SG11201811159SA - Methods for multi-resolution analysis of cell-free nucleic acids - Google Patents

Methods for multi-resolution analysis of cell-free nucleic acids

Info

Publication number
SG11201811159SA
SG11201811159SA SG11201811159SA SG11201811159SA SG11201811159SA SG 11201811159S A SG11201811159S A SG 11201811159SA SG 11201811159S A SG11201811159S A SG 11201811159SA SG 11201811159S A SG11201811159S A SG 11201811159SA SG 11201811159S A SG11201811159S A SG 11201811159SA
Authority
SG
Singapore
Prior art keywords
international
cell
genomic regions
pct
regions
Prior art date
Application number
SG11201811159SA
Other languages
English (en)
Inventor
Darya Chudova
Helmy Eltoukhy
Stefanie Ann Mortimer
Diana Abdueva
Marcin Sikora
Original Assignee
Guardant Health Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61760169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201811159S(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Guardant Health Inc filed Critical Guardant Health Inc
Publication of SG11201811159SA publication Critical patent/SG11201811159SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/159—Reduction of complexity, e.g. amplification of subsets, removing duplicated genomic regions

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medical Informatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Data Mining & Analysis (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Bioethics (AREA)
  • Physiology (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SG11201811159SA 2016-09-30 2017-09-29 Methods for multi-resolution analysis of cell-free nucleic acids SG11201811159SA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662402940P 2016-09-30 2016-09-30
US201762468201P 2017-03-07 2017-03-07
US201762489391P 2017-04-24 2017-04-24
PCT/US2017/054607 WO2018064629A1 (en) 2016-09-30 2017-09-29 Methods for multi-resolution analysis of cell-free nucleic acids

Publications (1)

Publication Number Publication Date
SG11201811159SA true SG11201811159SA (en) 2019-01-30

Family

ID=61760169

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201811159SA SG11201811159SA (en) 2016-09-30 2017-09-29 Methods for multi-resolution analysis of cell-free nucleic acids

Country Status (10)

Country Link
US (8) US20200013482A1 (ja)
EP (2) EP3792922A1 (ja)
JP (5) JP6560465B1 (ja)
KR (2) KR102344635B1 (ja)
CN (1) CN109642250B (ja)
AU (2) AU2017336153B2 (ja)
CA (2) CA3126055A1 (ja)
ES (1) ES2840003T3 (ja)
SG (1) SG11201811159SA (ja)
WO (1) WO2018064629A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2697397B1 (en) 2011-04-15 2017-04-05 The Johns Hopkins University Safe sequencing system
ES2886507T3 (es) 2012-10-29 2021-12-20 Univ Johns Hopkins Prueba de Papanicolaou para cánceres de ovario y de endometrio
SG10202009015SA (en) 2012-12-10 2020-10-29 Resolution Bioscience Inc Methods for targeted genomic analysis
WO2017027653A1 (en) 2015-08-11 2017-02-16 The Johns Hopkins University Assaying ovarian cyst fluid
KR20180113973A (ko) 2015-11-11 2018-10-17 레졸루션 바이오사이언스, 인크. Dna 라이브러리의 고효율 작제
EP3443066A4 (en) 2016-04-14 2019-12-11 Guardant Health, Inc. EARLY DETECTION METHODS FOR CANCER
US20190287645A1 (en) * 2016-07-06 2019-09-19 Guardant Health, Inc. Methods for fragmentome profiling of cell-free nucleic acids
AU2017315769B2 (en) 2016-08-25 2024-02-01 Resolution Bioscience, Inc. Methods for the detection of genomic copy changes in DNA samples
CA3126055A1 (en) 2016-09-30 2018-04-05 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
MX2020001575A (es) 2017-08-07 2020-11-18 Univ Johns Hopkins Materiales y métodos para evaluar y tratar el cáncer.
EP3781713A4 (en) * 2018-04-16 2022-01-12 Memorial Sloan-Kettering Cancer Center SYSTEMS AND METHODS FOR DETECTING CANCER THROUGH CFDNA SCREENING
WO2023282916A1 (en) 2021-07-09 2023-01-12 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
EP4205126A1 (en) 2020-08-25 2023-07-05 Guardant Health, Inc. Methods and systems for predicting an origin of a variant
CN117935921B (zh) * 2024-03-21 2024-06-11 北京贝瑞和康生物技术有限公司 确定缺失/重复类型的方法、设备、介质和程序产品

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH686982A5 (fr) 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US5648245A (en) 1995-05-09 1997-07-15 Carnegie Institution Of Washington Method for constructing an oligonucleotide concatamer library by rolling circle replication
EP0929694A4 (en) 1996-03-15 2002-05-02 Penn State Res Found DETECTION OF TUMOR-RELATED EXTRACELLULAR NUCLEIC ACID USING PLASMA OR BLOOD SERUM USING NUCLEIC ACID AMPLIFICATION TESTS
CA2250118C (en) 1996-03-26 2009-09-29 Michael S. Kopreski Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer
US6232066B1 (en) * 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
JP2002539849A (ja) 1999-03-26 2002-11-26 ホワイトヘッド インスチチュート フォアー バイオメディカル リサーチ ユニバーサルアレイ
AU767983B2 (en) 1999-04-09 2003-11-27 Esoterix Genetic Laboratories, Llc Methods for detecting nucleic acids indicative of cancer
EP1046717B1 (en) 1999-04-20 2010-10-06 National Institute of Advanced Industrial Science and Technology Method and probes for determining a concentration of target nucleic acid molecules and method for analyzing data obtained by the method
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6586177B1 (en) 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
CA2394921A1 (en) 1999-12-07 2001-06-14 Anthony P. Shuber Supracolonic aerodigestive neoplasm detection
GB2364054B (en) 2000-03-24 2002-05-29 Smithkline Beecham Corp Method of amplifying quinolone-resistance-determining-regions and identifying polymorphic variants thereof
EP1158055A1 (fr) 2000-05-26 2001-11-28 Xu Qi University of Teaxs Laboratoire de Leucémie Chen Méthode pour le diagnostic de cancers
AU2002246612B2 (en) 2000-10-24 2007-11-01 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic DNA
DE60207979T2 (de) 2002-03-05 2006-09-28 Epigenomics Ag Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7635564B2 (en) * 2002-10-25 2009-12-22 Agilent Technologies, Inc. Biopolymeric arrays having replicate elements
US10229244B2 (en) 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
EP2532745B1 (en) 2003-07-05 2015-09-09 The Johns Hopkins University Method and Compositions for Detection and Enumeration of Genetic Variations
ATE435301T1 (de) 2003-10-16 2009-07-15 Sequenom Inc Nicht invasiver nachweis fötaler genetischer merkmale
DE10348407A1 (de) 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
CA2899287A1 (en) * 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
US20100216153A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US7937225B2 (en) 2004-09-03 2011-05-03 New York University Systems, methods and software arrangements for detection of genome copy number variation
US20060073506A1 (en) 2004-09-17 2006-04-06 Affymetrix, Inc. Methods for identifying biological samples
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US7424371B2 (en) 2004-12-21 2008-09-09 Helicos Biosciences Corporation Nucleic acid analysis
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
ITRM20050068A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
PL1712639T3 (pl) 2005-04-06 2009-02-27 Maurice Stroun Sposób diagnozowania nowotworu przez wykrywanie krążącego DNA i RNA
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
ATE453728T1 (de) 2005-09-29 2010-01-15 Keygene Nv Screening mutagenisierter populationen mit hohem durchsatz
US7537897B2 (en) 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
US8383338B2 (en) 2006-04-24 2013-02-26 Roche Nimblegen, Inc. Methods and systems for uniform enrichment of genomic regions
CN101449162B (zh) 2006-05-18 2013-07-31 分子压型学会股份有限公司 确定针对病状的个性化医疗介入的系统和方法
US20080090239A1 (en) 2006-06-14 2008-04-17 Daniel Shoemaker Rare cell analysis using sample splitting and dna tags
EP2518162B1 (en) 2006-11-15 2018-03-07 Biospherex LLC Multitag sequencing and ecogenomics analysis
US20080131887A1 (en) 2006-11-30 2008-06-05 Stephan Dietrich A Genetic Analysis Systems and Methods
US20100196898A1 (en) 2007-05-24 2010-08-05 The Brigham & Women's Hospital, Inc. Disease-associated genetic variations and methods for obtaining and using same
US20090105959A1 (en) 2007-06-01 2009-04-23 Braverman Michael S System and method for identification of individual samples from a multiplex mixture
KR102516709B1 (ko) 2007-07-23 2023-04-03 더 차이니즈 유니버시티 오브 홍콩 핵산 서열 불균형의 결정
CN101911318A (zh) 2007-12-28 2010-12-08 3M创新有限公司 发射均匀波长的下变换光源
EP2245198A1 (en) 2008-02-04 2010-11-03 Massachusetts Institute of Technology Selection of nucleic acids by solution hybridization to oligonucleotide baits
MX2010008820A (es) 2008-02-12 2010-09-07 Novartis Ag Metodo para aislar acidos nucleicos fetales o apoptoticos libres de celulas.
MX2010010600A (es) 2008-03-28 2011-03-30 Pacific Biosciences California Inc Composiciones y metodos para secuenciacion de acidos nucleicos.
US20090318305A1 (en) 2008-06-18 2009-12-24 Xi Erick Lin Methods for selectively capturing and amplifying exons or targeted genomic regions from biological samples
WO2010021936A1 (en) 2008-08-16 2010-02-25 The Board Of Trustees Of The Leland Stanford Junior University Digital pcr calibration for high throughput sequencing
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US20100323348A1 (en) 2009-01-31 2010-12-23 The Regents Of The University Of Colorado, A Body Corporate Methods and Compositions for Using Error-Detecting and/or Error-Correcting Barcodes in Nucleic Acid Amplification Process
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
WO2011091046A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing
GB2485645B (en) 2010-01-19 2012-11-21 Verinata Health Inc Improved identification of partial aneuploidies using a normalising sequence
EP2591433A4 (en) 2010-07-06 2017-05-17 Life Technologies Corporation Systems and methods to detect copy number variation
SG187646A1 (en) 2010-07-29 2013-03-28 Toto Ltd Photocatalyst coated body and photocatalyst coating liquid
WO2012038839A2 (en) 2010-09-21 2012-03-29 Population Genetics Technologies Ltd. Increasing confidence of allele calls with molecular counting
US8725422B2 (en) 2010-10-13 2014-05-13 Complete Genomics, Inc. Methods for estimating genome-wide copy number variations
EP3461914A1 (en) 2010-10-22 2019-04-03 Cold Spring Harbor Laboratory Varietal counting of nucleic acids for obtaining genomic copy number information
KR20210131432A (ko) * 2010-12-30 2021-11-02 파운데이션 메디신 인코포레이티드 종양 샘플의 다유전자 분석의 최적화
RU2671980C2 (ru) * 2011-02-09 2018-11-08 Натера, Инк. Способы неинвазивного пренатального установления плоидности
WO2012129363A2 (en) 2011-03-24 2012-09-27 President And Fellows Of Harvard College Single cell nucleic acid detection and analysis
EP2697397B1 (en) 2011-04-15 2017-04-05 The Johns Hopkins University Safe sequencing system
EP3789498A1 (en) 2011-04-25 2021-03-10 Bio-rad Laboratories, Inc. Methods for nucleic acid analysis
WO2012162267A2 (en) 2011-05-20 2012-11-29 Fluidigm Corporation Nucleic acid encoding reactions
KR101454886B1 (ko) 2011-08-01 2014-11-03 주식회사 셀레믹스 핵산분자의 제조방법
PL2768985T3 (pl) 2011-10-21 2019-10-31 Chronix Biomedical Biomarkery będące krążącymi kwasami nukleinowymi związane z rakiem jelita grubego
WO2013060762A1 (en) 2011-10-25 2013-05-02 Roche Diagnostics Gmbh Method for diagnosing a disease based on plasma-dna distribution
RS61631B1 (sr) 2012-02-17 2021-04-29 Hutchinson Fred Cancer Res Kompozicije i postupci za preciznu identifikaciju mutacija
US11261494B2 (en) * 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
CA2883901C (en) 2012-09-04 2023-04-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
WO2014160352A1 (en) * 2013-03-13 2014-10-02 Abbott Molecular Inc. Target sequence enrichment
EP2971152B1 (en) 2013-03-15 2018-08-01 The Board Of Trustees Of The Leland Stanford Junior University Identification and use of circulating nucleic acid tumor markers
EP3882362B1 (en) 2013-03-15 2024-05-08 Guardant Health, Inc. Methods for sequencing of cell free polynucleotides
AU2014268710B2 (en) 2013-05-23 2018-10-18 The Board Of Trustees Of The Leland Stanford Junior University Transposition into native chromatin for personal epigenomics
EP3524694B1 (en) 2013-12-28 2020-07-15 Guardant Health, Inc. Methods and systems for detecting genetic variants
CN113774132A (zh) 2014-04-21 2021-12-10 纳特拉公司 检测染色体片段中的突变和倍性
WO2015175705A1 (en) 2014-05-13 2015-11-19 Board Of Regents, The University Of Texas System Gene mutations and copy number alterations of egfr, kras and met
SI3178941T1 (sl) 2014-07-25 2022-04-29 Bgi Genomics Co., Limited Postopek za določanje deleža brezceličnih fetalnih nukleinskih kislin v vzorcu periferne krvi nosečnice in njegova uporaba
KR20220127359A (ko) 2014-07-25 2022-09-19 유니버시티 오브 워싱톤 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
US11085084B2 (en) 2014-09-12 2021-08-10 The Board Of Trustees Of The Leland Stanford Junior University Identification and use of circulating nucleic acids
CN114807307A (zh) * 2014-10-29 2022-07-29 10X 基因组学有限公司 用于靶核酸测序的方法和组合物
ES2923602T3 (es) 2014-12-31 2022-09-28 Guardant Health Inc Detección y tratamiento de enfermedades que muestran heterogeneidad celular de enfermedad y sistemas y métodos para comunicar los resultados de las pruebas
ES2908347T3 (es) 2015-02-10 2022-04-28 Univ Hong Kong Chinese Detección de mutaciones para cribado de cáncer y análisis fetal
US20160281166A1 (en) * 2015-03-23 2016-09-29 Parabase Genomics, Inc. Methods and systems for screening diseases in subjects
ES2969767T3 (es) 2015-05-01 2024-05-22 Guardant Health Inc Métodos de diagnóstico
EP3325667B1 (en) 2015-07-21 2020-11-11 Guardant Health, Inc. Locked nucleic acids for capturing fusion genes
EP3325664B1 (en) 2015-07-23 2021-12-29 The Chinese University Of Hong Kong Analysis of fragmentation patterns of cell-free dna
US11302416B2 (en) 2015-09-02 2022-04-12 Guardant Health Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications
US20170058332A1 (en) 2015-09-02 2017-03-02 Guardant Health, Inc. Identification of somatic mutations versus germline variants for cell-free dna variant calling applications
WO2017062867A1 (en) 2015-10-09 2017-04-13 Helmy Eltoukhy Population based treatment recommender using cell free dna
EP3693459A1 (en) 2015-10-10 2020-08-12 Guardant Health, Inc. Methods and applications of gene fusion detection in cell-free dna analysis
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
CA3013366A1 (en) 2016-02-02 2017-08-10 Guardant Health, Inc. Cancer evolution detection and diagnostic
CA3126055A1 (en) 2016-09-30 2018-04-05 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids
US9850523B1 (en) * 2016-09-30 2017-12-26 Guardant Health, Inc. Methods for multi-resolution analysis of cell-free nucleic acids

Also Published As

Publication number Publication date
US20230253071A1 (en) 2023-08-10
CN109642250B (zh) 2024-06-04
CA3027919A1 (en) 2018-04-05
US20230260596A1 (en) 2023-08-17
CA3027919C (en) 2023-02-28
US20210358567A1 (en) 2021-11-18
WO2018064629A1 (en) 2018-04-05
EP3792922A1 (en) 2021-03-17
AU2017336153A1 (en) 2019-01-17
US20240087680A1 (en) 2024-03-14
JP2021040655A (ja) 2021-03-18
JP6806854B2 (ja) 2021-01-06
JP7385686B2 (ja) 2023-11-22
JP6560465B1 (ja) 2019-08-21
JP2019170401A (ja) 2019-10-10
EP3461274A4 (en) 2019-05-22
JP2019531048A (ja) 2019-10-31
AU2023204088A1 (en) 2023-08-17
EP3461274A1 (en) 2019-04-03
US20240136014A1 (en) 2024-04-25
US11817177B2 (en) 2023-11-14
JP2022058904A (ja) 2022-04-12
US11817179B2 (en) 2023-11-14
EP3461274B1 (en) 2020-11-04
ES2840003T3 (es) 2021-07-06
JP2024012567A (ja) 2024-01-30
KR102344635B1 (ko) 2021-12-31
CN109642250A (zh) 2019-04-16
KR20190053818A (ko) 2019-05-20
CA3126055A1 (en) 2018-04-05
AU2017336153B2 (en) 2023-07-13
US20200185060A1 (en) 2020-06-11
US20240087681A1 (en) 2024-03-14
JP7022188B2 (ja) 2022-02-17
KR20210158870A (ko) 2021-12-31
US11062791B2 (en) 2021-07-13
US20200013482A1 (en) 2020-01-09

Similar Documents

Publication Publication Date Title
SG11201811159SA (en) Methods for multi-resolution analysis of cell-free nucleic acids
SG11201805119QA (en) Methods to determine tumor gene copy number by analysis of cell-free dna
SG11201908658TA (en) Nucleobase editors comprising nucleic acid programmable dna binding proteins
SG11201906161VA (en) Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
SG11201907618RA (en) Automated storage and retrieval systems and methods
SG11201903697WA (en) Liver organoid compositions and methods of making and using same
SG11201804836RA (en) Treatment of fibrosis
SG11201903882VA (en) Il-2 variants for the treatment of autoimmune diseases
SG11201805217XA (en) Compositions and methods for the treatment of hemoglobinopathies
SG11201908489XA (en) De novo synthesized combinatorial nucleic acid libraries
SG11201807487WA (en) Generation of midbrain-specific organoids from human pluripotent stem cells
SG11201809963XA (en) Application framework using blockchain-based asset ownership
SG11201900752PA (en) Cybersecurity vulnerability management system and method
SG11201908319WA (en) Methods and systems for printing biological material
SG11201806002SA (en) Methods for extending the replicative capacity of somatic cells during an ex vivo cultivation process
SG11201807077RA (en) Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
SG11201806630QA (en) Self-propelled personal transportation device
SG11201811025VA (en) Systems and methods for automated annotation and screening of biological sequences
SG11201804814YA (en) Materials and methods for delivering nucleic acids to cochlear and vestibular cells
SG11201407486PA (en) Compositions and methods for modulating utrn expression
SG11201808721YA (en) Cell-free production of ribonucleic acid
SG11201806609TA (en) Cancer evolution detection and diagnostic
SG11201811232XA (en) Treatment of amd using aav2 variant with aflibercept
SG11201407483YA (en) Compositions and methods for modulating smn gene family expression
SG11201805680SA (en) Methods and compositions for the treatment of neurologic disease