GB2543616B - Microfluidic arrangements - Google Patents

Microfluidic arrangements Download PDF

Info

Publication number
GB2543616B
GB2543616B GB1614139.2A GB201614139A GB2543616B GB 2543616 B GB2543616 B GB 2543616B GB 201614139 A GB201614139 A GB 201614139A GB 2543616 B GB2543616 B GB 2543616B
Authority
GB
United Kingdom
Prior art keywords
microfluidic arrangements
microfluidic
arrangements
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1614139.2A
Other versions
GB2543616A (en
GB201614139D0 (en
Inventor
Richard Cook Peter
Feuerborn Alexander
Walsh Edmond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB1518392.4A priority Critical patent/GB201518392D0/en
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Publication of GB201614139D0 publication Critical patent/GB201614139D0/en
Priority claimed from CA3001954A external-priority patent/CA3001954A1/en
Priority claimed from GBGB1705118.6A external-priority patent/GB201705118D0/en
Publication of GB2543616A publication Critical patent/GB2543616A/en
Publication of GB2543616B publication Critical patent/GB2543616B/en
Application granted granted Critical
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F13/00Other mixers; Mixing plant, including combinations of mixers, e.g. of dissimilar mixers
    • B01F13/0059Micromixers
    • B01F13/0069Micromixers the components flowing in the form of droplets
    • B01F13/0071Micromixers the components flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F13/00Other mixers; Mixing plant, including combinations of mixers, e.g. of dissimilar mixers
    • B01F13/0059Micromixers
    • B01F13/0074Micromixers using mixing means not otherwise provided for
    • B01F13/0083Micromixers using mixing means not otherwise provided for using surface tension to mix, move or hold the fluids
    • B01F13/0084Micromixers using mixing means not otherwise provided for using surface tension to mix, move or hold the fluids using hydrophilic/hydrophobic surfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
    • B01F13/00Other mixers; Mixing plant, including combinations of mixers, e.g. of dissimilar mixers
    • B01F13/0059Micromixers
    • B01F13/0074Micromixers using mixing means not otherwise provided for
    • B01F13/0083Micromixers using mixing means not otherwise provided for using surface tension to mix, move or hold the fluids
    • B01F13/0086Micromixers using mixing means not otherwise provided for using surface tension to mix, move or hold the fluids using roughness of the surfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00646Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/0065Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of liquid beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0694Creating chemical gradients in a fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0472Diffusion
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • B01L2400/088Passive control of flow resistance by specific surface properties
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0241Drop counters; Drop formers
GB1614139.2A 2015-10-16 2016-08-18 Microfluidic arrangements Active GB2543616B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GBGB1518392.4A GB201518392D0 (en) 2015-10-16 2015-10-16 Microfluidic arrangements

Applications Claiming Priority (30)

Application Number Priority Date Filing Date Title
CA3001954A CA3001954A1 (en) 2015-10-16 2016-10-14 Microfluidic arrangements
CN201680073970.1A CN108472647A (en) 2015-10-16 2016-10-14 Microfluid is arranged
PCT/GB2016/053204 WO2017064514A1 (en) 2015-10-16 2016-10-14 Microfluidic arrangements
EP16784266.5A EP3362177A1 (en) 2015-10-16 2016-10-14 Microfluidic arrangements
JP2018519827A JP2018538124A (en) 2015-10-16 2016-10-14 Microfluidic device
AU2016337312A AU2016337312A1 (en) 2015-10-16 2016-10-14 Microfluidic arrangements
US15/768,323 US20180311671A1 (en) 2015-10-16 2016-10-14 Microfluidic arrangements
GBGB1705118.6A GB201705118D0 (en) 2016-08-18 2017-03-30 Methods and apparatus for driving flow in a microfluid arrangement
GBGB1705117.8A GB201705117D0 (en) 2016-08-18 2017-03-30 Methods and apparatus for controlling flow in a microfluid arrangement, and a microfluid arrangement
CA3034310A CA3034310A1 (en) 2016-08-18 2017-04-18 Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
US16/326,129 US20190176148A1 (en) 2016-08-18 2017-04-18 Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
JP2019509509A JP2019534773A (en) 2016-08-18 2017-04-18 Method and apparatus for manufacturing a microfluidic arrangement and microfluidic arrangement
CN201780050766.2A CN109661272A (en) 2016-08-18 2017-04-18 For manufacturing the method and apparatus and microfluid arrangement of microfluid arrangement
EP17718979.2A EP3500364A1 (en) 2016-08-18 2017-04-18 Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
AU2017313352A AU2017313352A1 (en) 2016-08-18 2017-04-18 Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
PCT/GB2017/051065 WO2018033692A1 (en) 2016-08-18 2017-04-18 Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement
US16/326,134 US20190168212A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement
CN201780048922.1A CN109661271A (en) 2016-08-18 2017-08-16 The flow driving method and apparatus arranged using microfluid
EP17755226.2A EP3500367A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for driving flow in a microfluidic arrangement
CA3034290A CA3034290A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement
CA3034297A CA3034297A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for driving flow in a microfluidic arrangement
AU2017313384A AU2017313384A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for driving flow in a microfluidic arrangement
PCT/GB2017/052420 WO2018033734A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement
JP2019509493A JP2019535490A (en) 2016-08-18 2017-08-16 Method and apparatus for generating flow in a microfluidic arrangement
JP2019509495A JP2019528446A (en) 2016-08-18 2017-08-16 Method and apparatus for controlling flow in a microfluidic arrangement and microfluidic arrangement
CN201780048920.2A CN109641209A (en) 2016-08-18 2017-08-16 Using the flow control method and equipment and microfluid arrangement of microfluid arrangement
US16/326,137 US20200129977A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for driving flow in a microfluidic arrangement
EP17755225.4A EP3500366A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement
PCT/GB2017/052422 WO2018033736A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for driving flow in a microfluidic arrangement
AU2017313382A AU2017313382A1 (en) 2016-08-18 2017-08-16 Methods and apparatus for controlling flow in a microfluidic arrangement, and a microfluidic arrangement

Publications (3)

Publication Number Publication Date
GB201614139D0 GB201614139D0 (en) 2016-10-05
GB2543616A GB2543616A (en) 2017-04-26
GB2543616B true GB2543616B (en) 2020-04-08

Family

ID=55131190

Family Applications (6)

Application Number Title Priority Date Filing Date
GBGB1518392.4A Ceased GB201518392D0 (en) 2015-10-16 2015-10-16 Microfluidic arrangements
GB1614157.4A Active GB2543619B (en) 2015-10-16 2016-08-18 A method of rehydrating a microfluidic arrangement
GB1614139.2A Active GB2543616B (en) 2015-10-16 2016-08-18 Microfluidic arrangements
GB1905712.4A Active GB2572699B (en) 2015-10-16 2016-08-18 A method of rehydrating a microfluidic arrangement
GB1614153.3A Active GB2543618B (en) 2015-10-16 2016-08-18 Microfluidic arrangements
GB1614146.7A Active GB2543617B (en) 2015-10-16 2016-08-18 Microfluidic arrangements

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GBGB1518392.4A Ceased GB201518392D0 (en) 2015-10-16 2015-10-16 Microfluidic arrangements
GB1614157.4A Active GB2543619B (en) 2015-10-16 2016-08-18 A method of rehydrating a microfluidic arrangement

Family Applications After (3)

Application Number Title Priority Date Filing Date
GB1905712.4A Active GB2572699B (en) 2015-10-16 2016-08-18 A method of rehydrating a microfluidic arrangement
GB1614153.3A Active GB2543618B (en) 2015-10-16 2016-08-18 Microfluidic arrangements
GB1614146.7A Active GB2543617B (en) 2015-10-16 2016-08-18 Microfluidic arrangements

Country Status (1)

Country Link
GB (6) GB201518392D0 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201802819D0 (en) * 2018-02-21 2018-04-04 Univ Oxford Innovation Ltd Methods and apparatus for manufacturing a microfluidic arrangement, and a microfluidic arrangement

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19949735A1 (en) * 1999-10-15 2001-05-10 Bruker Daltonik Gmbh Processing of samples in solutions with a defined small wall contact area
US20020176072A1 (en) * 1999-10-05 2002-11-28 Stefan Beseki Device and method for controlling the quality of microdroplets deposited on a substrate
EP1525472A2 (en) * 2002-07-23 2005-04-27 Commissariat A L'energie Atomique Method and device for screening molecules in cells
EP1527888A2 (en) * 2003-10-30 2005-05-04 Hewlett-Packard Development Company, L.P. Printing growth medium for culture and analysis of biological material
JP2009118798A (en) * 2007-11-16 2009-06-04 Tokyo Medical & Dental Univ Apparatus and method for amplifying nucleic acid, and method of culturing cell and amplifying nucleic acid
WO2014101575A1 (en) * 2012-12-31 2014-07-03 浙江大学 Application method for automatic micro-droplet array screening system with picoliter precision
CN104004652A (en) * 2014-06-16 2014-08-27 东南大学 Method for manufacturing digital PCR liquid drop array chip based on single-jet ink-jet printing
CN104492508A (en) * 2014-11-13 2015-04-08 浙江大学 Ultramicro droplets manipulator based on liquid residues and method thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US176072A (en) * 1876-04-11 Improvement in combined plows and harrows
US125718A (en) * 1872-04-16 Improvement in attaching shoes to sleigh-runners
JPH07245467A (en) * 1994-03-07 1995-09-19 Ibiden Co Ltd Manufacture of printed wiring board
FR2857451B1 (en) * 2003-07-11 2005-09-30 Commissariat Energie Atomique Method and device for analysis of live reaction environments
WO2005122672A2 (en) * 2004-06-16 2005-12-29 The University Of British Columbia Microfluidic transport by electrostatic deformation of fluidic interfaces
WO2008063135A1 (en) * 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
US20080264506A1 (en) * 2007-04-30 2008-10-30 Timothy Beerling System and method for using electrowetting on dielectric (EWOD) for controlling fluid in a microfluidic circuit
US9631244B2 (en) * 2007-10-17 2017-04-25 Advanced Liquid Logic, Inc. Reagent storage on a droplet actuator
US9296241B1 (en) * 2009-12-18 2016-03-29 The United States Of America As Represented By The Secretary Of The Army Ink jet printing and patterning of explosive materials
WO2011097677A1 (en) * 2010-02-12 2011-08-18 Monash University Printed multi-zone microzone plates
US9228104B2 (en) * 2012-11-02 2016-01-05 Electronics For Imaging, Inc. Method and apparatus for controlling lightness in colored inkjet inks by means of a transparent white ink composition
JP6251475B2 (en) * 2012-12-19 2017-12-20 株式会社ミマキエンジニアリング Inkjet printer and printing method

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020176072A1 (en) * 1999-10-05 2002-11-28 Stefan Beseki Device and method for controlling the quality of microdroplets deposited on a substrate
DE19949735A1 (en) * 1999-10-15 2001-05-10 Bruker Daltonik Gmbh Processing of samples in solutions with a defined small wall contact area
EP1525472A2 (en) * 2002-07-23 2005-04-27 Commissariat A L'energie Atomique Method and device for screening molecules in cells
EP1527888A2 (en) * 2003-10-30 2005-05-04 Hewlett-Packard Development Company, L.P. Printing growth medium for culture and analysis of biological material
JP2009118798A (en) * 2007-11-16 2009-06-04 Tokyo Medical & Dental Univ Apparatus and method for amplifying nucleic acid, and method of culturing cell and amplifying nucleic acid
WO2014101575A1 (en) * 2012-12-31 2014-07-03 浙江大学 Application method for automatic micro-droplet array screening system with picoliter precision
CN104004652A (en) * 2014-06-16 2014-08-27 东南大学 Method for manufacturing digital PCR liquid drop array chip based on single-jet ink-jet printing
CN104492508A (en) * 2014-11-13 2015-04-08 浙江大学 Ultramicro droplets manipulator based on liquid residues and method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ACS Combinatorial Science, 2011 Vol 13, A Liberski et al "One cell-One well: A new approach to inkjet printing single cell microarrays" pages 190-195 *
IEEE Transactions on industry applications, Vol 34, No.4, M Washizue "Electrostatic actuation of liquid droplets for microreactor applications" *

Also Published As

Publication number Publication date
GB2543619A (en) 2017-04-26
GB2543619B (en) 2020-04-08
GB201518392D0 (en) 2015-12-02
GB201905712D0 (en) 2019-06-05
GB201614146D0 (en) 2016-10-05
GB2543618B (en) 2020-06-10
GB2572699A (en) 2019-10-09
GB201614139D0 (en) 2016-10-05
GB2543618A (en) 2017-04-26
GB2543617A (en) 2017-04-26
GB2572699B (en) 2020-04-08
GB2543617B (en) 2020-08-26
GB2543616A (en) 2017-04-26
GB201614153D0 (en) 2016-10-05
GB201614157D0 (en) 2016-10-05

Similar Documents

Publication Publication Date Title
IL254030D0 (en) שימוש בפרידופידין לשיפור תפקוד קוגניטיבי ולטיפול במחלת אלצהיימר
GB201514938D0 (en) Braring calculation
SG10201912505YA (en) Exosuit
HK1252089A1 (en) Solid forms
IL253311D0 (en) גידול ירוק תוך מבני
GB201506824D0 (en) TrailReach Multitrial
GB201500806D0 (en) Aerosol-gnerating aticle
DK3167044T3 (en) microfluidic
AU201616678S (en) Cylindres
SG10201706761TA (en) Gyrostabilisers
GB201521751D0 (en) Novel uses
GB201509585D0 (en) -
PL3238827T3 (en) Bonemill
DK3307436T3 (en) microfluidic
GB201615693D0 (en) Combinations
GB201614150D0 (en) Microfluidic arrangements
GB201600712D0 (en) Back-or-seat element
GB201501723D0 (en) Winics
DK3390996T3 (en) Trykbart tids-temperaturindikatorsystem
GB201514917D0 (en) Polytunnel arrangement
GB201513390D0 (en) Aortopathy
GB201611955D0 (en) Fluidic system
HK1251968A1 (en) Motorized-yoyo
HK1251001A1 (en) Il-37 variants
DK3380145T3 (en) Injektionsapparat