SG11201803732PA - Novel anti-angiogenic fusion polypeptides - Google Patents
Novel anti-angiogenic fusion polypeptidesInfo
- Publication number
- SG11201803732PA SG11201803732PA SG11201803732PA SG11201803732PA SG11201803732PA SG 11201803732P A SG11201803732P A SG 11201803732PA SG 11201803732P A SG11201803732P A SG 11201803732PA SG 11201803732P A SG11201803732P A SG 11201803732PA SG 11201803732P A SG11201803732P A SG 11201803732PA
- Authority
- SG
- Singapore
- Prior art keywords
- fusion
- international
- polypeptides
- fusion polypeptides
- ang
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 11
- 230000004927 fusion Effects 0.000 title abstract 10
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 10
- 229920001184 polypeptide Polymers 0.000 title abstract 9
- 230000001772 anti-angiogenic effect Effects 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 abstract 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000013382 Gelatinases Human genes 0.000 abstract 1
- 108010026132 Gelatinases Proteins 0.000 abstract 1
- 102000019298 Lipocalin Human genes 0.000 abstract 1
- 108050006654 Lipocalin Proteins 0.000 abstract 1
- 241000255972 Pieris <butterfly> Species 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 238000007500 overflow downdraw method Methods 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15197019 | 2015-11-30 | ||
| PCT/AU2016/051168 WO2017091850A1 (en) | 2015-11-30 | 2016-11-30 | Novel anti-angiogenic fusion polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201803732PA true SG11201803732PA (en) | 2018-06-28 |
Family
ID=54754521
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201803732PA SG11201803732PA (en) | 2015-11-30 | 2016-11-30 | Novel anti-angiogenic fusion polypeptides |
| SG10201911499TA SG10201911499TA (en) | 2015-11-30 | 2016-11-30 | Novel anti-angiogenic fusion polypeptides |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201911499TA SG10201911499TA (en) | 2015-11-30 | 2016-11-30 | Novel anti-angiogenic fusion polypeptides |
Country Status (12)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015104406A2 (en) * | 2014-01-13 | 2015-07-16 | Pieris Ag | Multi-specific polypeptide useful for localized tumor immunomodulation |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| CN108712911A (zh) | 2015-12-30 | 2018-10-26 | 科达制药股份有限公司 | 抗体及其缀合物 |
| BR112020017872A2 (pt) | 2018-03-02 | 2020-12-22 | Kodiak Sciences Inc. | Anticorpos de il-6 e construtos de fusão e conjugados dos mesmos |
| CN109829882B (zh) * | 2018-12-18 | 2020-10-27 | 广州比格威医疗科技有限公司 | 一种糖尿病视网膜病变分期预测方法 |
| US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN117083305A (zh) * | 2021-03-25 | 2023-11-17 | 南京金斯瑞生物科技有限公司 | 抗体融合蛋白及其用途 |
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| JPH01215289A (ja) | 1988-02-22 | 1989-08-29 | Toa Nenryo Kogyo Kk | 遺伝子組換えによる正常ヒト血清アルブミンａの製造方法 |
| FR2649991B2 (fr) | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
| US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| KR100384353B1 (ko) | 1994-05-18 | 2003-10-04 | 네크타르 테라퓨틱스 | 인터페론의건조분말제형을제조하기위한방법및조성물 |
| DE4417598A1 (de) | 1994-05-19 | 1995-12-14 | Max Planck Gesellschaft | Verwendung des Tetracyclinpromotors zur stringent regulierten Produktion von rekombinanten Proteinen in prokaryontischen Zellen |
| AU5132096A (en) | 1995-01-30 | 1996-08-21 | Terrapin Technologies, Inc. | Glubodies - multiplicities of proteins capable of binding a variety of small molecules |
| US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
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| DE19641876B4 (de) | 1996-10-10 | 2011-09-29 | Iba Gmbh | Streptavidinmuteine |
| WO1998016873A1 (fr) | 1996-10-14 | 1998-04-23 | Firm Forsat Ltd. | Procede de preparation de dispersions a base de composants chromogenes |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| CA2233725A1 (en) | 1998-03-31 | 1999-09-30 | Hemosol Inc. | Hemoglobin-hydroxyethyl starch complexes |
| DE69927971T2 (de) | 1998-06-08 | 2006-07-27 | F. Hoffmann-La Roche Ag | Verwendung von peg-ifn-alpha und ribavirin zur behandlung chronischer hepatitis c |
| US6403564B1 (en) | 1998-10-16 | 2002-06-11 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
| DE19926068C1 (de) | 1999-06-08 | 2001-01-11 | Arne Skerra | Muteine des Bilin-Bindungsproteins |
| CA2440582A1 (en) | 2001-03-09 | 2002-10-03 | Dyax Corp. | Serum albumin binding moieties |
| WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
| WO2003029471A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of apolipoprotein d |
| WO2005019255A1 (en) | 2003-08-25 | 2005-03-03 | Pieris Proteolab Ag | Muteins of tear lipocalin |
| WO2005019254A1 (en) | 2003-08-25 | 2005-03-03 | Pieris Proteolab Ag | Muteins of a bilin-binding protein with affinity for a given target |
| JP2007284351A (ja) | 2004-07-27 | 2007-11-01 | Osaka Bioscience Institute | アミロイド蛋白質の凝集を抑制する物質とその作用 |
| EP1814988A2 (en) | 2004-11-26 | 2007-08-08 | Pieris AG | Compound with affinity for the cytotoxic t lymphocyte-associated antigen (ctla-4) |
| US20090305963A1 (en) * | 2005-01-19 | 2009-12-10 | Sukhatme Vikas P | Lipocalin 2 for the Treatment, Prevention, and Management of Cancer Metastasis, Angiogenesis, and Fibrosis |
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| KR101974044B1 (ko) | 2009-12-07 | 2019-04-30 | 피어이스 파마슈티컬즈 게엠베하 | 주어진 표적에 대한 친화성을 갖는 인간의 리포칼린 2의 뮤테인 |
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| SG187695A1 (en) * | 2010-08-16 | 2013-03-28 | Pieris Ag | Binding proteins for hepcidin |
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| SMT202100621T1 (it) * | 2012-07-13 | 2022-01-10 | Roche Glycart Ag | Anticorpi bispecifici anti-vegf/anti-ang-2 e loro impiego nel trattamento delle malattie vascolari oculari |
| EP2920202B1 (en) | 2012-11-19 | 2018-08-29 | Pieris Pharmaceuticals GmbH | Novel specific-binding polypeptides and uses thereof |
| PE20151807A1 (es) * | 2013-04-29 | 2015-12-02 | Hoffmann La Roche | Anticuerpos modificados de union a fcrn humano y metodo de utilizacion |
| WO2015104406A2 (en) * | 2014-01-13 | 2015-07-16 | Pieris Ag | Multi-specific polypeptide useful for localized tumor immunomodulation |
| EP3145945B1 (en) * | 2014-05-22 | 2020-07-15 | Pieris Pharmaceuticals GmbH | Novel specific-binding polypeptides and uses thereof |
| SG10201906859PA (en) * | 2015-01-28 | 2019-08-27 | Pieris Pharmaceuticals Gmbh | Novel proteins specific for angiogenesis |
| AR103477A1 (es) * | 2015-01-28 | 2017-05-10 | Lilly Co Eli | Compuestos de vegfa / ang2 |
| AU2016221816B2 (en) | 2015-02-18 | 2020-07-02 | Pieris Pharmaceuticals Gmbh | Novel proteins specific for pyoverdine and pyochelin |
| JP6884708B2 (ja) | 2015-05-04 | 2021-06-09 | ピエリス ファーマシューティカルズ ゲーエムベーハー | Ｃｄ１３７に特異的なタンパク質 |
| JP6942060B2 (ja) | 2015-05-18 | 2021-09-29 | ピエリス ファーマシューティカルズ ゲーエムベーハー | グリピカン−３（ｇｐｃ３）に対する親和性を有するヒトリポカリン２のムテイン |
-
2016
- 2016-11-30 WO PCT/AU2016/051168 patent/WO2017091850A1/en active Application Filing
- 2016-11-30 SG SG11201803732PA patent/SG11201803732PA/en unknown
- 2016-11-30 CN CN201680080597.2A patent/CN108699162A/zh active Pending
- 2016-11-30 MX MX2018006559A patent/MX2018006559A/es unknown
- 2016-11-30 AU AU2016363668A patent/AU2016363668A1/en not_active Abandoned
- 2016-11-30 SG SG10201911499TA patent/SG10201911499TA/en unknown
- 2016-11-30 JP JP2018546726A patent/JP2019505565A/ja active Pending
- 2016-11-30 KR KR1020187018593A patent/KR20180083943A/ko not_active Withdrawn
- 2016-11-30 US US15/777,340 patent/US10703810B2/en not_active Expired - Fee Related
- 2016-11-30 CA CA3004918A patent/CA3004918A1/en not_active Abandoned
- 2016-11-30 BR BR112018010887A patent/BR112018010887A2/pt not_active Application Discontinuation
- 2016-11-30 EP EP16869402.4A patent/EP3383921A4/en not_active Withdrawn
- 2016-11-30 EA EA201891141A patent/EA035586B1/ru not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SG10201911499TA (en) | 2020-01-30 |
| CA3004918A1 (en) | 2017-06-08 |
| AU2016363668A1 (en) | 2018-05-24 |
| JP2019505565A (ja) | 2019-02-28 |
| MX2018006559A (es) | 2019-06-12 |
| EP3383921A4 (en) | 2019-04-17 |
| EA201891141A1 (ru) | 2018-10-31 |
| US20180334499A1 (en) | 2018-11-22 |
| WO2017091850A1 (en) | 2017-06-08 |
| US10703810B2 (en) | 2020-07-07 |
| CN108699162A (zh) | 2018-10-23 |
| BR112018010887A2 (pt) | 2018-11-21 |
| EA035586B1 (ru) | 2020-07-10 |
| KR20180083943A (ko) | 2018-07-23 |
| EP3383921A1 (en) | 2018-10-10 |
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