SG11201707148PA - Maytansinoid derivatives, conjugates thereof, and methods of use - Google Patents
Maytansinoid derivatives, conjugates thereof, and methods of useInfo
- Publication number
- SG11201707148PA SG11201707148PA SG11201707148PA SG11201707148PA SG11201707148PA SG 11201707148P A SG11201707148P A SG 11201707148PA SG 11201707148P A SG11201707148P A SG 11201707148PA SG 11201707148P A SG11201707148P A SG 11201707148PA SG 11201707148P A SG11201707148P A SG 11201707148PA
- Authority
- SG
- Singapore
- Prior art keywords
- conjugates
- methods
- maytansinoid derivatives
- maytansinoid
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562139044P | 2015-03-27 | 2015-03-27 | |
US201562252239P | 2015-11-06 | 2015-11-06 | |
PCT/US2016/024343 WO2016160615A1 (fr) | 2015-03-27 | 2016-03-25 | Dérivés de maytansinoïde, conjugués de ceux-ci, et procédés d'utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201707148PA true SG11201707148PA (en) | 2017-10-30 |
Family
ID=55650789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201707148PA SG11201707148PA (en) | 2015-03-27 | 2016-03-25 | Maytansinoid derivatives, conjugates thereof, and methods of use |
Country Status (17)
Country | Link |
---|---|
US (3) | US20160375147A1 (fr) |
EP (1) | EP3273998B1 (fr) |
JP (2) | JP6948950B2 (fr) |
KR (1) | KR20170131587A (fr) |
CN (2) | CN115645543A (fr) |
AU (1) | AU2016243527B2 (fr) |
BR (1) | BR112017020149A8 (fr) |
CA (1) | CA2978340A1 (fr) |
CL (1) | CL2017002422A1 (fr) |
CO (1) | CO2017010890A2 (fr) |
EA (1) | EA034950B1 (fr) |
IL (1) | IL254267B (fr) |
MX (2) | MX2017012380A (fr) |
PH (1) | PH12017501780A1 (fr) |
SG (1) | SG11201707148PA (fr) |
WO (1) | WO2016160615A1 (fr) |
ZA (1) | ZA201706040B (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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MX2015011348A (es) | 2013-03-15 | 2016-01-15 | Regeneron Pharma | Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos. |
CN105530942B (zh) | 2013-08-26 | 2019-10-11 | 瑞泽恩制药公司 | 一种包含大环内酯类非对映体的药物组合物、其制备方法和用途 |
EP3273998B1 (fr) * | 2015-03-27 | 2019-09-04 | Regeneron Pharmaceuticals, Inc. | Dérivés de maytansinoïde, conjugués de ceux-ci, et procédés d'utilisation |
EP3319994B1 (fr) | 2015-07-06 | 2024-02-07 | Regeneron Pharmaceuticals, Inc. | Molécules multispécifiques de liaison à l'antigène et leurs utilisations |
CN114478801A (zh) | 2016-01-25 | 2022-05-13 | 里珍纳龙药品有限公司 | 美登素类化合物衍生物、其偶联物和使用方法 |
WO2017190079A1 (fr) | 2016-04-28 | 2017-11-02 | Regeneron Pharmaceuticals, Inc. | Procédés de production de molécules multispécifiques se liant à l'antigène |
MD3515487T2 (ro) | 2016-09-23 | 2023-11-30 | Regeneron Pharma | Anticorpi bispecifici anti-MUC16-CD3 și conjugate anticorp anti-MUC16-medicament |
CA3037732A1 (fr) | 2016-09-23 | 2018-03-29 | Regeneron Pharmaceuticals, Inc. | Anticorps anti-steap2, conjugues anticorps-medicament, et molecules bispecifiques de liaison a l'antigene qui se lient a steap2 et cd3, et leurs utilisations |
TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法 |
MX2019006131A (es) | 2016-11-29 | 2019-08-21 | Regeneron Pharma | Metodos para tratar cancer de mama positivo para prlr. |
CN110944718A (zh) | 2017-05-18 | 2020-03-31 | 里珍纳龙药品有限公司 | 环糊精蛋白质药物偶联物 |
WO2019094395A2 (fr) | 2017-11-07 | 2019-05-16 | Regeneron Pharmaceuticals, Inc. | Lieurs hydrophiles pour conjugués anticorps-médicament |
IL305268A (en) * | 2017-11-30 | 2023-10-01 | Centurion Biopharma Corp | Maytansinoid-based drug delivery systems |
EP3788075A1 (fr) * | 2018-04-30 | 2021-03-10 | Regeneron Pharmaceuticals, Inc. | Anticorps et molécules de liaison à l'antigène bispécifiques se liant à her2 et/ou aplp2, conjugués et utilisations associées |
JP7477462B2 (ja) | 2018-05-17 | 2024-05-01 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗cd63抗体、コンジュゲート、及び、それらの使用 |
WO2020057543A1 (fr) * | 2018-09-21 | 2020-03-26 | 中国人民解放军军事科学院军事医学研究院 | Lieur à base d'aryle nitro, conjugué anticorps-médicament contenant un lieur et utilisation de lieur |
WO2020172475A1 (fr) | 2019-02-21 | 2020-08-27 | Regeneron Pharmaceuticals, Inc. | Méthodes de traitement du cancer oculaire à l'aide d'anticorps anti-met et de molécules bispécifiques de liaison à l'antigène qui se lient à met |
CN114340684A (zh) | 2019-09-16 | 2022-04-12 | 瑞泽恩制药公司 | 用于免疫pet成像的放射性标记的met结合蛋白 |
US11814428B2 (en) | 2019-09-19 | 2023-11-14 | Regeneron Pharmaceuticals, Inc. | Anti-PTCRA antibody-drug conjugates and uses thereof |
WO2021097220A1 (fr) | 2019-11-15 | 2021-05-20 | Seagen Inc. | Méthodes de traitement du cancer du sein her2 positif avec du tucatinib en combinaison avec un conjugué médicament-anticorps anti-her2 |
CN113292574B (zh) * | 2020-02-21 | 2022-05-03 | 四川大学 | 一类手性多环的托品烷化合物及其制备方法和用途 |
CA3166619A1 (fr) | 2020-02-28 | 2021-09-02 | Julian Andreev | Molecules bispecifiques de liaison a l'antigene qui se lient a her2, et leurs procedes d'utilisation |
WO2021211984A1 (fr) | 2020-04-16 | 2021-10-21 | Regeneron Pharmaceuticals, Inc. | Procédés de conjugaison de diels-alder |
CA3190569A1 (fr) | 2020-10-22 | 2022-04-28 | Christopher Daly | Anticorps anti-fgfr2 et leurs methodes d'utilisation |
WO2022103724A1 (fr) | 2020-11-10 | 2022-05-19 | Regeneron Pharmaceuticals, Inc. | Conjugués d'anticorps au sélénium |
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JPS5566585A (en) * | 1978-11-14 | 1980-05-20 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
JPS55164686A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
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BRPI0510883B8 (pt) | 2004-06-01 | 2021-05-25 | Genentech Inc | composto conjugado de droga e anticorpo, composição farmacêutica, método de fabricação de composto conjugado de droga e anticorpo e usos de uma formulação, de um conjugado de droga e anticorpo e um agente quimioterapêutico e de uma combinação |
JP2008521828A (ja) | 2004-11-29 | 2008-06-26 | シアトル ジェネティックス, インコーポレイテッド | 操作された抗体およびイムノコンジュゲート |
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AU2006330562B2 (en) | 2005-12-22 | 2013-05-02 | Baxter Healthcare S.A. | Improved monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medical products |
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RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
WO2008122039A2 (fr) | 2007-04-02 | 2008-10-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Molécules d'anticorps hybrides médiées par la sélénocystéine |
EP2167963B1 (fr) | 2007-05-23 | 2019-04-17 | Ventana Medical Systems, Inc. | Supports polymères pour immunohistochimie et hybridation in situ |
BRPI0911442A2 (pt) | 2008-04-30 | 2019-03-12 | Immunogen, Inc. | conjugados potentes e ligantes hidrofílicos |
AU2009275358C1 (en) | 2008-07-21 | 2015-09-24 | Polytherics Limited | Novel reagents and method for conjugating biological molecules |
JO3182B1 (ar) | 2009-07-29 | 2018-03-08 | Regeneron Pharma | مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2 |
DK2889624T3 (en) | 2009-08-10 | 2018-12-10 | Ucl Business Plc | Reversible covalent bonding of functional molecules |
US20130028917A1 (en) | 2010-04-15 | 2013-01-31 | Spirogen Developments Sàrl | Pyrrolobenzodiazepines and conjugates thereof |
WO2012005982A2 (fr) | 2010-07-06 | 2012-01-12 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Rapporteur pour une terminaison par la arn polymérase ii |
NZ707327A (en) | 2010-08-02 | 2017-01-27 | Regeneron Pharma | Mice that make binding proteins comprising vl domains |
EP2714685B1 (fr) | 2011-05-27 | 2016-10-19 | Ambrx, Inc. | Compositions contenant des dérivés de dolastatine liés à des acides aminés non naturel |
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WO2012177837A2 (fr) * | 2011-06-21 | 2012-12-27 | Immunogen, Inc. | Nouveaux dérivés de maytansinoïde comprenant un lieur peptidique et conjugués correspondants |
KR101891859B1 (ko) | 2011-10-14 | 2018-08-24 | 메디뮨 리미티드 | 피롤로벤조디아제핀 |
WO2013053872A1 (fr) | 2011-10-14 | 2013-04-18 | Spirogen Sàrl | Procédé de synthèse et intermédiaires pouvant servir à préparer des pyrrolobenzodiazépines |
CN103997893B (zh) | 2011-10-14 | 2019-04-12 | 西雅图基因公司 | 吡咯并苯并二氮杂卓和靶向结合物 |
WO2013055990A1 (fr) | 2011-10-14 | 2013-04-18 | Seattle Genetics, Inc. | Pyrrolobenzodiazépines et conjugués ciblés |
WO2013068874A1 (fr) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Conjugués anticorps-médicament |
IN2014CN04961A (fr) | 2011-12-05 | 2015-09-18 | Igenica Biotherapeutics Inc | |
CN110201186A (zh) | 2012-10-23 | 2019-09-06 | 西纳福克斯股份有限公司 | 经修饰的抗体、抗体-缀合物及其制备方法 |
ES2701076T3 (es) * | 2012-11-24 | 2019-02-20 | Hangzhou Dac Biotech Co Ltd | Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células |
MX2015011348A (es) * | 2013-03-15 | 2016-01-15 | Regeneron Pharma | Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos. |
WO2014197854A1 (fr) | 2013-06-06 | 2014-12-11 | Igenica Biotherapeutics, Inc. | Nouveaux lieurs pour conjugués anticorps-médicament et composés connexes, compositions, et procédés d'utilisation |
TWI641620B (zh) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗-prlr抗體及其用途 |
CN105530942B (zh) * | 2013-08-26 | 2019-10-11 | 瑞泽恩制药公司 | 一种包含大环内酯类非对映体的药物组合物、其制备方法和用途 |
EP3273998B1 (fr) * | 2015-03-27 | 2019-09-04 | Regeneron Pharmaceuticals, Inc. | Dérivés de maytansinoïde, conjugués de ceux-ci, et procédés d'utilisation |
-
2016
- 2016-03-25 EP EP16714199.3A patent/EP3273998B1/fr active Active
- 2016-03-25 WO PCT/US2016/024343 patent/WO2016160615A1/fr active Application Filing
- 2016-03-25 JP JP2017550548A patent/JP6948950B2/ja active Active
- 2016-03-25 US US15/081,759 patent/US20160375147A1/en not_active Abandoned
- 2016-03-25 SG SG11201707148PA patent/SG11201707148PA/en unknown
- 2016-03-25 AU AU2016243527A patent/AU2016243527B2/en active Active
- 2016-03-25 EA EA201700464A patent/EA034950B1/ru unknown
- 2016-03-25 CN CN202210829028.0A patent/CN115645543A/zh active Pending
- 2016-03-25 KR KR1020177030678A patent/KR20170131587A/ko not_active Application Discontinuation
- 2016-03-25 CA CA2978340A patent/CA2978340A1/fr active Granted
- 2016-03-25 MX MX2017012380A patent/MX2017012380A/es unknown
- 2016-03-25 BR BR112017020149A patent/BR112017020149A8/pt not_active Application Discontinuation
- 2016-03-25 CN CN201680030443.2A patent/CN107995912A/zh active Pending
-
2017
- 2017-09-01 IL IL254267A patent/IL254267B/en active IP Right Grant
- 2017-09-05 ZA ZA2017/06040A patent/ZA201706040B/en unknown
- 2017-09-26 CL CL2017002422A patent/CL2017002422A1/es unknown
- 2017-09-27 PH PH12017501780A patent/PH12017501780A1/en unknown
- 2017-09-27 MX MX2021008101A patent/MX2021008101A/es unknown
- 2017-10-26 CO CONC2017/0010890A patent/CO2017010890A2/es unknown
-
2019
- 2019-12-12 US US16/712,941 patent/US20200385402A1/en not_active Abandoned
-
2021
- 2021-03-17 JP JP2021044152A patent/JP2021113191A/ja not_active Withdrawn
- 2021-11-16 US US17/528,144 patent/US20220259225A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2016160615A1 (fr) | 2016-10-06 |
BR112017020149A2 (pt) | 2018-09-11 |
EP3273998B1 (fr) | 2019-09-04 |
CA2978340A1 (fr) | 2016-10-06 |
JP2018516851A (ja) | 2018-06-28 |
EA034950B1 (ru) | 2020-04-09 |
PH12017501780A1 (en) | 2018-04-30 |
KR20170131587A (ko) | 2017-11-29 |
JP6948950B2 (ja) | 2021-10-13 |
CO2017010890A2 (es) | 2020-04-13 |
CL2017002422A1 (es) | 2018-03-16 |
US20220259225A1 (en) | 2022-08-18 |
CN107995912A (zh) | 2018-05-04 |
JP2021113191A (ja) | 2021-08-05 |
IL254267A (en) | 2018-06-28 |
AU2016243527B2 (en) | 2021-04-29 |
EP3273998A1 (fr) | 2018-01-31 |
ZA201706040B (en) | 2020-05-27 |
IL254267B (en) | 2021-03-25 |
BR112017020149A8 (pt) | 2023-05-02 |
CN115645543A (zh) | 2023-01-31 |
US20200385402A1 (en) | 2020-12-10 |
MX2017012380A (es) | 2018-04-11 |
EA201700464A1 (ru) | 2018-11-30 |
US20160375147A1 (en) | 2016-12-29 |
MX2021008101A (es) | 2021-08-05 |
AU2016243527A1 (en) | 2017-09-21 |
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