SG11202109603SA - Pyrazine derivative and application thereof in inhibiting shp2 - Google Patents
Pyrazine derivative and application thereof in inhibiting shp2Info
- Publication number
- SG11202109603SA SG11202109603SA SG11202109603SA SG11202109603SA SG 11202109603S A SG11202109603S A SG 11202109603SA SG 11202109603S A SG11202109603S A SG 11202109603SA SG 11202109603S A SG11202109603S A SG 11202109603SA
- Authority
- SG
- Singapore
- Prior art keywords
- application
- pyrazine derivative
- inhibiting shp2
- shp2
- inhibiting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910160960.7A CN111647000B (zh) | 2019-03-04 | 2019-03-04 | 吡嗪类衍生物及其在抑制shp2中的应用 |
PCT/CN2020/077391 WO2020177653A1 (fr) | 2019-03-04 | 2020-03-02 | Dérivé de pyrazine et son application dans l'inhibition de shp2 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202109603SA true SG11202109603SA (en) | 2021-10-28 |
Family
ID=72337672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202109603S SG11202109603SA (en) | 2019-03-04 | 2020-03-02 | Pyrazine derivative and application thereof in inhibiting shp2 |
Country Status (14)
Country | Link |
---|---|
US (2) | US20220127276A1 (fr) |
EP (1) | EP3936502A4 (fr) |
JP (1) | JP2022523786A (fr) |
KR (1) | KR20210135561A (fr) |
CN (2) | CN111647000B (fr) |
AU (1) | AU2020233038A1 (fr) |
BR (1) | BR112021017495A2 (fr) |
CA (1) | CA3132395A1 (fr) |
CL (1) | CL2021002308A1 (fr) |
CO (1) | CO2021013140A2 (fr) |
IL (1) | IL286069A (fr) |
MX (1) | MX2021010625A (fr) |
SG (1) | SG11202109603SA (fr) |
WO (1) | WO2020177653A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112867718A (zh) | 2018-09-29 | 2021-05-28 | 诺华股份有限公司 | 用于抑制shp2活性的化合物和组合物的制造 |
IL299131A (en) | 2020-06-18 | 2023-02-01 | Revolution Medicines Inc | Methods for delaying, preventing and treating acquired resistance to RAS inhibitors |
WO2022006780A1 (fr) * | 2020-07-08 | 2022-01-13 | Novartis Ag | Fabrication de composés et de compositions pour inhiber l'activité de shp2 |
EP4208261A1 (fr) | 2020-09-03 | 2023-07-12 | Revolution Medicines, Inc. | Utilisation d'inhibiteurs de sos1 pour traiter des malignités à mutations de shp2 |
EP4214209A1 (fr) | 2020-09-15 | 2023-07-26 | Revolution Medicines, Inc. | Dérivés d'indole servant d'inhibiteurs dans le traitement du cancer |
WO2022235866A1 (fr) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Inhibiteurs de ras covalents et leurs utilisations |
EP4334321A1 (fr) | 2021-05-05 | 2024-03-13 | Revolution Medicines, Inc. | Inhibiteurs de ras |
EP4334318A1 (fr) * | 2021-05-05 | 2024-03-13 | Huyabio International, LLC | Polythérapies comprenant des inhibiteurs de shp2 et des inhibiteurs de pd-1 |
WO2022235822A1 (fr) * | 2021-05-05 | 2022-11-10 | Huabio International, Llc | Monothérapie d'inhibiteur de shp2 et ses utilisations |
CA3217092A1 (fr) * | 2021-05-05 | 2022-11-10 | Farbod Shojaei | Polytherapies comprenant des inhibiteurs de shp2 et des inhibiteurs de tyrosine kinase de l'egfr |
CN117616031A (zh) | 2021-05-05 | 2024-02-27 | 锐新医药公司 | 用于治疗癌症的ras抑制剂 |
CN115340561A (zh) * | 2021-05-14 | 2022-11-15 | 药雅科技(上海)有限公司 | Shp2磷酸酶稠环类抑制剂的制备及其应用 |
CN115340559A (zh) * | 2021-05-12 | 2022-11-15 | 药雅科技(上海)有限公司 | Shp2磷酸酶杂环类抑制剂的制备及其应用 |
KR20240007279A (ko) * | 2021-05-13 | 2024-01-16 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | Shp2활성을 억제하는 헤테로고리 화합물, 이의 제조 방법 및 용도 |
WO2022259157A1 (fr) | 2021-06-09 | 2022-12-15 | Novartis Ag | Combinaison pharmaceutique triple comprenant du dabrafenib, du trametinib et un inhibiteur de shp2 |
TW202317100A (zh) | 2021-06-23 | 2023-05-01 | 瑞士商諾華公司 | 包含kras g12c抑制劑的藥物組合及其用於治療癌症之用途 |
KR20240055778A (ko) | 2021-09-01 | 2024-04-29 | 노파르티스 아게 | Tead 억제제를 포함하는 제약 조합물 및 암의 치료를 위한 이의 용도 |
AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
WO2023122938A1 (fr) * | 2021-12-28 | 2023-07-06 | Js Innomed Holdings Ltd. | Composés hétérocycliques utilisés en tant qu'inhibiteurs de shp2, compositions comprenant le composé hétérocyclique, et leurs procédés d'utilisation |
WO2023172940A1 (fr) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Méthodes de traitement du cancer du poumon réfractaire immunitaire |
WO2023240263A1 (fr) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Inhibiteurs de ras macrocycliques |
CN115521305A (zh) * | 2022-09-20 | 2022-12-27 | 中国药科大学 | Shp2&nampt双靶向化合物及其药物组合物和用途 |
WO2024081674A1 (fr) | 2022-10-11 | 2024-04-18 | Aadi Bioscience, Inc. | Polythérapies pour le traitement du cancer |
CN115677661B (zh) * | 2022-10-27 | 2024-04-19 | 中国药科大学 | 杂环硫醚类化合物及其用途和药物组合物 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9815813B2 (en) | 2014-01-17 | 2017-11-14 | Novartis Ag | 1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine derivatives and compositions therefor for inhibiting the activity of SHP2 |
JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
CN112625028A (zh) * | 2015-06-19 | 2021-04-09 | 诺华股份有限公司 | 用于抑制shp2活性的化合物和组合物 |
CA3026784A1 (fr) | 2016-06-07 | 2017-12-14 | Jacobio Pharmaceuticals Co., Ltd. | Derives de pyrazine heterocycliques utiles en tant qu'inhibiteurs de shp2 |
MX2018015625A (es) * | 2016-06-14 | 2019-03-06 | Novartis Ag | Compuestos y composiciones para inhibir la actividad de shp2. |
SG11201900157RA (en) * | 2016-07-12 | 2019-02-27 | Revolution Medicines Inc | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
WO2018130928A1 (fr) | 2017-01-10 | 2018-07-19 | Novartis Ag | Combinaison pharmaceutique comprenant un inhibiteur d'alk et un inhibiteur de shp2 |
EP3601239A4 (fr) * | 2017-03-23 | 2020-05-13 | Jacobio Pharmaceuticals Co., Ltd. | Nouveaux dérivés hétérocycliques utiles en tant qu'inhibiteurs de shp2 |
WO2019051084A1 (fr) | 2017-09-07 | 2019-03-14 | Revolution Medicines, Inc. | Compositions d'inhibiteur de la shp2 et méthodes de traitement du cancer |
WO2019075265A1 (fr) | 2017-10-12 | 2019-04-18 | Revolution Medicines, Inc. | Pyridine, pyrazine et composés de triazine utilisés en tant qu'inhibiteurs allostériques de shp2 |
WO2019126736A1 (fr) | 2017-12-21 | 2019-06-27 | New York University | Thérapie anticancéreuse en relation avec pd-1 |
US11426422B2 (en) | 2018-01-30 | 2022-08-30 | Research Development Foundation | SHP2 inhibitors and methods of use thereof |
US10561655B2 (en) | 2018-03-21 | 2020-02-18 | Synblia Therapeutics, Inc. | SHP2 inhibitors and uses thereof |
CN112203689A (zh) | 2018-04-10 | 2021-01-08 | 锐新医药公司 | 治疗癌症的shp2抑制剂组合物和方法 |
-
2019
- 2019-03-04 CN CN201910160960.7A patent/CN111647000B/zh active Active
-
2020
- 2020-03-02 CA CA3132395A patent/CA3132395A1/fr active Pending
- 2020-03-02 JP JP2021551865A patent/JP2022523786A/ja active Pending
- 2020-03-02 EP EP20766519.1A patent/EP3936502A4/fr active Pending
- 2020-03-02 US US17/436,223 patent/US20220127276A1/en active Pending
- 2020-03-02 AU AU2020233038A patent/AU2020233038A1/en active Pending
- 2020-03-02 SG SG11202109603S patent/SG11202109603SA/en unknown
- 2020-03-02 WO PCT/CN2020/077391 patent/WO2020177653A1/fr unknown
- 2020-03-02 MX MX2021010625A patent/MX2021010625A/es unknown
- 2020-03-02 BR BR112021017495A patent/BR112021017495A2/pt unknown
- 2020-03-02 CN CN202080014053.2A patent/CN113474338A/zh active Pending
- 2020-03-02 KR KR1020217031808A patent/KR20210135561A/ko unknown
-
2021
- 2021-09-02 IL IL286069A patent/IL286069A/en unknown
- 2021-09-03 CL CL2021002308A patent/CL2021002308A1/es unknown
- 2021-09-30 CO CONC2021/0013140A patent/CO2021013140A2/es unknown
-
2023
- 2023-01-25 US US18/101,511 patent/US11827644B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US11827644B2 (en) | 2023-11-28 |
CA3132395A1 (fr) | 2020-09-10 |
WO2020177653A1 (fr) | 2020-09-10 |
IL286069A (en) | 2021-10-31 |
US20230227464A1 (en) | 2023-07-20 |
BR112021017495A2 (pt) | 2021-12-14 |
MX2021010625A (es) | 2021-10-26 |
US20220127276A1 (en) | 2022-04-28 |
CO2021013140A2 (es) | 2021-11-30 |
KR20210135561A (ko) | 2021-11-15 |
CN111647000A (zh) | 2020-09-11 |
CL2021002308A1 (es) | 2022-05-20 |
CN111647000B (zh) | 2021-10-12 |
CN113474338A (zh) | 2021-10-01 |
AU2020233038A1 (en) | 2021-10-21 |
EP3936502A4 (fr) | 2023-02-15 |
JP2022523786A (ja) | 2022-04-26 |
EP3936502A1 (fr) | 2022-01-12 |
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