SG11201907744QA - Replacement of cytotoxic preconditioning before cellular immunotherapy - Google Patents
Replacement of cytotoxic preconditioning before cellular immunotherapyInfo
- Publication number
- SG11201907744QA SG11201907744QA SG11201907744QA SG11201907744QA SG11201907744QA SG 11201907744Q A SG11201907744Q A SG 11201907744QA SG 11201907744Q A SG11201907744Q A SG 11201907744QA SG 11201907744Q A SG11201907744Q A SG 11201907744QA SG 11201907744Q A SG11201907744Q A SG 11201907744QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- pct
- cytotoxic preconditioning
- cellular
- cytotoxic
- Prior art date
Links
- 230000001413 cellular effect Effects 0.000 title abstract 4
- 231100000433 cytotoxic Toxicity 0.000 title abstract 4
- 230000001472 cytotoxic effect Effects 0.000 title abstract 4
- 238000009169 immunotherapy Methods 0.000 title abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/26—Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762480414P | 2017-04-01 | 2017-04-01 | |
US201862613697P | 2018-01-04 | 2018-01-04 | |
US201862624454P | 2018-01-31 | 2018-01-31 | |
PCT/US2018/025517 WO2018183927A1 (fr) | 2017-04-01 | 2018-03-30 | Remplacement de préconditionnement cytotoxique avant une immunothérapie cellulaire |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201907744QA true SG11201907744QA (en) | 2019-09-27 |
Family
ID=62111173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201907744QA SG11201907744QA (en) | 2017-04-01 | 2018-03-30 | Replacement of cytotoxic preconditioning before cellular immunotherapy |
Country Status (13)
Country | Link |
---|---|
US (2) | US11219628B2 (fr) |
EP (1) | EP3490605B1 (fr) |
JP (2) | JP6748221B2 (fr) |
KR (1) | KR102509006B1 (fr) |
CN (1) | CN110475571B (fr) |
AU (1) | AU2018243753A1 (fr) |
BR (1) | BR112019020214A2 (fr) |
CA (1) | CA3054443A1 (fr) |
ES (1) | ES2954311T3 (fr) |
IL (1) | IL269209B2 (fr) |
MX (1) | MX2019011679A (fr) |
SG (1) | SG11201907744QA (fr) |
WO (1) | WO2018183927A1 (fr) |
Families Citing this family (28)
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US10426740B1 (en) | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
WO2018183927A1 (fr) | 2017-04-01 | 2018-10-04 | Avm Biotechnology, Llc | Remplacement de préconditionnement cytotoxique avant une immunothérapie cellulaire |
EP3634528B1 (fr) | 2017-06-07 | 2023-06-07 | Shifamed Holdings, LLC | Dispositifs de déplacement de fluide intravasculaire, systèmes et procédés d'utilisation |
EP3710076B1 (fr) | 2017-11-13 | 2023-12-27 | Shifamed Holdings, LLC | Dispositifs de déplacement de liquide intravasculaire, systèmes et procédés d'utilisation |
EP4085965A1 (fr) | 2018-02-01 | 2022-11-09 | Shifamed Holdings, LLC | Pompes à sang intravasculaires et procédés d'utilisation et de fabrication |
MX2020010913A (es) | 2018-04-17 | 2021-01-08 | Celldex Therapeutics Inc | Anticuerpos anti-cd27 y anti-pd-l1 y constructos biespecíficos. |
EP3632446B3 (fr) | 2018-10-03 | 2024-01-24 | AVM Biotechnology, LLC | Thérapies immunoablatives |
EP3488851A1 (fr) | 2018-10-03 | 2019-05-29 | AVM Biotechnology, LLC | Thérapies immunoablatives |
EP3706721A1 (fr) * | 2018-11-14 | 2020-09-16 | AVM Biotechnology, LLC | Formulation stable de glucocorticoïde |
US20220016168A1 (en) * | 2018-12-11 | 2022-01-20 | Celldex Therapeutics, Inc. | Methods of using cd27 antibodies as conditioning treatment for adoptive cell therapy |
US11964145B2 (en) | 2019-07-12 | 2024-04-23 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of manufacture and use |
US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
WO2021062265A1 (fr) | 2019-09-25 | 2021-04-01 | Shifamed Holdings, Llc | Dispositifs et systèmes de pompes à sang intravasculaires et leurs procédés d'utilisation et de commande |
MX2022005389A (es) * | 2019-11-06 | 2022-07-27 | Kite Pharma Inc | Terapia de celulas t con receptor de antigeno quimerico. |
CN113189340A (zh) * | 2020-01-14 | 2021-07-30 | 中国医学科学院基础医学研究所 | 细胞焦亡通路在细胞治疗中的用途 |
US20220016165A1 (en) * | 2020-02-20 | 2022-01-20 | Kite Pharma, Inc. | Chimeric antigen receptor t cell therapy |
US20230096897A1 (en) | 2020-02-28 | 2023-03-30 | Avm Biotechnology, Llc | Lymphocyte Population and Methods for Producing Same |
EP4132585A2 (fr) * | 2020-04-10 | 2023-02-15 | North Carolina State University | Transduction virale améliorée de cellules de mammifère à l'aide d'échafaudages de matériaux |
CN111443210B (zh) * | 2020-04-10 | 2023-09-22 | 青海大学附属医院 | 泡型包虫病早期诊疗生物标志物及其应用 |
EP4142736A1 (fr) | 2020-04-29 | 2023-03-08 | AVM Biotechnology, LLC | Modulateurs de récepteurs de glucocorticoïde (gr) destinés au traitement d'un virus sars-cov-2 |
WO2021247000A1 (fr) | 2020-06-01 | 2021-12-09 | Avm Biotechnology, Llc | Méthodes de traitement faisant appel à des agents de modulation d'icam |
WO2022049572A1 (fr) * | 2020-09-01 | 2022-03-10 | The National Institute for Biotechnology in the Negev Ltd. | Restauration d'un système immunitaire par thérapie cellulaire |
CN113322233A (zh) * | 2021-04-19 | 2021-08-31 | 格源致善(上海)生物科技有限公司 | 一种改进的基于新生抗原反应性t细胞的制备方法及应用 |
CN113480614B (zh) * | 2021-08-13 | 2023-01-10 | 中国人民解放军总医院 | 一类靶向pd-l1的超高亲和力小蛋白及用途 |
WO2023034377A1 (fr) | 2021-09-01 | 2023-03-09 | Avm Biotechnology, Llc | Population de lymphocytes et leurs méthodes de production |
CN114031678A (zh) * | 2021-12-08 | 2022-02-11 | 中国科学院新疆理化技术研究所 | 一种条斑钳蝎毒素多肽组分的制备方法及其应用 |
CN115785203B (zh) * | 2022-06-10 | 2024-03-12 | 河北博海生物工程开发有限公司 | 肺癌特异性分子靶标10及其用途 |
CN116606352B (zh) * | 2023-07-14 | 2023-09-29 | 诺赛联合(北京)生物医学科技有限公司 | 一种抗菌修复功能的组合物凝胶在妇科疾病中的应用 |
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ES2320314T3 (es) | 1997-12-16 | 2009-05-21 | University Of Zurich | Diagnostico para encefalopatia espongiforme transmisible. |
US6406699B1 (en) | 1999-10-05 | 2002-06-18 | Gary W. Wood | Composition and method of cancer antigen immunotherapy |
US20030099621A1 (en) * | 2001-11-29 | 2003-05-29 | Robert Chow | Stem cell screening and transplantation therapy for HIV infection |
IL146970A0 (en) | 2001-12-06 | 2002-08-14 | Yeda Res & Dev | Migration of haematopoietic stem cells and progenitor cells to the liver |
KR20050013531A (ko) | 2002-03-15 | 2005-02-04 | 디파트먼트 오브 베테랑스 어페어스 오피스 오브 더 제네럴 카운셀 (024) | 세포의 아시알로결정자 및 당접합체를 이용하여 세포를조직 및 기관으로 표적화하는 방법 및 이를 위한 조성물 |
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MX2010012576A (es) * | 2008-05-23 | 2011-04-05 | Argos Therapeutics Inc | Nuevos polipeptidos cd83 solubles, formulaciones y metodos de uso. |
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US20100055107A1 (en) * | 2008-07-31 | 2010-03-04 | Defu Zeng | Methods for preventing hematological malignancies and graft versus host disease by anti-cd3 preconditioning |
US10426740B1 (en) * | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
AU2011291651B2 (en) * | 2010-08-18 | 2016-01-14 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
DK2649086T3 (en) | 2010-12-09 | 2017-09-18 | Univ Pennsylvania | USING CHEMICAL ANTIGEN RECEPTOR-MODIFIED T-CELLS TO TREAT CANCER |
CN103442768A (zh) | 2011-01-18 | 2013-12-11 | 宾夕法尼亚大学董事会 | 治疗癌的组合物和方法 |
EP2532740A1 (fr) | 2011-06-11 | 2012-12-12 | Michael Schmück | Préparations de lymphocytes T à mémoire centrale CD4+ et CD8+ spécifiques aux antigènes pour thérapie de lymphocyte T adoptif |
KR20140060541A (ko) | 2011-09-16 | 2014-05-20 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 암을 치료하기 위한 rna 조작된 t 세포 |
US10117896B2 (en) | 2012-10-05 | 2018-11-06 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
JP6765966B2 (ja) * | 2014-04-07 | 2020-10-07 | ノバルティス アーゲー | 抗cd19キメラ抗原受容体を使用する癌の処置 |
CA2973529A1 (fr) * | 2015-01-26 | 2016-08-04 | Cellectis | Recepteur d'antigene chimerique a chaines multiples specifique de cll1 |
US9855298B2 (en) * | 2015-05-28 | 2018-01-02 | Kite Pharma, Inc. | Methods of conditioning patients for T cell therapy |
JP2019536786A (ja) * | 2016-11-30 | 2019-12-19 | イントレキソン コーポレーション | ステロイドの投与および免疫療法 |
WO2018183927A1 (fr) | 2017-04-01 | 2018-10-04 | Avm Biotechnology, Llc | Remplacement de préconditionnement cytotoxique avant une immunothérapie cellulaire |
-
2018
- 2018-03-30 WO PCT/US2018/025517 patent/WO2018183927A1/fr unknown
- 2018-03-30 CN CN201880021900.0A patent/CN110475571B/zh active Active
- 2018-03-30 KR KR1020197031661A patent/KR102509006B1/ko active IP Right Grant
- 2018-03-30 CA CA3054443A patent/CA3054443A1/fr active Pending
- 2018-03-30 ES ES18722262T patent/ES2954311T3/es active Active
- 2018-03-30 IL IL269209A patent/IL269209B2/en unknown
- 2018-03-30 MX MX2019011679A patent/MX2019011679A/es unknown
- 2018-03-30 JP JP2018551293A patent/JP6748221B2/ja active Active
- 2018-03-30 AU AU2018243753A patent/AU2018243753A1/en not_active Abandoned
- 2018-03-30 SG SG11201907744QA patent/SG11201907744QA/en unknown
- 2018-03-30 EP EP18722262.5A patent/EP3490605B1/fr active Active
- 2018-03-30 BR BR112019020214A patent/BR112019020214A2/pt unknown
- 2018-05-10 US US15/976,630 patent/US11219628B2/en active Active
-
2020
- 2020-03-19 JP JP2020049116A patent/JP7162632B2/ja active Active
-
2021
- 2021-12-06 US US17/542,712 patent/US20220160729A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20180296572A1 (en) | 2018-10-18 |
CN110475571B (zh) | 2023-04-04 |
KR20190130624A (ko) | 2019-11-22 |
AU2018243753A1 (en) | 2019-10-10 |
ES2954311T3 (es) | 2023-11-21 |
JP6748221B2 (ja) | 2020-08-26 |
CN110475571A (zh) | 2019-11-19 |
KR102509006B1 (ko) | 2023-03-13 |
WO2018183927A1 (fr) | 2018-10-04 |
BR112019020214A2 (pt) | 2020-04-22 |
JP2020114837A (ja) | 2020-07-30 |
US11219628B2 (en) | 2022-01-11 |
EP3490605C0 (fr) | 2023-06-07 |
IL269209B2 (en) | 2023-11-01 |
EP3490605A1 (fr) | 2019-06-05 |
MX2019011679A (es) | 2019-11-01 |
EP3490605B1 (fr) | 2023-06-07 |
IL269209B1 (en) | 2023-07-01 |
JP2019515888A (ja) | 2019-06-13 |
IL269209A (en) | 2019-11-28 |
CA3054443A1 (fr) | 2018-10-14 |
JP7162632B2 (ja) | 2022-10-28 |
US20220160729A1 (en) | 2022-05-26 |
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