SG11202011133VA - Systems and methods for pre-analytical substrate processing - Google Patents

Systems and methods for pre-analytical substrate processing

Info

Publication number
SG11202011133VA
SG11202011133VA SG11202011133VA SG11202011133VA SG11202011133VA SG 11202011133V A SG11202011133V A SG 11202011133VA SG 11202011133V A SG11202011133V A SG 11202011133VA SG 11202011133V A SG11202011133V A SG 11202011133VA SG 11202011133V A SG11202011133V A SG 11202011133VA
Authority
SG
Singapore
Prior art keywords
systems
methods
substrate processing
analytical substrate
analytical
Prior art date
Application number
SG11202011133VA
Other languages
English (en)
Inventor
Hubert Yeung
Amy Lee Hsieh Yuan
Chun Wai Lee
Gabriel Jesus Samuel Perlas Moraleda
Jonathan M Cassel
Original Assignee
Genomic Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomic Health Inc filed Critical Genomic Health Inc
Publication of SG11202011133VA publication Critical patent/SG11202011133VA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6865Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N1/04Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/4833Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00Reactions characterised by treatment of reaction samples
    • C12Q2523/10Characterised by chemical treatment
    • C12Q2523/115Characterised by chemical treatment oxidising agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00Reactions characterised by treatment of reaction samples
    • C12Q2523/30Characterised by physical treatment
    • C12Q2523/301Sonication
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00Reactions characterised by treatment of reaction samples
    • C12Q2523/30Characterised by physical treatment
    • C12Q2523/305Denaturation or renaturation by physical action
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00Reactions characterised by treatment of reaction samples
    • C12Q2523/30Characterised by physical treatment
    • C12Q2523/31Electrostatic interactions, e.g. use of cationic polymers in hybridisation reactions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N1/04Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N2001/045Laser ablation; Microwave vaporisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2873Cutting or cleaving
    • G01N2001/2886Laser cutting, e.g. tissue catapult

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Exposure Of Semiconductors, Excluding Electron Or Ion Beam Exposure (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SG11202011133VA 2018-06-21 2019-06-21 Systems and methods for pre-analytical substrate processing SG11202011133VA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862687887P 2018-06-21 2018-06-21
US201962821371P 2019-03-20 2019-03-20
PCT/US2019/038581 WO2019246584A1 (en) 2018-06-21 2019-06-21 Systems and methods for pre-analytical substrate processing

Publications (1)

Publication Number Publication Date
SG11202011133VA true SG11202011133VA (en) 2020-12-30

Family

ID=68980561

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011133VA SG11202011133VA (en) 2018-06-21 2019-06-21 Systems and methods for pre-analytical substrate processing

Country Status (13)

Country Link
US (1) US11807900B2 (es)
EP (1) EP3811050A4 (es)
JP (1) JP7324785B2 (es)
KR (1) KR20210003288A (es)
CN (1) CN112534237A (es)
AU (2) AU2019288754A1 (es)
BR (1) BR112020026088A2 (es)
CA (1) CA3102281A1 (es)
CO (1) CO2020015467A2 (es)
MX (1) MX2020013835A (es)
SG (1) SG11202011133VA (es)
TW (1) TW202018295A (es)
WO (1) WO2019246584A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022125887A (ja) * 2021-02-17 2022-08-29 シスメックス株式会社 検体剥離方法および検体剥離装置
KR102597565B1 (ko) * 2021-05-03 2023-11-06 성균관대학교산학협력단 Pcr 장치
EP4352483A1 (en) * 2021-06-11 2024-04-17 Xyall B.V. Apparatus comprising an interface for detachable coupling of a dissection tool
CN114965823A (zh) * 2021-08-18 2022-08-30 上海交通大学 基于激光捕获显微切割技术的空间分辨蛋白质组学方法
WO2023137340A1 (en) * 2022-01-11 2023-07-20 TriMetis Life Sciences, LLC Tissue coring and analysis system
EP4246119A1 (en) * 2022-03-17 2023-09-20 Leica Microsystems CMS GmbH Method and system for extracting a part of a microscopic sample

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6669685B1 (en) * 1997-11-06 2003-12-30 Biolase Technology, Inc. Tissue remover and method
DE19616216A1 (de) * 1996-04-23 1997-10-30 P A L M Gmbh Verfahren und Vorrichtung zur Gewinnung von laserdissektierten Partikeln wie biologische Zellen bzw. Zellorganellen, Chromosomenteilchen etc.
WO1997029354A1 (de) 1996-02-05 1997-08-14 Bayer Aktiengesellschaft Verfahren und vorrichtung zum sortieren und zur gewinnung von planar ausgebrachten biologischen objekten wie biologische zellen bzw. zellorganellen, histologischen schnitten, chromosomenteilchen etc. mit laserstrahlen
JP2000146782A (ja) * 1998-11-12 2000-05-26 Yoshio Kawai 自動固定標本作製装置および方法
US8469295B2 (en) 2002-02-15 2013-06-25 Implant Sciences Corporation Trace chemical particle release nozzle
US7468161B2 (en) * 2002-04-15 2008-12-23 Ventana Medical Systems, Inc. Automated high volume slide processing system
WO2006036182A2 (en) * 2004-09-28 2006-04-06 Singulex, Inc. System and method for spectroscopic analysis of single particles
US7892836B2 (en) * 2005-02-11 2011-02-22 The Regents Of The University Of California Pneumatic capillary gun for ballistic delivery of microscopic particles into tissue
US7138626B1 (en) * 2005-05-05 2006-11-21 Eai Corporation Method and device for non-contact sampling and detection
DE102005061561A1 (de) * 2005-12-22 2007-06-28 P.A.L.M. Microlaser Technologies Ag Laser-Mikrodissektionsverfahren, Steuersystem für eine Laser-Mikrodissektionsvorrichtung und Trägervorrichtung
US8210028B2 (en) * 2007-10-08 2012-07-03 Moore Robert R Methods and apparatus for extraction of particles from surfaces
US8353223B2 (en) * 2008-05-14 2013-01-15 Implant Sciences Corporation Trace particle collection system
CA3004416A1 (en) * 2008-08-29 2010-03-04 Lee H. Angros Multiplexed microscope slide staining apparatus
CN102869975B (zh) 2010-02-09 2015-10-14 国际基因组学协会 用于激光切割的系统和方法
US9102979B2 (en) * 2010-02-23 2015-08-11 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
WO2011150316A1 (en) * 2010-05-28 2011-12-01 Sridharan Rajagopalan Obtaining analytes from a tissue specimen
US9546935B1 (en) 2010-08-25 2017-01-17 Thomas W. Astle Dried specimen storage slides, systems and methods
EP2423661A1 (de) 2010-08-30 2012-02-29 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Vorrichtung und Verfahren zum automatisierten Isolieren und Transferieren mindestens einer mikroskopischen Probe von einem Probenträger zu einem Auffangsystem
US20150045232A1 (en) * 2010-12-28 2015-02-12 Bexmart Integrated and versatile methods for systems diagnosis of diseases
US8530228B2 (en) * 2010-12-28 2013-09-10 Bexmart Integrated versatile and systems preparation of specimens
WO2014054016A1 (en) * 2012-10-03 2014-04-10 Koninklijke Philips N.V. Sample isolation unit
CA2895945C (en) * 2012-12-19 2022-09-06 Nanomr, Inc. Target capture system
EP2948750B1 (en) * 2013-01-24 2016-11-30 Roche Diagnostics GmbH Rt-qpcr analysis of micro-dissected material from stained ffpet section
US9789073B2 (en) * 2013-03-14 2017-10-17 Pathak Holdings, Llc Compositions, methods and devices for local drug delivery
WO2014184005A1 (en) * 2013-05-15 2014-11-20 Koninklijke Philips N.V. Tissue separation from a sample
US20150247844A1 (en) * 2014-02-28 2015-09-03 Stanislav L. Karsten Method for Obtaining Cell and Tissue Specific Biomolecules
KR101572683B1 (ko) * 2014-03-14 2015-11-27 케이맥(주) 오일과 친수성 자성 비드를 이용한 핵산 추출 및 증폭 방법
JP7099951B2 (ja) * 2015-07-24 2022-07-12 セファイド 組織試料からのdna及びrna抽出のための組成物及び方法
US20180258473A1 (en) * 2015-11-10 2018-09-13 Administracion General De La Comunidad Autonoma De Euskadi Diagnostic methods and devices
JP6684027B2 (ja) * 2016-10-11 2020-04-22 株式会社日立製作所 付着物収集装置及び付着物解析システム

Also Published As

Publication number Publication date
CN112534237A (zh) 2021-03-19
AU2022204864A1 (en) 2022-07-28
EP3811050A4 (en) 2022-04-13
AU2022204864B2 (en) 2023-09-21
CO2020015467A2 (es) 2021-03-19
KR20210003288A (ko) 2021-01-11
TW202018295A (zh) 2020-05-16
AU2019288754A1 (en) 2020-11-26
EP3811050A1 (en) 2021-04-28
US11807900B2 (en) 2023-11-07
BR112020026088A2 (pt) 2021-03-23
JP2021527817A (ja) 2021-10-14
US20190390252A1 (en) 2019-12-26
WO2019246584A1 (en) 2019-12-26
MX2020013835A (es) 2021-03-25
JP7324785B2 (ja) 2023-08-10
CA3102281A1 (en) 2019-12-26

Similar Documents

Publication Publication Date Title
EP3485484A4 (en) IMAGE PROCESSING METHOD AND ELECTRONIC DEVICE SUPPORTING IT
EP3704634A4 (en) SYSTEMS AND METHODS FOR IMAGE PROCESSING
EP3774020A4 (en) TREATMENT SYSTEMS AND METHODS
SG11202011133VA (en) Systems and methods for pre-analytical substrate processing
EP3332338A4 (en) Question and answer processing method and electronic device for supporting the same
EP3698316A4 (en) IMAGE PROCESSING METHODS AND SYSTEMS
EP3519925A4 (en) METHOD FOR PROCESSING VARIOUS INPUTS, ELECTRONIC DEVICE AND SERVER THEREFOR
EP3521932A4 (en) MEASURING SYSTEM, SUBSTRATE PROCESSING SYSTEM, AND DEVICE MANUFACTURING METHOD
EP3506012A4 (en) MEASURING SYSTEM, SUBSTRATE PROCESSING SYSTEM, AND DEVICE MANUFACTURING METHOD
EP3710402A4 (en) DEVICES AND METHODS FOR CHEMICAL TREATMENT OF THIN FILM
EP3282475A4 (en) Substrate holding method, substrate holding device, processing method and processing device
SG10201911998QA (en) Substrate processing method and substrate processing apparatus
SG11201710329TA (en) Substrate processing system and substrate processing method
EP3419253A4 (en) DATA PROCESSING METHOD AND RELATED DEVICES AND SYSTEMS
EP3872840A4 (en) SUBSTRATE TREATMENT DEVICE AND SUBSTRATE TREATMENT METHOD
EP3424204A4 (en) METHOD FOR PROCESSING EVENT NOTIFICATION AND ELECTRONIC DEVICE FOR SUPPORTING THIS METHOD
EP3625761A4 (en) IMAGE PROCESSING SYSTEMS AND METHODS
EP3861570A4 (en) SUBSTRATE TREATMENT APPARATUS
EP3733575A4 (en) SUBSTRATE TREATMENT DEVICE AND SUBSTRATE TREATMENT PROCESS
SG11202112854XA (en) Substrate processing system
EP3682024A4 (en) METHODS AND SYSTEMS FOR AUTOMATIC SAMPLE PROCESSING
EP3264448A4 (en) Substrate inspection method and system
EP3437003A4 (en) SYSTEM AND METHOD USING REDUCED TIME DEVICE PROCESSING
EP3704854A4 (en) IMAGE PROCESSING SYSTEMS AND METHODS
EP3692496A4 (en) IMAGE PROCESSING SYSTEMS AND METHODS