SG11201701149SA - Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer - Google Patents

Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer

Info

Publication number
SG11201701149SA
SG11201701149SA SG11201701149SA SG11201701149SA SG11201701149SA SG 11201701149S A SG11201701149S A SG 11201701149SA SG 11201701149S A SG11201701149S A SG 11201701149SA SG 11201701149S A SG11201701149S A SG 11201701149SA SG 11201701149S A SG11201701149S A SG 11201701149SA
Authority
SG
Singapore
Prior art keywords
listeria
antagonist
combination
prostate cancer
based vaccine
Prior art date
Application number
SG11201701149SA
Other languages
English (en)
Inventor
Robert Petit
David J Mauro
Rodolfo F Perini
Original Assignee
Advaxis Inc
Merck Sharpe And Dohme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advaxis Inc, Merck Sharpe And Dohme Corp filed Critical Advaxis Inc
Publication of SG11201701149SA publication Critical patent/SG11201701149SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001194—Prostate specific antigen [PSA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/884—Vaccine for a specifically defined cancer prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11201701149SA 2014-07-18 2015-07-17 Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer SG11201701149SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462026221P 2014-07-18 2014-07-18
US201462039011P 2014-08-19 2014-08-19
PCT/US2015/040916 WO2016011357A1 (fr) 2014-07-18 2015-07-17 Combinaison d'un antagoniste de pd-1 et d'un vaccin à base de listeria pour le traitement du cancer

Publications (1)

Publication Number Publication Date
SG11201701149SA true SG11201701149SA (en) 2017-04-27

Family

ID=55079087

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201913696YA SG10201913696YA (en) 2014-07-18 2015-07-17 Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer
SG11201701149SA SG11201701149SA (en) 2014-07-18 2015-07-17 Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201913696YA SG10201913696YA (en) 2014-07-18 2015-07-17 Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer

Country Status (11)

Country Link
US (2) US9907849B2 (fr)
EP (1) EP3193921A4 (fr)
KR (1) KR20170052569A (fr)
CN (2) CN114984228A (fr)
AU (1) AU2015289533B2 (fr)
CA (1) CA2955612C (fr)
IL (1) IL250187B (fr)
MA (1) MA40344A (fr)
MX (1) MX2017000857A (fr)
SG (2) SG10201913696YA (fr)
WO (1) WO2016011357A1 (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012141B2 (en) 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
US8771702B2 (en) * 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
NZ600758A (en) * 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
CA2829960A1 (fr) 2011-03-11 2012-09-20 John Rothman Adjuvants a base de listeria
JP2015511602A (ja) 2012-03-12 2015-04-20 アドバクシス， インコーポレイテッド リステリアワクチン処理後のサプレッサー細胞機能抑制
SG11201407190TA (en) 2012-05-15 2014-12-30 Bristol Myers Squibb Co Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
EA035037B1 (ru) 2013-12-12 2020-04-21 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Антитело к pd-1, его антигенсвязывающий фрагмент и их медицинское применение
CN106456726A (zh) 2014-02-18 2017-02-22 阿德瓦希斯公司 生物标志物导向的多靶点免疫治疗
EP3134510B1 (fr) 2014-04-24 2023-11-01 Advaxis, Inc. Souches de listeria utilisées comme vaccin recombinant et procédé de production
MA41644A (fr) 2015-03-03 2018-01-09 Advaxis Inc Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation
CN114702586A (zh) 2015-03-13 2022-07-05 西托姆克斯治疗公司 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
JP2018515474A (ja) * 2015-04-28 2018-06-14 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗ｐｄ−１抗体を使用するｐｄ−ｌ１陽性黒色腫の処置
KR20170138555A (ko) 2015-04-28 2017-12-15 브리스톨-마이어스 스큅 컴퍼니 항-pd-1 항체 및 항-ctla-4 항체를 사용한 pd-l1-음성 흑색종의 치료
CA2991976A1 (fr) 2015-07-13 2017-01-19 Cytomx Therapeutics, Inc. Anticorps anti-pd-1, anticorps anti-pd-1 activables, et leurs procedes d'utilisation
WO2017011666A1 (fr) * 2015-07-14 2017-01-19 Bristol-Myers Squibb Company Méthode destinée à traiter le cancer à l'aide d'un inhibiteur des points de contrôle immunitaires
SG11201804957VA (en) 2015-12-16 2018-07-30 Gritstone Oncology Inc Neoantigen identification, manufacture, and use
CN109071632B (zh) * 2016-02-05 2022-12-30 奥里尼斯生物科学私人有限公司 靶向性治疗剂及其用途
WO2017139628A1 (fr) * 2016-02-12 2017-08-17 Madison Vaccines Inc. Cancérothérapie
WO2018027524A1 (fr) 2016-08-09 2018-02-15 Innovent Biologics (Suzhou) Co., Ltd. Formule d'anticorps anti-pd-1.
SG11201901979SA (en) 2016-11-30 2019-04-29 Advaxis Inc Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof
TW201834639A (zh) * 2017-03-06 2018-10-01 德商馬克專利公司 水性抗體調配物
WO2018204374A1 (fr) 2017-05-02 2018-11-08 Merck Sharp & Dohme Corp. Formulations d'anticorps anti-lag3 etco-formulations d'anticorps anti-lag3 et d'anticorps anti-pd-1
JOP20190260A1 (ar) 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
EP3630838A1 (fr) 2017-06-01 2020-04-08 CytomX Therapeutics, Inc. Anticorps anti-pdl1 activables, et leurs procédés d'utilisation
AU2018336988B2 (en) 2017-09-19 2023-06-22 Advaxis, Inc. Compositions and methods for lyophilization of bacteria or Listeria strains
JP7227237B2 (ja) 2017-10-10 2023-02-21 グリットストーン バイオ インコーポレイテッド ホットスポットを利用した新生抗原の特定
CN111630602A (zh) 2017-11-22 2020-09-04 磨石肿瘤生物技术公司 减少新抗原的接合表位呈递
EP3752180A4 (fr) 2018-02-13 2021-12-15 Merck Sharp & Dohme Corp. Méthodes de traitement du cancer avec des anticorps anti-pd-1
CN112533939B (zh) * 2018-08-02 2024-03-19 苏州若泰医药科技有限公司 一种基于减毒李斯特菌激活的抗原提呈细胞的肿瘤免疫治疗组合物、制备方法和应用
WO2020033283A1 (fr) * 2018-08-09 2020-02-13 Merck Sharp & Dohme Corp. Compositions et méthodes de traitement du cancer avec une association d'anticorps anti-récepteur de mort programmée (pd-1) et de vicriviroc
WO2020055702A1 (fr) * 2018-09-13 2020-03-19 Merck Sharp & Dohme Corp. Association d'un antagoniste de pd-1 et d'un antagoniste de lag3 pour le traitement du cancer colorectal à réparation efficace des mésappariements/ne présentant pas d'instabilité élevée des microsatellites
EP3730153A1 (fr) 2019-04-26 2020-10-28 Medizinische Hochschule Hannover Immunothérapie personnalisée pour le traitement du cancer
WO2021062056A1 (fr) * 2019-09-24 2021-04-01 Novome Biotechnologies, Inc. Administration orale de bactéries génétiquement modifiées
CN110898012B (zh) * 2019-12-06 2021-08-10 北京大学 一种包载过氧化氢酶且连接pd-l1抗体的脂质体及其制备方法
KR20230038486A (ko) 2020-06-23 2023-03-20 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 호흡기 병원체를 진단하는 방법 및 covid-19 관련 결과를 예측하는 방법
WO2023211868A1 (fr) * 2022-04-29 2023-11-02 Merck Sharp & Dohme Llc Formulations stables d'anticorps anti-ilt4 ou de fragments de liaison à l'antigène de ceux-ci en combinaison avec des anticorps anti-pd-1 et leurs procédés d'utilisation
WO2024026253A1 (fr) * 2022-07-25 2024-02-01 Agensys, Inc. Méthodes de traitement de patients atteints d'un cancer urothélial localement avancé ou métastatique avec des conjugués anticorps-médicament (cam) qui se lient à des protéines 191p4d12 en combinaison avec du pembrolizumab
WO2024047585A2 (fr) * 2022-08-31 2024-03-07 Proviva Therapeutics (Hong Kong) Limited Protéines de fusion anticorps-procytokine il-15

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US7635479B2 (en) 2000-03-29 2009-12-22 The Trustees Of The University Of Pennsylvania Composition and methods for enhancing immunogenecity of antigens
EP0831854A4 (fr) 1995-06-06 2001-01-24 Isis Pharmaceuticals Inc Oligonucleotides de grande purete chirale ayant des liaisons phosphorothioate
US5985662A (en) 1995-07-13 1999-11-16 Isis Pharmaceuticals Inc. Antisense inhibition of hepatitis B virus replication
JP2001500738A (ja) 1996-09-17 2001-01-23 カイロン コーポレイション 細胞内疾患を処置するための組成物および方法
GB9726555D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Vaccine
US9012141B2 (en) 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
US6855320B2 (en) 2000-03-29 2005-02-15 The Trustees Of The University Of Pennsylvania Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity
US8771702B2 (en) 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
JP4409430B2 (ja) 2002-07-03 2010-02-03 小野薬品工業株式会社 免疫賦活組成物
CN101899114A (zh) 2002-12-23 2010-12-01 惠氏公司 抗pd-1抗体及其用途
US7563869B2 (en) 2003-01-23 2009-07-21 Ono Pharmaceutical Co., Ltd. Substance specific to human PD-1
CN117534755A (zh) 2005-05-09 2024-02-09 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
KR101888321B1 (ko) 2005-07-01 2018-08-13 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
NZ600758A (en) 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
US9017660B2 (en) * 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
ES2741730T3 (es) 2008-05-19 2020-02-12 Advaxis Inc Sistema de administración doble para antígenos heterólogos que comprende una cepa de Listeria recombinante atenuada por la mutación de dal/dat y la deleción de ActA que comprende una molécula de ácido nucleico que codifica una proteína de fusión de listeriolisina O - antígeno prostático específico
JP2012510429A (ja) 2008-08-25 2012-05-10 アンプリミューン、インコーポレーテッド Ｐｄ−１アンタゴニストおよびその使用方法
US8552154B2 (en) 2008-09-26 2013-10-08 Emory University Anti-PD-L1 antibodies and uses therefor
CN102245640B (zh) 2008-12-09 2014-12-31 霍夫曼-拉罗奇有限公司 抗-pd-l1抗体及它们用于增强t细胞功能的用途
US20130017199A1 (en) 2009-11-24 2013-01-17 AMPLIMMUNE ,Inc. a corporation Simultaneous inhibition of pd-l1/pd-l2
CN102469782A (zh) 2010-06-18 2012-05-23 哈洛资源公司 包含壳聚糖的固态共混物的制剂及方法
CA2829960A1 (fr) * 2011-03-11 2012-09-20 John Rothman Adjuvants a base de listeria
TR201810298T4 (tr) * 2011-03-31 2018-08-27 Merck Sharp & Dohme İnsan programlı ölüm reseptörü PD-1'e karşı antikorların stabil formülasyonları ve ilgili tedaviler.
TW202114735A (zh) 2011-08-01 2021-04-16 美商建南德克公司 利用pd-1軸結合拮抗劑及mek抑制劑治療癌症之方法
CN104254531B (zh) 2012-02-21 2017-05-03 默克专利股份公司 环状二氨基嘧啶衍生物
AR093984A1 (es) 2012-12-21 2015-07-01 Merck Sharp & Dohme Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
KR102160322B1 (ko) 2012-12-27 2020-09-25 아두로 바이오테크, 인코포레이티드 항원 서열의 리스테리아 발현을 용이하게 하는 신호 펩타이드 융합 상대 및 이의 제조방법 및 용도

Also Published As

Publication number Publication date
EP3193921A1 (fr) 2017-07-26
MX2017000857A (es) 2017-10-11
US20180185483A1 (en) 2018-07-05
WO2016011357A1 (fr) 2016-01-21
IL250187A0 (en) 2017-03-30
MA40344A (fr) 2016-01-21
CN106999561A (zh) 2017-08-01
US9907849B2 (en) 2018-03-06
CN114984228A (zh) 2022-09-02
CA2955612C (fr) 2022-05-17
EP3193921A4 (fr) 2018-04-25
SG10201913696YA (en) 2020-03-30
AU2015289533B2 (en) 2021-04-01
IL250187B (en) 2020-10-29
CA2955612A1 (fr) 2016-01-21
AU2015289533A1 (en) 2017-03-02
US20160022814A1 (en) 2016-01-28
KR20170052569A (ko) 2017-05-12

Similar Documents

Publication Publication Date Title
IL250187A0 (en) Combination of a pd-1 antagonist and a listeria-based vaccine for the treatment of prostate cancer
HK1232153A1 (zh) 用於治療癌症的 拮抗劑和 抑制劑的組合
HK1252652A1 (zh) 用於治療癌症的pd-1拮抗劑和cpg-c型寡核苷酸的組合產品
IL246760A0 (en) Combination of pd-1 antagonist and vegfr inhibitor for cancer treatment
HK1251862A1 (zh) 治療癌症的方法和組合物
HK1251409A1 (zh) 治療癌症的方法
IL249658A0 (en) Methods of treating cancer using tigit inhibitors and anticancer agents
IL254133B (en) Combination of pd-1 antagonist and eribulin for cancer treatment
SG10201801562PA (en) Combination method for treatment of cancer
WO2016154412A9 (fr) Combinaison d'un antagoniste de pd-1 et d'un vaccin à base de listeria pour le traitement d'un cancer du pancréas
RS61929B1 (sr) Postupci i sastavi za tretman raka
SG11201605745VA (en) Targeting clptm1l for treatment and prevention of cancer
GB201408297D0 (en) Treatment of cancer
GB201407837D0 (en) Methods of cancer therapy
GB201417456D0 (en) Treatment of cancer
GB201418640D0 (en) Agents and methods for treatment of cancer
GB201414904D0 (en) Materials and methods for treating cancer
GB201409362D0 (en) Treatment of cancer
GB201405449D0 (en) Treatment of cancer
GB201405075D0 (en) Treatment of cancer