SG11202106377XA - Automated production of viral vectors - Google Patents

Automated production of viral vectors

Info

Publication number
SG11202106377XA
SG11202106377XA SG11202106377XA SG11202106377XA SG11202106377XA SG 11202106377X A SG11202106377X A SG 11202106377XA SG 11202106377X A SG11202106377X A SG 11202106377XA SG 11202106377X A SG11202106377X A SG 11202106377XA SG 11202106377X A SG11202106377X A SG 11202106377XA
Authority
SG
Singapore
Prior art keywords
viral vectors
automated production
automated
production
viral
Prior art date
Application number
SG11202106377XA
Other languages
English (en)
Inventor
Matthew Hewitt
Young Shin
Bingnan Gu
Caitlin M Guenther
Anandita Seth
Original Assignee
Lonza Walkersville Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Walkersville Inc filed Critical Lonza Walkersville Inc
Publication of SG11202106377XA publication Critical patent/SG11202106377XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
    • C12N2740/16052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/005—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB
    • C12N2830/006—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination repressible enhancer/promoter combination, e.g. KRAB tet repressible

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11202106377XA 2018-12-21 2019-12-19 Automated production of viral vectors SG11202106377XA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862783589P 2018-12-21 2018-12-21
US201962866092P 2019-06-25 2019-06-25
US201962890904P 2019-08-23 2019-08-23
US201962949848P 2019-12-18 2019-12-18
PCT/US2019/067354 WO2020132177A1 (en) 2018-12-21 2019-12-19 Automated production of viral vectors

Publications (1)

Publication Number Publication Date
SG11202106377XA true SG11202106377XA (en) 2021-07-29

Family

ID=71101856

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202106377XA SG11202106377XA (en) 2018-12-21 2019-12-19 Automated production of viral vectors

Country Status (9)

Country Link
US (2) US11718833B2 (ja)
EP (1) EP3898994A4 (ja)
JP (1) JP2022514761A (ja)
KR (1) KR20210108406A (ja)
CN (1) CN113195725A (ja)
CA (1) CA3123449A1 (ja)
IL (1) IL284217A (ja)
SG (1) SG11202106377XA (ja)
WO (1) WO2020132177A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201809805WA (en) 2016-05-05 2018-12-28 Southwest Res Inst Three-dimensional bioreactor for cell expansion and related applications
US11149244B2 (en) 2018-04-04 2021-10-19 Southwest Research Institute Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy
KR20210064299A (ko) 2018-09-24 2021-06-02 사우스웨스트 리서치 인스티튜트 3d 생물반응기
IL294079A (en) * 2019-12-19 2022-08-01 Lonza Walkersville Inc Automated production of viral vectors
CN114045305B (zh) * 2021-10-15 2023-03-24 深圳市深研生物科技有限公司 多转座子系统

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1356794A (en) 1970-11-20 1974-06-12 Defence Secratary Of State For Apparatus and method for the production of a single cell suspen sion from tissue
IL68218A (en) 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
IL82746A (en) 1986-06-06 1994-10-07 Genentech Inc A process for producing a biologically active tissue plasminogen activator
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US6022742A (en) 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
US5081036A (en) 1987-01-23 1992-01-14 Hoffmann-La Roche Inc. Method and apparatus for cell culture
EP0345588A1 (de) 1988-06-03 1989-12-13 Gesellschaft für Biotechnologische Forschung mbH (GBF) Verfahren und Anordnung zur Regelung eines biologischen Wachstumsprozesses
CA2000181A1 (en) 1988-10-14 1990-04-14 Chung-Faye Chao Process for producing cultured epidermal sheet, product and method of use
JPH02119772A (ja) 1988-10-29 1990-05-07 Shimadzu Corp 細胞培養装置
US4939151A (en) 1988-10-31 1990-07-03 Baxter International Inc. Adherent cell culture flask
US5240854A (en) 1989-06-05 1993-08-31 Berry Eric S Continuous high-density cell culture system
DE4021123A1 (de) 1989-10-07 1991-04-11 Sartorius Gmbh Fuer den laborbetrieb bestimmte vorrichtung zur behandlung fluessiger medien
CA2067348A1 (en) 1989-10-10 1991-04-11 Mark E. Huntley Process and apparatus for the production of photosynthetic microbes
GB9010356D0 (en) 1990-05-09 1990-06-27 Ciba Geigy Ag Maturation of hemopoietic cells
WO1993003142A1 (en) 1991-08-07 1993-02-18 Albert Einstein College Of Medicine Proliferation of hepatocyte precursors
JPH0654678A (ja) 1992-08-07 1994-03-01 Chuo Setsubi Eng Kk 微生物の自動流加培養法
DE4306661C2 (de) 1993-03-03 1995-04-20 Michael Dipl Biol Sittinger Verfahren zum Herstellen eines Implantates aus Zellkulturen
JP3453161B2 (ja) 1993-03-18 2003-10-06 宇宙開発事業団 液体培養ユニット
US5424209A (en) 1993-03-19 1995-06-13 Kearney; George P. Automated cell culture and testing system
US5478479A (en) 1994-05-20 1995-12-26 Haemonetics Corporation Two-stage cell wash process controlled by optical sensor
US5549134A (en) 1994-05-27 1996-08-27 Marcvalve Corporation Diaphragm valve
JP3549949B2 (ja) 1994-06-17 2004-08-04 山陽電子工業株式会社 低酸素培養器
US6297046B1 (en) 1994-10-28 2001-10-02 Baxter International Inc. Multilayer gas-permeable container for the culture of adherent and non-adherent cells
US5906934A (en) 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
US5846828A (en) 1995-06-07 1998-12-08 Advanced Tissue Sciences Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing tissue, synthetic, or mechanical heart valves orvalve segments
US6121042A (en) 1995-04-27 2000-09-19 Advanced Tissue Sciences, Inc. Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs
US5792603A (en) 1995-04-27 1998-08-11 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts
US6228635B1 (en) 1995-06-07 2001-05-08 Aastrom Bioscience, Inc. Portable cell growth cassette for use in maintaining and growing biological cells
US5688687A (en) 1995-06-07 1997-11-18 Aastrom Biosciences, Inc. Bioreactor for mammalian cell growth and maintenance
AU5931896A (en) 1995-06-07 1996-12-30 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, st oring, shipping, and testing replacement cartilage tissue co nstructs
US6096532A (en) 1995-06-07 2000-08-01 Aastrom Biosciences, Inc. Processor apparatus for use in a system for maintaining and growing biological cells
US6238908B1 (en) 1995-06-07 2001-05-29 Aastrom Biosciences, Inc. Apparatus and method for maintaining and growth biological cells
US5728581A (en) 1995-06-07 1998-03-17 Systemix, Inc. Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
US5985653A (en) 1995-06-07 1999-11-16 Aastrom Biosciences, Inc. Incubator apparatus for use in a system for maintaining and growing biological cells
WO1996040858A1 (en) 1995-06-07 1996-12-19 Aastrom Biosciences, Inc. Apparatus and method for maintaining and growing biological cells
CA2230057C (en) 1995-09-01 2008-10-21 Millenium Biologix, Inc. An artificial stabilized composition of calcium phosphate phases particularly adapted for supporting bone cell activity
ATE274052T1 (de) 1995-10-06 2004-09-15 Az Univ Amsterdam Fester träger für die zellkultur insbesondere für leberzellenkultur, biologischer reaktor und diese träger enthaltendes biologischer reaktor und ihre verwendung in einem künstliche leber vorrichtung
AU1059997A (en) 1995-11-08 1997-05-29 Trustees Of Boston University Cellular physiology workstations for automated data acquisition and perfusion control
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US5827729A (en) 1996-04-23 1998-10-27 Advanced Tissue Sciences Diffusion gradient bioreactor and extracorporeal liver device using a three-dimensional liver tissue
DE69605062T2 (de) 1996-04-24 2000-07-13 Claude Fell Zelltrennungsvorrichtung für biologische flüssigkeiten wie blut
US6008010A (en) 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
US6399375B2 (en) 1997-01-08 2002-06-04 Demtek A/S Method and apparatus for culturing cells and tissues
US5928936A (en) 1997-04-09 1999-07-27 Huntington Medical Research Institutes Cell culture container that self-seals after cannula penetration made of porous sheets
US5786207A (en) 1997-05-28 1998-07-28 University Of Pittsburgh Tissue dissociating system and method
US5922604A (en) 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
JP2001517428A (ja) 1997-09-25 2001-10-09 サイトマトリックス，エルエルシー 造血前駆体細胞の長期間培養のための方法およびデバイス
US6197575B1 (en) 1998-03-18 2001-03-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US5882929A (en) 1998-04-07 1999-03-16 Tissue Engineering, Inc. Methods and apparatus for the conditioning of cartilage replacement tissue
US5989913A (en) 1998-07-02 1999-11-23 Charles Daniel Anderson Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using the same
NZ513303A (en) 1999-02-04 2003-03-28 Technion Res & Dev Foundation Three dimensional plug flow bioreactor, and its use for the maintenance and expansion of hemopoietic stem cells and/or progenitor cells
WO2001000783A2 (en) 1999-06-25 2001-01-04 Advanced Tissue Sciences, Inc. Monitorable three-dimensional scaffolds and tissue culture systems
US6632651B1 (en) 1999-07-06 2003-10-14 Ramot At Tel Aviv University Ltd. Tissue maintenance system that applies rhythmic pulses of pressure
US6402941B1 (en) 2000-02-07 2002-06-11 Wastewater Biological Solutions, Corp Apparatus for biological treatment of environmental contaminants and waste
JP3865354B2 (ja) 2000-03-02 2007-01-10 高木産業株式会社 細胞又は組織の培養方法
JP4402249B2 (ja) 2000-03-31 2010-01-20 正仁 田谷 細胞培養方法、細胞培養装置及び記録媒体
GB0009960D0 (en) 2000-04-25 2000-06-14 Oncoprobe Limited Electrochemical sensing
US7585323B2 (en) 2000-05-05 2009-09-08 Medlden, Llc In vitro mechanical loading of musculoskeletal tissues
US6485963B1 (en) 2000-06-02 2002-11-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Growth stimulation of biological cells and tissue by electromagnetic fields and uses thereof
WO2002014539A1 (en) 2000-08-14 2002-02-21 University Of Maryland Baltimore County Bioreactor and bioprocessing technique
US6864084B2 (en) 2000-08-18 2005-03-08 Levitronix Llc Bioreactor and method for fluidly suspending a product
JP4195287B2 (ja) 2000-10-02 2008-12-10 エフ．キャノン トーマス 自動化されたバイオカルチャー及びバイオカルチャー実験システム
US20020146817A1 (en) 2000-10-02 2002-10-10 Cannon Thomas F. Automated bioculture and bioculture experiments system
DE10049437A1 (de) 2000-10-06 2002-04-25 Fraunhofer Ges Forschung Bioreaktor für die Kultivierung von Mikroorganismen sowie Verfahren zur Herstellung desselben
US7198940B2 (en) 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system
MXPA03006147A (es) 2001-01-09 2005-02-14 Aqua Novus Corp Equipo y metodo para tratamiento biologico de contaminantes y desechos ambientales.
US20050130297A1 (en) 2001-04-26 2005-06-16 Societe Nouvelle Cell Tissue Progress Cell and tissue culture device with temperature regulation
FR2824071B1 (fr) 2001-04-26 2003-08-01 Cell Tissue Progress Dispositif de culture cellulaire et tissulaire a regulation thermique
US7169578B2 (en) 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US6673595B2 (en) 2001-08-27 2004-01-06 Biocrystal, Ltd Automated cell management system for growth and manipulation of cultured cells
GB0121986D0 (en) 2001-09-11 2001-10-31 Isis Innovation Method and structure for growing living organic tissue
US7348175B2 (en) 2002-03-15 2008-03-25 St3 Development Corporation Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products
JP2005531300A (ja) 2002-04-08 2005-10-20 ミレニアム・バイオロジクス，インコーポレイテッド 自動的な組織工学モジュール
US20030215935A1 (en) 2002-05-14 2003-11-20 Coon David James Apparatus and method for isolating living cells from an encapsulated organ tissue sample
EP1649056A1 (en) 2003-07-02 2006-04-26 Caliper Life Sciences, Inc. Methods for amplifying and detecting nucleic acids in microfluidic devices under continuous and non-continuous flow conditions.
EP1756262B1 (en) 2004-05-26 2013-12-04 Octane Biotech Inc. Advanced tissue engineering system
JP5456689B2 (ja) 2007-12-07 2014-04-02 ミルテンイ バイオテック ゲーエムベーハー 試料を少なくとも２つの成分に分離する遠心分離機
CA2833001C (en) 2010-04-21 2020-06-23 Yves Larcher Automated cell culture system
ES2828982T3 (es) 2013-05-14 2021-05-28 Univ Texas Aplicación humana de células t de receptor de antígeno quimérico (car) diseñadas
KR20210020165A (ko) 2014-02-04 2021-02-23 카이트 파마 인코포레이티드 B 세포 악성종양 및 다른 암을 치료하는데 유용한 자가 t 세포 및 그의 조성물의 생산 방법
ES2759260T3 (es) 2014-04-23 2020-05-08 Juno Therapeutics Inc Métodos para aislar, cultivar y modificar genéticametne poblaciones de células inmunes para la terapia adoptiva
CA2946222C (en) 2014-04-24 2020-12-22 Miltenyi Biotec Gmbh Method for automated generation of genetically modified t cells
RU2741899C2 (ru) 2014-04-25 2021-01-29 Блубёрд Био, Инк. Улучшенные способы производства средств адоптивной клеточной терапии
EP3217989B1 (en) 2014-10-31 2022-01-05 The Trustees of the University of Pennsylvania Compositions and methods of stimulating and expanding t cells
CA2966538A1 (en) 2014-11-05 2016-05-12 Juno Therapeutics, Inc. Methods for transduction and cell processing
EP3240803B1 (en) 2014-12-29 2021-11-24 Novartis AG Methods of making chimeric antigen receptor-expressing cells
JP6734283B2 (ja) 2015-01-21 2020-08-05 フレッド ハッチンソン キャンサー リサーチ センター 遺伝子治療用ポイントオブケア及び／又はポータブルプラットフォーム
KR20170135966A (ko) 2015-04-13 2017-12-08 맥스시티 인코포레이티드 게놈 dna를 변형시키기 위한 방법 및 조성물
GB201508752D0 (en) 2015-05-21 2015-07-01 Mason Christopher And Veraitch Farlan S Cell culture device, system and methods of use thereof
MA45489A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés de culture de cellules, kits et appareil associés
JP7090548B2 (ja) * 2016-01-29 2022-06-24 ジリオン バイオテック ゲーエムベーハー Ａａｖ系条件的発現系
GB201603374D0 (en) * 2016-02-26 2016-04-13 Ucl Business Plc Packaging cell
CA3031152A1 (en) 2016-07-21 2018-01-25 Celyad Method and apparatus for automated independent parallel batch-processing of cells
CN109843417B (zh) 2016-08-21 2022-09-02 艾德瓦生物技术股份有限公司 生物反应器及其使用方法
US20190367876A1 (en) 2017-01-18 2019-12-05 F1 Oncology, Inc. Methods of transducing and expanding immune cells and uses thereof
CN110785495A (zh) * 2017-04-18 2020-02-11 葛兰素史克知识产权开发有限公司 腺相关病毒载体的生产方法
RS63202B1 (sr) 2017-06-30 2022-06-30 Inscripta Inc Automatizovani postupci, moduli, instrumenti i sistemi za obradu ćelija
CN111373030A (zh) 2017-09-01 2020-07-03 隆萨沃克斯维尔股份有限公司 端到端细胞治疗自动化
US11603527B2 (en) 2017-12-27 2023-03-14 Global Life Sciences Solutions Usa Llc Method and kit for viral vector isolation

Also Published As

Publication number Publication date
US20240026306A1 (en) 2024-01-25
KR20210108406A (ko) 2021-09-02
EP3898994A4 (en) 2022-12-14
CN113195725A (zh) 2021-07-30
JP2022514761A (ja) 2022-02-15
EP3898994A1 (en) 2021-10-27
WO2020132177A1 (en) 2020-06-25
US11718833B2 (en) 2023-08-08
CA3123449A1 (en) 2020-06-25
US20200208121A1 (en) 2020-07-02
IL284217A (en) 2021-08-31

Similar Documents

Publication Publication Date Title
IL284217A (en) Automated production of viral vectors
GB201814590D0 (en) Viral vector production system
PL3630738T3 (pl) Sposób wytwarzania ozanimodu
GB201516516D0 (en) Process of manufacture
IL280840A (en) Production methods for viral vectors
ZA201903015B (en) Production of iron
PL3417498T3 (pl) Sposób wytwarzania anod na bazie krzemu do baterii wtórnych
HUP1700197A2 (en) Industrial procedure for production of cariprazine
GB201518792D0 (en) Production of proteins
GB201806072D0 (en) Methods of manufacture
GB201804594D0 (en) Bonegraft substituteand method of manufacture
ZA201902125B (en) Process for the production of 2-alkylalkanol
EP3565923C0 (en) PROCESSES FOR AUTOMATED MANUFACTURING OF FLEXIBLE ARTICLES
GB201802839D0 (en) Method of manufacture
PL3272616T3 (pl) Sposób montażu pojazdu kolejowego
PL3755681T3 (pl) Sposób wytwarzania 4-boronofenyloalaniny
GB201807945D0 (en) Vector production
IL262544A (en) A method for producing a recombinant protein
GB201805904D0 (en) Methods of Manufacture
GB2566572B (en) Methods for adeno-associated viral vector production
GB201814291D0 (en) Process for the production of gallium radionculides
GB201601249D0 (en) Production of manool
EP3621982A4 (en) VIRAL VECTOR PRODUCTION
GB201700973D0 (en) Process of manufacture
SG11202104260RA (en) Production of hydroxyethylpiperazine