SG11201604886WA - Non-human animals having humanized fc-gamma receptors - Google Patents

Non-human animals having humanized fc-gamma receptors

Info

Publication number
SG11201604886WA
SG11201604886WA SG11201604886WA SG11201604886WA SG11201604886WA SG 11201604886W A SG11201604886W A SG 11201604886WA SG 11201604886W A SG11201604886W A SG 11201604886WA SG 11201604886W A SG11201604886W A SG 11201604886WA SG 11201604886W A SG11201604886W A SG 11201604886WA
Authority
SG
Singapore
Prior art keywords
humanized
human animals
gamma receptors
receptors
gamma
Prior art date
Application number
SG11201604886WA
Other languages
English (en)
Inventor
Andrew J Murphy
Lynn Macdonald
Cagan Gurer
Karolina A Meagher
Naxin Tu
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11201604886WA publication Critical patent/SG11201604886WA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11201604886WA 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors SG11201604886WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461977037P 2014-04-08 2014-04-08
PCT/US2015/024920 WO2015157415A1 (fr) 2014-04-08 2015-04-08 Animaux non humains ayant des récepteurs fc-gamma humanisés

Publications (1)

Publication Number Publication Date
SG11201604886WA true SG11201604886WA (en) 2016-07-28

Family

ID=52997579

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201908800Y SG10201908800YA (en) 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors
SG11201604886WA SG11201604886WA (en) 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201908800Y SG10201908800YA (en) 2014-04-08 2015-04-08 Non-human animals having humanized fc-gamma receptors

Country Status (23)

Country Link
US (4) US9474255B2 (fr)
EP (2) EP3129400B1 (fr)
JP (2) JP6652931B2 (fr)
KR (2) KR102223264B1 (fr)
CN (2) CN106163273B (fr)
AU (2) AU2015243865C1 (fr)
CA (1) CA2935472C (fr)
CY (1) CY1123046T1 (fr)
DK (1) DK3129400T3 (fr)
ES (1) ES2794942T3 (fr)
HR (1) HRP20200899T1 (fr)
HU (1) HUE051088T2 (fr)
IL (2) IL246497B (fr)
LT (1) LT3129400T (fr)
MX (1) MX2016013241A (fr)
PH (1) PH12016501341A1 (fr)
PL (1) PL3129400T3 (fr)
PT (1) PT3129400T (fr)
RS (1) RS60398B1 (fr)
RU (2) RU2019128394A (fr)
SG (2) SG10201908800YA (fr)
SI (1) SI3129400T1 (fr)
WO (1) WO2015157415A1 (fr)

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SG10201908800YA (en) 2014-04-08 2019-11-28 Regeneron Pharma Non-human animals having humanized fc-gamma receptors
NO2785538T3 (fr) 2014-05-07 2018-08-04
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HUE059417T2 (hu) 2014-11-24 2022-11-28 Regeneron Pharma Humanizált CD3-komplexet expresszáló nem humán állatok
EP4296278A3 (fr) 2014-12-05 2024-03-27 Regeneron Pharmaceuticals, Inc. Animaux non humains ayant un groupe humanisé de gène de différenciation 47
KR102457921B1 (ko) 2014-12-09 2022-10-25 리제너론 파마슈티칼스 인코포레이티드 인간화 분화 클러스터 274 유전자를 갖는 비인간 동물
KR102454546B1 (ko) 2015-11-20 2022-10-14 리제너론 파마슈티칼스 인코포레이티드 인간화 림프구 활성화 유전자 3을 갖는 비인간 동물
ES2886958T3 (es) 2016-02-29 2021-12-21 Regeneron Pharma Roedores que tienen un gen TMPRSS humanizado
CN116064611A (zh) 2017-11-30 2023-05-05 瑞泽恩制药公司 包含人源化trkb基因座的非人动物
SG11202008620VA (en) * 2018-03-26 2020-10-29 Regeneron Pharma Humanized rodents for testing therapeutic agents
AU2019308205A1 (en) 2018-07-16 2020-11-19 Regeneron Pharmaceuticals, Inc. Non-human animal models of DITRA disease and uses thereof
WO2022132943A1 (fr) 2020-12-16 2022-06-23 Regeneron Pharmaceuticals, Inc. Souris exprimant des récepteurs humanisés fc alpha

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Also Published As

Publication number Publication date
JP2017510285A (ja) 2017-04-13
AU2015243865B2 (en) 2020-05-14
RS60398B1 (sr) 2020-07-31
JP2020062051A (ja) 2020-04-23
HUE051088T2 (hu) 2021-03-01
IL246497B (en) 2019-06-30
CA2935472C (fr) 2024-02-20
IL264364A (en) 2019-02-28
US20230232795A1 (en) 2023-07-27
US9474255B2 (en) 2016-10-25
ES2794942T3 (es) 2020-11-19
CN106163273B (zh) 2020-07-24
CY1123046T1 (el) 2021-10-29
MX2016013241A (es) 2017-05-03
KR102439412B1 (ko) 2022-09-02
RU2016143036A (ru) 2018-05-08
AU2020217312A1 (en) 2020-08-27
AU2015243865A1 (en) 2016-08-18
IL246497A0 (en) 2016-08-31
CN111690052A (zh) 2020-09-22
HRP20200899T1 (hr) 2020-09-04
EP3693383A1 (fr) 2020-08-12
SG10201908800YA (en) 2019-11-28
RU2016143036A3 (fr) 2018-10-24
US20170086432A1 (en) 2017-03-30
AU2020217312C1 (en) 2023-10-26
PL3129400T3 (pl) 2020-09-07
WO2015157415A1 (fr) 2015-10-15
KR20210024249A (ko) 2021-03-04
LT3129400T (lt) 2020-06-25
IL264364B (en) 2021-03-25
RU2019128394A (ru) 2019-10-07
US10555507B2 (en) 2020-02-11
EP3129400B1 (fr) 2020-03-25
RU2700484C2 (ru) 2019-09-17
US20200288684A1 (en) 2020-09-17
CN106163273A (zh) 2016-11-23
US11503812B2 (en) 2022-11-22
KR102223264B1 (ko) 2021-03-09
KR20160142309A (ko) 2016-12-12
CN111690052B (zh) 2024-06-04
JP6652931B2 (ja) 2020-02-26
PT3129400T (pt) 2020-05-27
JP6858283B2 (ja) 2021-04-14
DK3129400T3 (da) 2020-06-08
AU2015243865C1 (en) 2020-11-26
AU2020217312B2 (en) 2023-04-13
CA2935472A1 (fr) 2015-10-15
SI3129400T1 (sl) 2020-07-31
EP3129400A1 (fr) 2017-02-15
PH12016501341A1 (en) 2016-08-15
US20150282463A1 (en) 2015-10-08

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