SG11201607075TA - Compositions and methods for the reduction or prevention of hepatic steatosis - Google Patents
Compositions and methods for the reduction or prevention of hepatic steatosisInfo
- Publication number
- SG11201607075TA SG11201607075TA SG11201607075TA SG11201607075TA SG11201607075TA SG 11201607075T A SG11201607075T A SG 11201607075TA SG 11201607075T A SG11201607075T A SG 11201607075TA SG 11201607075T A SG11201607075T A SG 11201607075TA SG 11201607075T A SG11201607075T A SG 11201607075TA
- Authority
- SG
- Singapore
- Prior art keywords
- prevention
- compositions
- reduction
- methods
- hepatic steatosis
- Prior art date
Links
- 206010019708 Hepatic steatosis Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461945412P | 2014-02-27 | 2014-02-27 | |
PCT/US2015/018182 WO2015131152A1 (en) | 2014-02-27 | 2015-02-27 | Compositions and methods for the reduction or prevention of hepatic steatosis |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201607075TA true SG11201607075TA (en) | 2016-09-29 |
Family
ID=54009689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201607075TA SG11201607075TA (en) | 2014-02-27 | 2015-02-27 | Compositions and methods for the reduction or prevention of hepatic steatosis |
Country Status (14)
Country | Link |
---|---|
US (3) | US9724319B2 (ja) |
EP (1) | EP3110507B1 (ja) |
JP (1) | JP2017506651A (ja) |
KR (1) | KR20160119863A (ja) |
CN (1) | CN106456997B (ja) |
AU (1) | AU2015222754B2 (ja) |
CA (1) | CA2939833A1 (ja) |
IL (1) | IL247263A0 (ja) |
MX (1) | MX2016011063A (ja) |
PH (1) | PH12016501668A1 (ja) |
RU (1) | RU2016138136A (ja) |
SG (1) | SG11201607075TA (ja) |
WO (1) | WO2015131152A1 (ja) |
ZA (2) | ZA201605795B (ja) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2637668B1 (en) | 2010-11-08 | 2016-05-11 | Albireo AB | Ibat inhibitors for the treatment of liver diseases |
CA2841748C (en) | 2011-07-15 | 2021-06-15 | Nusirt Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
MX2015006023A (es) | 2012-11-13 | 2016-03-31 | Nusirt Sciences Inc | Composiciones y metodos para incrementar el metabolismo energetico. |
CA2902879C (en) | 2013-03-15 | 2023-09-26 | Nusirt Sciences, Inc. | Leucine and nicotinic acid reduces lipid levels |
US9724319B2 (en) | 2014-02-27 | 2017-08-08 | Nusirt Sciences, Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
JP6751020B2 (ja) | 2014-06-25 | 2020-09-02 | Eaファーマ株式会社 | 固形製剤及びその着色防止又は着色低減方法 |
TW201613600A (en) * | 2014-09-02 | 2016-04-16 | Jansfat Biotechnology Co Ltd | Piperazinyl derivative reduces HFD-induced accumulation of fat in the liver, therapeutically |
EA201791982A1 (ru) | 2015-03-09 | 2020-02-17 | Интекрин Терапьютикс, Инк. | Способы лечения неалкогольной жировой болезни печени и/или липодистрофии |
US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
CN107174593B (zh) * | 2016-03-09 | 2021-03-02 | 中国农业大学 | 银杏叶提取物与支链氨基酸在制备预防/治疗脂肪肝和/或脂肪变性的药物中的应用 |
US20170312286A1 (en) * | 2016-05-02 | 2017-11-02 | Jansfat Biotechnology Co., Ltd. | Compositions and methods for lipid metabolism disorder |
WO2017214383A1 (en) * | 2016-06-10 | 2017-12-14 | The Johns Hopkins University | USE OF C1q/TNF-RELATED PROTEIN-1 (CTRP1) TO TREAT FATTY LIVER DISEASE |
JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
CN110996951A (zh) | 2017-04-03 | 2020-04-10 | 科赫罗斯生物科学股份有限公司 | 治疗进行性核上性麻痹的PPARγ激动剂 |
WO2019032026A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE |
US10682325B2 (en) | 2017-08-14 | 2020-06-16 | Axcella Health Inc. | Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting |
EP3706726A4 (en) * | 2017-11-07 | 2021-07-28 | Poviva Corp. | FOOD AND BEVERAGE COMPOSITIONS CONTAINING PDE5 INHIBITORS |
WO2019118519A1 (en) | 2017-12-11 | 2019-06-20 | Filtricine, Inc. | Compositions, methods, kits and systems for cancer treatment and metabolic intervention therapy |
US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
CA3100113A1 (en) | 2018-06-05 | 2019-12-12 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
KR20210024033A (ko) | 2018-06-20 | 2021-03-04 | 알비레오 에이비 | 오데빅시바트의 약학 제제 |
US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10568352B1 (en) | 2018-10-25 | 2020-02-25 | Wiser Concepts, LLC | Nutritional compositions and methods of treatment therewith |
WO2020142365A1 (en) | 2018-12-31 | 2020-07-09 | Christos Mantzoros | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
LT3921028T (lt) | 2019-02-06 | 2023-02-10 | Albireo Ab | Benzotiadiazepino junginiai ir jų naudojimas kaip tulžies rūgšties moduliatorių |
US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
TWI835997B (zh) | 2019-02-06 | 2024-03-21 | 瑞典商艾爾比瑞歐公司 | 苯并噻氮呯化合物及其用作膽酸調節劑之用途 |
US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
EP3946336A1 (en) | 2019-04-02 | 2022-02-09 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
US20220288054A1 (en) | 2019-04-04 | 2022-09-15 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
EP3946335A1 (en) | 2019-04-04 | 2022-02-09 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
US20220175758A1 (en) | 2019-04-04 | 2022-06-09 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
WO2020205026A1 (en) | 2019-04-04 | 2020-10-08 | Christos Mantzoros | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
CA3143834A1 (en) * | 2019-07-19 | 2021-01-28 | Xiyan LI | Compositions, methods, kits and systems for cancer treatment and metabolic intervention therapy and other uses |
EP4045042A1 (en) | 2019-10-15 | 2022-08-24 | Coherus Biosciences, Inc. | Compositions and methods to treat non-alcoholic fatty liver diseases (nafld) |
ES2973549T3 (es) | 2019-12-04 | 2024-06-20 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores de los ácidos biliares |
TW202134220A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
AR120674A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiazepina y su uso como ácido biliar |
ES2973355T3 (es) | 2019-12-04 | 2024-06-19 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
TW202134222A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯化合物及其作為膽酸調節劑之用途 |
CA3158184A1 (en) | 2019-12-04 | 2021-08-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
WO2021110885A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
JP2023504647A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチア(ジ)アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
TW202134223A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
CN111000854B (zh) * | 2019-12-30 | 2023-06-09 | 昆药集团股份有限公司 | 曲札茋苷在制备治疗和/或预防非酒精性脂肪肝病产品中的应用 |
WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
CN116157389A (zh) | 2020-08-03 | 2023-05-23 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
WO2022051321A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a fxr agonist |
WO2022051319A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a dpp-4 inhibitor |
WO2022051318A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a thyroid receptor beta agonist |
WO2022051323A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a ppar agonist |
WO2022051316A1 (en) | 2020-09-03 | 2022-03-10 | Coherus Biosciences, Inc. | Fixed dose combinations of chs-131 and a sglt-2 inhibitor |
KR20230106651A (ko) | 2020-11-12 | 2023-07-13 | 알비레오 에이비 | 진행성 가족성 간내 담즙정체증(pfic)을 치료하기 위한 오데빅시바트 |
BR112023010799A2 (pt) | 2020-12-04 | 2023-10-03 | Albireo Ab | Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares |
TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
CN113197884A (zh) * | 2021-06-24 | 2021-08-03 | 云南大学 | α-酮丁酸在制备预防和/或治疗非酒精性脂肪肝的药物中的应用 |
US20240067617A1 (en) | 2022-07-05 | 2024-02-29 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
CN115181721A (zh) * | 2022-07-13 | 2022-10-14 | 山东省农业科学院畜牧兽医研究所 | 一种抑制肉羊皮下脂肪细胞增殖和脂肪合成代谢的方法 |
Family Cites Families (178)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3936527A (en) | 1969-12-19 | 1976-02-03 | Damon Corporation | Treatment of pets |
US3810994A (en) | 1972-06-01 | 1974-05-14 | Ethyl Corp | Method and composition for treating obesity |
NL7804375A (nl) | 1977-05-16 | 1978-11-20 | Ralston Purina Co | Voedsel voor dieren. |
DK150008C (da) | 1981-11-20 | 1987-05-25 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat |
US4769027A (en) | 1984-08-15 | 1988-09-06 | Burroughs Wellcome Co. | Delivery system |
IE58246B1 (en) | 1984-12-21 | 1993-08-11 | Byk Gulden Lomberg Chem Fab | Theophylline sustained release formulation |
US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
US5087624A (en) | 1989-03-21 | 1992-02-11 | Nutrition 21 | Chromic picolinate treatment |
US5886012A (en) | 1989-03-22 | 1999-03-23 | Peter K. T. Pang | Method of treatment for disease associated with excessive PHF using combination therapy involving exogenous calcium and calcium channel blockers |
GB8919131D0 (en) | 1989-08-23 | 1989-10-04 | Riker Laboratories Inc | Inhaler |
US4992470A (en) | 1990-02-08 | 1991-02-12 | Iowa State University Research Foundation, Inc. | Method of enhancing immune response of mammals |
US5250534A (en) | 1990-06-20 | 1993-10-05 | Pfizer Inc. | Pyrazolopyrimidinone antianginal agents |
US6764697B1 (en) | 1991-06-27 | 2004-07-20 | Alza Corporation | System for delaying drug delivery up to seven hours |
US5419283A (en) | 1992-04-08 | 1995-05-30 | Ciuffo Gatto S.R.L. | Animal chew toy of starch material and degradable ethylene copolymer |
JP3219838B2 (ja) | 1992-05-12 | 2001-10-15 | 沖電気工業株式会社 | 半導体素子の製造方法 |
GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
LU88369A1 (fr) | 1993-07-12 | 1994-04-01 | Michel Urso Prof Medecin Et Ch | Acides aminés à chaînes ramifiées |
US5339771A (en) | 1993-09-15 | 1994-08-23 | Axelrod Herbert R | Animal chew toy containing animal meal |
US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
US5395626A (en) | 1994-03-23 | 1995-03-07 | Ortho Pharmaceutical Corporation | Multilayered controlled release pharmaceutical dosage form |
US5616569A (en) | 1994-03-28 | 1997-04-01 | The Iams Company | Pet food product containing fermentable fibers and process for treating gastrointestinal disorders |
US6048903A (en) | 1994-05-03 | 2000-04-11 | Robert Toppo | Treatment for blood cholesterol with trans-resveratrol |
US5776913A (en) | 1995-10-10 | 1998-07-07 | Colgate Palmolive Company | Therapeutic diet for metabolic abnormalities found in animals with lymphoma |
WO1997025060A1 (fr) | 1996-01-09 | 1997-07-17 | The Institute Of Physical And Chemical Research | Compositions d'acides amines |
US6395292B2 (en) | 1996-02-02 | 2002-05-28 | Alza Corporation | Sustained delivery of an active agent using an implantable system |
US6919373B1 (en) | 1996-11-12 | 2005-07-19 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
PT862863E (pt) | 1997-01-09 | 2002-04-29 | Nestle Sa | Produto cerealifero contendo probioticos |
US6004996A (en) | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
IT1291113B1 (it) | 1997-03-20 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizione nutritiva terapeutica per soggetti affetti da diabete mellito |
MY125849A (en) | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems |
US6063414A (en) | 1997-08-18 | 2000-05-16 | Seal Rock Technologies Incorporated | Combination container and dry pet food for increased shelf life, freshness, palatability, and nutritional value |
JP3611456B2 (ja) | 1997-09-30 | 2005-01-19 | 日研化学株式会社 | テオフィリン徐放性錠剤 |
WO1999057124A1 (en) | 1998-05-04 | 1999-11-11 | Andreas Johannes Kesel | Monomeric, oligomeric and polymeric knoevenagel condensation products |
DK1083800T3 (da) | 1998-06-02 | 2003-03-17 | Biofiber Damino As | Fremgangsmåde til fodring af smågrise |
US6031000A (en) | 1998-06-23 | 2000-02-29 | Iowa State University Research Foundation, Inc. | Composition comprising β-hydroxy-β-methylbutyric acid and at least one amino acid and methods of use |
US6403142B1 (en) | 1998-12-11 | 2002-06-11 | Ralston Purina Company | Hypoallergenic pet food |
CA2354472C (en) | 1998-12-17 | 2009-02-24 | Alza Corporation | Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings |
US6797283B1 (en) | 1998-12-23 | 2004-09-28 | Alza Corporation | Gastric retention dosage form having multiple layers |
BR0008857A (pt) | 1999-03-08 | 2001-12-18 | Medicure Inc | Análogos de piridoxal para distúrbios da vitaminab-6 |
FR2790645B1 (fr) | 1999-03-12 | 2001-06-08 | Arkopharma Laboratoires | Complement alimentaire et procede de traitement cosmetique a base d' un extrait de raisin riche en polyphenols |
AU7596100A (en) | 1999-09-21 | 2001-04-24 | Rutgers, The State University | Resveratrol analogs for prevention of disease |
US6527711B1 (en) | 1999-10-18 | 2003-03-04 | Bodymedia, Inc. | Wearable human physiological data sensors and reporting system therefor |
US6280779B1 (en) | 1999-12-28 | 2001-08-28 | Colgate-Palmolive Company | Pet food for maintaining normal bowel health |
US20010043983A1 (en) | 2000-01-25 | 2001-11-22 | Hamilton Nathan D. | Nutritional supplements for aged pets |
US7261690B2 (en) | 2000-06-16 | 2007-08-28 | Bodymedia, Inc. | Apparatus for monitoring health, wellness and fitness |
US6605038B1 (en) | 2000-06-16 | 2003-08-12 | Bodymedia, Inc. | System for monitoring health, wellness and fitness |
US7689437B1 (en) | 2000-06-16 | 2010-03-30 | Bodymedia, Inc. | System for monitoring health, wellness and fitness |
BRPI0414359A (pt) | 2000-06-16 | 2006-11-14 | Bodymedia Inc | sistema para a monitoração e gerenciamento do peso corpóreo e demais condições psicológicas que abrangem um planejamento interativo e personalizado, intervenção e capacidade de formular relatórios |
US20020165237A1 (en) | 2000-08-11 | 2002-11-07 | Fryburg David Albert | Treatment of the insulin resistance syndrome |
US6384087B1 (en) | 2000-09-01 | 2002-05-07 | University Of Tennesseee Research Corporation, Inc. | Materials and methods for the treatment or prevention of obesity |
DE60039726D1 (de) | 2000-12-29 | 2008-09-11 | Martin Francis Gannon | Tiernahrungsmittelzusammensetzung |
IL157367A0 (en) | 2001-03-09 | 2004-02-19 | Nestle Sa | Composition improving age-related physiological deficits and increasing longevity |
US6338862B1 (en) | 2001-03-26 | 2002-01-15 | Sarfaraz K Niazi | Composition and method of use in treating sexual dysfunction using cGMP-specific phosphodiesterase type 5 inhibitors |
US6595929B2 (en) | 2001-03-30 | 2003-07-22 | Bodymedia, Inc. | System for monitoring health, wellness and fitness having a method and apparatus for improved measurement of heat flow |
US7091006B2 (en) | 2001-11-09 | 2006-08-15 | Dana-Farber Cancer Institute, Inc. | PGC-1β, a novel PGC-1 homologue and uses therefor |
US20030187055A1 (en) | 2002-02-25 | 2003-10-02 | Riker Donald K. | Synergistic pharmaceutical combinations for treating obesity |
JP4545584B2 (ja) | 2002-05-17 | 2010-09-15 | デューク ユニバーシティ | 肥満を治療するための方法 |
CA2490544C (en) | 2002-06-26 | 2011-04-19 | Alza Corporation | Minimally compliant, volume efficient piston for osmotic drug delivery systems |
FR2841784B1 (fr) | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
US7020508B2 (en) | 2002-08-22 | 2006-03-28 | Bodymedia, Inc. | Apparatus for detecting human physiological and contextual information |
WO2004034221A2 (en) | 2002-10-09 | 2004-04-22 | Bodymedia, Inc. | Apparatus for detecting, receiving, deriving and displaying human physiological and contextual information |
US20050064070A1 (en) | 2002-10-11 | 2005-03-24 | Jeffrey Liebrecht | Beverage compositions for use in rehydration and nutrition during athletic exercise and methods of making same |
US7744930B2 (en) | 2002-11-22 | 2010-06-29 | Shaklee Corporation | Compositions, methods and kits for enhancing weight loss while inhibiting loss of lean body mass |
JP2004305201A (ja) | 2002-11-27 | 2004-11-04 | Hayashibara Biochem Lab Inc | アクリルアミドの生成抑制方法とその用途 |
CN1504424A (zh) | 2002-12-05 | 2004-06-16 | 上海金创投资管理有限公司 | 含亮氨酸婴儿饮用水 |
US20040254357A1 (en) | 2002-12-19 | 2004-12-16 | Zaloga Gary P. | Fatty acid phenolic conjugates |
US7288570B2 (en) | 2002-12-20 | 2007-10-30 | Nutricia N.V. | Stimulation of in vivo production of proteins |
US20040120983A1 (en) | 2002-12-23 | 2004-06-24 | Philip Connolly | Nutritional supplement |
EP1605779A1 (en) | 2003-03-13 | 2005-12-21 | Red Arrow Products Co., LLC | Browning composition for application to a film for holding a food product |
US20040186046A1 (en) | 2003-03-17 | 2004-09-23 | Pfizer Inc | Treatment of type 1 diabetes with PDE5 inhibitors |
JP2006520335A (ja) | 2003-03-18 | 2006-09-07 | ノバルティス アクチエンゲゼルシャフト | 脂肪酸とアミノ酸を含有する組成物 |
US7160565B2 (en) | 2003-03-31 | 2007-01-09 | Breakthru Products, Llc | Hydration beverage and method of delivering nutrients |
US20050042362A1 (en) | 2003-04-02 | 2005-02-24 | Clark Harry M. | Pet food composition and method |
EP1638586B1 (en) | 2003-05-14 | 2008-03-26 | Indus Biotech Pvt. Ltd. | A synergistic composition for the treatment of diabetes mellitus |
US20070203083A1 (en) | 2003-06-13 | 2007-08-30 | Mootha Vamsi K | Methods Of Regulating Metabolism And Mitochondrial Function |
US8633247B2 (en) | 2003-08-11 | 2014-01-21 | Hill's Pet Nutrition, Inc. | Method for decreasing cartilage damage in dogs |
JP2005097273A (ja) | 2003-08-19 | 2005-04-14 | Toyo Shinyaku:Kk | 運動能力向上組成物 |
JP5174348B2 (ja) | 2003-09-12 | 2013-04-03 | ボディーメディア インコーポレイテッド | 心臓関連状態パラメータのモニター方法及び装置 |
CA2544078C (en) | 2003-11-03 | 2013-08-06 | Hill's Pet Nutrition, Inc. | Coated pet food composition |
JP2007511558A (ja) | 2003-11-19 | 2007-05-10 | ディーエスエム アイピー アセッツ ビー.ブイ. | ビタミンb6の製造 |
JPWO2005049006A1 (ja) | 2003-11-21 | 2007-11-29 | 味の素株式会社 | 糖尿病治療剤 |
US7722905B2 (en) | 2003-11-26 | 2010-05-25 | Hill's Pet Nutrition, Inc. | Method to reduce odor of excreta from companion animals |
US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
CN101247793B (zh) | 2003-12-29 | 2013-04-10 | 哈佛大学校长及研究员协会 | 治疗或预防肥胖和胰岛素抗性病症的组合物 |
US20050215882A1 (en) | 2004-03-23 | 2005-09-29 | The Regents Of The University Of Michigan | Noninvasive method to determine fat content of tissues using MRI |
CA2569015A1 (en) | 2004-06-17 | 2006-01-26 | Forest Laboratories, Inc. | Modified release formulation of memantine |
US20070244202A1 (en) | 2004-06-28 | 2007-10-18 | Kao Corporation | Ampk Activator |
US8299083B2 (en) | 2004-08-17 | 2012-10-30 | The Johns Hopkins University | PDE5 inhibitor compositions and methods for treating cardiac indications |
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
WO2006057073A1 (ja) | 2004-11-29 | 2006-06-01 | Toyo Shinyaku Co., Ltd. | 運動能力向上組成物 |
US20060165824A1 (en) | 2005-01-26 | 2006-07-27 | The Procter & Gamble Company | Compositions, kits, and methods for enhancing gastrointestinal health |
EP1845994B1 (en) | 2005-02-11 | 2009-01-21 | Argenta Discovery Limited | Combination of methylxanthine compounds and steroids to treat chronic respiratory diseases |
US20060188611A1 (en) | 2005-02-18 | 2006-08-24 | Emine Unlu | Edible pet chew |
WO2006094236A1 (en) | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N-phenyl benzamide derivatives as sirtuin modulators |
US20070014833A1 (en) | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
CN101175501B (zh) | 2005-05-13 | 2012-03-21 | 雀巢技术公司 | 由植物物种生产葡糖胺 |
CA2607600A1 (en) | 2005-06-16 | 2006-12-28 | Forest Laboratories, Inc. | Modified and immediate release memantine bead formulation |
US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US20070037865A1 (en) | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US7855289B2 (en) | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
US20070077310A1 (en) | 2005-10-03 | 2007-04-05 | University Of Tennessee Research Foundation | Methods of reducing the production of reactive oxygen species and methods of screening or identifying compounds and compositions that reduce the production of reactive oxygen species |
BRPI0619085A2 (pt) | 2005-12-02 | 2012-07-03 | Hills Pet Nutrition Inc | métodos para melhorar a qualidade das fezes e para alterar a frequência de eliminação das fezes, kit, meios para comunicar informações ou instruções, e, uso de uma composição |
US20070185210A1 (en) | 2006-01-10 | 2007-08-09 | Yamka Ryan M | Compositions and Methods for Promoting Fat Loss |
WO2007100695A2 (en) | 2006-02-28 | 2007-09-07 | Trustees Of Boston University | Metabolic regulators and uses thereof |
DE102006016903A1 (de) | 2006-04-11 | 2007-10-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalator |
WO2007128461A1 (en) | 2006-05-10 | 2007-11-15 | Dsm Ip Assets B.V. | Animal food composition comprising genistein and polyunsaturated fatty acids |
JP2007306851A (ja) | 2006-05-18 | 2007-11-29 | 仁 ▲吉▼井 | 食塩組成物およびその製造方法 |
US20070286909A1 (en) | 2006-06-07 | 2007-12-13 | Daniel S. Smith | Amino acid compositions |
US20090291958A1 (en) | 2006-06-08 | 2009-11-26 | Auspex Pharmaceuticals, Inc. | Substituted PDE5 inhibitors |
EA018258B1 (ru) | 2006-07-12 | 2013-06-28 | Юниверсити Оф Теннесси Рисерч Фаундейшн | Замещенный ациланилид и содержащие его композиции и способы лечения |
ITRM20060427A1 (it) | 2006-08-04 | 2008-02-05 | Nuraging Biotech S R L | Composizioni antiossidanti comprendenti estratti di rosmarino e mirto |
JP2008063328A (ja) | 2006-08-07 | 2008-03-21 | Kowa Co | 糸球体疾患治療剤 |
JP5507802B2 (ja) | 2006-08-10 | 2014-05-28 | 花王株式会社 | 筋肉老化抑制剤 |
US8703174B2 (en) | 2006-09-15 | 2014-04-22 | I Did It Inc | Joint preserving nutritional vitamin, mineral and herbal pet supplement |
US20080102137A1 (en) | 2006-10-31 | 2008-05-01 | Guffey Manning V R | Composition and method for etiological treatment and prevention of diseases and/or complications associated with chronic glucose metabolism destabilization |
EP2114396A4 (en) | 2006-12-29 | 2010-03-10 | Salk Inst For Biological Studi | METHOD FOR IMPROVING TRAINING PERFORMANCE |
KR101460820B1 (ko) | 2007-01-16 | 2014-11-11 | 아이피아이엔티엘, 엘엘씨 | 대사 증후군의 치료를 위한 신규한 조성물 |
US20080320029A1 (en) | 2007-02-16 | 2008-12-25 | Stivoric John M | Lifeotype interfaces |
ES2345461T3 (es) | 2007-02-23 | 2010-09-23 | Hill's Pet Nutrition, Inc. | Composiciones y metodos para controlar el peso de animales. |
US20080233245A1 (en) | 2007-03-19 | 2008-09-25 | Lesley Joan White | Liquid nutrient composition for improving performance |
US20080242727A1 (en) | 2007-03-27 | 2008-10-02 | Tim Romero | Dietary compositions containing alpha amino n-butyrate and methods of enhancing lean body mass |
US20100210692A1 (en) | 2007-03-28 | 2010-08-19 | Farmer Stephen R | Methods of treatment using sirt modulators and compositions containing sirt1 modulators |
US20080268038A1 (en) | 2007-04-26 | 2008-10-30 | Wolfe Robert R | Compositions and Approaches for Increasing Diet Induced Thermogenesis, Inducing Weight Loss and Maintaining Muscle Mass and Strength |
JPWO2008143182A1 (ja) | 2007-05-17 | 2010-08-05 | 株式会社カネカ | 甘草ポリフェノールを含有する組成物 |
EP2167043A4 (en) | 2007-06-06 | 2013-05-01 | Univ South Florida | NEW USE CO-CRYSTAL COMPOSITIONS |
WO2008157537A2 (en) * | 2007-06-19 | 2008-12-24 | Ironwood Pharmaceuticals, Inc | Compositions and methods of use for treating or preventing lipid related disorders |
TW200918542A (en) | 2007-06-20 | 2009-05-01 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
CL2008001822A1 (es) | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras. |
WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
US7989007B2 (en) | 2007-07-03 | 2011-08-02 | Vincent James Enterprises, Llc | Weight loss composition |
WO2009003798A1 (en) | 2007-07-05 | 2009-01-08 | Unilever N.V. | Food composition comprising trans-resveratrol and its use to control blood pressure |
WO2009008991A2 (en) | 2007-07-06 | 2009-01-15 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | Dna-pkcs modulates energy regulation and brain function |
US8529965B2 (en) | 2007-07-09 | 2013-09-10 | Hill's Pet Nutrition, Inc. | Compositions and methods for altering stool quality in an animal |
WO2009033034A1 (en) | 2007-09-07 | 2009-03-12 | Nike, Inc. | Wearable device assembly having athletic functionality |
US20110082189A1 (en) | 2007-10-23 | 2011-04-07 | President And Fellows Of Harvard College | Use of compounds activating sirt-3 for mimicking exercise |
US20090156648A1 (en) | 2007-12-12 | 2009-06-18 | Iovate T. & P. Inc. | Preparations containing pyridoxine and alpha-hydroxyisocaproic acid (HICA) |
AU2008345571B2 (en) | 2007-12-21 | 2011-10-13 | Hill's Pet Nutrition, Inc. | Pet food composition |
US8716249B2 (en) | 2008-01-31 | 2014-05-06 | Energy Light Llc | Compositions and methods for improving cardiovascular health |
BRPI0905952A2 (pt) | 2008-02-04 | 2015-06-30 | Mercury Therapeutics | Composto e sais do mesmo e compição farmacêutica |
WO2009111472A2 (en) | 2008-03-03 | 2009-09-11 | Nike, Inc. | Interactive athletic equipment system |
RU2483708C2 (ru) | 2008-03-17 | 2013-06-10 | Дзе Проктер Энд Гэмбл Компани | Дозирующее устройство, приспосабливаемое к требованиям пользователя |
EP2700434A3 (en) | 2008-04-02 | 2014-07-02 | Nike International Ltd. | Wearable device assembly having athletic functionality |
KR20110039249A (ko) | 2008-07-07 | 2011-04-15 | 모치다 세이야쿠 가부시키가이샤 | 지질 이상증의 개선 또는 치료약 |
US20100021573A1 (en) | 2008-07-22 | 2010-01-28 | Michael J Gonzalez | Compositions and methods for the prevention of cardiovascular disease |
JP2012504554A (ja) | 2008-08-15 | 2012-02-23 | ネステク ソシエテ アノニム | エネルギー代謝を向上させる方法 |
CA2745376A1 (en) | 2008-12-01 | 2010-06-10 | Lifespan Extension Llc | Methods and compositions for altering health, wellbeing, and lifespan |
US20120035105A1 (en) | 2009-01-09 | 2012-02-09 | Sdg, Inc. | Insulin Therapies for the Treatment of Diabetes, Diabetes Related Ailments, and/or Diseases or Conditions Other Than Diabetes or Diabetes Related Ailments |
WO2010129221A1 (en) | 2009-04-26 | 2010-11-11 | Nike International, Ltd. | Gps features and functionality in an athletic watch system |
US20100303967A1 (en) | 2009-05-28 | 2010-12-02 | Gregory Dean Sunvold | Pet Food Having Improved Animal Preference |
US20100303966A1 (en) | 2009-05-28 | 2010-12-02 | Gregory Dean Sunvold | Pet Food in the Form of a Coated Kibble |
WO2011003045A1 (en) | 2009-07-01 | 2011-01-06 | Magceutics, Inc. | Slow release magnesium composition and uses thereof |
US20120129785A1 (en) | 2009-07-21 | 2012-05-24 | Hill's Pet Nutrition, Inc. | Companion animal nutrition system |
US8691303B2 (en) | 2009-07-31 | 2014-04-08 | The Iams Company | Dusted animal food |
US20110064720A1 (en) | 2009-09-16 | 2011-03-17 | Daniel Moses Amato | Dietary Supplement Compositions and Methods of Making and Using the Same |
CN102630161A (zh) | 2009-09-18 | 2012-08-08 | 珀利弗诺斯自然有限公司 | 通过用岩藻黄质和石榴油酸的组合激活去乙酰化酶Sirtuin来延缓衰老过程的方法 |
WO2011051974A1 (en) | 2009-10-29 | 2011-05-05 | Nutracryst Therapeutics Private Limited | Metformin and a-amino acids |
US8173181B2 (en) | 2009-11-09 | 2012-05-08 | Bio-Engineered Supplements & Nutrition, Inc. | Method and composition for improved anabolism |
EP2519115B1 (en) | 2009-12-29 | 2017-02-15 | Hill's Pet Nutrition, Inc. | Compositions including pyruvate for companion animals and methods of use thereof |
JP5820819B2 (ja) | 2010-01-06 | 2015-11-24 | ネステク ソシエテ アノニム | カロリー制限の模倣に有効な食餌療法 |
US20110208153A1 (en) | 2010-02-24 | 2011-08-25 | John Alvey | Formulations and methods for nutrient delivery |
EP2564858A4 (en) | 2010-04-28 | 2013-10-30 | Nihon Pharmaceutical Co Ltd | COMPOSITION FOR THE TREATMENT OF ASTHENOPIA |
US20120058088A1 (en) | 2010-06-28 | 2012-03-08 | Resveratrol Partners, Llc | Resveratrol-Containing Compositions And Methods Of Use |
CN102077936B (zh) | 2010-09-20 | 2013-04-24 | 王强 | 一种糖尿病患者专用的海洋特膳食品 |
US9167991B2 (en) | 2010-09-30 | 2015-10-27 | Fitbit, Inc. | Portable monitoring devices and methods of operating same |
WO2012094636A2 (en) * | 2011-01-07 | 2012-07-12 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
WO2012097064A1 (en) | 2011-01-13 | 2012-07-19 | Abbott Laboratories | Nutritional compositions and methods for controlling blood glucose |
CA2841748C (en) | 2011-07-15 | 2021-06-15 | Nusirt Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
US20140356479A1 (en) | 2011-08-19 | 2014-12-04 | Musclepharm Corporation | Compositions and methods for use in promoting lean body mass |
US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
KR101409330B1 (ko) | 2012-05-11 | 2014-06-18 | 안국약품 주식회사 | 복용순응도가 향상된 서방성 당뇨병 치료용 복합제제 및 이의 제조방법 |
MX2015006023A (es) | 2012-11-13 | 2016-03-31 | Nusirt Sciences Inc | Composiciones y metodos para incrementar el metabolismo energetico. |
JP2016505023A (ja) | 2013-01-15 | 2016-02-18 | ニューサート サイエンシーズ, インコーポレイテッド | 肺の状態の処置 |
CA2902879C (en) | 2013-03-15 | 2023-09-26 | Nusirt Sciences, Inc. | Leucine and nicotinic acid reduces lipid levels |
JP2016513966A (ja) | 2013-03-15 | 2016-05-19 | ニューサート サイエンシーズ, インコーポレイテッド | サーチュイン活性化剤によるペットの処置 |
WO2015053379A1 (en) | 2013-10-07 | 2015-04-16 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
US9724319B2 (en) | 2014-02-27 | 2017-08-08 | Nusirt Sciences, Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
WO2017040407A1 (en) | 2015-09-01 | 2017-03-09 | Nusirt Sciences, Inc. | Compositions and methods for the reduction or prevention of non-alcoholic steatohepatitis (nash) |
-
2015
- 2015-02-27 US US15/119,695 patent/US9724319B2/en active Active
- 2015-02-27 CN CN201580023614.4A patent/CN106456997B/zh not_active Expired - Fee Related
- 2015-02-27 KR KR1020167026157A patent/KR20160119863A/ko unknown
- 2015-02-27 AU AU2015222754A patent/AU2015222754B2/en not_active Ceased
- 2015-02-27 EP EP15755565.7A patent/EP3110507B1/en active Active
- 2015-02-27 MX MX2016011063A patent/MX2016011063A/es unknown
- 2015-02-27 RU RU2016138136A patent/RU2016138136A/ru not_active Application Discontinuation
- 2015-02-27 SG SG11201607075TA patent/SG11201607075TA/en unknown
- 2015-02-27 CA CA2939833A patent/CA2939833A1/en not_active Abandoned
- 2015-02-27 JP JP2016554211A patent/JP2017506651A/ja active Pending
- 2015-02-27 WO PCT/US2015/018182 patent/WO2015131152A1/en active Application Filing
- 2015-09-02 US US14/843,873 patent/US9872844B2/en active Active
-
2016
- 2016-08-14 IL IL247263A patent/IL247263A0/en unknown
- 2016-08-19 ZA ZA2016/05795A patent/ZA201605795B/en unknown
- 2016-08-22 PH PH12016501668A patent/PH12016501668A1/en unknown
-
2017
- 2017-08-30 ZA ZA2017/05908A patent/ZA201705908B/en unknown
- 2017-12-15 US US15/844,101 patent/US20180169043A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2016138136A3 (ja) | 2018-09-26 |
CN106456997A (zh) | 2017-02-22 |
JP2017506651A (ja) | 2017-03-09 |
US9724319B2 (en) | 2017-08-08 |
AU2015222754B2 (en) | 2020-06-25 |
US20160067201A1 (en) | 2016-03-10 |
CN106456997B (zh) | 2018-12-28 |
AU2015222754A1 (en) | 2016-09-08 |
MX2016011063A (es) | 2016-11-30 |
IL247263A0 (en) | 2016-09-29 |
PH12016501668A1 (en) | 2016-11-07 |
US20180169043A1 (en) | 2018-06-21 |
EP3110507A1 (en) | 2017-01-04 |
EP3110507B1 (en) | 2020-11-18 |
WO2015131152A1 (en) | 2015-09-03 |
CA2939833A1 (en) | 2015-09-03 |
US20170065545A1 (en) | 2017-03-09 |
ZA201605795B (en) | 2018-05-30 |
EP3110507A4 (en) | 2017-11-01 |
RU2016138136A (ru) | 2018-04-02 |
US9872844B2 (en) | 2018-01-23 |
KR20160119863A (ko) | 2016-10-14 |
ZA201705908B (en) | 2019-05-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA201705908B (en) | Compositions and methods for the reduction or prevention of hepatic steatosis | |
IL285565B (en) | Methods and preparations for immune modulation | |
HRP20192145T1 (hr) | Pripravci nosača-antitijela i metode pripreme i uporabe istih | |
GB2535253B (en) | Compositions and methods | |
HUE056172T2 (hu) | Szelenoorganikus vegyületeket tartalmazó készítmények és eljárások alkalmazásukra | |
PL3349743T3 (pl) | Sposoby i kompozycje do hamowania oddziaływania dcn1-ubc12 | |
SG11201702554QA (en) | Compositions and methods for the treatment of multiple sclerosis | |
IL249226A0 (en) | Methods and preparations for immune modulation | |
PL3113774T3 (pl) | Kompozycje grapiprantu i sposoby ich zastosowania | |
HK1243404A1 (zh) | 色酰胺組合物和使用方法 | |
IL252016A0 (en) | Long-term combination preparations and methods for jaundice c | |
GB201705626D0 (en) | Compositions and methods | |
IL248513B (en) | Preparations and methods for immunomodulation against lyst | |
PL3183308T3 (pl) | Kompozycja do ochrony przedmiotu przed korozją | |
ZA201807665B (en) | Methods and compositions | |
GB201715820D0 (en) | Compositions and methods | |
ZA201705100B (en) | Jasmonate derivatives and compositions thereof | |
ZA201606594B (en) | Defoamer compositions and methods of using the same | |
GB201402915D0 (en) | Compositions and methods | |
ZA201807782B (en) | Methods and compositions | |
SG11201704282UA (en) | Compositions and methods for the treatment of multiple sclerosis | |
GB201403212D0 (en) | Compositions and methods |