CY1122690T1 - Διαδικασια για την παρασκευη βητα-3 αγωνιστων και ενδιαμεσων - Google Patents
Διαδικασια για την παρασκευη βητα-3 αγωνιστων και ενδιαμεσωνInfo
- Publication number
- CY1122690T1 CY1122690T1 CY20191101059T CY191101059T CY1122690T1 CY 1122690 T1 CY1122690 T1 CY 1122690T1 CY 20191101059 T CY20191101059 T CY 20191101059T CY 191101059 T CY191101059 T CY 191101059T CY 1122690 T1 CY1122690 T1 CY 1122690T1
- Authority
- CY
- Cyprus
- Prior art keywords
- intermediates
- beta
- friday
- competitors
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφαρμογή αναφέρεται σε αποτελεσματικές και οικονομικές διαδικασίες, όπως περιγράφονται λεπτομερέστερα κατωτέρω, για την παρασκευή των βήτα 3 αγωνιστών του τύπου I-7 και των ενδιάμεσων ενώσεων που μπορούν να χρησιμοποιηθούν για την παρασκευή αυτών των αγωνιστών. Η παρούσα αποκάλυψη σχετίζεται με μια διαδικασία παρασκευής βήτα-3 αγωνιστών και ενδιαμέσων, χρησιμοποιώντας ένζυμα βιοκαταλύτη κετορεδουκτάσης (KRED) και μεθόδους χρήσης των βιοκαταλυτών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361791247P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/023858 WO2014150639A1 (en) | 2013-03-15 | 2014-03-12 | Process for preparing beta 3 agonists and intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122690T1 true CY1122690T1 (el) | 2021-03-12 |
Family
ID=51580798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191101059T CY1122690T1 (el) | 2013-03-15 | 2019-10-09 | Διαδικασια για την παρασκευη βητα-3 αγωνιστων και ενδιαμεσων |
Country Status (15)
Country | Link |
---|---|
US (4) | US10287289B2 (el) |
EP (2) | EP2968269B1 (el) |
JP (1) | JP6383403B2 (el) |
CY (1) | CY1122690T1 (el) |
DK (1) | DK2968269T3 (el) |
ES (1) | ES2746801T3 (el) |
HR (1) | HRP20191546T1 (el) |
HU (1) | HUE045260T2 (el) |
LT (1) | LT2968269T (el) |
ME (1) | ME03506B (el) |
PL (1) | PL2968269T3 (el) |
PT (1) | PT2968269T (el) |
RS (1) | RS59402B1 (el) |
SI (1) | SI2968269T1 (el) |
WO (1) | WO2014150639A1 (el) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150087832A1 (en) | 2011-10-27 | 2015-03-26 | Merck Sharp & Dohme, Corp. | Process for making beta 3 agonists and intermediates |
JP6088535B2 (ja) | 2011-10-27 | 2017-03-08 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | ベータ3アゴニストおよび中間体を製造するプロセス |
SI2968269T1 (sl) * | 2013-03-15 | 2019-12-31 | Merck Sharp & Dohme Corp. | Postopek priprave antagonistov beta 3 in vmesnih spojin |
CN104496875B (zh) * | 2014-12-12 | 2017-09-08 | 常州大学 | 2‑烯丙基‑2‑甲醛基‑n‑苯基吡咯碄的合成方法 |
CA3064973A1 (en) | 2017-06-06 | 2018-12-13 | Urovant Sciences Gmbh | Dosing of vibegron for treatment of overactive bladder |
EP4410295A2 (en) | 2017-06-06 | 2024-08-07 | Urovant Sciences GmbH | Use of vibegron to treat overactive bladder |
SG11202010683PA (en) | 2018-05-23 | 2020-12-30 | Urovant Sciences Gmbh | Use of vibegron to treat pain associated with irritable bowel syndrome |
AU2019393372A1 (en) | 2018-12-05 | 2021-05-13 | Urovant Sciences Gmbh | Vibegron for the treatment of overactive bladder symptoms |
EP3941473A1 (en) | 2019-03-18 | 2022-01-26 | Urovant Sciences GmbH | Use of vibegron to treat overactive bladder |
CA3202926A1 (en) | 2020-12-22 | 2022-06-30 | Paul N. Mudd Jr. | Methods of monitoring digoxin with concomitant use of vibegron to treat overactive bladder |
JP2024516061A (ja) | 2021-02-16 | 2024-04-12 | ウロバント サイエンシズ ゲーエムベーハー | ビベグロンによる心不全の処置方法 |
CN113816917B (zh) * | 2021-11-19 | 2022-02-18 | 奥锐特药业(天津)有限公司 | 一种维贝格龙中间体的制备方法 |
CN115850286B (zh) * | 2022-12-05 | 2023-08-22 | 奥锐特药业(天津)有限公司 | 一种维贝格龙中间体及其制备方法 |
CN117467628B (zh) * | 2023-09-18 | 2024-04-16 | 长兴制药股份有限公司 | 一种酮还原酶及其制备高光学纯度β-3肾上腺素能激动剂中间体的方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6525202B2 (en) | 2000-07-17 | 2003-02-25 | Wyeth | Cyclic amine phenyl beta-3 adrenergic receptor agonists |
DOP2003000587A (es) | 2002-02-27 | 2003-08-30 | Pfizer Prod Inc | AGONISTAS DEL RECEPTOR ß3-ADRENERGICO |
FR2874011B1 (fr) | 2004-08-03 | 2007-06-15 | Sanofi Synthelabo | Derives de sulfonamides, leur preparation et leur application en therapeutique |
CN101855342B (zh) | 2007-09-13 | 2013-07-10 | 科德克希思公司 | 用于还原苯乙酮的酮还原酶多肽 |
PE20091825A1 (es) | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
SI2329014T1 (sl) * | 2008-08-29 | 2015-01-30 | Codexis, Inc. | Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona |
JP5738871B2 (ja) | 2009-10-07 | 2015-06-24 | メルク・シャープ・エンド・ドーム・コーポレイション | β3アドレナリン作動性受容体アゴニスト及び抗ムスカリン剤を用いる併用療法 |
WO2011137054A1 (en) * | 2010-04-30 | 2011-11-03 | Merck Sharp & Dohme Corp. | Novel beta 3 adrenergic receptor agonists |
US20150087832A1 (en) | 2011-10-27 | 2015-03-26 | Merck Sharp & Dohme, Corp. | Process for making beta 3 agonists and intermediates |
JP6088535B2 (ja) | 2011-10-27 | 2017-03-08 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | ベータ3アゴニストおよび中間体を製造するプロセス |
CN106479990B (zh) * | 2011-11-18 | 2020-09-18 | 科德克希思公司 | 用于制备羟基取代的氨基甲酸酯的生物催化剂 |
SI2968269T1 (sl) | 2013-03-15 | 2019-12-31 | Merck Sharp & Dohme Corp. | Postopek priprave antagonistov beta 3 in vmesnih spojin |
-
2014
- 2014-03-12 SI SI201431333T patent/SI2968269T1/sl unknown
- 2014-03-12 PL PL14768236T patent/PL2968269T3/pl unknown
- 2014-03-12 RS RSP20191136 patent/RS59402B1/sr unknown
- 2014-03-12 JP JP2016501364A patent/JP6383403B2/ja active Active
- 2014-03-12 ME MEP-2019-255A patent/ME03506B/me unknown
- 2014-03-12 WO PCT/US2014/023858 patent/WO2014150639A1/en active Application Filing
- 2014-03-12 HU HUE14768236A patent/HUE045260T2/hu unknown
- 2014-03-12 US US14/776,366 patent/US10287289B2/en active Active
- 2014-03-12 EP EP14768236.3A patent/EP2968269B1/en active Active
- 2014-03-12 EP EP19184972.8A patent/EP3597737A1/en active Pending
- 2014-03-12 ES ES14768236T patent/ES2746801T3/es active Active
- 2014-03-12 PT PT147682363T patent/PT2968269T/pt unknown
- 2014-03-12 DK DK14768236.3T patent/DK2968269T3/da active
- 2014-03-12 LT LT14768236T patent/LT2968269T/lt unknown
-
2019
- 2019-03-11 US US16/298,467 patent/US10696681B2/en active Active
- 2019-08-28 HR HRP20191546 patent/HRP20191546T1/hr unknown
- 2019-10-09 CY CY20191101059T patent/CY1122690T1/el unknown
-
2020
- 2020-06-26 US US16/914,138 patent/US11091493B2/en active Active
-
2021
- 2021-08-11 US US17/399,274 patent/US11649243B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
RS59402B1 (sr) | 2019-11-29 |
HRP20191546T1 (hr) | 2019-11-29 |
ME03506B (me) | 2020-04-20 |
US20170145014A1 (en) | 2017-05-25 |
PT2968269T (pt) | 2019-10-08 |
DK2968269T3 (da) | 2019-10-07 |
US20200392141A1 (en) | 2020-12-17 |
US10696681B2 (en) | 2020-06-30 |
SI2968269T1 (sl) | 2019-12-31 |
US11091493B2 (en) | 2021-08-17 |
EP3597737A1 (en) | 2020-01-22 |
EP2968269A4 (en) | 2016-12-28 |
US20190194211A1 (en) | 2019-06-27 |
PL2968269T3 (pl) | 2020-03-31 |
EP2968269B1 (en) | 2019-07-10 |
JP2016515117A (ja) | 2016-05-26 |
HUE045260T2 (hu) | 2019-12-30 |
EP2968269A1 (en) | 2016-01-20 |
WO2014150639A1 (en) | 2014-09-25 |
US20220073523A1 (en) | 2022-03-10 |
ES2746801T3 (es) | 2020-03-06 |
US10287289B2 (en) | 2019-05-14 |
JP6383403B2 (ja) | 2018-08-29 |
LT2968269T (lt) | 2019-10-25 |
US11649243B2 (en) | 2023-05-16 |
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