SG11201803143YA - Microfluidic model of the blood brain barrier - Google Patents

Microfluidic model of the blood brain barrier

Info

Publication number
SG11201803143YA
SG11201803143YA SG11201803143YA SG11201803143YA SG11201803143YA SG 11201803143Y A SG11201803143Y A SG 11201803143YA SG 11201803143Y A SG11201803143Y A SG 11201803143YA SG 11201803143Y A SG11201803143Y A SG 11201803143YA SG 11201803143Y A SG11201803143Y A SG 11201803143YA
Authority
SG
Singapore
Prior art keywords
brain barrier
blood brain
microfluidic model
microfluidic
model
Prior art date
Application number
SG11201803143YA
Other languages
English (en)
Inventor
S Kerns
Norman Wen
Carol Lucchesi
Chris Hinojosa
Jacob Fraser
Geraldine Hamilton
Gad Vatine
Samuel Sances
Clive Svendsen
Daniel Levner
Dhruv Sareen
Original Assignee
Emulate Inc
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emulate Inc, Cedars Sinai Medical Center filed Critical Emulate Inc
Publication of SG11201803143YA publication Critical patent/SG11201803143YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C12N5/0692—Stem cells; Progenitor cells; Precursor cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
    • C12N2502/081—Coculture with; Conditioned medium produced by cells of the nervous system neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
    • C12N2502/086—Coculture with; Conditioned medium produced by cells of the nervous system glial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/56—Fibrin; Thrombin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • C12N2535/10—Patterned coating
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2539/00—Supports and/or coatings for cell culture characterised by properties
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Fluid Mechanics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SG11201803143YA 2015-10-19 2016-10-19 Microfluidic model of the blood brain barrier SG11201803143YA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562243642P 2015-10-19 2015-10-19
US201662277723P 2016-01-12 2016-01-12
US201662332727P 2016-05-06 2016-05-06
US201662380780P 2016-08-29 2016-08-29
PCT/US2016/057724 WO2017070224A1 (fr) 2015-10-19 2016-10-19 Modèle microfluidique de la barrière hémato-encéphalique

Publications (1)

Publication Number Publication Date
SG11201803143YA true SG11201803143YA (en) 2018-05-30

Family

ID=58558248

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201803143YA SG11201803143YA (en) 2015-10-19 2016-10-19 Microfluidic model of the blood brain barrier

Country Status (9)

Country Link
US (3) US20180305651A1 (fr)
EP (1) EP3365424A4 (fr)
JP (4) JP2018533940A (fr)
KR (1) KR102410389B1 (fr)
AU (1) AU2016341880B2 (fr)
CA (1) CA3002399C (fr)
GB (1) GB2561312B (fr)
SG (1) SG11201803143YA (fr)
WO (1) WO2017070224A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11414648B2 (en) 2017-03-24 2022-08-16 Cedars-Sinai Medical Center Methods and compositions for production of fallopian tube epithelium
US11767513B2 (en) 2017-03-14 2023-09-26 Cedars-Sinai Medical Center Neuromuscular junction
US11913022B2 (en) 2017-01-25 2024-02-27 Cedars-Sinai Medical Center In vitro induction of mammary-like differentiation from human pluripotent stem cells
US11981918B2 (en) 2018-04-06 2024-05-14 Cedars-Sinai Medical Center Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
AU2015267148B2 (en) 2014-05-28 2021-07-29 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
EP3207123A1 (fr) 2014-10-17 2017-08-23 Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center Modèle in vivo d'intestin grêle humain faisant intervenir des cellules souches pluripotentes et ses procédés de fabrication et d'utilisation
US20180057788A1 (en) * 2016-08-29 2018-03-01 EMULATE, Inc. Development of spinal cord on a microfluidic chip
WO2017136479A1 (fr) 2016-02-01 2017-08-10 Cedars-Sinai Medical Center Systèmes et procédés de mise en croissance de cellules intestinales dans des dispositifs microfluidiques
CA3013077A1 (fr) * 2016-02-16 2017-08-24 President And Fellows Of Harvard College Cellules endotheliales de barriere hematoencephalique amelioree derivees de cellules souches pluripotentes pour modeles de barriere hematoencephalique
CN116790476A (zh) 2016-05-05 2023-09-22 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
AU2017306698B2 (en) 2016-08-04 2023-03-30 Wake Forest University Health Sciences Blood brain barrier model and methods of making and using the same
CA3045145A1 (fr) 2016-12-05 2018-06-14 Children's Hospital Medical Center Organoides du colon et leurs procedes de preparation et d'utilisation
SG11201912152PA (en) 2017-06-14 2020-01-30 Emulate Inc Effects of space travel on human brain cells
FR3070045B1 (fr) * 2017-08-10 2021-06-25 Univ Poitiers Dispositif pouvant servir de modele de barriere hemato-encephalique
GB2586724B (en) * 2018-03-14 2023-05-24 Emulate Inc Brain on chip comprising glutamatergic/gabaergic neurons and intestine on chip comprising neural crest cells
JP7464532B2 (ja) 2018-04-06 2024-04-09 シーダーズ－サイナイ メディカル センター マイクロ流体チップ上のヒト多能性幹細胞由来の神経変性疾患モデル
CN112567022A (zh) * 2018-08-21 2021-03-26 豪夫迈·罗氏有限公司 用于评定跨内皮屏障完整性的方法
US20210348098A1 (en) * 2018-09-19 2021-11-11 Cellartgen Inc. Microfluidic device for cerebrovascular simulation and high-efficiency blood-brain barrier simulation system comprising same
US11198842B1 (en) 2019-02-22 2021-12-14 University Of South Florida Microfluidic-coupled in vitro model of the blood-brain barrier
JP7277874B2 (ja) * 2019-03-27 2023-05-19 国立大学法人大阪大学 脳血管モデル及びデバイス
GB2597030B (en) * 2019-05-09 2023-11-15 Emulate Inc Compositions and methods of using partial gel layers in a microfluidic device
US20230147702A1 (en) * 2020-04-22 2023-05-11 The Board Of Trustees Of The Leland Stanford Junior University Microfluidic chips and microphysiological systems using the same
CN113583939A (zh) * 2021-07-13 2021-11-02 华侨大学 一种腺相关病毒跨越血脑屏障模型的构建方法
WO2023201047A1 (fr) * 2022-04-14 2023-10-19 University Of Cincinnati Récapitulation d'architectures natives de tissu dans hydrogels bio-imprimables

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766948A (en) * 1993-01-06 1998-06-16 The Regents Of The University Of California Method for production of neuroblasts
JP2001238681A (ja) 2000-03-03 2001-09-04 Japan Science & Technology Corp 共培養による血液脳関門再構築モデル
WO2007030469A2 (fr) * 2005-09-06 2007-03-15 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Niche de croissance cellulaire transplantable, compositions et methodes associees
US20080044847A1 (en) * 2006-06-23 2008-02-21 Shusta Eric V Blood-Brain Barrier Model
EP3693454A1 (fr) 2008-07-16 2020-08-12 Children's Medical Center Corporation Dispositif simulateur d'organe comportant des microcanaux et ses procédés d'utilisation et de fabrication
EP2302353A1 (fr) * 2009-09-28 2011-03-30 Sanofi-Aventis Mesure TEER en ligne dans un système pour la détermination de la perméation au moyen d'une cellule de perméation à flux (FTPC) dotée d'électrodes structurellement intégrées
DK3162386T3 (da) * 2010-12-13 2020-01-02 Theradep Tech Inc Implanterbare medicinske indretninger
US20120211373A1 (en) * 2011-02-22 2012-08-23 The Regents Of The University Of Michigan Microfluidic system for measuring cell barrier function
US9513280B2 (en) 2012-08-28 2016-12-06 University Of Utah Research Foundation Microfluidic biological barrier model and associated method
US9932559B2 (en) * 2012-11-16 2018-04-03 The Johns Hopkins University Platform for creating an artificial blood brain barrier
KR101426056B1 (ko) 2013-04-08 2014-08-01 서울대학교산학협력단 생체 외 혈관 생성 장치 및 이를 이용한 혈관 투과성 측정 방법
GB2583047B (en) * 2013-12-20 2021-03-24 Harvard College Organomimetic devices and methods of use and manufacturing thereof
CA2970173A1 (fr) * 2014-12-09 2016-06-16 National Research Council Of Canada Modele de barriere hemato-encephalique humaine
WO2017035119A1 (fr) 2015-08-24 2017-03-02 National University Of Singapore Modèle de barrière hémato-encéphalique dans un système microfluidique 3d de co-culture
CN113774495A (zh) * 2015-09-25 2021-12-10 阿布维特罗有限责任公司 用于对天然配对t细胞受体序列进行t细胞受体靶向鉴别的高通量方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11913022B2 (en) 2017-01-25 2024-02-27 Cedars-Sinai Medical Center In vitro induction of mammary-like differentiation from human pluripotent stem cells
US11767513B2 (en) 2017-03-14 2023-09-26 Cedars-Sinai Medical Center Neuromuscular junction
US11414648B2 (en) 2017-03-24 2022-08-16 Cedars-Sinai Medical Center Methods and compositions for production of fallopian tube epithelium
US11981918B2 (en) 2018-04-06 2024-05-14 Cedars-Sinai Medical Center Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells

Also Published As

Publication number Publication date
GB2561312A (en) 2018-10-10
US20180298331A1 (en) 2018-10-18
KR102410389B1 (ko) 2022-06-16
JP2018533940A (ja) 2018-11-22
GB201808143D0 (en) 2018-07-11
JP2023100993A (ja) 2023-07-19
CA3002399A1 (fr) 2017-04-27
GB2561312B (en) 2021-03-24
KR20180069882A (ko) 2018-06-25
JP2021151265A (ja) 2021-09-30
JP7100096B2 (ja) 2022-07-12
AU2016341880B2 (en) 2021-01-21
AU2016341880A1 (en) 2018-05-10
EP3365424A1 (fr) 2018-08-29
CA3002399C (fr) 2024-06-11
US20180298332A1 (en) 2018-10-18
US11174462B2 (en) 2021-11-16
JP2021000133A (ja) 2021-01-07
JP7282129B2 (ja) 2023-05-26
US20180305651A1 (en) 2018-10-25
WO2017070224A1 (fr) 2017-04-27
EP3365424A4 (fr) 2019-04-17

Similar Documents

Publication Publication Date Title
GB2561312B (en) Microfluidic model of the blood brain barrier
AU201712948S (en) Catheter
AU201715384S (en) Patient interface
HK1249389A1 (zh) 超聲波導管
EP3288455C0 (fr) Méthodes de diagnostic
IL246861A0 (en) Passive separation of whole blood
SG10201913800UA (en) Patient interfaces
EP3230439C0 (fr) Modèle de barrière hémato-encéphalique humaine
SG10202102729UA (en) Patient interfaces
IL246384A0 (en) Blood-brain barrier shuttle
SG11201900053QA (en) Patient simulator
AU201710323S (en) Medical Flow Component
GB201613187D0 (en) Blood brain barrier model
HK1256190A1 (zh) 治療流體製備系統
HK1251022A1 (zh) 診斷方法
GB201608781D0 (en) Non-invasive blood analysis
HUE065145T2 (hu) Kanülegység
IL254023B (en) Altered blood clots
GB2552455B (en) Blood monitoring
GB2543616B (en) Microfluidic arrangements
GB201516447D0 (en) Microfluidic structure
EP3406230C0 (fr) Canule
GB201513797D0 (en) Catheter
EP3535421C0 (fr) Méthodes de diagnostic
GB201421403D0 (en) Blood filter