实施例10抗-CD3抗体与高亲和性αβ异质二聚TCR的融合体的细胞功能及特异性
本实施例证明了抗-CD3抗体与高亲和性αβ异质二聚TCR的融合体能够介导效应细胞识别RHAMM抗原阳性癌细胞识别与激活功能。
将实施例八中制备的抗-CD3抗体与高亲和性αβ异质二聚TCR的融合体通过ELISPOT实验检测其在细胞中的功能及特异性。本领域技术人员熟知利用ELISPOT实验检测细胞功能的方法。本实施例IFN-γELISPOT实验中所用的效应细胞为从健康志愿者的血液中分离到的CD8+T细胞,靶细胞系为抗原(RHAMM)阳性的IM9(674)和Mel526(390)细胞,对照组为HLA阴性(A2-)的SK-BR-3细胞。
首先准备ELISPOT平板。实验第0天,ELISPOT平板乙醇活化包被,4℃过夜。实验第1天,去掉包被液,洗涤封闭,室温下孵育两个小时,去除封闭液,按以下顺序将试验的各个组分加入ELISPOT平板:培养基调整CD8+T细胞至8X104个细胞/毫升,培养基调整各靶细胞系至2X105个细胞/毫升,培养基将蛋白稀释至浓度为0.04μM,逐一10倍梯度稀释,共6个浓度梯度。混合均匀后取50μL蛋白稀释液、100μL靶细胞系2X105个细胞/毫升(即20,000个细胞/孔)、50μL效应细胞8X104个细胞/毫升(即40,00个效应细胞/孔)加入对应孔中,并设置二个复孔。温育过夜(37℃,5%CO2)。实验第2天,洗涤平板并进行二级检测和显色,干燥平板,再利用免疫斑点平板读数计(ELISPOT READER system;AID20公司)计数膜上形成的斑点。实验结果如图14所示,相较于对照组SK-BR-3细胞,抗-CD3抗体与高亲和性αβ异质二聚TCR的融合体介导的效应细胞在抗原(RHAMM)阳性的IM9和Mel526细胞系有特异性反应。
在本发明提及的所有文献都在本申请中引用作为参考,就如同每一篇文献被单独引用作为参考那样。此外应理解,在阅读了本发明的上述讲授内容之后,本领域技术人员可以对本发明作各种改动或修改,这些等价形式同样落于本申请所附权利要求书所限定的范围。
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<110> 广州市香雪制药股份有限公司
<120> 针对RHAMM抗原短肽的高亲和力T细胞受体
<130> P2016-1675
<150> CN201510570265.X
<151> 2015-09-09
<160> 84
<170> PatentIn version 3.5
<210> 1
<211> 247
<212> PRT
<213> 人工序列
<400> 1
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Arg Val Ser Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Ser Gly Tyr
85 90 95
Ala Leu Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Gly Thr Ser Asn Pro Asn Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Val Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Ala Ala
245
<210> 2
<211> 741
<212> DNA
<213> 人工序列
<400> 2
caaaaagaag ttgaacaaaa ctcaggcccg ctgtcggtcc cggaaggcga aaatgtctca 60
atcaactgta cctactcaga tcgtgtgtca cagtcgtttt tctggtatcg tcaatatccg 120
ggcaaaagtc cggaactgat tatgtcaatc tattcgaacg gcgataaaga agacggtcgt 180
ttcacggcac agctggataa aagctctcaa tatgttagcc tggaaattcg cgatattcag 240
ccgaacgaca gcgcgacgta tttttgcgcg gccaccaact ctggctacgc cctgaatttc 300
ggcaaaggca ccaaactgtc agtccataat ggcggtggca gcgaaggtgg cggttctgaa 360
ggcggtggca gtgaaggtgg cggttccgaa ggcggcaccg gttctcagac gattcaccaa 420
accccgcgta cgctgtcagt gccgaccggc tcgccggtta ccctggaatg tacggtcgaa 480
ggcacctcaa acccgaatct gtattggtat cgtcaagatc cgggccgtgg tctgcgcctg 540
ctgttttatt cggtgggcat tggtcagatc agttccgaag ttccgcaacg ctacagcgca 600
tctcgtccgc aggaccgcca atttgaactg agtatcaaaa aagtcacgcc gagtgattcc 660
gcattctatc tgtgcgcttg gtccgtggac ggtgctgaac agtactttgg tccgggcacc 720
cgtctggaag ttgatgcggc c 741
<210> 3
<211> 110
<212> PRT
<213> 人工序列
<400> 3
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Arg Val Ser Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Ser Gly Tyr
85 90 95
Ala Leu Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 4
<211> 113
<212> PRT
<213> 人工序列
<400> 4
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro Asn
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp Ala
100 105 110
Ala
<210> 5
<211> 24
<212> PRT
<213> 人工序列
<400> 5
Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly
1 5 10 15
Gly Gly Ser Glu Gly Gly Thr Gly
20
<210> 6
<211> 110
<212> PRT
<213> 人工序列
<400> 6
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Ser Gly Tyr
85 90 95
Ala Leu Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 7
<211> 110
<212> PRT
<213> 人工序列
<400> 7
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Lys Leu Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Ser Gly Tyr
85 90 95
Ala Leu Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 8
<211> 110
<212> PRT
<213> 人工序列
<400> 8
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Lys Leu Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
His Met Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 9
<211> 110
<212> PRT
<213> 人工序列
<400> 9
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Lys Leu Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 10
<211> 110
<212> PRT
<213> 人工序列
<400> 10
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 11
<211> 110
<212> PRT
<213> 人工序列
<400> 11
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Lys Leu Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
His Met Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 12
<211> 110
<212> PRT
<213> 人工序列
<400> 12
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Lys Leu Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
His Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 13
<211> 110
<212> PRT
<213> 人工序列
<400> 13
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ala
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
Val Met Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 14
<211> 110
<212> PRT
<213> 人工序列
<400> 14
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Arg Val Ser Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Phe Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 15
<211> 110
<212> PRT
<213> 人工序列
<400> 15
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Leu Tyr Arg Gly Gly Ser Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
His Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 16
<211> 110
<212> PRT
<213> 人工序列
<400> 16
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
His Met Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 17
<211> 110
<212> PRT
<213> 人工序列
<400> 17
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Met Leu Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
His Met Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 18
<211> 110
<212> PRT
<213> 人工序列
<400> 18
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Leu Tyr Arg Gly Gly Ser Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Leu Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 19
<211> 110
<212> PRT
<213> 人工序列
<400> 19
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 20
<211> 110
<212> PRT
<213> 人工序列
<400> 20
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Leu Tyr Arg Gly Gly Ser Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
Val Met Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 21
<211> 110
<212> PRT
<213> 人工序列
<400> 21
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Leu Tyr Arg Gly Gly Ser Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 22
<211> 110
<212> PRT
<213> 人工序列
<400> 22
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Leu Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn
100 105 110
<210> 23
<211> 113
<212> PRT
<213> 人工序列
<400> 23
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Pro His Ser Pro Arg Leu
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp Ala
100 105 110
Ala
<210> 24
<211> 113
<212> PRT
<213> 人工序列
<400> 24
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Leu Ser Asn Thr Arg Ala
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp Ala
100 105 110
Ala
<210> 25
<211> 113
<212> PRT
<213> 人工序列
<400> 25
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro Asn
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Val Arg Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp Ala
100 105 110
Ala
<210> 26
<211> 113
<212> PRT
<213> 人工序列
<400> 26
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro Asn
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ser Tyr Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp Ala
100 105 110
Ala
<210> 27
<211> 113
<212> PRT
<213> 人工序列
<400> 27
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Leu Arg Tyr Ile Arg Ala
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Val Arg Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp Ala
100 105 110
Ala
<210> 28
<211> 113
<212> PRT
<213> 人工序列
<400> 28
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Leu Arg Tyr Ile Arg Ala
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ala Trp Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp Ala
100 105 110
Ala
<210> 29
<211> 113
<212> PRT
<213> 人工序列
<400> 29
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Pro His Ser Pro Arg Leu
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ser Tyr Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp Ala
100 105 110
Ala
<210> 30
<211> 111
<212> PRT
<213> 人工序列
<400> 30
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Leu Asp Asp Leu Arg Ile
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ala Trp Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp
100 105 110
<210> 31
<211> 111
<212> PRT
<213> 人工序列
<400> 31
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Leu Arg Tyr Ile Arg Ala
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ser Tyr Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp
100 105 110
<210> 32
<211> 111
<212> PRT
<213> 人工序列
<400> 32
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Pro His Ser Pro Arg Leu
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ala Trp Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp
100 105 110
<210> 33
<211> 111
<212> PRT
<213> 人工序列
<400> 33
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Pro His Ser Pro Arg Leu
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Val Arg Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp
100 105 110
<210> 34
<211> 111
<212> PRT
<213> 人工序列
<400> 34
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Leu Asp Asp Leu Arg Ile
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ser Tyr Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp
100 105 110
<210> 35
<211> 111
<212> PRT
<213> 人工序列
<400> 35
Ser Gln Thr Ile His Gln Thr Pro Arg Thr Leu Ser Val Pro Thr Gly
1 5 10 15
Ser Pro Val Thr Leu Glu Cys Thr Val Glu Leu Asp Asp Leu Arg Ile
20 25 30
Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg Gly Leu Arg Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Arg Tyr
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Glu Leu Ser Ile Lys Lys
65 70 75 80
Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Glu Val Asp
100 105 110
<210> 36
<211> 111
<212> PRT
<213> 人工序列
<400> 36
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Val Ser Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Ser Gly Tyr
85 90 95
Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 37
<211> 111
<212> PRT
<213> 人工序列
<400> 37
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro Asn
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 38
<211> 204
<212> PRT
<213> 人工序列
<400> 38
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Val Ser Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Ser Gly Tyr
85 90 95
Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His Ile
100 105 110
Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser
115 120 125
Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val
130 135 140
Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu
145 150 155 160
Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser
165 170 175
Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile
180 185 190
Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser
195 200
<210> 39
<211> 241
<212> PRT
<213> 人工序列
<400> 39
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro Asn
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu
100 105 110
Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
115 120 125
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
130 135 140
Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
145 150 155 160
Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu
165 170 175
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
180 185 190
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
195 200 205
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
210 215 220
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
225 230 235 240
Asp
<210> 40
<211> 111
<212> PRT
<213> 人工序列
<400> 40
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Ser Gly Tyr
85 90 95
Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 41
<211> 111
<212> PRT
<213> 人工序列
<400> 41
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Lys Leu Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Ser Gly Tyr
85 90 95
Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 42
<211> 111
<212> PRT
<213> 人工序列
<400> 42
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Val Ser Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
His Met Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 43
<211> 111
<212> PRT
<213> 人工序列
<400> 43
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Val Ser Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 44
<211> 111
<212> PRT
<213> 人工序列
<400> 44
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 45
<211> 111
<212> PRT
<213> 人工序列
<400> 45
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Lys Leu Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
Val Met Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 46
<211> 111
<212> PRT
<213> 人工序列
<400> 46
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
His Ile Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 47
<211> 111
<212> PRT
<213> 人工序列
<400> 47
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ala
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
Val Met Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 48
<211> 111
<212> PRT
<213> 人工序列
<400> 48
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Val Ser Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Phe Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 49
<211> 111
<212> PRT
<213> 人工序列
<400> 49
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Leu Tyr Arg Gly Gly Ser Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
His Ile Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 50
<211> 111
<212> PRT
<213> 人工序列
<400> 50
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
His Met Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 51
<211> 111
<212> PRT
<213> 人工序列
<400> 51
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Met Leu Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
His Met Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 52
<211> 111
<212> PRT
<213> 人工序列
<400> 52
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Leu Tyr Arg Gly Gly Ser Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Leu Ile Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 53
<211> 111
<212> PRT
<213> 人工序列
<400> 53
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 54
<211> 111
<212> PRT
<213> 人工序列
<400> 54
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Leu Tyr Arg Gly Gly Ser Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
Val Met Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 55
<211> 111
<212> PRT
<213> 人工序列
<400> 55
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Leu Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 56
<211> 111
<212> PRT
<213> 人工序列
<400> 56
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Leu Ile Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His
100 105 110
<210> 57
<211> 111
<212> PRT
<213> 人工序列
<400> 57
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Pro His Ser Pro Arg Leu
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 58
<211> 111
<212> PRT
<213> 人工序列
<400> 58
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Leu Ser Asn Thr Arg Ala
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 59
<211> 111
<212> PRT
<213> 人工序列
<400> 59
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro Asn
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Val Arg Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 60
<211> 111
<212> PRT
<213> 人工序列
<400> 60
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro Asn
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ser Tyr Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 61
<211> 111
<212> PRT
<213> 人工序列
<400> 61
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Leu Arg Tyr Ile Arg Ala
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Val Arg Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 62
<211> 111
<212> PRT
<213> 人工序列
<400> 62
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Leu Arg Tyr Ile Arg Ala
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 63
<211> 111
<212> PRT
<213> 人工序列
<400> 63
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Pro His Ser Pro Arg Leu
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ser Tyr Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 64
<211> 111
<212> PRT
<213> 人工序列
<400> 64
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Leu Asp Asp Leu Arg Ile
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 65
<211> 111
<212> PRT
<213> 人工序列
<400> 65
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Leu Arg Tyr Ile Arg Ala
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ser Tyr Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 66
<211> 111
<212> PRT
<213> 人工序列
<400> 66
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Pro His Ser Pro Arg Leu
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 67
<211> 111
<212> PRT
<213> 人工序列
<400> 67
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Pro His Ser Pro Arg Leu
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Val Arg Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 68
<211> 111
<212> PRT
<213> 人工序列
<400> 68
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Leu Asp Asp Leu Arg Ile
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ser Tyr Ser Leu Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 69
<211> 111
<212> PRT
<213> 人工序列
<400> 69
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Leu Asp Asp Leu Arg Ile
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr
100 105 110
<210> 70
<211> 496
<212> PRT
<213> 人工序列
<400> 70
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Ser Gly Tyr
85 90 95
Ala Leu Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Gly Thr Ser Asn Pro Asn Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Val Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 71
<211> 496
<212> PRT
<213> 人工序列
<400> 71
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Leu Tyr Arg Gly Gly Ser Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
Val Met Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Leu Asp Asp Leu Arg Ile Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Leu Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 72
<211> 496
<212> PRT
<213> 人工序列
<400> 72
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Leu Arg Tyr Ile Arg Ala Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ser Tyr Ser Leu Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 73
<211> 496
<212> PRT
<213> 人工序列
<400> 73
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Asp
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Leu Arg Tyr Ile Arg Ala Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Leu Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 74
<211> 496
<212> PRT
<213> 人工序列
<400> 74
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
His Met Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Pro His Ser Pro Arg Leu Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Leu Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 75
<211> 496
<212> PRT
<213> 人工序列
<400> 75
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Tyr
85 90 95
His Met Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Pro His Ser Pro Arg Leu Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Val Arg Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Val Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 76
<211> 496
<212> PRT
<213> 人工序列
<400> 76
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Leu Tyr Arg Gly Gly Ser Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Leu Arg Tyr Ile Arg Ala Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Val Arg Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Val Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 77
<211> 496
<212> PRT
<213> 人工序列
<400> 77
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Leu Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Leu Asp Asp Leu Arg Ile Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ser Tyr Ser Leu Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 78
<211> 496
<212> PRT
<213> 人工序列
<400> 78
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Leu Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Leu Arg Tyr Ile Arg Ala Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Val Arg Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Val Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 79
<211> 496
<212> PRT
<213> 人工序列
<400> 79
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Leu Tyr Arg Gly Gly Ser Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
His Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Leu Ser Asn Thr Arg Ala Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Val Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 80
<211> 496
<212> PRT
<213> 人工序列
<400> 80
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Asp Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Leu Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Leu Asp Asp Leu Arg Ile Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Val Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 81
<211> 496
<212> PRT
<213> 人工序列
<400> 81
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
His Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Gly Thr Ser Asn Pro Asn Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Val Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 82
<211> 496
<212> PRT
<213> 人工序列
<400> 82
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Glu Asn Val Ser Ile Asn Cys Thr Tyr Ser Asp Ile Tyr Asn Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Pro Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Arg Asn Gly Thr Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asp Lys Ser Ser Gln Tyr Val Ser Leu Glu Ile Arg Asp Ile Gln
65 70 75 80
Pro Asn Asp Ser Ala Thr Tyr Phe Cys Ala Ala Thr Asn Asp Gly Ile
85 90 95
Ile Ile Asn Phe Gly Lys Gly Thr Lys Leu Ser Val His Asn Gly Gly
100 105 110
Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
115 120 125
Ser Glu Gly Gly Thr Gly Ser Gln Thr Ile His Gln Thr Pro Arg Thr
130 135 140
Leu Ser Val Pro Thr Gly Ser Pro Val Thr Leu Glu Cys Thr Val Glu
145 150 155 160
Leu Arg Tyr Ile Arg Ala Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Arg
165 170 175
Gly Leu Arg Leu Leu Phe Tyr Ser Val Gly Val Arg Gln Ile Ser Ser
180 185 190
Glu Val Pro Gln Arg Tyr Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe
195 200 205
Glu Leu Ser Ile Lys Lys Val Thr Pro Ser Asp Ser Ala Phe Tyr Leu
210 215 220
Cys Ala Trp Ser Val Asp Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr
225 230 235 240
Arg Leu Glu Val Asp Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu
245 250 255
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys
260 265 270
Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Arg
275 280 285
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro Tyr
290 295 300
Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr Ile
305 310 315 320
Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu
325 330 335
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr
340 345 350
Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu Val
355 360 365
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
370 375 380
Gly Gly Ser Gly Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu
385 390 395 400
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln
405 410 415
Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala
420 425 430
Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro
435 440 445
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile
450 455 460
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly
465 470 475 480
Asn Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
485 490 495
<210> 83
<211> 204
<212> PRT
<213> 人工序列
<400> 83
Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly
1 5 10 15
Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Val Ser Gln Ser
20 25 30
Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met
35 40 45
Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln
50 55 60
Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln
65 70 75 80
Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Thr Asn Ser Gly Tyr
85 90 95
Ala Leu Asn Phe Gly Lys Gly Thr Ser Leu Leu Val Thr Pro His Ile
100 105 110
Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser
115 120 125
Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val
130 135 140
Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu
145 150 155 160
Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser
165 170 175
Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile
180 185 190
Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser
195 200
<210> 84
<211> 241
<212> PRT
<213> 人工序列
<400> 84
Ser Gln Thr Ile His Gln Trp Pro Ala Thr Leu Val Gln Pro Val Gly
1 5 10 15
Ser Pro Leu Ser Leu Glu Cys Thr Val Glu Gly Thr Ser Asn Pro Asn
20 25 30
Leu Tyr Trp Tyr Arg Gln Ala Ala Gly Arg Gly Leu Gln Leu Leu Phe
35 40 45
Tyr Ser Val Gly Ile Gly Gln Ile Ser Ser Glu Val Pro Gln Asn Leu
50 55 60
Ser Ala Ser Arg Pro Gln Asp Arg Gln Phe Ile Leu Ser Ser Lys Lys
65 70 75 80
Leu Leu Leu Ser Asp Ser Gly Phe Tyr Leu Cys Ala Trp Ser Val Asp
85 90 95
Gly Ala Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu
100 105 110
Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser
115 120 125
Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala
130 135 140
Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly
145 150 155 160
Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu
165 170 175
Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg
180 185 190
Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln
195 200 205
Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg
210 215 220
Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala
225 230 235 240
Asp