SG11201901206SA - Trimer stabilizing hiv envelope protein mutations - Google Patents
Trimer stabilizing hiv envelope protein mutationsInfo
- Publication number
- SG11201901206SA SG11201901206SA SG11201901206SA SG11201901206SA SG11201901206SA SG 11201901206S A SG11201901206S A SG 11201901206SA SG 11201901206S A SG11201901206S A SG 11201901206SA SG 11201901206S A SG11201901206S A SG 11201901206SA SG 11201901206S A SG11201901206S A SG 11201901206SA
- Authority
- SG
- Singapore
- Prior art keywords
- archimedesweg
- leiden
- international
- rule
- hiv
- Prior art date
Links
- 101710091045 Envelope protein Proteins 0.000 title abstract 9
- 101710188315 Protein X Proteins 0.000 title abstract 9
- 102100021696 Syncytin-1 Human genes 0.000 title abstract 9
- 239000013638 trimer Substances 0.000 title abstract 4
- 230000035772 mutation Effects 0.000 title abstract 3
- 230000000087 stabilizing effect Effects 0.000 title abstract 2
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 8
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 239000013598 vector Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
- C07K14/162—HIV-1 ; HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, CD4-Binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16188866 | 2016-09-15 | ||
| PCT/EP2017/073141 WO2018050747A1 (en) | 2016-09-15 | 2017-09-14 | Trimer stabilizing hiv envelope protein mutations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201901206SA true SG11201901206SA (en) | 2019-04-29 |
Family
ID=57017955
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201901206SA SG11201901206SA (en) | 2016-09-15 | 2017-09-14 | Trimer stabilizing hiv envelope protein mutations |
| SG10202001956UA SG10202001956UA (en) | 2016-09-15 | 2017-09-14 | Trimer stabilizing hiv envelope protein mutations |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202001956UA SG10202001956UA (en) | 2016-09-15 | 2017-09-14 | Trimer stabilizing hiv envelope protein mutations |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US10793607B2 (ja) |
| EP (2) | EP3747463A1 (ja) |
| JP (2) | JP7178344B2 (ja) |
| KR (1) | KR102513146B1 (ja) |
| CN (1) | CN109689091A (ja) |
| AR (1) | AR109528A1 (ja) |
| AU (2) | AU2017327672B2 (ja) |
| BR (1) | BR112019004593A2 (ja) |
| CA (1) | CA3036959A1 (ja) |
| CY (1) | CY1124518T1 (ja) |
| DK (1) | DK3512543T3 (ja) |
| EA (1) | EA201990715A1 (ja) |
| ES (1) | ES2824525T3 (ja) |
| HR (1) | HRP20201458T1 (ja) |
| HU (1) | HUE052008T2 (ja) |
| IL (2) | IL294832A (ja) |
| LT (1) | LT3512543T (ja) |
| MA (1) | MA46230B1 (ja) |
| MD (1) | MD3512543T2 (ja) |
| MX (1) | MX2019002938A (ja) |
| MY (1) | MY190534A (ja) |
| PH (1) | PH12019500280A1 (ja) |
| PL (1) | PL3512543T3 (ja) |
| PT (1) | PT3512543T (ja) |
| RS (1) | RS60919B1 (ja) |
| SG (2) | SG11201901206SA (ja) |
| SI (1) | SI3512543T1 (ja) |
| TW (1) | TWI742158B (ja) |
| WO (1) | WO2018050747A1 (ja) |
| ZA (1) | ZA201901597B (ja) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA038974B1 (ru) | 2015-12-15 | 2021-11-17 | Янссен Вэксинс Энд Превеншн Б.В. | Антигены вируса иммунодефицита человека, векторы, композиции и способы их применения |
| US11318197B2 (en) | 2016-03-03 | 2022-05-03 | Duke University | Compositions and methods for inducing HIV-1 antibodies |
| EP3423091A4 (en) | 2016-03-03 | 2019-10-30 | Duke University | COMPOSITIONS AND METHODS OF INDUCING HIV-1 ANTIBODIES |
| CA3022826A1 (en) * | 2016-05-02 | 2017-11-09 | Leopold KONG | Compositions and methods related to hiv-1 immunogens |
| AU2017286375B2 (en) | 2016-06-16 | 2019-04-18 | Janssen Vaccines & Prevention B.V. | HIV vaccine formulation |
| EP3506937A1 (en) | 2016-09-02 | 2019-07-10 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
| IL294832A (en) | 2016-09-15 | 2022-09-01 | Janssen Vaccines Prevention B V | HIV envelope proteins with trimer-stabilizing mutations |
| EP3519428A4 (en) | 2016-10-03 | 2020-07-08 | Duke University | METHOD FOR IDENTIFYING IMMUNOGENIC BY TARGETING UNLIKIBLE MUTATIONS |
| CN110958887B (zh) | 2017-06-15 | 2023-10-31 | 扬森疫苗与预防公司 | 编码hiv抗原的痘病毒载体及其使用方法 |
| WO2019016062A1 (en) | 2017-07-19 | 2019-01-24 | Janssen Vaccines & Prevention B.V. | HIV ENVELOPE PROTEIN MUTATIONS STABILIZING TRIMERIC FORM |
| CN112469661B (zh) | 2018-06-13 | 2024-04-26 | 斯克里普斯研究学院 | 具有新结构组分的纳米粒疫苗 |
| EA038287B1 (ru) * | 2018-06-18 | 2021-08-04 | Янссен Вэксинс Энд Превеншн Б.В. | Стабилизирующие тример мутации белка оболочки hiv |
| WO2020072169A1 (en) * | 2018-10-01 | 2020-04-09 | Duke University | Hiv-1 envelope stabilizing mutations |
| EP3914067A4 (en) * | 2019-01-22 | 2022-11-02 | 2seventy bio, Inc. | METHODS AND SYSTEMS FOR MAKING VIRAL VECTORS |
| CN110184298B (zh) * | 2019-05-15 | 2023-05-16 | 武汉璟泓科技股份有限公司 | Hiv突变型表面糖蛋白及其纳米化抗原与制备方法 |
| US20220401546A1 (en) * | 2019-11-14 | 2022-12-22 | Emory University | HIV Immunogens, Vaccines, and Methods Related Thereto |
| WO2022100703A1 (zh) * | 2020-11-12 | 2022-05-19 | 厦门大学 | 经改造的人免疫缺陷病毒膜蛋白及其应用 |
| AU2022224967A1 (en) | 2021-02-23 | 2023-07-27 | Janssen Vaccines & Prevention B.V. | Trimer stabilizing hiv envelope protein mutation |
| WO2023156505A1 (en) | 2022-02-17 | 2023-08-24 | Janssen Vaccines & Prevention B.V. | Trimer stabilizing hiv envelope protein mutations r304v, n302m and t320l |
| WO2023192835A1 (en) * | 2022-03-27 | 2023-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Base-covered hiv-1 envelope ectodomains and their use |
| WO2024091921A1 (en) * | 2022-10-24 | 2024-05-02 | Duke University | Stabilization of human immunodeficiency virus (hiv) envelopes |
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| US5505947A (en) | 1994-05-27 | 1996-04-09 | The University Of North Carolina At Chapel Hill | Attenuating mutations in Venezuelan Equine Encephalitis virus |
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| US20080274134A1 (en) | 2004-06-15 | 2008-11-06 | Norbert Schulke | Hiv-1 Neutralizing Antibodies Elicited By Trimeric Hiv-1 Envelope Glycoprotein Complex |
| ATE527281T1 (de) | 2004-07-16 | 2011-10-15 | Us Gov Health & Human Serv | Impfstoffe gegen aids umfassend cmv/r nucleinsäurekonstrukte |
| EA010433B1 (ru) | 2004-10-13 | 2008-08-29 | Круселл Холланд Б.В. | Усовершенствованные аденовирусные векторы и их применение |
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| CA2656741A1 (en) | 2005-07-06 | 2007-01-11 | University Of Maryland Biotechnology Institute | Constrained hiv envelope-based immunogen that simultaneously presents receptor and coreceptor binding sites |
| CN101969996A (zh) | 2005-08-23 | 2011-02-09 | 加利福尼亚大学董事会 | 多价疫苗 |
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| WO2008140579A2 (en) | 2006-11-17 | 2008-11-20 | New York University | Induction of broadly reactive neutralizing antibodies by focusing the immune response on v3 epitopes of the hiv-1 gp120 envelope |
| US20100055166A1 (en) | 2007-03-02 | 2010-03-04 | Gerald Hermann Voss | Novel method and compositions |
| EP3335728B8 (en) | 2008-10-10 | 2020-03-11 | Children's Medical Center Corporation | Biochemically stabilized hiv-1 env trimer vaccine |
| EP2358757B1 (en) | 2008-11-18 | 2018-09-12 | Beth Israel Deaconess Medical Center | Antiviral vaccines with improved cellular immunogenicity |
| WO2010096561A1 (en) | 2009-02-18 | 2010-08-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synthetic hiv/siv gag proteins and uses thereof |
| US9241986B2 (en) | 2010-01-04 | 2016-01-26 | Kj Biosciences Llc | DPS fusion proteins for use in vaccines and diagnostics |
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| NZ710727A (en) | 2013-01-07 | 2020-03-27 | Beth Israel Deaconess Medical Ct Inc | Stabilized human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using the same |
| US10248758B2 (en) | 2013-02-07 | 2019-04-02 | University Of Washington Through Its Center For Commercialization | Self-assembling protein nanostructures |
| EP3052132B1 (en) | 2013-09-30 | 2020-07-29 | Beth Israel Deaconess Medical Center, Inc. | Antibody therapies for human immunodeficiency virus (hiv) |
| US10400015B2 (en) * | 2014-09-04 | 2019-09-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant HIV-1 envelope proteins and their use |
| EA202092521A1 (ru) | 2014-09-26 | 2021-05-31 | Бет Изрейэл Диконисс Медикал Сентер, Инк. | Способы и композиции для индукции защитного иммунитета против инфекции вирусом иммунодефицита человека |
| US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
| HUE051897T2 (hu) | 2015-03-18 | 2021-03-29 | Janssen Vaccines & Prevention Bv | Vizsgálatok rekombináns expressziós rendszerekre |
| EA038974B1 (ru) | 2015-12-15 | 2021-11-17 | Янссен Вэксинс Энд Превеншн Б.В. | Антигены вируса иммунодефицита человека, векторы, композиции и способы их применения |
| AU2017286375B2 (en) | 2016-06-16 | 2019-04-18 | Janssen Vaccines & Prevention B.V. | HIV vaccine formulation |
| EP3506937A1 (en) | 2016-09-02 | 2019-07-10 | Janssen Vaccines & Prevention B.V. | Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment |
| IL294832A (en) | 2016-09-15 | 2022-09-01 | Janssen Vaccines Prevention B V | HIV envelope proteins with trimer-stabilizing mutations |
| WO2019016062A1 (en) * | 2017-07-19 | 2019-01-24 | Janssen Vaccines & Prevention B.V. | HIV ENVELOPE PROTEIN MUTATIONS STABILIZING TRIMERIC FORM |
-
2017
- 2017-09-14 IL IL294832A patent/IL294832A/en unknown
- 2017-09-14 PT PT177690278T patent/PT3512543T/pt unknown
- 2017-09-14 EA EA201990715A patent/EA201990715A1/ru unknown
- 2017-09-14 MY MYPI2019001242A patent/MY190534A/en unknown
- 2017-09-14 LT LTEP17769027.8T patent/LT3512543T/lt unknown
- 2017-09-14 MX MX2019002938A patent/MX2019002938A/es unknown
- 2017-09-14 US US15/704,651 patent/US10793607B2/en active Active
- 2017-09-14 CN CN201780054555.6A patent/CN109689091A/zh active Pending
- 2017-09-14 ES ES17769027T patent/ES2824525T3/es active Active
- 2017-09-14 WO PCT/EP2017/073141 patent/WO2018050747A1/en active Search and Examination
- 2017-09-14 HU HUE17769027A patent/HUE052008T2/hu unknown
- 2017-09-14 BR BR112019004593A patent/BR112019004593A2/pt unknown
- 2017-09-14 SI SI201730416T patent/SI3512543T1/sl unknown
- 2017-09-14 RS RS20201208A patent/RS60919B1/sr unknown
- 2017-09-14 EP EP20179463.3A patent/EP3747463A1/en active Pending
- 2017-09-14 KR KR1020197007592A patent/KR102513146B1/ko active IP Right Grant
- 2017-09-14 AR ARP170102536A patent/AR109528A1/es unknown
- 2017-09-14 JP JP2019514316A patent/JP7178344B2/ja active Active
- 2017-09-14 MD MDE20190798T patent/MD3512543T2/ro unknown
- 2017-09-14 SG SG11201901206SA patent/SG11201901206SA/en unknown
- 2017-09-14 IL IL265186A patent/IL265186B/en unknown
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