SG11202010909RA - Anti-msr1 antibodies and methods of use thereof - Google Patents

Anti-msr1 antibodies and methods of use thereof

Info

Publication number
SG11202010909RA
SG11202010909RA SG11202010909RA SG11202010909RA SG11202010909RA SG 11202010909R A SG11202010909R A SG 11202010909RA SG 11202010909R A SG11202010909R A SG 11202010909RA SG 11202010909R A SG11202010909R A SG 11202010909RA SG 11202010909R A SG11202010909R A SG 11202010909RA
Authority
SG
Singapore
Prior art keywords
methods
msr1 antibodies
msr1
antibodies
Prior art date
Application number
SG11202010909RA
Other languages
English (en)
Inventor
Christos Kyratsous
Thomas Nittoli
Anna Zumsteg
Jesper Gromada
Viktoria Gusarova
Amy Han
Sokol Haxhinasto
Andrew J Murphy
William Olson
Matthew Sleeman
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11202010909RA publication Critical patent/SG11202010909RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K—PEPTIDES
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/77—Internalization into the cell
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
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  • Diabetes (AREA)
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  • Hematology (AREA)
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  • Rheumatology (AREA)
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SG11202010909RA 2018-05-09 2019-05-08 Anti-msr1 antibodies and methods of use thereof SG11202010909RA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862669276P 2018-05-09 2018-05-09
US201862678200P 2018-05-30 2018-05-30
US201862769946P 2018-11-20 2018-11-20
US201962789987P 2019-01-08 2019-01-08
US201962821362P 2019-03-20 2019-03-20
PCT/US2019/031383 WO2019217591A1 (en) 2018-05-09 2019-05-08 Anti-msr1 antibodies and methods of use thereof

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US (2) US11377502B2 (enrdf_load_stackoverflow)
EP (1) EP3790899A1 (enrdf_load_stackoverflow)
JP (2) JP7590871B2 (enrdf_load_stackoverflow)
KR (1) KR20210008008A (enrdf_load_stackoverflow)
CN (2) CN112533951A (enrdf_load_stackoverflow)
AU (1) AU2019265703A1 (enrdf_load_stackoverflow)
BR (1) BR112020022400A2 (enrdf_load_stackoverflow)
CA (1) CA3098453A1 (enrdf_load_stackoverflow)
CL (1) CL2020002873A1 (enrdf_load_stackoverflow)
CO (1) CO2020015084A2 (enrdf_load_stackoverflow)
MX (1) MX2020011546A (enrdf_load_stackoverflow)
MY (1) MY209590A (enrdf_load_stackoverflow)
PH (1) PH12020551865A1 (enrdf_load_stackoverflow)
SG (1) SG11202010909RA (enrdf_load_stackoverflow)
WO (1) WO2019217591A1 (enrdf_load_stackoverflow)

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CN112533951A (zh) 2021-03-19
AU2019265703A1 (en) 2020-11-19
EP3790899A1 (en) 2021-03-17
US20190367631A1 (en) 2019-12-05
US11377502B2 (en) 2022-07-05

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