SG11201808595WA - Chimeric receptors and methods of use thereof - Google Patents

Chimeric receptors and methods of use thereof

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Publication number
SG11201808595WA
SG11201808595WA SG11201808595WA SG11201808595WA SG11201808595WA SG 11201808595W A SG11201808595W A SG 11201808595WA SG 11201808595W A SG11201808595W A SG 11201808595WA SG 11201808595W A SG11201808595W A SG 11201808595WA SG 11201808595W A SG11201808595W A SG 11201808595WA
Authority
SG
Singapore
Prior art keywords
methods
chimeric receptors
chimeric
receptors
Prior art date
Application number
SG11201808595WA
Other languages
English (en)
Inventor
Jed Wiltzius
Rodriguez Ruben Alvarez
Alice Bakker
Tara Arvedson
Lawren Wu
Original Assignee
Kite Pharma Inc
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kite Pharma Inc, Amgen Inc filed Critical Kite Pharma Inc
Publication of SG11201808595WA publication Critical patent/SG11201808595WA/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/46—Cellular immunotherapy
    • A61K39/463—Cellular immunotherapy characterised by recombinant expression
    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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SG11201808595WA 2016-04-01 2017-03-31 Chimeric receptors and methods of use thereof SG11201808595WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662317068P 2016-04-01 2016-04-01
PCT/US2017/025573 WO2017173384A1 (en) 2016-04-01 2017-03-31 Chimeric receptors and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11201808595WA true SG11201808595WA (en) 2018-10-30

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SG10201912519VA SG10201912519VA (en) 2016-04-01 2017-03-31 Chimeric receptors and methods of use thereof
SG11201808595WA SG11201808595WA (en) 2016-04-01 2017-03-31 Chimeric receptors and methods of use thereof

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Country Status (32)

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US (3) US10597456B2 (uk)
EP (2) EP4180449A1 (uk)
JP (4) JP2019513370A (uk)
KR (5) KR102120815B1 (uk)
CN (2) CN109641008B (uk)
AR (1) AR108066A1 (uk)
AU (3) AU2017240788B2 (uk)
BR (1) BR112018070260A2 (uk)
CA (2) CA3177398A1 (uk)
CL (5) CL2018002797A1 (uk)
CO (1) CO2018010547A2 (uk)
CR (2) CR20180480A (uk)
DK (1) DK3436030T3 (uk)
EA (1) EA201891992A1 (uk)
ES (1) ES2930058T3 (uk)
HR (1) HRP20221348T1 (uk)
HU (1) HUE060645T2 (uk)
IL (1) IL262041A (uk)
LT (1) LT3436030T (uk)
MA (1) MA43603A1 (uk)
MX (2) MX2018012019A (uk)
MY (1) MY197669A (uk)
PE (3) PE20211418A1 (uk)
PH (1) PH12018502113A1 (uk)
PL (1) PL3436030T3 (uk)
PT (1) PT3436030T (uk)
RS (1) RS63735B1 (uk)
SG (2) SG10201912519VA (uk)
SI (1) SI3436030T1 (uk)
TW (3) TW201803896A (uk)
UA (1) UA123276C2 (uk)
WO (1) WO2017173384A1 (uk)

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