SG11201607183PA - Piperidine derivatives as orexin receptor antagonist - Google Patents
Piperidine derivatives as orexin receptor antagonistInfo
- Publication number
- SG11201607183PA SG11201607183PA SG11201607183PA SG11201607183PA SG11201607183PA SG 11201607183P A SG11201607183P A SG 11201607183PA SG 11201607183P A SG11201607183P A SG 11201607183PA SG 11201607183P A SG11201607183P A SG 11201607183PA SG 11201607183P A SG11201607183P A SG 11201607183PA
- Authority
- SG
- Singapore
- Prior art keywords
- receptor antagonist
- piperidine derivatives
- orexin receptor
- orexin
- piperidine
- Prior art date
Links
- 229940123730 Orexin receptor antagonist Drugs 0.000 title 1
- 150000003053 piperidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410081220 | 2014-03-06 | ||
| PCT/CN2015/073330 WO2015131773A1 (zh) | 2014-03-06 | 2015-02-27 | 作为食欲素受体拮抗剂的哌啶衍生物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201607183PA true SG11201607183PA (en) | 2016-10-28 |
Family
ID=54054589
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201607183PA SG11201607183PA (en) | 2014-03-06 | 2015-02-27 | Piperidine derivatives as orexin receptor antagonist |
| SG10201900536TA SG10201900536TA (en) | 2014-03-06 | 2015-02-27 | Piperidine derivatives as orexin receptor antagonist |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201900536TA SG10201900536TA (en) | 2014-03-06 | 2015-02-27 | Piperidine derivatives as orexin receptor antagonist |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10100047B2 (ko) |
| EP (1) | EP3115362B1 (ko) |
| JP (1) | JP6262885B2 (ko) |
| KR (1) | KR101920472B1 (ko) |
| CN (1) | CN106414439B (ko) |
| AU (1) | AU2015226679B2 (ko) |
| CA (1) | CA2941663C (ko) |
| CL (1) | CL2016002240A1 (ko) |
| IL (1) | IL247584A0 (ko) |
| MX (1) | MX2016011549A (ko) |
| NZ (1) | NZ723671A (ko) |
| PE (1) | PE20170184A1 (ko) |
| RU (1) | RU2669701C2 (ko) |
| SG (2) | SG11201607183PA (ko) |
| WO (1) | WO2015131773A1 (ko) |
| ZA (1) | ZA201606141B (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6426694B2 (ja) | 2013-03-15 | 2018-11-21 | グローバル ブラッド セラピューティクス インコーポレイテッド | ヘモグロビンの修飾のための化合物及びその使用 |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| WO2017012502A1 (en) | 2015-07-17 | 2017-01-26 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
| JP6772251B2 (ja) * | 2015-08-14 | 2020-10-21 | シャンハイ ハイヤン ファーマシューティカル テクノロジー カンパニー リミテッドＳｈａｎｇｈａｉ Ｈａｉｙａｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． | オレキシン受容体拮抗薬の化合物の結晶形およびその製造方法と使用 |
| AU2016360245B2 (en) | 2015-11-23 | 2020-07-09 | Sunshine Lake Pharma Co., Ltd. | Octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof |
| EP3984994B1 (en) | 2016-02-04 | 2024-07-03 | Takeda Pharmaceutical Company Limited | Substituted piperidine compound as orexin type 2 agonist for the treatment of narcolepsy |
| AU2021256788B2 (en) * | 2020-04-17 | 2024-06-13 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Solid pharmaceutical preparation, preparation method therefor and use thereof |
| CN112480107B (zh) * | 2020-11-30 | 2022-08-16 | 上海海雁医药科技有限公司 | 取代的氮杂双环辛烷化合物及其中间体和制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2308206T3 (es) * | 2003-05-13 | 2008-12-01 | Schering Corporation | N-arilsulfonilpiperidinas con fuentes como inhibidores de gamma-secretasa. |
| US20090247499A1 (en) * | 2006-08-21 | 2009-10-01 | Fletcher Joan M | Sulfonylated piperazines as cannabinoid-1 receptor modulators |
| US8263586B2 (en) * | 2007-05-18 | 2012-09-11 | Merck Sharp & Dohme Corp. | OXO bridged diazepan orexin receptor antagonists |
| WO2008150364A1 (en) * | 2007-05-23 | 2008-12-11 | Merck & Co., Inc. | Cyclopropyl pyrrolidine orexin receptor antagonists |
| US8242121B2 (en) * | 2007-05-23 | 2012-08-14 | Merck Sharp & Dohme Corp. | Pyridyl piperidine orexin receptor antagonists |
| CA2711399C (en) * | 2008-02-06 | 2016-10-11 | Banyu Pharmaceutical Co., Ltd. | 3-substituted sulfonylpiperidine derivative |
| ATE555107T1 (de) | 2008-02-21 | 2012-05-15 | Actelion Pharmaceuticals Ltd | 2-aza-bicyclo-ä2,2,1-üheptan-derivate |
| AU2009307920A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,3-disubstituted piperidine orexin receptor antagonists |
| AU2009307915A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted piperidine orexin receptor antagonists |
| JP2012506377A (ja) * | 2008-10-21 | 2012-03-15 | メルク・シャープ・エンド・ドーム・コーポレイション | ２，４−二置換フェニルカルボキサミド・オレキシン受容体アンタゴニスト |
| EP2350066B1 (en) * | 2008-10-21 | 2013-08-28 | Merck Sharp & Dohme Corp. | 2,5-disubstituted piperidine orexin receptor antagonists |
| EP2563780B1 (en) * | 2010-04-29 | 2015-05-06 | The University Of Edinburgh | 3,3-disubstituted-(8-aza-bicyclo[3.2.1]oct-8-yl)-[5-(1h-pyrazol-4-yl)-thiophen-3-yl]-methanones as inhibitors of 11(beta)-hsd1 |
| MX338707B (es) * | 2010-07-29 | 2016-04-28 | Rigel Pharmaceuticals Inc | Compuestos heterociclicos activadores de proteina cinasa activada por 5'-amp (ampk) y metodos para emplearlos. |
| JPWO2013005755A1 (ja) * | 2011-07-05 | 2015-02-23 | 大正製薬株式会社 | メチルピペリジン誘導体 |
| AR088352A1 (es) * | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| AR089653A1 (es) * | 2011-10-25 | 2014-09-10 | Shionogi & Co | Derivados heterociclicos que tienen actividad antagonista del receptor de pgd2 |
| JOP20130213B1 (ar) * | 2012-07-17 | 2021-08-17 | Takeda Pharmaceuticals Co | معارضات لمستقبلht3-5 |
| CA2891009A1 (en) * | 2012-11-16 | 2014-05-22 | Merck Sharp & Dohme Corp. | Purine inhibitors of human phosphatidylinositol 3-kinase delta |
| TW201444849A (zh) * | 2013-03-13 | 2014-12-01 | Janssen Pharmaceutica Nv | 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途 |
| TWI621618B (zh) | 2013-03-13 | 2018-04-21 | 比利時商健生藥品公司 | 經取代２－氮雜雙環類及其作為食慾素受體調控劑之用途 |
-
2015
- 2015-02-27 CN CN201580012396.4A patent/CN106414439B/zh active Active
- 2015-02-27 MX MX2016011549A patent/MX2016011549A/es unknown
- 2015-02-27 SG SG11201607183PA patent/SG11201607183PA/en unknown
- 2015-02-27 NZ NZ723671A patent/NZ723671A/en unknown
- 2015-02-27 KR KR1020167027668A patent/KR101920472B1/ko active IP Right Grant
- 2015-02-27 AU AU2015226679A patent/AU2015226679B2/en active Active
- 2015-02-27 EP EP15758792.4A patent/EP3115362B1/en active Active
- 2015-02-27 RU RU2016130937A patent/RU2669701C2/ru active
- 2015-02-27 US US15/123,014 patent/US10100047B2/en active Active
- 2015-02-27 PE PE2016001578A patent/PE20170184A1/es not_active Application Discontinuation
- 2015-02-27 WO PCT/CN2015/073330 patent/WO2015131773A1/zh active Application Filing
- 2015-02-27 JP JP2016572879A patent/JP6262885B2/ja active Active
- 2015-02-27 CA CA2941663A patent/CA2941663C/en active Active
- 2015-02-27 SG SG10201900536TA patent/SG10201900536TA/en unknown
-
2016
- 2016-08-31 IL IL247584A patent/IL247584A0/en unknown
- 2016-09-05 ZA ZA2016/06141A patent/ZA201606141B/en unknown
- 2016-09-06 CL CL2016002240A patent/CL2016002240A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN106414439B (zh) | 2017-12-08 |
| JP6262885B2 (ja) | 2018-01-17 |
| AU2015226679A1 (en) | 2016-09-15 |
| RU2669701C2 (ru) | 2018-10-15 |
| RU2016130937A (ru) | 2018-04-09 |
| KR20160143668A (ko) | 2016-12-14 |
| CA2941663A1 (en) | 2015-09-11 |
| WO2015131773A1 (zh) | 2015-09-11 |
| US20170233385A1 (en) | 2017-08-17 |
| EP3115362A1 (en) | 2017-01-11 |
| AU2015226679B2 (en) | 2017-05-25 |
| JP2017507185A (ja) | 2017-03-16 |
| IL247584A0 (en) | 2016-11-30 |
| US10100047B2 (en) | 2018-10-16 |
| KR101920472B1 (ko) | 2019-02-08 |
| EP3115362A4 (en) | 2017-08-16 |
| CN106414439A (zh) | 2017-02-15 |
| MX2016011549A (es) | 2017-05-08 |
| ZA201606141B (en) | 2017-05-31 |
| PE20170184A1 (es) | 2017-04-07 |
| EP3115362B1 (en) | 2019-06-12 |
| CA2941663C (en) | 2020-02-18 |
| CL2016002240A1 (es) | 2017-02-17 |
| SG10201900536TA (en) | 2019-02-27 |
| NZ723671A (en) | 2017-05-26 |
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