SG11201807021UA - Heteroaryl inhibitors of pad4 - Google Patents

Heteroaryl inhibitors of pad4

Info

Publication number
SG11201807021UA
SG11201807021UA SG11201807021UA SG11201807021UA SG11201807021UA SG 11201807021U A SG11201807021U A SG 11201807021UA SG 11201807021U A SG11201807021U A SG 11201807021UA SG 11201807021U A SG11201807021U A SG 11201807021UA SG 11201807021U A SG11201807021U A SG 11201807021UA
Authority
SG
Singapore
Prior art keywords
oxfordshire
abingdon
milton park
innovation
international
Prior art date
Application number
SG11201807021UA
Other languages
English (en)
Inventor
Rajesh Devraj
Gnanasambandam Kumaravel
Holly Atton
Edward Beaumont
Elise Gadouleau
Laura Gleave
Philip Stephen Kerry
Cristina Lecci
Mirco Meniconi
Nat Monck
Jordan Palfrey
Kostas Papadopoulos
Heather Tye
Philip A Woods
Original Assignee
Padlock Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Padlock Therapeutics Inc filed Critical Padlock Therapeutics Inc
Publication of SG11201807021UA publication Critical patent/SG11201807021UA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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SG11201807021UA 2016-02-23 2017-02-22 Heteroaryl inhibitors of pad4 SG11201807021UA (en)

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ES2828623T3 (es) 2016-07-27 2021-05-27 Padlock Therapeutics Inc Inhibidores covalentes de PAD4
KR102502992B1 (ko) 2016-09-12 2023-02-24 패들락 테라퓨틱스, 인코포레이티드 Pad4의 헤테로아릴 억제제
MX2020003242A (es) * 2017-09-22 2020-09-18 Jubilant Epipad LLC Compuestos heterociclicos como inhibidores de pad.
BR112020007607A2 (pt) 2017-10-18 2020-09-29 Jubilant Epipad LLC compostos das fórmulas (i), (ii) e (iii); processos de preparação de compostos das fórmulas (i), (ii) e (iii); composição farmacêutica; compostos; método para a inibição de uma ou mais famílias de pad em uma célula; método de tratamento de uma afecção mediada por uma ou mais pad; composto da fórmula (i), fórmula (ii) e fórmula (iii); uso do composto; método para o tratamento e/ou prevenção de uma afecção; método para o tratamento de artrite reumatoide; e método de tratamento de câncer
CN111386265A (zh) 2017-11-06 2020-07-07 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1活化的抑制剂的嘧啶衍生物
MX2020005363A (es) 2017-11-24 2020-10-01 Jubilant Episcribe Llc Compuestos heterociclicos como inhibidores de prmt5.
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WO2019175897A1 (en) 2018-03-13 2019-09-19 Jubilant Biosys Limited Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
JP7434281B2 (ja) * 2018-08-08 2024-02-20 ブリストル－マイヤーズ スクイブ カンパニー Ｐａｄ酵素のベンズイミダゾール阻害剤
AU2019319835A1 (en) 2018-08-08 2021-03-25 Bristol-Myers Squibb Company Indole and azaindole inhibitors of PAD enzymes
WO2020033490A1 (en) * 2018-08-08 2020-02-13 Bristol-Myers Squibb Company Substituted thienopyrroles as pad4 inhibitors
CN114555595B (zh) * 2019-08-30 2023-12-26 Tsd生命科学有限公司 咪唑并吡啶衍生物及将其作为有效成分的药学组合物
WO2021057910A1 (zh) * 2019-09-27 2021-04-01 南京药捷安康生物科技有限公司 肽酰精氨酸脱亚胺酶抑制剂及其用途
JP2023509452A (ja) 2020-01-03 2023-03-08 バーグ エルエルシー がんを処置するためのｕｂｅ２ｋモジュレータとしての多環式アミド
CN113248507A (zh) * 2020-02-09 2021-08-13 上海茂晟康慧科技有限公司 瑞德西韦关键中间体7-卤代吡咯并[1,2-f][1,2,4]三嗪-4-胺的合成方法
WO2021222353A1 (en) 2020-04-30 2021-11-04 Gilead Sciences, Inc. Macrocyclic inhibitors of peptidylarginine deiminases
WO2022140390A1 (en) 2020-12-22 2022-06-30 Gilead Sciences, Inc. Inhibitors of peptidylarginine deiminases
CN112618546B (zh) * 2020-12-22 2022-03-01 陈昊 Pad4抑制剂在制备放射治疗增敏药物方面的应用
KR20220122879A (ko) * 2021-02-26 2022-09-05 주식회사 티에스디라이프사이언스 이미다조피리딘 유도체 및 이를 유효성분으로 함유하는 약학적 조성물

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WO2016185279A1 (en) 2015-05-21 2016-11-24 Glaxosmithkline Intellectual Property Development Limited Benzoimidazole derivatives as pad4 inhibitors
AR107032A1 (es) * 2015-12-09 2018-03-14 Padlock Therapeutics Inc Inhibidores bicíclicos de pad4
AR107030A1 (es) * 2015-12-09 2018-03-14 Padlock Therapeutics Inc Inhibidores aza-bencimidazol de pad4
US11198681B2 (en) 2016-02-23 2021-12-14 Padlock Therapeutics, Inc. Heteroaryl inhibitors of PAD4
ES2828623T3 (es) * 2016-07-27 2021-05-27 Padlock Therapeutics Inc Inhibidores covalentes de PAD4
KR102502992B1 (ko) 2016-09-12 2023-02-24 패들락 테라퓨틱스, 인코포레이티드 Pad4의 헤테로아릴 억제제

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EP3419969B1 (en) 2019-12-18
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CA3015482A1 (en) 2017-08-31
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US11198681B2 (en) 2021-12-14
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BR112018016433A2 (pt) 2018-12-26

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