
| EP2968269A4 (en) | 2016-12-28 |
| US10696681B2 (en) | 2020-06-30 |
| US11091493B2 (en) | 2021-08-17 |
| WO2014150639A1 (en) | 2014-09-25 |
| JP6383403B2 (ja) | 2018-08-29 |
| EP2968269A1 (en) | 2016-01-20 |
| US10287289B2 (en) | 2019-05-14 |
| US20170145014A1 (en) | 2017-05-25 |
| US20200392141A1 (en) | 2020-12-17 |
| HRP20191546T1 (hr) | 2019-11-29 |
| RS59402B1 (sr) | 2019-11-29 |
| HUE045260T2 (hu) | 2019-12-30 |
| US20190194211A1 (en) | 2019-06-27 |
| EP3597737A1 (en) | 2020-01-22 |
| EP2968269B1 (en) | 2019-07-10 |
| US11649243B2 (en) | 2023-05-16 |
| US20220073523A1 (en) | 2022-03-10 |
| JP2016515117A (ja) | 2016-05-26 |
| ME03506B (me) | 2020-04-20 |
| PT2968269T (pt) | 2019-10-08 |
| LT2968269T (lt) | 2019-10-25 |
| PL2968269T3 (pl) | 2020-03-31 |
| DK2968269T3 (da) | 2019-10-07 |
| CY1122690T1 (el) | 2021-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2968269A4 (en) | PROCESS FOR THE PREPARATION OF BETA-3 AGONISTS AND INTERMEDIATES | |
| HK1224287A1 (zh) | 二氫嘧啶衍生物的製備方法及其中間體 | |
| EP2981522A4 (en) | ANTAGONISTS OF PPAR | |
| EP2770996A4 (en) | METHOD OF PREPARING BETA-3-AGONISTS AND INTERMEDIATE PRODUCTS THEREOF | |
| IL242437B (en) | Compound 9, 5-dimethyl-9-hydroxy-decan-4-al, its use and its preparation process | |
| IL245474B (en) | Process for preparing 5-fluoro-1h-pyrazoles | |
| IL245476B (en) | Process for the preparation of 5-fluoro-1h-pyrazoles | |
| IL242943A0 (en) | A process for the preparation of abiraterone and its intermediates | |
| IL243455B (en) | A process for the preparation of fluoxastrobin | |
| SG11201601432WA (en) | Process for obtaining methionine | |
| EP2963105A4 (en) | CULTURE APPARATUS | |
| ZA201401073B (en) | Process for preparing atazanavir sulphate | |
| HK1219695A1 (zh) | 製備聚噁唑啉類的連續方法 | |
| HK1200874A1 (en) | Process for preparing insulin | |
| IL229326A (en) | Process for making n-iodine-affluent | |
| IL242897A0 (en) | A process for the preparation of pyridylpyrazole compounds and their derivatives from pyridylhydrazine | |
| GB201322992D0 (en) | New Process | |
| HK1220085A1 (zh) | 用於製備甜食的工序 | |
| SG11201602693QA (en) | Methods and intermediates for preparing macrolactams | |
| IL239815A0 (en) | Process for preparing derivatives of 4-methylpent-3-en-1-ol | |
| GB201317756D0 (en) | New process | |
| GB201313211D0 (en) | New process | |
| HK1213554A1 (zh) | 用於製備硼酸中間體的方法 | |
| GB201719307D0 (en) | Process for preparing ciomazone a novel form and use of the same | |
| IL244646A0 (en) | Process for preparing 5-fluoro-1-alkyl-3-fluoroalkyl-1h-pyrazole-4-carbaldehyde |