SG11201705685VA - Using size and number aberrations in plasma dna for detecting cancer - Google Patents

Using size and number aberrations in plasma dna for detecting cancer

Info

Publication number
SG11201705685VA
SG11201705685VA SG11201705685VA SG11201705685VA SG11201705685VA SG 11201705685V A SG11201705685V A SG 11201705685VA SG 11201705685V A SG11201705685V A SG 11201705685VA SG 11201705685V A SG11201705685V A SG 11201705685VA SG 11201705685V A SG11201705685V A SG 11201705685VA
Authority
SG
Singapore
Prior art keywords
size
plasma dna
detecting cancer
number aberrations
aberrations
Prior art date
Application number
SG11201705685VA
Other languages
English (en)
Inventor
Yuk-Ming Dennis Lo
Rossa Wai Kwun Chiu
Kwan Chee Chan
Peiyong Jiang
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Publication of SG11201705685VA publication Critical patent/SG11201705685VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
SG11201705685VA 2015-01-13 2016-01-13 Using size and number aberrations in plasma dna for detecting cancer SG11201705685VA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562102867P 2015-01-13 2015-01-13
US201562111534P 2015-02-03 2015-02-03
PCT/CN2016/070785 WO2016112850A1 (fr) 2015-01-13 2016-01-13 Utilisation des aberrations en taille et nombre dans l'adn plasmatique pour dépister le cancer

Publications (1)

Publication Number Publication Date
SG11201705685VA true SG11201705685VA (en) 2017-08-30

Family

ID=56367113

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201705685VA SG11201705685VA (en) 2015-01-13 2016-01-13 Using size and number aberrations in plasma dna for detecting cancer

Country Status (10)

Country Link
US (2) US10364467B2 (fr)
EP (1) EP3245299A4 (fr)
JP (4) JP6480591B2 (fr)
KR (5) KR102357959B1 (fr)
CN (2) CN113462781A (fr)
AU (3) AU2016207171B2 (fr)
CA (1) CA2973025A1 (fr)
SG (1) SG11201705685VA (fr)
TW (3) TWI777276B (fr)
WO (1) WO2016112850A1 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US11062789B2 (en) 2014-07-18 2021-07-13 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a DNA mixture
JP2017522908A (ja) 2014-07-25 2017-08-17 ユニヴァーシティ オブ ワシントン セルフリーｄｎａを生じる組織及び／又は細胞タイプを決定する方法、並びにそれを用いて疾患又は異常を識別する方法
EP3230469B1 (fr) 2014-12-12 2019-04-03 Verinata Health, Inc. Utilisation de la taille de fragments d'adn acellulaire pour déterminer les variations du nombre de copies
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
US10319463B2 (en) * 2015-01-23 2019-06-11 The Chinese University Of Hong Kong Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations
EP3390668A4 (fr) 2015-12-17 2020-04-01 Guardant Health, Inc. Procédés de détermination du nombre de copies du gène tumoral par analyse d'adn acellulaire
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
US11514289B1 (en) * 2016-03-09 2022-11-29 Freenome Holdings, Inc. Generating machine learning models using genetic data
IL262953B2 (en) 2016-05-30 2023-11-01 Univ Hong Kong Chinese Detection of hematological disorders using cell-free DNA in blood
WO2018031808A1 (fr) * 2016-08-10 2018-02-15 Cirina, Inc. Méthodes d'analyse de fragments d'acides nucléiques
EP3535415A4 (fr) * 2016-10-24 2020-07-01 The Chinese University of Hong Kong Méthodes et systèmes de détection d'une tumeur
WO2018085862A2 (fr) 2016-11-07 2018-05-11 Grail, Inc. Procédés d'identification de signatures mutationnelles somatiques pour la détection précoce du cancer
KR20230062684A (ko) 2016-11-30 2023-05-09 더 차이니즈 유니버시티 오브 홍콩 소변 및 기타 샘플에서의 무세포 dna의 분석
WO2018119452A2 (fr) 2016-12-22 2018-06-28 Guardant Health, Inc. Procédés et systèmes pour analyser des molécules d'acide nucléique
SG11201906397UA (en) 2017-01-25 2019-08-27 Univ Hong Kong Chinese Diagnostic applications using nucleic acid fragments
US11342047B2 (en) 2017-04-21 2022-05-24 Illumina, Inc. Using cell-free DNA fragment size to detect tumor-associated variant
US11535896B2 (en) 2017-05-15 2022-12-27 Katholieke Universiteit Leuven Method for analysing cell-free nucleic acids
US11168356B2 (en) * 2017-11-02 2021-11-09 The Chinese University Of Hong Kong Using nucleic acid size range for noninvasive cancer detection
GB201819134D0 (en) * 2018-11-23 2019-01-09 Cancer Research Tech Ltd Improvements in variant detection
EP3776555A2 (fr) * 2018-04-13 2021-02-17 Grail, Inc. Modèle de prédiction de dosages multiples pour la détection du cancer
TW202012639A (zh) * 2018-04-24 2020-04-01 美商格瑞爾公司 使用病原體核酸負荷確定個體是否患有癌症病況的系統及方法
CA3105349A1 (fr) 2018-05-03 2019-11-07 The Chinese University Of Hong Kong Extremites preferees etiquetees par taille et analyse sensible a l'orientation pour mesures des proprietes de melanges sans cellule
KR102175857B1 (ko) * 2019-03-06 2020-11-09 (주)지놈오피니언 무세포 dna 무결성 평가 방법
CN109852714B (zh) * 2019-03-07 2020-06-16 南京世和基因生物技术有限公司 一种肠癌早期诊断和腺瘤诊断标志物及用途
CN111690740B (zh) * 2019-03-11 2022-09-27 中国医学科学院肿瘤医院 肝细胞癌早筛试剂盒及其制备方法和用途
CA3125647A1 (fr) 2019-03-13 2020-09-17 Grail, Inc. Systemes et procedes d'enrichissement de fragments derives du cancer en utilisant la taille de fragment
CA3130810A1 (fr) 2019-03-25 2020-10-01 The Chinese University Of Hong Kong Determination de formes lineaires et circulaires d'acides nucleiques circulants
US20220290244A1 (en) * 2019-08-02 2022-09-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for screening a subject for a cancer
JP2022544626A (ja) * 2019-08-19 2022-10-19 グリーン クロス ゲノム コーポレーション 核酸断片間距離情報を用いた染色体異常検出方法
US11427874B1 (en) 2019-08-26 2022-08-30 Epi One Inc. Methods and systems for detection of prostate cancer by DNA methylation analysis
EP4041919A1 (fr) 2019-09-30 2022-08-17 Guardant Health, Inc. Compositions et procédés d'analyse d'adn acellulaire dans des dosages de partitionnement de méthylation
US20210166813A1 (en) 2019-11-27 2021-06-03 Grail, Inc. Systems and methods for evaluating longitudinal biological feature data
TWI749414B (zh) * 2019-11-29 2021-12-11 高雄醫學大學 細胞學抹片影像自動分析及診察結果自動批改方法
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
GB2596271A (en) * 2020-05-06 2021-12-29 Nottingham Univ Hospitals Nhs Trust Cancer screening test
KR102228852B1 (ko) * 2020-06-17 2021-03-17 (주)지놈오피니언 무세포 dna 무결성 평가 방법
WO2022203093A1 (fr) * 2021-03-22 2022-09-29 이원다이애그노믹스(주) Méthode de diagnostic ou de prédiction de l'apparition d'un cancer
CN113643759B (zh) * 2021-10-15 2022-01-11 臻和(北京)生物科技有限公司 基于液体活检的染色体稳定性评价方法和装置、终端设备及存储介质
KR20230114952A (ko) * 2022-01-26 2023-08-02 권창혁 암 판별 장치 및 암 판별 방법
WO2023170298A1 (fr) * 2022-03-11 2023-09-14 Belgian Volition Srl Procédé de diagnostic différentiel

Family Cites Families (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641628A (en) 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
AU2765992A (en) 1991-10-03 1993-05-03 Indiana University Foundation Method for screening for alzheimer's disease
US6100029A (en) 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US20010051341A1 (en) 1997-03-04 2001-12-13 Isis Innovation Limited Non-invasive prenatal diagnosis
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6566101B1 (en) 1997-06-16 2003-05-20 Anthony P. Shuber Primer extension methods for detecting nucleic acids
US20030022207A1 (en) 1998-10-16 2003-01-30 Solexa, Ltd. Arrayed polynucleotides and their use in genome analysis
US6613513B1 (en) 1999-02-23 2003-09-02 Caliper Technologies Corp. Sequencing by incorporation
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
KR20020064298A (ko) 1999-10-13 2002-08-07 시쿼넘, 인코포레이티드 다형성 유전 마커를 동정하기 위한 데이타베이스 및 이의제조 방법
US6664056B2 (en) 2000-10-17 2003-12-16 The Chinese University Of Hong Kong Non-invasive prenatal monitoring
US8898021B2 (en) 2001-02-02 2014-11-25 Mark W. Perlin Method and system for DNA mixture analysis
JP2002272497A (ja) 2001-03-15 2002-09-24 Venture Link Co Ltd 癌の診断方法、およびその診断用ベクター
WO2002081729A2 (fr) 2001-04-06 2002-10-17 California Institute Of Technology Amplification d'acide nucleique au moyen de dispositifs microfluidiques
US20020164816A1 (en) 2001-04-06 2002-11-07 California Institute Of Technology Microfluidic sample separation device
US7118907B2 (en) 2001-06-06 2006-10-10 Li-Cor, Inc. Single molecule detection systems and methods
US20050037388A1 (en) 2001-06-22 2005-02-17 University Of Geneva Method for detecting diseases caused by chromosomal imbalances
US6927028B2 (en) 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
WO2003030823A2 (fr) 2001-10-05 2003-04-17 Combinatorx, Incorporated Combinaisons permettant le traitement des troubles inflammatoires
JP2005509871A (ja) 2001-11-20 2005-04-14 エグザクト サイエンシーズ コーポレイション 自動化サンプル調製方法および装置
JP4355210B2 (ja) 2001-11-30 2009-10-28 フルイディグム コーポレイション 微小流体デバイスおよび微小流体デバイスの使用方法
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US20030180765A1 (en) 2002-02-01 2003-09-25 The Johns Hopkins University Digital amplification for detection of mismatch repair deficient tumor cells
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
NZ535045A (en) 2002-03-01 2008-04-30 Ravgen Inc Rapid analysis of variations in a genome
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US20070178478A1 (en) 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
EP2236614A3 (fr) 2002-08-15 2011-01-26 Genzyme Corporation Motifs d'expression des cellules endothéliales du cerveau
US7704687B2 (en) 2002-11-15 2010-04-27 The Johns Hopkins University Digital karyotyping
EP1583846B1 (fr) 2003-01-17 2011-11-16 The Chinese University Of Hong Kong Arnm circulant utilises comme marqueurs diagnostiques pour des troubles de la grossesse
JP2006521086A (ja) 2003-02-28 2006-09-21 ラブジェン， インコーポレイテッド 遺伝子疾患の検出方法
US8394582B2 (en) 2003-03-05 2013-03-12 Genetic Technologies, Inc Identification of fetal DNA and fetal cell markers in maternal plasma or serum
WO2004081183A2 (fr) 2003-03-07 2004-09-23 Rubicon Genomics, Inc. Immortalisation d'adn in vitro et amplification genomique complete a l'aide de bibliotheques generees a partir d'adn fragmente de manière aleatoire
WO2004089810A2 (fr) 2003-04-03 2004-10-21 Fluidigm Corp. Dispositifs microfluidiques et leurs procedes d'utilisation
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US20040197832A1 (en) 2003-04-03 2004-10-07 Mor Research Applications Ltd. Non-invasive prenatal genetic diagnosis using transcervical cells
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
RU2249820C1 (ru) 2003-08-18 2005-04-10 Лактионов Павел Петрович Способ ранней диагностики заболеваний, связанных с нарушением функционирования генетического аппарата клетки
EP2354253A3 (fr) 2003-09-05 2011-11-16 Trustees of Boston University Procede de diagnostic prenatal non effractif
US20050282213A1 (en) 2003-09-22 2005-12-22 Trisogen Biotechnology Limited Partnership Methods and kits useful for detecting an alteration in a locus copy number
WO2005035725A2 (fr) 2003-10-08 2005-04-21 The Trustees Of Boston University Methodes de diagnostic prenatal d'anomalies chromosomiques
EP1524321B2 (fr) 2003-10-16 2014-07-23 Sequenom, Inc. Détection non invasive de traits génétiques létaux
WO2005039389A2 (fr) 2003-10-22 2005-05-06 454 Corporation Caryotypage base sur des séquences
WO2005044086A2 (fr) 2003-10-30 2005-05-19 Tufts-New England Medical Center Diagnostic prenatal a l'aide d'adn foetal acellulaire dans le liquide amniotique
US20100216151A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US20060046258A1 (en) 2004-02-27 2006-03-02 Lapidus Stanley N Applications of single molecule sequencing
US20100216153A1 (en) 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
US7709194B2 (en) 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
DE102004036285A1 (de) 2004-07-27 2006-02-16 Advalytix Ag Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe
CN1779688A (zh) 2004-11-22 2006-05-31 寰硕数码股份有限公司 交互式医疗信息系统及方法
US7645576B2 (en) 2005-03-18 2010-01-12 The Chinese University Of Hong Kong Method for the detection of chromosomal aneuploidies
CN101137761B (zh) 2005-03-18 2010-12-08 香港中文大学 产前诊断和监测的标记
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
ATE406463T1 (de) 2005-04-06 2008-09-15 Maurice Stroun Methode zur krebsdiagnose mittels nachweis von dna und rna im kreislauf
US20090317798A1 (en) 2005-06-02 2009-12-24 Heid Christian A Analysis using microfluidic partitioning devices
WO2007001259A1 (fr) 2005-06-16 2007-01-04 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methodes et materiels utilises pour identifier des variantes polymorphes, diagnostiquer des predispositions a des pathologies et traiter des maladies
US20070059680A1 (en) 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20070122823A1 (en) 2005-09-01 2007-05-31 Bianchi Diana W Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis
PL1981995T5 (pl) 2006-02-02 2019-10-31 Univ Leland Stanford Junior Nieinwazyjne genetyczne badania przesiewowe płodu metodą analizy cyfrowej
DK1996728T3 (da) 2006-02-28 2011-08-15 Univ Louisville Res Found Detektering af føtale chromosomale abnormiteter under anvendelse af tandem-enkeltnukleotid-polymorfismer
US20080038733A1 (en) 2006-03-28 2008-02-14 Baylor College Of Medicine Screening for down syndrome
US8058055B2 (en) 2006-04-07 2011-11-15 Agilent Technologies, Inc. High resolution chromosomal mapping
US7754428B2 (en) 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
US7901884B2 (en) 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
WO2008111990A1 (fr) 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Analyse de cellules rares par division d'échantillon et utilisation de marqueurs d'adn
EP2029779A4 (fr) 2006-06-14 2010-01-20 Living Microsystems Inc Utilisation de génotypage snp fortement parallèle pour diagnostic fétal
EP3406736B1 (fr) 2006-06-14 2022-09-07 Verinata Health, Inc. Procédés pour le diagnostic d'anomalies fétales
EP2589668A1 (fr) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse de cellules rares utilisant la division d'échantillons et les marqueurs d'ADN
WO2009035447A1 (fr) 2006-06-14 2009-03-19 Living Microsystems, Inc. Diagnostic d'anomalies fœtales par une analyse par hybridation génomique comparative
EP2029778B1 (fr) 2006-06-14 2018-05-02 Verinata Health, Inc Diagnostic d'anomalies foetales
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
JP2009540802A (ja) 2006-06-16 2009-11-26 セクエノム， インコーポレイテッド サンプルからの核酸を増幅、検出および定量するための方法および組成物
WO2008014516A2 (fr) 2006-07-28 2008-01-31 Living Microsystems, Inc. Sélection de cellules au moyen de biomarqueurs
JP4379742B2 (ja) 2006-10-23 2009-12-09 ソニー株式会社 再生装置および再生方法、並びにプログラム
WO2008098142A2 (fr) 2007-02-08 2008-08-14 Sequenom, Inc. Tests a base d'acide nucléique destinés au typage rhd, à la détermination du sexe et la quantification d'acide nucléique
EP2153361A4 (fr) 2007-05-04 2010-09-29 Genes It Software Ltd Système, procédé et dispositif pour des informations génétiques individualisées complètes ou une consultation génétique
CA2688032C (fr) 2007-05-24 2015-11-03 Apceth Gmbh & Co. Kg Procedes et compositions associes a des cellules souches cd34
HUE030510T2 (hu) 2007-07-23 2017-05-29 Univ Hong Kong Chinese Magzati kromoszómális aneuploidia diagnosztizálása genomszekvenálás alkalmazásával
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
EP3103463B1 (fr) 2007-09-19 2020-01-01 Pluristem Ltd. Cellules adhérentes provenant de tissus adipeux ou placentaires et leur utilisation en thérapie
WO2009051842A2 (fr) 2007-10-18 2009-04-23 The Johns Hopkins University Détection d'un cancer par mesure du nombre de copies génomiques et de la longueur des brins dans de l'adn exempt de cellules
US20100112575A1 (en) * 2008-09-20 2010-05-06 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive Diagnosis of Fetal Aneuploidy by Sequencing
WO2010053980A2 (fr) 2008-11-04 2010-05-14 The Johns Hopkins University Essai d'intégrité d'adn pour diagnostic de cancer, utilisant la spectroscopie de fluorescence confocale
NZ595993A (en) 2009-03-31 2013-05-31 Oridis Biomarkers Gmbh Method for diagnosis of cancer and monitoring of cancer treatments
WO2011053790A2 (fr) 2009-10-30 2011-05-05 Fluidigm Corporation Dosage de cibles étroitement liées en diagnostic foetal et dosage de détection de coïncidence pour l'analyse génétique
CA2779695C (fr) 2009-11-05 2016-05-24 The Chinese University Of Hong Kong Analyse genomique fƒtale a partir d'un echantillon biologique maternel
EP3406737B1 (fr) 2009-11-06 2023-05-31 The Chinese University of Hong Kong Analyse génomique bassé sur la taille
US9361426B2 (en) 2009-11-12 2016-06-07 Esoterix Genetic Laboratories, Llc Copy number analysis of genetic locus
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
WO2011090556A1 (fr) 2010-01-19 2011-07-28 Verinata Health, Inc. Procédés pour déterminer une fraction d'acide nucléique fœtal dans des échantillons maternels
US9260745B2 (en) * 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
WO2011103236A2 (fr) 2010-02-18 2011-08-25 The Johns Hopkins University Biomarqueurs tumoraux personnalisés
CA2801468C (fr) 2010-06-04 2018-09-04 Chronix Biomedical Biomarqueurs d'acides nucleiques circulants associes au cancer de la prostate
EP2426217A1 (fr) 2010-09-03 2012-03-07 Centre National de la Recherche Scientifique (CNRS) Procédés analytiques pour acides nucléiques libres dans les cellules et applications
CN108899091B (zh) 2010-11-30 2022-04-15 香港中文大学 与癌症相关的遗传或分子畸变的检测
US20130059738A1 (en) 2011-04-28 2013-03-07 Life Technologies Corporation Methods and compositions for multiplex pcr
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
CA3069089A1 (fr) 2011-09-22 2013-03-28 Lineage Biosciences, Inc. Compositions et procedes pour analyser des echantillons heterogenes
EP2764458B1 (fr) 2011-10-06 2021-04-07 Sequenom, Inc. Méthodes et procédés pour évaluation non invasive de variations génétiques
US10196681B2 (en) * 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013060762A1 (fr) 2011-10-25 2013-05-02 Roche Diagnostics Gmbh Méthode pour diagnostiquer une maladie basée sur la distribution de l'adn plasmatique
US9845552B2 (en) 2011-10-27 2017-12-19 Verinata Health, Inc. Set membership testers for aligning nucleic acid samples
US9757458B2 (en) * 2011-12-05 2017-09-12 Immunomedics, Inc. Crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in hematopoietic cancer cells
US20140364439A1 (en) 2011-12-07 2014-12-11 The Broad Institute, Inc. Markers associated with chronic lymphocytic leukemia prognosis and progression
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US20130261984A1 (en) 2012-03-30 2013-10-03 Illumina, Inc. Methods and systems for determining fetal chromosomal abnormalities
US11261494B2 (en) 2012-06-21 2022-03-01 The Chinese University Of Hong Kong Method of measuring a fractional concentration of tumor DNA
US20150197785A1 (en) 2012-08-10 2015-07-16 The Broad Institute, Inc. Methods and apparatus for analyzing and quantifying dna alterations in cancer
CN104781421B (zh) 2012-09-04 2020-06-05 夸登特健康公司 检测稀有突变和拷贝数变异的系统和方法
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
KR20230145530A (ko) 2012-09-20 2023-10-17 더 차이니즈 유니버시티 오브 홍콩 혈장으로부터 태아 또는 종양 메틸롬의 비침습적 결정
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US20140287937A1 (en) 2013-02-21 2014-09-25 Toma Biosciences, Inc. Methods for assessing cancer
CA3156663A1 (fr) 2013-03-15 2014-09-18 Verinata Health, Inc. Generation de bibliotheques d'adn acellulaire directement a partir du sang
CN113337604A (zh) 2013-03-15 2021-09-03 莱兰斯坦福初级大学评议会 循环核酸肿瘤标志物的鉴别和用途
JP6088710B2 (ja) 2013-08-19 2017-03-01 シンギュラー・バイオ・インコーポレイテッド 単分子検出アッセイおよびその使用
US10262755B2 (en) * 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
EP3061021B1 (fr) 2013-10-21 2023-05-10 Verinata Health, Inc. Procédé destiné à l'amélioration de la sensibilité de détection dans la détemrination des variations du nombre de copies
GB201319779D0 (en) 2013-11-08 2013-12-25 Cartagenia N V Genetic analysis method
US10465238B2 (en) 2013-12-19 2019-11-05 The Board Of Trustees Of The Leland Stanford Junior University Quantification of mutant alleles and copy number variation using digital PCR with nonspecific DNA-binding dyes
GB2524948A (en) 2014-03-07 2015-10-14 Oxford Gene Technology Operations Ltd Detecting Increase or Decrease in the Amount of a Nucleic Acid having a Sequence of Interest
CN106460070B (zh) 2014-04-21 2021-10-08 纳特拉公司 检测染色体片段中的突变和倍性
EP3143163B1 (fr) 2014-05-13 2020-11-25 Board of Regents, The University of Texas System Mutations géniques et altérations du nombre de copies de egfr, kras et met
EP3149199B1 (fr) * 2014-05-30 2020-03-25 Verinata Health, Inc. Détection d'aneuploïdies sous-chromosomiques eventuellement foetales et de variations du nombre de copies
MX2016016904A (es) 2014-06-26 2017-03-27 10X Genomics Inc Analisis de secuencias de acidos nucleicos.
US11062789B2 (en) 2014-07-18 2021-07-13 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a DNA mixture
JP2017522908A (ja) 2014-07-25 2017-08-17 ユニヴァーシティ オブ ワシントン セルフリーｄｎａを生じる組織及び／又は細胞タイプを決定する方法、並びにそれを用いて疾患又は異常を識別する方法
SG11201701113WA (en) 2014-08-22 2017-03-30 Resolution Bioscience Inc Methods for quantitative genetic analysis of cell free dna
US11085084B2 (en) 2014-09-12 2021-08-10 The Board Of Trustees Of The Leland Stanford Junior University Identification and use of circulating nucleic acids
DK3191993T3 (da) 2014-09-12 2022-07-25 Illumina Cambridge Ltd Detektion af repeatudvidelser med short read-sekventeringsdata
EP3018213A1 (fr) 2014-11-04 2016-05-11 Genesupport SA Procédé pour déterminer la présence d'un état biologique par la détermination de la quantité totale et la quantité relative de deux acides nucléaires differentes
ES2790823T3 (es) 2014-11-14 2020-10-29 Liquid Genomics Inc Uso de ARN sin células circulante para el diagnóstico y/o la monitorización de cáncer
EP3230469B1 (fr) 2014-12-12 2019-04-03 Verinata Health, Inc. Utilisation de la taille de fragments d'adn acellulaire pour déterminer les variations du nombre de copies
WO2016097251A1 (fr) 2014-12-19 2016-06-23 Danmarks Tekniske Universitet Procédé d'identification de la localisation d'une tumeur au sein d'un tissu ou d'un organe
CN107406876B (zh) 2014-12-31 2021-09-07 夸登特健康公司 表现出病变细胞异质性的疾病的检测和治疗以及用于传送测试结果的系统和方法
US10364467B2 (en) * 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
US10319463B2 (en) 2015-01-23 2019-06-11 The Chinese University Of Hong Kong Combined size- and count-based analysis of maternal plasma for detection of fetal subchromosomal aberrations
ES2908347T3 (es) 2015-02-10 2022-04-28 Univ Hong Kong Chinese Detección de mutaciones para cribado de cáncer y análisis fetal
CA2978628A1 (fr) 2015-03-03 2016-09-09 Caris Mpi, Inc. Profilage moleculaire du cancer
WO2016179049A1 (fr) 2015-05-01 2016-11-10 Guardant Health, Inc Méthodes de diagnostic
EP3292221B1 (fr) 2015-05-06 2021-06-23 Seracare Life Sciences Inc. Préparations liposomales pour analyse prénatale ou dépistage du cancer non invasifs
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
EP3636777A1 (fr) 2015-07-13 2020-04-15 Agilent Technologies Belgium NV Système et méthodologie pour l'analyse de données génomiques obtenues à partir d'un sujet
ES2960201T3 (es) * 2015-07-23 2024-03-01 Univ Hong Kong Chinese Análisis de los patrones de fragmentación del ADN acelular
CA2993267A1 (fr) 2015-08-07 2017-02-16 Dana-Farber Cancer Institute, Inc. Anomalies genetiques dans des dyscrasies de cellules du plasma
CN116640849A (zh) 2015-10-09 2023-08-25 夸登特健康公司 使用无细胞dna的基于群体的治疗推荐
WO2017070497A1 (fr) 2015-10-21 2017-04-27 Dana-Farber Cancer Institute, Inc. Procédés et compositions pour utiliser des mutations conductrices dans la llc
EP3390668A4 (fr) 2015-12-17 2020-04-01 Guardant Health, Inc. Procédés de détermination du nombre de copies du gène tumoral par analyse d'adn acellulaire
US10982286B2 (en) 2016-01-22 2021-04-20 Mayo Foundation For Medical Education And Research Algorithmic approach for determining the plasma genome abnormality PGA and the urine genome abnormality UGA scores based on cell free cfDNA copy number variations in plasma and urine
US20170342477A1 (en) 2016-05-27 2017-11-30 Sequenom, Inc. Methods for Detecting Genetic Variations
EP3535415A4 (fr) 2016-10-24 2020-07-01 The Chinese University of Hong Kong Méthodes et systèmes de détection d'une tumeur
WO2019051842A1 (fr) 2017-09-18 2019-03-21 陈坚胜 Casserole non inductive haute-fréquence

Also Published As

Publication number Publication date
CN107406885B (zh) 2021-07-30
TWI710639B (zh) 2020-11-21
JP2022191459A (ja) 2022-12-27
KR102605348B1 (ko) 2023-11-22
JP6817259B2 (ja) 2021-01-20
JP2018512042A (ja) 2018-05-10
CA2973025A1 (fr) 2016-07-21
EP3245299A1 (fr) 2017-11-22
TWI777276B (zh) 2022-09-11
WO2016112850A1 (fr) 2016-07-21
TW202246526A (zh) 2022-12-01
TW202108769A (zh) 2021-03-01
US20160201142A1 (en) 2016-07-14
AU2016207171B2 (en) 2020-07-30
JP6480591B2 (ja) 2019-03-13
KR20190014121A (ko) 2019-02-11
CN113462781A (zh) 2021-10-01
CN107406885A (zh) 2017-11-28
KR20200145864A (ko) 2020-12-30
JP7169002B2 (ja) 2022-11-10
US20190292607A1 (en) 2019-09-26
JP2021061844A (ja) 2021-04-22
AU2016207171A1 (en) 2017-07-20
AU2020260534A1 (en) 2020-11-26
KR102357959B1 (ko) 2022-02-08
TW201639969A (zh) 2016-11-16
KR20170106372A (ko) 2017-09-20
AU2020260534B2 (en) 2023-05-25
JP2019022495A (ja) 2019-02-14
KR101945024B1 (ko) 2019-02-01
KR102197373B1 (ko) 2021-01-04
AU2020260534C1 (en) 2024-01-11
EP3245299A4 (fr) 2018-07-04
KR20230162136A (ko) 2023-11-28
KR20220020393A (ko) 2022-02-18
US10364467B2 (en) 2019-07-30
AU2023219906A1 (en) 2023-09-14

Similar Documents

Publication Publication Date Title
SG11201705685VA (en) Using size and number aberrations in plasma dna for detecting cancer
IL252126A0 (en) Transduction methods and cellular processing
EP3265113A4 (fr) Anticorps anti-lilrb et leur utilisation pour détecter et traiter un cancer
GB201718457D0 (en) Cancer cell enrichment system
IL254414A0 (en) Systems and methods for mobile capsule dispensers
GB201607629D0 (en) Mutational signatures in cancer
HUE053281T2 (hu) Rák kimutatási rendszerek és eljárások
EP3125907A4 (fr) Utilisation d'adn double brin dans des exosomes : un nouveau biomarqueur dans la détection du cancer
HK1257686A1 (zh) 用於匹配腫瘤學特徵的系統和方法
HK1213987A1 (zh) 標本處理系統和用於保持載片的方法
HK1243177A1 (zh) 平行細胞處理方法和設施
SG11201707649SA (en) Method and device for analyzing gene
EP3288459A4 (fr) Appareil de prélèvement et de distribution de spécimens
IL246607B (en) Improved cellular preparations and methods for cancer treatment
ZA201706850B (en) System and method for processing vouchers
HK1257519A1 (zh) 用於 galgt2 基因治療的方法和物質
IL252118A0 (en) Analytical methods and arrays for their use
GB201419167D0 (en) Molecular and bioinformatics methods for direct sequencing
SG10201605375YA (en) Sample holder and sample holder set
IL260314B (en) Systems and methods for RNA analysis in functional confirmation of mutations in cancer
EP3361871A4 (fr) Procédés pour induire l'apoptose dans des cellules cancéreuses
SG11201707650SA (en) Normalization methods for measuring gene copy number and expression
SG10201509087QA (en) Methods and systems for dispensing physical currency
SG11201707653TA (en) Method and device for analyzing genes
SG11201702260RA (en) Anti-cancer agent and cancer cell killing method