AU2020253491A1 - Compositions and methods for T-cell receptor gene assembly - Google Patents

Compositions and methods for T-cell receptor gene assembly Download PDF

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Publication number
AU2020253491A1
AU2020253491A1 AU2020253491A AU2020253491A AU2020253491A1 AU 2020253491 A1 AU2020253491 A1 AU 2020253491A1 AU 2020253491 A AU2020253491 A AU 2020253491A AU 2020253491 A AU2020253491 A AU 2020253491A AU 2020253491 A1 AU2020253491 A1 AU 2020253491A1
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Prior art keywords
nucleic acid
tcr
acid molecule
sequence
cdr3
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Abandoned
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AU2020253491A
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English (en)
Inventor
Xi Chen
Ely PORTER
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Rootpath Genomics Inc
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Rootpath Genomics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2020253491A 2019-04-05 2020-04-03 Compositions and methods for T-cell receptor gene assembly Abandoned AU2020253491A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962829813P 2019-04-05 2019-04-05
US62/829,813 2019-04-05
US201962838465P 2019-04-25 2019-04-25
US62/838,465 2019-04-25
US201962898053P 2019-09-10 2019-09-10
US62/898,053 2019-09-10
US202062972231P 2020-02-10 2020-02-10
US62/972,231 2020-02-10
PCT/US2020/026558 WO2020206238A2 (en) 2019-04-05 2020-04-03 Compositions and methods for t-cell receptor gene assembly

Publications (1)

Publication Number Publication Date
AU2020253491A1 true AU2020253491A1 (en) 2021-10-28

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ID=72667365

Family Applications (1)

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AU2020253491A Abandoned AU2020253491A1 (en) 2019-04-05 2020-04-03 Compositions and methods for T-cell receptor gene assembly

Country Status (11)

Country Link
US (2) US12365742B2 (https=)
EP (1) EP3947436A4 (https=)
JP (1) JP2022527364A (https=)
KR (1) KR20220004060A (https=)
CN (1) CN113906047B (https=)
AU (1) AU2020253491A1 (https=)
CA (1) CA3135850A1 (https=)
IL (1) IL286977A (https=)
MX (1) MX2021012207A (https=)
SG (1) SG11202110956RA (https=)
WO (1) WO2020206238A2 (https=)

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WO2023096890A1 (en) * 2021-11-24 2023-06-01 Rootpath Genomics, Inc. Compositions and methods for polynucleotide assembly
CN116199749A (zh) * 2023-02-01 2023-06-02 北京可瑞生物科技有限公司 2A序列和/或截短的2A序列在TCR αβ单链扩增中的应用
CN116716327B (zh) * 2023-08-04 2023-10-20 科士华(南京)生物技术有限公司 一种构建tcr载体的方法

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Also Published As

Publication number Publication date
EP3947436A2 (en) 2022-02-09
SG11202110956RA (en) 2021-10-28
IL286977A (en) 2021-12-01
CN113906047B (zh) 2025-02-14
US20220106377A1 (en) 2022-04-07
US12365742B2 (en) 2025-07-22
WO2020206238A2 (en) 2020-10-08
MX2021012207A (es) 2021-12-10
US11746162B2 (en) 2023-09-05
EP3947436A4 (en) 2022-12-28
US20220089785A1 (en) 2022-03-24
WO2020206238A3 (en) 2020-11-12
JP2022527364A (ja) 2022-06-01
CA3135850A1 (en) 2020-10-08
CN113906047A (zh) 2022-01-07
KR20220004060A (ko) 2022-01-11

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