SG11202110956RA - Compositions and methods for t-cell receptor gene assembly - Google Patents

Compositions and methods for t-cell receptor gene assembly

Info

Publication number
SG11202110956RA
SG11202110956RA SG11202110956RA SG11202110956RA SG11202110956RA SG 11202110956R A SG11202110956R A SG 11202110956RA SG 11202110956R A SG11202110956R A SG 11202110956RA SG 11202110956R A SG11202110956R A SG 11202110956RA SG 11202110956R A SG11202110956R A SG 11202110956RA
Authority
SG
Singapore
Prior art keywords
compositions
methods
cell receptor
receptor gene
gene assembly
Prior art date
Application number
SG11202110956RA
Other languages
English (en)
Inventor
Xi Chen
Ely Porter
Original Assignee
Rootpath Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rootpath Genomics Inc filed Critical Rootpath Genomics Inc
Publication of SG11202110956RA publication Critical patent/SG11202110956RA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11202110956RA 2019-04-05 2020-04-03 Compositions and methods for t-cell receptor gene assembly SG11202110956RA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962829813P 2019-04-05 2019-04-05
US201962838465P 2019-04-25 2019-04-25
US201962898053P 2019-09-10 2019-09-10
US202062972231P 2020-02-10 2020-02-10
PCT/US2020/026558 WO2020206238A2 (en) 2019-04-05 2020-04-03 Compositions and methods for t-cell receptor gene assembly

Publications (1)

Publication Number Publication Date
SG11202110956RA true SG11202110956RA (en) 2021-10-28

Family

ID=72667365

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202110956RA SG11202110956RA (en) 2019-04-05 2020-04-03 Compositions and methods for t-cell receptor gene assembly

Country Status (11)

Country Link
US (2) US12365742B2 (https=)
EP (1) EP3947436A4 (https=)
JP (1) JP2022527364A (https=)
KR (1) KR20220004060A (https=)
CN (1) CN113906047B (https=)
AU (1) AU2020253491A1 (https=)
CA (1) CA3135850A1 (https=)
IL (1) IL286977A (https=)
MX (1) MX2021012207A (https=)
SG (1) SG11202110956RA (https=)
WO (1) WO2020206238A2 (https=)

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* Cited by examiner, † Cited by third party
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CN116298309B (zh) 2018-08-13 2024-04-02 根路径基因组学公司 成对的二分免疫受体多核苷酸的高通量克隆及其应用
WO2020206238A2 (en) 2019-04-05 2020-10-08 Rootpath Genomics, Inc. Compositions and methods for t-cell receptor gene assembly
WO2023096890A1 (en) * 2021-11-24 2023-06-01 Rootpath Genomics, Inc. Compositions and methods for polynucleotide assembly
CN116199749A (zh) * 2023-02-01 2023-06-02 北京可瑞生物科技有限公司 2A序列和/或截短的2A序列在TCR αβ单链扩增中的应用
CN116716327B (zh) * 2023-08-04 2023-10-20 科士华(南京)生物技术有限公司 一种构建tcr载体的方法

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Also Published As

Publication number Publication date
EP3947436A2 (en) 2022-02-09
IL286977A (en) 2021-12-01
CN113906047B (zh) 2025-02-14
US20220106377A1 (en) 2022-04-07
US12365742B2 (en) 2025-07-22
WO2020206238A2 (en) 2020-10-08
AU2020253491A1 (en) 2021-10-28
MX2021012207A (es) 2021-12-10
US11746162B2 (en) 2023-09-05
EP3947436A4 (en) 2022-12-28
US20220089785A1 (en) 2022-03-24
WO2020206238A3 (en) 2020-11-12
JP2022527364A (ja) 2022-06-01
CA3135850A1 (en) 2020-10-08
CN113906047A (zh) 2022-01-07
KR20220004060A (ko) 2022-01-11

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