FR3070045B1 - Dispositif pouvant servir de modele de barriere hemato-encephalique - Google Patents
Dispositif pouvant servir de modele de barriere hemato-encephalique Download PDFInfo
- Publication number
- FR3070045B1 FR3070045B1 FR1757643A FR1757643A FR3070045B1 FR 3070045 B1 FR3070045 B1 FR 3070045B1 FR 1757643 A FR1757643 A FR 1757643A FR 1757643 A FR1757643 A FR 1757643A FR 3070045 B1 FR3070045 B1 FR 3070045B1
- Authority
- FR
- France
- Prior art keywords
- model
- blood
- encephalic barrier
- bbb
- relates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 230000004888 barrier function Effects 0.000 title 1
- 230000008499 blood brain barrier function Effects 0.000 abstract 3
- 210000001218 blood-brain barrier Anatomy 0.000 abstract 3
- 0 CCCOC1C(*)C(*)C(CO)C1 Chemical compound CCCOC1C(*)C(*)C(CO)C1 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/06—Tubular
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
- C12M3/04—Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Instructional Devices (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
La présente invention concerne un dispositif pouvant servir de modèle de barrière hémato-encéphalique (BHE) comprenant deux compartiments dans lesquels certains types cellulaires sont disposés. L'invention concerne également le procédé de préparation dudit dispositif et son utilisation comme modèle de la BHE.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1757643A FR3070045B1 (fr) | 2017-08-10 | 2017-08-10 | Dispositif pouvant servir de modele de barriere hemato-encephalique |
EP18756178.2A EP3665264A1 (fr) | 2017-08-10 | 2018-08-10 | Dispositif pouvant servir de modèle de barrière hémato-encéphalique |
JP2020529822A JP2020529871A (ja) | 2017-08-10 | 2018-08-10 | 血液脳関門モデルとして機能できる装置 |
US16/637,998 US20220010258A1 (en) | 2017-08-10 | 2018-08-10 | Device that can serve as a hemato-encephalitic barrier model |
PCT/EP2018/071759 WO2019030380A1 (fr) | 2017-08-10 | 2018-08-10 | Dispositif pouvant servir de modèle de barrière hémato-encéphalique |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1757643 | 2017-08-10 | ||
FR1757643A FR3070045B1 (fr) | 2017-08-10 | 2017-08-10 | Dispositif pouvant servir de modele de barriere hemato-encephalique |
Publications (2)
Publication Number | Publication Date |
---|---|
FR3070045A1 FR3070045A1 (fr) | 2019-02-15 |
FR3070045B1 true FR3070045B1 (fr) | 2021-06-25 |
Family
ID=60765756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR1757643A Active FR3070045B1 (fr) | 2017-08-10 | 2017-08-10 | Dispositif pouvant servir de modele de barriere hemato-encephalique |
Country Status (5)
Country | Link |
---|---|
US (1) | US20220010258A1 (fr) |
EP (1) | EP3665264A1 (fr) |
JP (1) | JP2020529871A (fr) |
FR (1) | FR3070045B1 (fr) |
WO (1) | WO2019030380A1 (fr) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001238681A (ja) * | 2000-03-03 | 2001-09-04 | Japan Science & Technology Corp | 共培養による血液脳関門再構築モデル |
JP5113332B2 (ja) * | 2005-12-19 | 2013-01-09 | 正美 丹羽 | 血液脳関門インヴィトロ・モデル、病態血液脳関門インヴィトロ・モデル、及びこれを用いた薬物スクリーニング方法、病態血液脳関門機能解析方法、病因解析方法 |
CA2983821A1 (fr) * | 2015-04-24 | 2017-01-05 | President And Fellows Of Harvard College | Dispositifs de simulation d'une fonction d'un tissu et leurs procedes d'utilisation et fabrication |
SG11201803143YA (en) * | 2015-10-19 | 2018-05-30 | Emulate Inc | Microfluidic model of the blood brain barrier |
-
2017
- 2017-08-10 FR FR1757643A patent/FR3070045B1/fr active Active
-
2018
- 2018-08-10 WO PCT/EP2018/071759 patent/WO2019030380A1/fr unknown
- 2018-08-10 US US16/637,998 patent/US20220010258A1/en active Pending
- 2018-08-10 JP JP2020529822A patent/JP2020529871A/ja active Pending
- 2018-08-10 EP EP18756178.2A patent/EP3665264A1/fr active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2019030380A1 (fr) | 2019-02-14 |
US20220010258A1 (en) | 2022-01-13 |
EP3665264A1 (fr) | 2020-06-17 |
JP2020529871A (ja) | 2020-10-15 |
FR3070045A1 (fr) | 2019-02-15 |
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