SG11201705444QA - Blood based biomarkers for diagnosing atherosclerotic coronary artery disease - Google Patents
Blood based biomarkers for diagnosing atherosclerotic coronary artery diseaseInfo
- Publication number
- SG11201705444QA SG11201705444QA SG11201705444QA SG11201705444QA SG11201705444QA SG 11201705444Q A SG11201705444Q A SG 11201705444QA SG 11201705444Q A SG11201705444Q A SG 11201705444QA SG 11201705444Q A SG11201705444Q A SG 11201705444QA SG 11201705444Q A SG11201705444Q A SG 11201705444QA
- Authority
- SG
- Singapore
- Prior art keywords
- coronary artery
- artery disease
- blood based
- atherosclerotic coronary
- based biomarkers
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/492—Determining multiple analytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ecology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562101445P | 2015-01-09 | 2015-01-09 | |
| PCT/US2016/012725 WO2016112337A1 (en) | 2015-01-09 | 2016-01-08 | Blood based biomarkers for diagnosing atherosclerotic coronary artery disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201705444QA true SG11201705444QA (en) | 2017-07-28 |
Family
ID=56356500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201705444QA SG11201705444QA (en) | 2015-01-09 | 2016-01-08 | Blood based biomarkers for diagnosing atherosclerotic coronary artery disease |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10254272B2 (de) |
| EP (3) | EP3242588B1 (de) |
| KR (1) | KR20170102983A (de) |
| CN (2) | CN113156096A (de) |
| CA (1) | CA2973116C (de) |
| HU (2) | HUE056203T2 (de) |
| IL (1) | IL253179A0 (de) |
| MX (1) | MX2017008904A (de) |
| SG (1) | SG11201705444QA (de) |
| TW (2) | TWI610079B (de) |
| WO (1) | WO2016112337A1 (de) |
| ZA (1) | ZA201705032B (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3242588B1 (de) * | 2015-01-09 | 2019-10-16 | Global Genomics Group, LLC | Blutbasierte biomarker zur diagnostizierung atherosklerotischer koronararterienerkrankung |
| JOP20190112A1 (ar) * | 2016-11-14 | 2019-05-14 | Amgen Inc | علاجات مدمجة لتصلب الشرايين، شاملة مرض قلبي وعائي تصلبي |
| CN107491656B (zh) * | 2017-09-04 | 2020-01-14 | 北京航空航天大学 | 一种基于相对危险度决策树模型的妊娠结局影响因子评估方法 |
| US11513131B2 (en) * | 2018-01-22 | 2022-11-29 | Global Genomics Group, LLC | Low density lipoprotein triglycerides (LDL-TG) as a biomarker of cardiovascular disease and uses thereof |
| WO2019173709A1 (en) * | 2018-03-09 | 2019-09-12 | Nearing Bruce D | High throughput ecg heterogeneity assessment to determine presence of coronary artery stenosis |
| CN111919120A (zh) * | 2018-03-29 | 2020-11-10 | 学校法人庆应义塾 | 包含伊立替康的抗癌剂疗法的敏感性判定标志物 |
| US11036779B2 (en) * | 2018-04-23 | 2021-06-15 | Verso Biosciences, Inc. | Data analytics systems and methods |
| CN109060977B (zh) * | 2018-07-13 | 2024-07-02 | 深圳市绘云生物科技有限公司 | 用于肝纤维化和肝硬化诊断的生物标志物和试剂盒及使用方法 |
| CN109164183A (zh) * | 2018-09-29 | 2019-01-08 | 中国检验检疫科学研究院 | 肝脏损伤相关差异性内源性标志物及其筛选方法和应用 |
| CN110487922B (zh) * | 2018-12-17 | 2022-09-27 | 广西中烟工业有限责任公司 | 一种烟叶中苏糖酸和苏糖酸酯的gc-ms分析方法 |
| EP3935581A4 (de) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | Datenkompression und -kommunikation mit maschinenlernung |
| KR102177280B1 (ko) * | 2019-05-09 | 2020-11-10 | 고려대학교 세종산학협력단 | 호모시스테인 설핀산 또는 시스테인산을 포함하는 급성심근경색 진단용 바이오마커 조성물 |
| CN111505131B (zh) * | 2020-01-02 | 2023-03-31 | 东莞东华医院有限公司 | 基于血清代谢组学改变建立的预测冠心病斑块不稳定性临床模型 |
| CN111983160B (zh) * | 2020-08-14 | 2022-08-09 | 中元伯瑞生物科技(珠海横琴)有限公司 | 神经酸在治疗脑卒中药物中的应用 |
| WO2022155555A1 (en) * | 2021-01-15 | 2022-07-21 | My Lua Llc | Systems and methods for deriving health indicators from user-generated content |
| CN113484453B (zh) * | 2021-07-07 | 2022-08-09 | 天津中医药大学 | 一种缺血性脑卒中预警方法 |
| CN113777203A (zh) * | 2021-07-21 | 2021-12-10 | 嘉兴学院 | 二甲基甘氨酸作为胎儿先天性心脏病血清标志物的应用 |
| CN114324641A (zh) * | 2021-12-22 | 2022-04-12 | 山东英盛生物技术有限公司 | 一种冠心病代谢标志物及在诊断、预后方面的应用 |
| CN114324662B (zh) * | 2021-12-30 | 2022-09-16 | 中南大学 | 用于诊断或预防糖尿病的血清生物标志物的应用 |
| CN114705782B (zh) * | 2022-04-07 | 2023-12-01 | 中国人民解放军总医院第一医学中心 | 用于诊断或监测结直肠癌的血浆代谢标志物组合及应用 |
| CN117110627B (zh) * | 2023-10-18 | 2024-01-09 | 天津云检医学检验所有限公司 | 用于新生儿干血斑先天性心脏病及其亚型评估的标志物 |
| CN117405870B (zh) * | 2023-12-15 | 2024-03-19 | 北京市心肺血管疾病研究所 | 基于血清脂质代谢物构建冠心病患者不稳定斑块表型的预测模型 |
| CN118010893B (zh) * | 2024-04-09 | 2024-07-23 | 北京市心肺血管疾病研究所 | 类花生酸在用于评估急性冠脉综合征患者血运重建术后发生不良心血管事件风险中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002089657A2 (en) * | 2001-05-04 | 2002-11-14 | Biosite, Inc. | Diagnostic markers of acute coronary syndromes and methods of use thereof |
| WO2005051298A2 (en) * | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| WO2008118413A2 (en) | 2007-03-26 | 2008-10-02 | Bg Medicine, Inc. | Methods for detecting coronary artery disease |
| WO2009006583A1 (en) * | 2007-07-03 | 2009-01-08 | Joslin Diabetes Center, Inc. | Treatment of cardiovascular disease with salicylates |
| US8187830B2 (en) * | 2007-07-17 | 2012-05-29 | Metabolon, Inc. | Method for determining insulin sensitivity with biomarkers |
| CN102573500A (zh) * | 2009-08-06 | 2012-07-11 | 纽拉尔图斯制药公司 | 巨噬细胞相关疾病的治疗 |
| US9110086B2 (en) * | 2009-11-27 | 2015-08-18 | Baker Idi Heart And Diabetes Institute Holdings Limited | Lipid biomarkers for stable and unstable heart disease |
| KR20130056855A (ko) * | 2010-03-01 | 2013-05-30 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 치료진단용 생물학적 지표들 |
| ES2455124T5 (es) | 2010-05-05 | 2018-05-08 | Zora Biosciences Oy | Biomarcadores lipidómicos para la aterosclerosis y afección cardíaca |
| CN103140498B (zh) * | 2010-07-19 | 2017-05-17 | 奥塔哥创新有限公司 | 信号生物标志物 |
| KR20140091688A (ko) * | 2011-10-06 | 2014-07-22 | 미라젠 세러퓨틱스 인코포레이티드 | 마이크로rna 조절에 의한 전신 에너지 항상성의 제어 |
| CA2903946A1 (en) * | 2013-03-08 | 2014-09-12 | Zora Biosciences Oy | Non-high density lipoprotein derived cvd markers |
| MX365061B (es) * | 2013-05-14 | 2019-05-22 | Metabolon Inc | Biomarcadores relacionados a la funcion renal y metodos para usar los mismos. |
| CN106537145B (zh) * | 2014-04-08 | 2020-08-25 | 麦特博隆股份有限公司 | 用于疾病诊断和健康评估的个体受试者的小分子生物化学特征分析 |
| US9176113B1 (en) * | 2014-04-11 | 2015-11-03 | Synapdx Corporation | Methods and systems for determining autism spectrum disorder risk |
| JP2017536543A (ja) * | 2014-11-05 | 2017-12-07 | メタボロン，インコーポレイテッド | 遺伝的変異体の影響を決定するためのシステム、方法、および装置 |
| EP3242588B1 (de) * | 2015-01-09 | 2019-10-16 | Global Genomics Group, LLC | Blutbasierte biomarker zur diagnostizierung atherosklerotischer koronararterienerkrankung |
-
2016
- 2016-01-08 EP EP16735507.2A patent/EP3242588B1/de active Active
- 2016-01-08 CA CA2973116A patent/CA2973116C/en active Active
- 2016-01-08 MX MX2017008904A patent/MX2017008904A/es unknown
- 2016-01-08 KR KR1020177022311A patent/KR20170102983A/ko unknown
- 2016-01-08 US US14/991,644 patent/US10254272B2/en active Active
- 2016-01-08 EP EP21191468.4A patent/EP3967217B1/de active Active
- 2016-01-08 CN CN202110212393.2A patent/CN113156096A/zh active Pending
- 2016-01-08 WO PCT/US2016/012725 patent/WO2016112337A1/en active Application Filing
- 2016-01-08 HU HUE19203073A patent/HUE056203T2/hu unknown
- 2016-01-08 EP EP19203073.2A patent/EP3650852B1/de active Active
- 2016-01-08 CN CN201680014800.6A patent/CN107427221B/zh active Active
- 2016-01-08 HU HUE16735507A patent/HUE047951T2/hu unknown
- 2016-01-08 SG SG11201705444QA patent/SG11201705444QA/en unknown
- 2016-02-01 TW TW105103174A patent/TWI610079B/zh not_active IP Right Cessation
- 2016-02-01 TW TW106132686A patent/TWI690707B/zh not_active IP Right Cessation
-
2017
- 2017-06-26 IL IL253179A patent/IL253179A0/en unknown
- 2017-07-24 ZA ZA2017/05032A patent/ZA201705032B/en unknown
-
2019
- 2019-02-28 US US16/289,347 patent/US20190391131A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3242588A1 (de) | 2017-11-15 |
| EP3242588B1 (de) | 2019-10-16 |
| IL253179A0 (en) | 2017-08-31 |
| WO2016112337A1 (en) | 2016-07-14 |
| EP3967217B1 (de) | 2024-08-14 |
| EP3650852A1 (de) | 2020-05-13 |
| ZA201705032B (en) | 2019-09-25 |
| EP3650852B1 (de) | 2021-08-18 |
| HUE056203T2 (hu) | 2022-01-28 |
| HUE047951T2 (hu) | 2020-05-28 |
| TWI690707B (zh) | 2020-04-11 |
| CN113156096A (zh) | 2021-07-23 |
| TW201802471A (zh) | 2018-01-16 |
| US20190391131A1 (en) | 2019-12-26 |
| TWI610079B (zh) | 2018-01-01 |
| KR20170102983A (ko) | 2017-09-12 |
| EP3967217A1 (de) | 2022-03-16 |
| US20160202239A1 (en) | 2016-07-14 |
| EP3242588A4 (de) | 2018-10-17 |
| US10254272B2 (en) | 2019-04-09 |
| MX2017008904A (es) | 2018-02-09 |
| CA2973116C (en) | 2023-08-15 |
| CA2973116A1 (en) | 2016-07-14 |
| TW201725387A (zh) | 2017-07-16 |
| CN107427221B (zh) | 2021-03-09 |
| CN107427221A (zh) | 2017-12-01 |
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