SG11201906161VA - Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells - Google Patents

Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells

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Publication number
SG11201906161VA
SG11201906161VA SG11201906161VA SG11201906161VA SG11201906161VA SG 11201906161V A SG11201906161V A SG 11201906161VA SG 11201906161V A SG11201906161V A SG 11201906161VA SG 11201906161V A SG11201906161V A SG 11201906161VA SG 11201906161V A SG11201906161V A SG 11201906161VA
Authority
SG
Singapore
Prior art keywords
street
international
january
pct
microorganisms
Prior art date
Application number
SG11201906161VA
Inventor
Dean Falb
Jonathan Kotula
Vincent Isabella
Paul Miller
Suman Machinani
Saurabh Saha
Adam Fisher
Yves Millet
Ning Li
Jose Lora
Original Assignee
Synlogic Operating Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2017/013072 external-priority patent/WO2017123675A1/en
Application filed by Synlogic Operating Co Inc filed Critical Synlogic Operating Co Inc
Publication of SG11201906161VA publication Critical patent/SG11201906161VA/en

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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 July 2018 (12.07.2018) WIPO I PCT ill mu °million °nolo Oil Oil mo Ho IIIII m 111110 oimIE (10) International Publication Number WO 2018/129404 Al (51) International Patent Classification: A61K 35/74 (2015.01) Cl 2N 15/74 (2006.01) C12N 15/70 (2006.01) (21) International Application Number: PCT/US2018/012698 (22) International Filing Date: 05 January 2018 (05.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/443,639 06 January 2017 (06.01.2017) US 62/443,634 06 January 2017 (06.01.2017) US PCT/US2017/013072 11 January 2017 (11.01.2017) US 62/531,784 12 July 2017 (12.07.2017) US 62/543,322 09 August 2017 (09.08.2017) US 62/552,319 30 August 2017 (30.08.2017) US 62/592,317 29 November 2017 (29.11.2017) US 62/607,210 18 December 2017 (18.12.2017) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) W O 20 18/ 129 40 4 Al (71) Applicant: SYNLOGIC, INC. [US/US]; 200 Sidney Street, #320, Cambridge, MA 02139 (US). (72) Inventors: FALB, Dean; 180 Lake Street, Sherborn, MA 01770 (US). KOTULA, Jonathan, W.; 345 Washington Street, Somerville, MA 02143 (US). ISABELLA, Vincent, M.; 465 Putnam Avenue, Unit 1, Cambridge, MA 02139 (US). MILLER, Paul, F.; 39 Emerald Glen Lane, Salem, CT 06420 (US). FISHER, Adam; 240 Sidney Street, Apt. 306, Cambride, MA 02139 (US). MILLET, Yves; 15 Fred- erick Street, Newton, MA 02460 (US). LI, Ning; 322 Cam- bridge Street, Winchester, MA 01890 (US). LORA, Jose, M.; 45 Province Street, Apt. 902, Boston, MA 02108 (US). MACHINANI, Suman; 18 Centre Street, Apt. 302, Cam- bridge, MA 02139 (US). SAHA, Saurabh; 44 Carisbrooke Road, Wellesley Hills, MA 02481 (US). (74) Agent: HANLEY, Elizabeth, A. et al.; McCarter & Eng- lish, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: MICROORGANISMS PROGRAMMED TO PRODUCE IMMUNE MODULATORS AND ANTI-CANCER THERA- PEUTICS IN TUMOR CELLS (57) : Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.
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US201762443639P 2017-01-06 2017-01-06
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PCT/US2017/013072 WO2017123675A1 (en) 2016-01-11 2017-01-11 Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
US201762531784P 2017-07-12 2017-07-12
US201762543322P 2017-08-09 2017-08-09
US201762552319P 2017-08-30 2017-08-30
US201762592317P 2017-11-29 2017-11-29
US201762607210P 2017-12-18 2017-12-18
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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3011283A1 (en) 2016-01-11 2017-07-20 Synlogic Operating Company, Inc. Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
WO2018129404A1 (en) * 2017-01-06 2018-07-12 Synlogic, Inc. Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
US11168326B2 (en) 2017-07-11 2021-11-09 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
AU2018301668A1 (en) * 2017-07-12 2019-12-19 Synlogic Operating Company, Inc. Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
EP3820992A2 (en) 2018-07-11 2021-05-19 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
EP3823653A4 (en) * 2018-07-20 2022-05-18 The Trustees of Columbia University in the City of New York Programmable bacteria for the treatment of cancer
US11795203B2 (en) 2018-07-30 2023-10-24 Jinyu Zhang Protein heterodimer and use thereof
WO2020047161A2 (en) 2018-08-28 2020-03-05 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
AU2019376140A1 (en) * 2018-11-08 2021-06-03 Synlogic Operating Company, Inc. Combination therapies of microorganisms and immune modulators for use in treating cancer
CN109750054B (en) * 2019-02-21 2021-07-02 华中农业大学 Mycoplasma bovis protein gene MbovGdpp and application thereof
MX2021010273A (en) 2019-02-27 2021-09-23 Actym Therapeutics Inc Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment.
US12024709B2 (en) 2019-02-27 2024-07-02 Actym Therapeutics, Inc. Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment
CN110055188A (en) * 2019-03-07 2019-07-26 南京师范大学 One plant of Paenibacillus polymyxa XW4 for producing bacteriostatic peptide and its separation screening and application
JP2022530503A (en) 2019-04-29 2022-06-29 シンロジック オペレーティング カンパニー インコーポレイテッド Genetically engineered microorganisms
CA3140174A1 (en) * 2019-05-13 2020-11-19 Synlogic Operating Company, Inc. Synergistic combinations of arginine-producing bacteria and/or ammonia-consuming bacteria and checkpoint inhibitors and methods of use thereof
CN110734888B (en) * 2019-09-17 2021-08-03 广州维生君生物科技有限公司 TIM3 human single-chain antibody fusion gene transformed lactic acid bacteria and application thereof
EP4058578A2 (en) 2019-11-12 2022-09-21 Actym Therapeutics, Inc. Immunostimulatory bacteria delivery platforms and their use for delivery of therapeutic products
CN111254087B (en) * 2019-12-27 2021-12-17 杭州娃哈哈科技有限公司 Lactobacillus helveticus with high adhesion performance and function of enhancing immunity and application thereof
JP2023514553A (en) * 2020-02-13 2023-04-06 ザ・ジョンズ・ホプキンス・ユニバーシティ Recombinant therapeutic intervention for cancer
WO2021163490A1 (en) * 2020-02-14 2021-08-19 University Of Washington Targeted depletion of bacteria from mixed populations through programmable cell-cell adhesion
WO2021212122A2 (en) * 2020-04-17 2021-10-21 University Of Cincinnati Engineered probiotics for treatment and immunity against viruses
WO2021252519A1 (en) * 2020-06-08 2021-12-16 University Of Florida Research Foundation, Inc. Materials and methods for the diagnosis and treatment of cancer
CN111849805B (en) * 2020-06-17 2022-04-22 天津科技大学 Pediococcus acidilactici with cervical cancer resistance effect and application thereof
WO2022008550A1 (en) * 2020-07-07 2022-01-13 Danmarks Tekniske Universitet Bacterial vehicle for engineering of non-phagocytic immune cells
WO2022036159A2 (en) 2020-08-12 2022-02-17 Actym Therapeutics, Inc. Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms
CN114073777A (en) * 2020-08-18 2022-02-22 中国科学院深圳先进技术研究院 Bacterial targeting vector carrying cytokine or polynucleotide thereof and application thereof in tumor treatment
CA3195627A1 (en) * 2020-10-26 2022-05-05 Stefano FERRARA Il-2/il-15r.beta..gamma. agonist for treating squamous cell carcinoma
KR20230096047A (en) * 2020-10-26 2023-06-29 싸이튠 파마 IL-2/IL-15Rβγ agonists for the treatment of non-melanoma skin cancer
CN112342233B (en) * 2020-11-10 2022-08-26 上海陶宇晟生物技术有限责任公司 Polynucleotide for increasing c-di-AMP production when bacteria express DacA
CA3200887A1 (en) 2020-12-02 2022-06-09 Michael James Engineered microorganisms
KR102287114B1 (en) * 2021-01-25 2021-08-06 씨제이제일제당 주식회사 Novel cytosine permease variant and a method for producing L-tryptophan using the same
CN112877271B (en) * 2021-02-05 2023-03-14 江西师范大学 Method for improving L-arginine production of corynebacterium crenatum through anaerobic fermentation
AU2022259522A1 (en) * 2021-04-13 2023-10-19 Synlogic Operating Company, Inc. Bacteria engineered to secrete active proteins
US20240139280A1 (en) * 2021-04-14 2024-05-02 OncoC4, Inc. Use of hif-1-alpha inhibitors in cancer immunotherapy
CA3235418A1 (en) 2021-11-09 2023-05-19 Actym Therapeutics, Inc. Immunostimulatory bacteria for converting macrophages into a phenotype amenable to treatment, and companion diagnostic for identifying subjects for treatment
CN114181863B (en) * 2021-12-15 2023-06-23 安徽师范大学 Violet bacillus strain E1, preparation method thereof and application thereof in degradation of phthalate
WO2023161371A1 (en) * 2022-02-25 2023-08-31 Danmarks Tekniske Universitet Engineered bacteria secreting cytokines for use in cancer immunotherapy
CN116836283B (en) * 2022-05-17 2024-05-07 苏州万灏生物科技有限公司 Enhanced oncolytic virus with multiple immune regulatory factors, and preparation method and application thereof
CN114958891B (en) * 2022-05-24 2023-04-14 郑州大学 Escherichia coli recombinant expression vector and application thereof
WO2024075067A1 (en) * 2022-10-06 2024-04-11 Centro Di Riferimento Oncologico Cancer vaccine composition that comprises a host cell expressing glypican-1 (gpc-1)
WO2024129958A2 (en) * 2022-12-15 2024-06-20 Kalivir Immunotherapeutics, Inc. Compositions of cd47/sirp-alpha immune checkpoint inhibitors and uses thereof

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB9107305D0 (en) 1991-04-08 1991-05-22 Unilever Plc Probiotic
US6203797B1 (en) 1998-01-06 2001-03-20 Stephen C. Perry Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome
EP1034787A1 (en) 1999-03-11 2000-09-13 Société des Produits Nestlé S.A. Lactobacillus strains preventing diarrhea caused by pathogenic bacteria
US6962696B1 (en) * 1999-10-04 2005-11-08 Vion Pharmaceuticals Inc. Compositions and methods for tumor-targeted delivery of effector molecules
KR20020059605A (en) * 1999-10-04 2002-07-13 추후제출 Compositions and methods for tumor-targeted delivery of effector molecules
JP2005516917A (en) 2001-12-12 2005-06-09 アメリカ合衆国 Methods for enhancing immune response and inflammation using extracellular adenosine inhibitors and adenosine receptor inhibitors
US7731976B2 (en) 2003-08-29 2010-06-08 Cobb And Company, Llp Treatment of irritable bowel syndrome using probiotic composition
JP6092497B2 (en) 2006-03-30 2017-03-08 ユニバーシティー オブ カリフォルニア Methods and compositions for localized secretion of anti-CTLA-4 antibodies
TW200819540A (en) 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
US20080057034A1 (en) 2006-07-19 2008-03-06 North Carolina State University Attenuated FNR Deficient Enterobacteria
US9061048B2 (en) * 2010-12-15 2015-06-23 The Regents Of The University Of California Cyclic di-AMP induction of type I interferon
US9409950B2 (en) 2010-12-23 2016-08-09 Biogen Ma Inc. Linker peptides and polypeptides comprising same
CN102604949A (en) 2011-04-12 2012-07-25 南京大学 Anaerobic tissue selective gene expression method driven by alcohol dehydrogenase promoter and application thereof
RS60606B1 (en) 2012-01-17 2020-08-31 Univ Leland Stanford Junior High affinity sirp-alpha reagents
US9127284B2 (en) 2012-05-04 2015-09-08 The University Of Hong Kong Modified bacteria and their uses thereof for the treatment of cancer or tumor
US9994809B2 (en) 2012-09-13 2018-06-12 Massachusetts Institute Of Technology Programmable drug delivery profiles of tumor-targeted bacteria
CA2888678A1 (en) * 2012-11-06 2014-05-15 Aduro Biotech, Inc. Facultatively attenuated bacterial species and methods of preparation and use thereof
US9539290B2 (en) 2012-12-24 2017-01-10 Anticancer Inc. Individualized bacterial treatment of pancreatic cancer
WO2014198002A1 (en) 2013-06-14 2014-12-18 Ottawa Hospital Research Institute A bacterium producing an interferon binding protein and uses thereof
JP2016538344A (en) * 2013-11-19 2016-12-08 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ Use of STING agonists as cancer treatments
WO2015078840A1 (en) 2013-11-26 2015-06-04 Boehringer Ingelheim International Gmbh Full and partial protein secretion and cell surface display using type iii secretion system
SG10201809450VA (en) 2014-05-01 2018-11-29 Anaeropharma Science Inc Heterogeneous polypeptide expression cassette
JP7080053B2 (en) 2014-08-29 2022-06-03 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム Administration of kynurenine-depleting enzymes for the treatment of tumors
MX2017007148A (en) 2014-12-05 2017-10-11 Synlogic Inc Bacteria engineered to treat diseases associated with hyperammonemia.
US9688967B2 (en) 2014-12-05 2017-06-27 Synlogic, Inc. Bacteria engineered to treat diseases associated with hyperammonemia
WO2016183532A1 (en) 2015-05-13 2016-11-17 Synlogic, Inc. Bacteria engineered to treat a disease or disorder
US10617729B2 (en) 2014-12-24 2020-04-14 The Uab Research Foundation Multitargeting onocolytic adenovirus, methods of use, and methods of making
US20160220652A1 (en) * 2015-02-03 2016-08-04 Advaxis, Inc. Methods of using recombinant listeria vaccine strains in disease immunotherapy
WO2016130616A1 (en) * 2015-02-11 2016-08-18 The Johns Hopkins University Bacteria over-expressing c-di-amp and therapeutic methods
WO2016191283A2 (en) 2015-05-22 2016-12-01 University Of Houston System Enzymatic immunomodulation of solid tumors and user thereof
WO2016210373A2 (en) * 2015-06-24 2016-12-29 Synlogic, Inc. Recombinant bacteria engineered for biosafety, pharmaceutical compositions, and methods of use thereof
CA3011283A1 (en) 2016-01-11 2017-07-20 Synlogic Operating Company, Inc. Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
WO2018129404A1 (en) 2017-01-06 2018-07-12 Synlogic, Inc. Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
AU2018301668A1 (en) 2017-07-12 2019-12-19 Synlogic Operating Company, Inc. Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
EP3820992A2 (en) 2018-07-11 2021-05-19 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
WO2020047161A2 (en) 2018-08-28 2020-03-05 Actym Therapeutics, Inc. Engineered immunostimulatory bacterial strains and uses thereof
AU2019376140A1 (en) 2018-11-08 2021-06-03 Synlogic Operating Company, Inc. Combination therapies of microorganisms and immune modulators for use in treating cancer

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