CY1122690T1 - Διαδικασια για την παρασκευη βητα-3 αγωνιστων και ενδιαμεσων - Google Patents

Διαδικασια για την παρασκευη βητα-3 αγωνιστων και ενδιαμεσων

Info

Publication number
CY1122690T1
CY1122690T1 CY20191101059T CY191101059T CY1122690T1 CY 1122690 T1 CY1122690 T1 CY 1122690T1 CY 20191101059 T CY20191101059 T CY 20191101059T CY 191101059 T CY191101059 T CY 191101059T CY 1122690 T1 CY1122690 T1 CY 1122690T1
Authority
CY
Cyprus
Prior art keywords
intermediates
beta
friday
competitors
procedure
Prior art date
Application number
CY20191101059T
Other languages
English (en)
Inventor
Feng Xu
Zhuqing Liu
Richard Desmond
Jeonghan Park
Alexei Kalinin
Birgit Kosjek
Hallena Strotman
Hongmei Li
Johannah MONCECCHI
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51580798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1122690(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of CY1122690T1 publication Critical patent/CY1122690T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η εφαρμογή αναφέρεται σε αποτελεσματικές και οικονομικές διαδικασίες, όπως περιγράφονται λεπτομερέστερα κατωτέρω, για την παρασκευή των βήτα 3 αγωνιστών του τύπου I-7 και των ενδιάμεσων ενώσεων που μπορούν να χρησιμοποιηθούν για την παρασκευή αυτών των αγωνιστών. Η παρούσα αποκάλυψη σχετίζεται με μια διαδικασία παρασκευής βήτα-3 αγωνιστών και ενδιαμέσων, χρησιμοποιώντας ένζυμα βιοκαταλύτη κετορεδουκτάσης (KRED) και μεθόδους χρήσης των βιοκαταλυτών.
CY20191101059T 2013-03-15 2019-10-09 Διαδικασια για την παρασκευη βητα-3 αγωνιστων και ενδιαμεσων CY1122690T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361791247P 2013-03-15 2013-03-15
PCT/US2014/023858 WO2014150639A1 (en) 2013-03-15 2014-03-12 Process for preparing beta 3 agonists and intermediates

Publications (1)

Publication Number Publication Date
CY1122690T1 true CY1122690T1 (el) 2021-03-12

Family

ID=51580798

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191101059T CY1122690T1 (el) 2013-03-15 2019-10-09 Διαδικασια για την παρασκευη βητα-3 αγωνιστων και ενδιαμεσων

Country Status (15)

Country Link
US (4) US10287289B2 (el)
EP (2) EP2968269B1 (el)
JP (1) JP6383403B2 (el)
CY (1) CY1122690T1 (el)
DK (1) DK2968269T3 (el)
ES (1) ES2746801T3 (el)
HR (1) HRP20191546T1 (el)
HU (1) HUE045260T2 (el)
LT (1) LT2968269T (el)
ME (1) ME03506B (el)
PL (1) PL2968269T3 (el)
PT (1) PT2968269T (el)
RS (1) RS59402B1 (el)
SI (1) SI2968269T1 (el)
WO (1) WO2014150639A1 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150087832A1 (en) 2011-10-27 2015-03-26 Merck Sharp & Dohme, Corp. Process for making beta 3 agonists and intermediates
JP6088535B2 (ja) 2011-10-27 2017-03-08 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ベータ３アゴニストおよび中間体を製造するプロセス
SI2968269T1 (sl) * 2013-03-15 2019-12-31 Merck Sharp & Dohme Corp. Postopek priprave antagonistov beta 3 in vmesnih spojin
CN104496875B (zh) * 2014-12-12 2017-09-08 常州大学 2‑烯丙基‑2‑甲醛基‑n‑苯基吡咯碄的合成方法
CA3064973A1 (en) 2017-06-06 2018-12-13 Urovant Sciences Gmbh Dosing of vibegron for treatment of overactive bladder
EP4410295A2 (en) 2017-06-06 2024-08-07 Urovant Sciences GmbH Use of vibegron to treat overactive bladder
SG11202010683PA (en) 2018-05-23 2020-12-30 Urovant Sciences Gmbh Use of vibegron to treat pain associated with irritable bowel syndrome
AU2019393372A1 (en) 2018-12-05 2021-05-13 Urovant Sciences Gmbh Vibegron for the treatment of overactive bladder symptoms
EP3941473A1 (en) 2019-03-18 2022-01-26 Urovant Sciences GmbH Use of vibegron to treat overactive bladder
CA3202926A1 (en) 2020-12-22 2022-06-30 Paul N. Mudd Jr. Methods of monitoring digoxin with concomitant use of vibegron to treat overactive bladder
JP2024516061A (ja) 2021-02-16 2024-04-12 ウロバント サイエンシズ ゲーエムベーハー ビベグロンによる心不全の処置方法
CN113816917B (zh) * 2021-11-19 2022-02-18 奥锐特药业(天津)有限公司 一种维贝格龙中间体的制备方法
CN115850286B (zh) * 2022-12-05 2023-08-22 奥锐特药业(天津)有限公司 一种维贝格龙中间体及其制备方法
CN117467628B (zh) * 2023-09-18 2024-04-16 长兴制药股份有限公司 一种酮还原酶及其制备高光学纯度β-3肾上腺素能激动剂中间体的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6525202B2 (en) 2000-07-17 2003-02-25 Wyeth Cyclic amine phenyl beta-3 adrenergic receptor agonists
DOP2003000587A (es) 2002-02-27 2003-08-30 Pfizer Prod Inc AGONISTAS DEL RECEPTOR ß3-ADRENERGICO
FR2874011B1 (fr) 2004-08-03 2007-06-15 Sanofi Synthelabo Derives de sulfonamides, leur preparation et leur application en therapeutique
CN101855342B (zh) 2007-09-13 2013-07-10 科德克希思公司 用于还原苯乙酮的酮还原酶多肽
PE20091825A1 (es) 2008-04-04 2009-12-04 Merck & Co Inc Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3
SI2329014T1 (sl) * 2008-08-29 2015-01-30 Codexis, Inc. Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona
JP5738871B2 (ja) 2009-10-07 2015-06-24 メルク・シャープ・エンド・ドーム・コーポレイション β３アドレナリン作動性受容体アゴニスト及び抗ムスカリン剤を用いる併用療法
WO2011137054A1 (en) * 2010-04-30 2011-11-03 Merck Sharp & Dohme Corp. Novel beta 3 adrenergic receptor agonists
US20150087832A1 (en) 2011-10-27 2015-03-26 Merck Sharp & Dohme, Corp. Process for making beta 3 agonists and intermediates
JP6088535B2 (ja) 2011-10-27 2017-03-08 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ベータ３アゴニストおよび中間体を製造するプロセス
CN106479990B (zh) * 2011-11-18 2020-09-18 科德克希思公司 用于制备羟基取代的氨基甲酸酯的生物催化剂
SI2968269T1 (sl) 2013-03-15 2019-12-31 Merck Sharp & Dohme Corp. Postopek priprave antagonistov beta 3 in vmesnih spojin

Also Published As

Publication number Publication date
RS59402B1 (sr) 2019-11-29
HRP20191546T1 (hr) 2019-11-29
ME03506B (me) 2020-04-20
US20170145014A1 (en) 2017-05-25
PT2968269T (pt) 2019-10-08
DK2968269T3 (da) 2019-10-07
US20200392141A1 (en) 2020-12-17
US10696681B2 (en) 2020-06-30
SI2968269T1 (sl) 2019-12-31
US11091493B2 (en) 2021-08-17
EP3597737A1 (en) 2020-01-22
EP2968269A4 (en) 2016-12-28
US20190194211A1 (en) 2019-06-27
PL2968269T3 (pl) 2020-03-31
EP2968269B1 (en) 2019-07-10
JP2016515117A (ja) 2016-05-26
HUE045260T2 (hu) 2019-12-30
EP2968269A1 (en) 2016-01-20
WO2014150639A1 (en) 2014-09-25
US20220073523A1 (en) 2022-03-10
ES2746801T3 (es) 2020-03-06
US10287289B2 (en) 2019-05-14
JP6383403B2 (ja) 2018-08-29
LT2968269T (lt) 2019-10-25
US11649243B2 (en) 2023-05-16

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