SG11201901999XA - Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making - Google Patents

Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making

Info

Publication number
SG11201901999XA
SG11201901999XA SG11201901999XA SG11201901999XA SG11201901999XA SG 11201901999X A SG11201901999X A SG 11201901999XA SG 11201901999X A SG11201901999X A SG 11201901999XA SG 11201901999X A SG11201901999X A SG 11201901999XA SG 11201901999X A SG11201901999X A SG 11201901999XA
Authority
SG
Singapore
Prior art keywords
international
california
loxl2
methods
inhibitor
Prior art date
Application number
SG11201901999XA
Other languages
English (en)
Inventor
David Lonergan
Kevin Ross Holme
Martin W Rowbottom
Original Assignee
Pharmakea Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmakea Inc filed Critical Pharmakea Inc
Publication of SG11201901999XA publication Critical patent/SG11201901999XA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63Esters of sulfonic acids
    • C07C309/64Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66Methanesulfonates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201901999XA 2016-09-07 2017-09-06 Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making SG11201901999XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662384596P 2016-09-07 2016-09-07
PCT/US2017/050332 WO2018048943A1 (en) 2016-09-07 2017-09-06 Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making

Publications (1)

Publication Number Publication Date
SG11201901999XA true SG11201901999XA (en) 2019-04-29

Family

ID=61561660

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201901999XA SG11201901999XA (en) 2016-09-07 2017-09-06 Crystalline forms of a lysyl oxidase-like 2 inhibitor and methods of making

Country Status (14)

Country Link
US (2) US10774069B2 (enrdf_load_stackoverflow)
EP (1) EP3510023B1 (enrdf_load_stackoverflow)
JP (1) JP7079772B2 (enrdf_load_stackoverflow)
KR (1) KR102587178B1 (enrdf_load_stackoverflow)
CN (1) CN109983006B (enrdf_load_stackoverflow)
AU (1) AU2017324445A1 (enrdf_load_stackoverflow)
BR (1) BR112019004517A2 (enrdf_load_stackoverflow)
CA (1) CA3036064A1 (enrdf_load_stackoverflow)
EA (1) EA201990621A1 (enrdf_load_stackoverflow)
IL (1) IL265192A (enrdf_load_stackoverflow)
MA (1) MA46204A (enrdf_load_stackoverflow)
MX (1) MX390964B (enrdf_load_stackoverflow)
SG (1) SG11201901999XA (enrdf_load_stackoverflow)
WO (1) WO2018048943A1 (enrdf_load_stackoverflow)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6697809B2 (ja) 2015-03-06 2020-05-27 ファーマケア,インク. フッ素化リシルオキシダーゼ様2阻害剤とその使用
US10766860B2 (en) * 2015-03-06 2020-09-08 Pharmakea, Inc. Lysyl oxidase-like 2 inhibitors and uses thereof
CN108884049A (zh) 2016-02-09 2018-11-23 法玛克亚公司 喹啉酮赖氨酰氧化酶样2抑制剂及其用途
BR112019004517A2 (pt) 2016-09-07 2019-08-13 Pharmakea Inc formas cristalinas de um inibidor lisil-oxidase-semelhante 2 e métodos de preparação
MA46203A (fr) 2016-09-07 2019-07-17 Pharmakea Inc Utilisations d'un inhibiteur d'homologue 2 de lysyl-oxydase
GB201716871D0 (en) 2017-10-13 2017-11-29 Inst Of Cancer Research: Royal Cancer Hospital Compounds
CN114487139B (zh) * 2020-10-27 2025-01-14 鲁南制药集团股份有限公司 一种盐酸西替利嗪有关物质的检测方法

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MA46203A (fr) 2016-09-07 2019-07-17 Pharmakea Inc Utilisations d'un inhibiteur d'homologue 2 de lysyl-oxydase
BR112019004517A2 (pt) * 2016-09-07 2019-08-13 Pharmakea Inc formas cristalinas de um inibidor lisil-oxidase-semelhante 2 e métodos de preparação

Also Published As

Publication number Publication date
IL265192A (en) 2019-05-30
US20200361901A1 (en) 2020-11-19
EP3510023A1 (en) 2019-07-17
MX2019002615A (es) 2019-10-15
AU2017324445A1 (en) 2019-04-11
JP7079772B2 (ja) 2022-06-02
EA201990621A1 (ru) 2019-09-30
CN109983006A (zh) 2019-07-05
US20190202805A1 (en) 2019-07-04
EP3510023B1 (en) 2024-06-19
US11459309B2 (en) 2022-10-04
MX390964B (es) 2025-03-21
WO2018048943A1 (en) 2018-03-15
MA46204A (fr) 2021-03-17
CN109983006B (zh) 2022-02-25
KR20190052040A (ko) 2019-05-15
JP2019532919A (ja) 2019-11-14
EP3510023A4 (en) 2020-03-18
KR102587178B1 (ko) 2023-10-06
CA3036064A1 (en) 2018-03-15
BR112019004517A2 (pt) 2019-08-13
US10774069B2 (en) 2020-09-15

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