HK1251902A1 - 橋連哌啶衍生物 - Google Patents

橋連哌啶衍生物

Info

Publication number
HK1251902A1
HK1251902A1 HK18111223.6A HK18111223A HK1251902A1 HK 1251902 A1 HK1251902 A1 HK 1251902A1 HK 18111223 A HK18111223 A HK 18111223A HK 1251902 A1 HK1251902 A1 HK 1251902A1
Authority
HK
Hong Kong
Prior art keywords
piperidine derivatives
bridged piperidine
bridged
derivatives
piperidine
Prior art date
Application number
HK18111223.6A
Other languages
English (en)
Inventor
卡爾海因茨‧博伊曼
吉多‧加利
羅蘭‧雅各布-勒特
安雅‧林貝格
維爾納‧奈德哈特
羅莎‧馬麗亞‧羅得里格斯薩爾米恩托
比約恩‧巴特爾斯
哈薩內‧拉特尼
Original Assignee
豪夫邁．羅氏有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 豪夫邁．羅氏有限公司 filed Critical 豪夫邁．羅氏有限公司
Publication of HK1251902A1 publication Critical patent/HK1251902A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK18111223.6A 2015-09-09 2018-08-31 橋連哌啶衍生物 HK1251902A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15184480 2015-09-09

Publications (1)

Publication Number Publication Date
HK1251902A1 true HK1251902A1 (zh) 2019-04-26

Family

ID=54072754

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18111223.6A HK1251902A1 (zh) 2015-09-09 2018-08-31 橋連哌啶衍生物

Country Status (8)

Country Link
US (1) US10604517B2 (zh)
EP (1) EP3347363B1 (zh)
JP (1) JP6831372B2 (zh)
CN (1) CN107922437B (zh)
AR (1) AR105965A1 (zh)
HK (1) HK1251902A1 (zh)
TW (1) TWI716446B (zh)
WO (1) WO2017042114A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107922437B (zh) 2015-09-09 2021-12-10 豪夫迈·罗氏有限公司 桥连哌啶衍生物
WO2018001918A1 (en) * 2016-06-27 2018-01-04 F. Hoffmann-La Roche Ag Triazolopyridines as gamma-secretase modulators
SG11201901983PA (en) * 2016-09-09 2019-04-29 Hoffmann La Roche Process for preparation of 2-(6-nitropyridin-3-yl)-9h-dipyrido[2,3-b;3',4'-d]pyrrole
AR109829A1 (es) * 2016-09-29 2019-01-30 Hoffmann La Roche Derivados de piperidina puenteados
US10647721B2 (en) 2016-10-04 2020-05-12 Hoffmann-La Roche Inc. Bicyclic heteroaryl derivatives
AR110001A1 (es) * 2016-11-01 2019-02-13 Hoffmann La Roche Derivados heteroarilo bicíclicos
EP3728262B1 (en) * 2017-12-18 2023-03-15 F. Hoffmann-La Roche AG Triazolo-azepine derivatives
JP7335248B2 (ja) * 2018-01-22 2023-08-29 エフ． ホフマン－ラ ロシュ アーゲー トリアゾロ－アゼピン誘導体
IL281175B2 (en) * 2018-09-03 2024-01-01 Hoffmann La Roche Bicyclic heteroaryl compounds as ?-secretase modulators, their production, pharmaceutical preparations containing them and their use in the treatment of diseases associated with ?-amyloid deposition in the brain
EP3894411B1 (en) * 2018-12-13 2024-06-19 F. Hoffmann-La Roche AG 7-phenoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma-secretase modulators for the treatment of alzheimer's disease
EP3956330A4 (en) 2019-04-18 2023-01-18 The Johns Hopkins University SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A]PYRIDINE DERIVATIVES AND THEIR USE

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2003068776A1 (ja) * 2002-02-15 2005-06-02 協和醗酵工業株式会社 ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
BRPI0907577A2 (pt) * 2008-02-22 2015-07-21 Hoffmann La Roche Moduladores para amiloide beta
US8502193B2 (en) * 2008-04-16 2013-08-06 Lg Innotek Co., Ltd. Light-emitting device and fabricating method thereof
CN102209537A (zh) * 2008-11-10 2011-10-05 弗·哈夫曼-拉罗切有限公司 杂环γ分泌酶调节剂
TWI461425B (zh) * 2009-02-19 2014-11-21 Janssen Pharmaceuticals Inc 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類
US8835482B2 (en) * 2009-05-07 2014-09-16 Janssen Pharmaceuticals, Inc. Substituted indazole and aza-indazole derivatives as gamma secretase modulators
WO2010138901A1 (en) * 2009-05-29 2010-12-02 Biogen Idec Ma Inc Carboxylic acid-containing compounds, derivatives thereof, and related methods of use
EP2491524A4 (en) * 2009-10-23 2014-10-01 Apriva Llc SYSTEM AND DEVICE FOR CONSOLIDATING SIM, PERSONAL TOKEN AND ASSOCIATED APPLICATIONS
US20110190269A1 (en) 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
US8486967B2 (en) * 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
US8703763B2 (en) * 2011-03-02 2014-04-22 Hoffmann-La Roche Inc. Bridged piperidine derivatives
EP2687528A1 (en) * 2012-07-17 2014-01-22 Ares Trading S.A. Fused triazole derivatives as gamma secretase modulators
CN107922437B (zh) 2015-09-09 2021-12-10 豪夫迈·罗氏有限公司 桥连哌啶衍生物

Also Published As

Publication number Publication date
US10604517B2 (en) 2020-03-31
WO2017042114A1 (en) 2017-03-16
TWI716446B (zh) 2021-01-21
TW201718601A (zh) 2017-06-01
CN107922437B (zh) 2021-12-10
JP6831372B2 (ja) 2021-02-17
JP2018526410A (ja) 2018-09-13
EP3347363B1 (en) 2020-01-01
AR105965A1 (es) 2017-11-29
EP3347363A1 (en) 2018-07-18
US20180237432A1 (en) 2018-08-23
CN107922437A (zh) 2018-04-17

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