HUE045260T2 - Eljárás béta 3 antagonisták és köztitermékeik elõállítására - Google Patents

Eljárás béta 3 antagonisták és köztitermékeik elõállítására

Info

Publication number
HUE045260T2
HUE045260T2 HUE14768236A HUE14768236A HUE045260T2 HU E045260 T2 HUE045260 T2 HU E045260T2 HU E14768236 A HUE14768236 A HU E14768236A HU E14768236 A HUE14768236 A HU E14768236A HU E045260 T2 HUE045260 T2 HU E045260T2
Authority
HU
Hungary
Prior art keywords
agonists
intermediates
preparing beta
beta
preparing
Prior art date
Application number
HUE14768236A
Other languages
English (en)
Inventor
Feng Xu
Zhuqing Liu
Richard Desmond
Jeonghan Park
Alexei Kalinin
Birgit Kosjek
Hallena Strotman
Hongmei Li
Johannah Moncecchi
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51580798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE045260(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of HUE045260T2 publication Critical patent/HUE045260T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
HUE14768236A 2013-03-15 2014-03-12 Eljárás béta 3 antagonisták és köztitermékeik elõállítására HUE045260T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361791247P 2013-03-15 2013-03-15

Publications (1)

Publication Number Publication Date
HUE045260T2 true HUE045260T2 (hu) 2019-12-30

Family

ID=51580798

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE14768236A HUE045260T2 (hu) 2013-03-15 2014-03-12 Eljárás béta 3 antagonisták és köztitermékeik elõállítására

Country Status (15)

Country Link
US (4) US10287289B2 (hu)
EP (2) EP3597737A1 (hu)
JP (1) JP6383403B2 (hu)
CY (1) CY1122690T1 (hu)
DK (1) DK2968269T3 (hu)
ES (1) ES2746801T3 (hu)
HR (1) HRP20191546T1 (hu)
HU (1) HUE045260T2 (hu)
LT (1) LT2968269T (hu)
ME (1) ME03506B (hu)
PL (1) PL2968269T3 (hu)
PT (1) PT2968269T (hu)
RS (1) RS59402B1 (hu)
SI (1) SI2968269T1 (hu)
WO (1) WO2014150639A1 (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2584427T3 (es) 2011-10-27 2016-09-27 Merck Sharp & Dohme Corp. Proceso para la preparación de agonistas beta 3 y productos intermedios
JP6063948B2 (ja) 2011-10-27 2017-01-18 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ベータ３アゴニストおよび中間体を製造するプロセス
WO2014150639A1 (en) * 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Process for preparing beta 3 agonists and intermediates
CN104496875B (zh) * 2014-12-12 2017-09-08 常州大学 2‑烯丙基‑2‑甲醛基‑n‑苯基吡咯碄的合成方法
CN117695286A (zh) 2017-06-06 2024-03-15 住友制药(苏州)有限公司 使用维贝隆以治疗膀胱过度活动症
US20210077496A1 (en) 2017-06-06 2021-03-18 Urovant Sciences Gmbh Dosing of vibegron for treatment of overactive bladder
AU2019273837A1 (en) 2018-05-23 2020-11-19 Urovant Sciences Gmbh Use of vibegron to treat pain associated with irritable bowel syndrome
KR20210102892A (ko) 2018-12-05 2021-08-20 유로반트 사이언시즈 게엠베하 과민성 방광 증상의 치료를 위한 비베그론
AU2020243514A1 (en) 2019-03-18 2021-08-26 Urovant Sciences Gmbh Use of vibegron to treat overactive bladder
MX2023007413A (es) 2020-12-22 2023-07-21 Urovant Sciences Gmbh Metodos para monitorear digoxina con el uso de vibegron para tratar veiiga hiperactiva.
WO2022175848A1 (en) 2021-02-16 2022-08-25 Urovant Sciences Gmbh Methods of treating heart failure with vibegron
CN113816917B (zh) * 2021-11-19 2022-02-18 奥锐特药业(天津)有限公司 一种维贝格龙中间体的制备方法
CN115850286B (zh) * 2022-12-05 2023-08-22 奥锐特药业(天津)有限公司 一种维贝格龙中间体及其制备方法
CN117467628B (zh) * 2023-09-18 2024-04-16 长兴制药股份有限公司 一种酮还原酶及其制备高光学纯度β-3肾上腺素能激动剂中间体的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525202B2 (en) 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists
DOP2003000587A (es) 2002-02-27 2003-08-30 Pfizer Prod Inc AGONISTAS DEL RECEPTOR ß3-ADRENERGICO
FR2874011B1 (fr) 2004-08-03 2007-06-15 Sanofi Synthelabo Derives de sulfonamides, leur preparation et leur application en therapeutique
KR101586503B1 (ko) 2007-09-13 2016-01-18 코덱시스, 인코포레이티드 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드
PE20091825A1 (es) 2008-04-04 2009-12-04 Merck & Co Inc Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3
SI2329014T1 (sl) * 2008-08-29 2015-01-30 Codexis, Inc. Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona
NZ599233A (en) * 2009-10-07 2013-04-26 Merck Sharp & Dohme Combination therapy using a beta 3 adrenergic receptor agonist and an antimuscarinic agent
AU2011245499B2 (en) * 2010-04-30 2014-09-25 Merck Sharp & Dohme Corp. Novel beta 3 adrenergic receptor agonists
ES2584427T3 (es) 2011-10-27 2016-09-27 Merck Sharp & Dohme Corp. Proceso para la preparación de agonistas beta 3 y productos intermedios
JP6063948B2 (ja) 2011-10-27 2017-01-18 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ベータ３アゴニストおよび中間体を製造するプロセス
WO2013074650A1 (en) * 2011-11-18 2013-05-23 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
WO2014150639A1 (en) 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Process for preparing beta 3 agonists and intermediates

Also Published As

Publication number Publication date
JP2016515117A (ja) 2016-05-26
JP6383403B2 (ja) 2018-08-29
LT2968269T (lt) 2019-10-25
PL2968269T3 (pl) 2020-03-31
US20190194211A1 (en) 2019-06-27
ME03506B (me) 2020-04-20
ES2746801T3 (es) 2020-03-06
HRP20191546T1 (hr) 2019-11-29
US10287289B2 (en) 2019-05-14
US10696681B2 (en) 2020-06-30
US20170145014A1 (en) 2017-05-25
PT2968269T (pt) 2019-10-08
EP2968269B1 (en) 2019-07-10
EP2968269A1 (en) 2016-01-20
US20220073523A1 (en) 2022-03-10
US20200392141A1 (en) 2020-12-17
DK2968269T3 (da) 2019-10-07
SI2968269T1 (sl) 2019-12-31
RS59402B1 (sr) 2019-11-29
US11091493B2 (en) 2021-08-17
US11649243B2 (en) 2023-05-16
CY1122690T1 (el) 2021-03-12
EP3597737A1 (en) 2020-01-22
EP2968269A4 (en) 2016-12-28
WO2014150639A1 (en) 2014-09-25

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