SG11201901619WA - Bicyclic nitrogenated heterocyclic compound - Google Patents

Bicyclic nitrogenated heterocyclic compound

Info

Publication number
SG11201901619WA
SG11201901619WA SG11201901619WA SG11201901619WA SG11201901619WA SG 11201901619W A SG11201901619W A SG 11201901619WA SG 11201901619W A SG11201901619W A SG 11201901619WA SG 11201901619W A SG11201901619W A SG 11201901619WA SG 11201901619W A SG11201901619W A SG 11201901619WA
Authority
SG
Singapore
Prior art keywords
compound
heterocyclic compound
bicyclic
pde7 inhibitor
pde7
Prior art date
Application number
SG11201901619WA
Other languages
English (en)
Inventor
Tatsuo Nakajima
Norimitsu Hayashi
Kouhei Ishizawa
Yasunori Tsuzaki
Ryo Iwamura
Kazunari Tsuboike
Original Assignee
Mitsubishi Tanabe Pharma Corp
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp, Ube Industries filed Critical Mitsubishi Tanabe Pharma Corp
Publication of SG11201901619WA publication Critical patent/SG11201901619WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Cardiology (AREA)
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  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG11201901619WA 2016-08-26 2017-08-25 Bicyclic nitrogenated heterocyclic compound SG11201901619WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016166277 2016-08-26
PCT/JP2017/030609 WO2018038265A1 (ja) 2016-08-26 2017-08-25 二環式含窒素複素環化合物

Publications (1)

Publication Number Publication Date
SG11201901619WA true SG11201901619WA (en) 2019-03-28

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SG11201901619WA SG11201901619WA (en) 2016-08-26 2017-08-25 Bicyclic nitrogenated heterocyclic compound

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US (1) US20190185479A1 (ja)
EP (1) EP3505171A4 (ja)
JP (1) JPWO2018038265A1 (ja)
KR (1) KR20190040054A (ja)
CN (1) CN109937038A (ja)
AU (1) AU2017316965B2 (ja)
BR (1) BR112019003710A2 (ja)
CA (1) CA3034802A1 (ja)
CO (1) CO2019002246A2 (ja)
MX (1) MX2019002281A (ja)
PH (1) PH12019500394A1 (ja)
RU (1) RU2019108464A (ja)
SG (1) SG11201901619WA (ja)
TW (1) TW201811782A (ja)
WO (1) WO2018038265A1 (ja)

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AU2018350980B2 (en) 2017-10-18 2023-02-23 Incyte Corporation Condensed imidazole derivatives substituted by tertiary hydroxy groups as pi3k-y gamma inhibitors
LT3847175T (lt) 2018-09-05 2024-03-25 Incyte Corporation Fosfoinozitido 3-kinazės (pi3k) inhibitoriaus kristalinės formos
CN110078736B (zh) * 2019-06-05 2021-08-03 广州白云山医药集团股份有限公司白云山制药总厂 吡唑并嘧啶衍生物、其制备方法及其应用
WO2022176837A1 (ja) 2021-02-19 2022-08-25 株式会社エーピーアイ コーポレーション シクロヘキセノン化合物の製造方法
CN112979659B (zh) * 2021-02-22 2022-07-08 中国医科大学 一类HIF-2α小分子抑制剂的制备及用途
WO2023220433A1 (en) * 2022-05-12 2023-11-16 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
WO2024038090A1 (en) 2022-08-18 2024-02-22 Mitodicure Gmbh Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

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TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
JP2006219373A (ja) * 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
BRPI0809244A2 (pt) * 2007-03-27 2014-09-23 Omeros Corp Métodos de tratamento de uma anormalidade de movimento, e para identificação de um agente que inibe a atividade pde7.
CN102482281A (zh) * 2009-07-28 2012-05-30 宇部兴产株式会社 吡咯并[2，3-d]嘧啶衍生物
CA2871151C (en) 2012-05-07 2019-03-26 Omeros Corporation Treatment of addiction and impulse-control disorders using pde7 inhibitors
WO2015164573A1 (en) * 2014-04-25 2015-10-29 Vitae Pharmaceuticals, Inc. Purine derivatives as cd73 inhibitors for the treatment of cancer

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CN109937038A (zh) 2019-06-25
EP3505171A1 (en) 2019-07-03
CA3034802A1 (en) 2018-03-01
RU2019108464A3 (ja) 2020-09-28
CO2019002246A2 (es) 2019-06-28
BR112019003710A2 (pt) 2019-05-28
WO2018038265A1 (ja) 2018-03-01
AU2017316965B2 (en) 2020-09-10
JPWO2018038265A1 (ja) 2019-06-24
NZ751261A (en) 2021-03-26
AU2017316965A1 (en) 2019-04-11
TW201811782A (zh) 2018-04-01
PH12019500394A1 (en) 2020-01-20
EP3505171A4 (en) 2020-08-26
MX2019002281A (es) 2019-06-20
US20190185479A1 (en) 2019-06-20
KR20190040054A (ko) 2019-04-16
RU2019108464A (ru) 2020-09-28

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