SG11201602061YA - Novel antibody purification method and antibody obtained therefrom, and novel antibody purification method using cation exchanger and antibody obtained therefrom - Google Patents

Novel antibody purification method and antibody obtained therefrom, and novel antibody purification method using cation exchanger and antibody obtained therefrom

Info

Publication number
SG11201602061YA
SG11201602061YA SG11201602061YA SG11201602061YA SG11201602061YA SG 11201602061Y A SG11201602061Y A SG 11201602061YA SG 11201602061Y A SG11201602061Y A SG 11201602061YA SG 11201602061Y A SG11201602061Y A SG 11201602061YA SG 11201602061Y A SG11201602061Y A SG 11201602061YA
Authority
SG
Singapore
Prior art keywords
antibody
purification method
obtained therefrom
novel
antibody obtained
Prior art date
Application number
SG11201602061YA
Other languages
English (en)
Inventor
Kazunobu Minakuchi
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of SG11201602061YA publication Critical patent/SG11201602061YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/36Extraction; Separation; Purification by a combination of two or more processes of different types
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626Diabody or triabody

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11201602061YA 2013-09-17 2014-09-16 Novel antibody purification method and antibody obtained therefrom, and novel antibody purification method using cation exchanger and antibody obtained therefrom SG11201602061YA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013192378 2013-09-17
JP2013192379 2013-09-17
PCT/JP2014/074452 WO2015041218A1 (fr) 2013-09-17 2014-09-16 Nouveau procédé de purification d'anticorps et anticorps obtenu au moyen de ce procédé, nouveau procédé de purification d'anticorps à l'aide d'un échangeur de cations et anticorps obtenu au moyen de ce procédé

Publications (1)

Publication Number Publication Date
SG11201602061YA true SG11201602061YA (en) 2016-04-28

Family

ID=52688867

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201602061YA SG11201602061YA (en) 2013-09-17 2014-09-16 Novel antibody purification method and antibody obtained therefrom, and novel antibody purification method using cation exchanger and antibody obtained therefrom

Country Status (7)

Country Link
US (1) US10519195B2 (fr)
EP (1) EP3048109A4 (fr)
JP (2) JPWO2015041218A1 (fr)
KR (1) KR20160054597A (fr)
CN (1) CN105555795A (fr)
SG (1) SG11201602061YA (fr)
WO (1) WO2015041218A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016121701A1 (fr) 2015-01-26 2016-08-04 株式会社カネカ Matrice pour séparation par affinité destinée à la purification de protéines contenant la région variable de la chaîne kappa des immunoglobulines
CN108064286A (zh) 2015-01-26 2018-05-22 株式会社钟化 突变型免疫球蛋白κ链可变区结合性肽
JP6709024B2 (ja) * 2015-07-03 2020-06-10 国立研究開発法人医薬基盤・健康・栄養研究所 ペプチド又はタンパク質の分画方法
JP7084301B2 (ja) * 2015-08-21 2022-06-14 エフ.ホフマン-ラ ロシュ アーゲー 低伝導率洗浄緩衝液を用いたアフィニティークロマトグラフィー精製方法
CA3000965A1 (fr) * 2015-10-23 2017-04-27 Fujifilm Corporation Porteur de chromatographie d'affinite et methode de purification de substance biologique
JP6737579B2 (ja) * 2015-10-30 2020-08-12 Jsr株式会社 アフィニティークロマトグラフィー用担体、クロマトグラフィーカラム、精製方法、及び該方法で精製された標的物質
WO2017191747A1 (fr) * 2016-05-06 2017-11-09 株式会社カネカ Procédé de production d'une protéine comprenant une région variable de chaîne κ
WO2017195638A1 (fr) 2016-05-09 2017-11-16 株式会社カネカ Procédé de purification d'un anticorps ou d'un fragment d'anticorps comportant une région variable de chaîne κ
US20200360894A1 (en) 2017-08-23 2020-11-19 Jsr Corporation Chromatography carrier, ligand-immobilizing carrier, chromatography column, target substance purification method, and chromatography carrier production method
CN117920163A (zh) 2018-11-06 2024-04-26 Jsr株式会社 有机硫化合物的制造方法
JP7154414B2 (ja) * 2019-07-02 2022-10-17 日本メジフィジックス株式会社 226Ra含有溶液の精製方法、226Raターゲットの製造方法および225Acの製造方法
WO2022202467A1 (fr) 2021-03-25 2022-09-29 Jsr株式会社 Procédé de production de support pour une utilisation chromatographique, procédé de production de colonne de chromatographie, et support pour une utilisation chromatographique
WO2022202466A1 (fr) 2021-03-25 2022-09-29 Jsr株式会社 Procédé de production d'un vecteur chromatographique, procédé de production d'une colonne de chromatographie et vecteur chromatographique
WO2023058409A1 (fr) 2021-10-05 2023-04-13 Jsr株式会社 Procédé de remplissage de colonne avec un support de chromatographie, procédé de stockage de suspension épaisse, et suspension épaisse

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932557A (en) 1972-12-19 1976-01-13 Gulf Research & Development Company Reactive hydrophilic epoxy containing polymer
US4145366A (en) * 1974-11-18 1979-03-20 Teijin Limited Process for isomerizing one of the geometric isomers of an α,β-unsaturated aldehyde to its corresponding other geometric isomer
US4210723A (en) 1976-07-23 1980-07-01 The Dow Chemical Company Method of coupling a protein to an epoxylated latex
US4772653A (en) 1985-11-08 1988-09-20 Amoco Corporation Stain resistant cookware from blends comprising an interpolymer of an unsaturated dicarboxylic acid compound
US5260373A (en) 1987-03-13 1993-11-09 Repligen Corporation Immobilized immunoglobulin-binding proteins
SE467308B (sv) 1990-10-22 1992-06-29 Berol Nobel Ab Fast yta belagd med ett hydrofilt ytterskikt med kovalent bundna biopolymerer, saett att framstaella en saadan yta och ett konjugat daerfoer
JPH05202098A (ja) 1992-01-29 1993-08-10 Snow Brand Milk Prod Co Ltd 乳質原料から生理活性物質の製造法
JPH06228200A (ja) 1993-01-29 1994-08-16 Snow Brand Milk Prod Co Ltd 補体C3cの製造法
SE9503925D0 (sv) 1995-11-07 1995-11-07 Pharmacia Biotech Ab Separationsmedium för IgG
US5874165A (en) 1996-06-03 1999-02-23 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto polymeric subtrates
ATE370961T1 (de) * 1998-05-06 2007-09-15 Genentech Inc Reinigung von antikörpern durch ionenaustauschchromatographie
EP1105731B1 (fr) 1998-08-12 2006-10-18 Zycos Inc. Etablissement de profil et catalogage de marqueurs de proteines exprimees
US20040224338A1 (en) 1998-08-12 2004-11-11 Zycos Inc., A Delaware Corporation Profiling and cataloging expressed protein tags
SE0200943D0 (sv) 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
US7709209B2 (en) 2002-03-25 2010-05-04 Ge Healthcare Bio-Sciences Ab Protein ligands
ITMI20020729A1 (it) 2002-04-08 2003-10-08 Resindion S R L Supporti per l'immobilizzazione covalente di enzimi
ES2214136B1 (es) 2003-02-21 2007-05-16 Consejo Sup. De Invest. Cientificas. Nuevo metodo de inmovilizacion de enzimas y otras bio-macromoleculas sobre soportes activados con grupos epoxido conteniendo grupos ionizados en el brazo espaciador que une cada grupo epoxido a la superficie del soporte.
GB0304576D0 (en) * 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
SE0400501D0 (sv) 2004-02-27 2004-02-27 Amersham Biosciences Ab Antibody purification
CA2552639C (fr) 2004-02-27 2012-05-01 Ge Healthcare Bio-Sciences Ab Procede de purification d'anticorps
SE0400886D0 (sv) * 2004-04-02 2004-04-02 Amersham Biosciences Ab Process of purification
KR101248642B1 (ko) 2004-06-09 2013-03-28 페써겐 리무벌 앤드 다이어그너스틱 테크널라지스 인코포레이티드 샘플로부터 목적 약물을 제거하기 위한 다공성 기질 내함침된 입자들
RU2389552C2 (ru) 2004-10-21 2010-05-20 Джи-И Хелткер Байо-Сайенсиз АБ Способ очистки антител
US9266041B2 (en) 2004-10-21 2016-02-23 Ge Healthcare Bio-Sciences Ab Chromatography ligand
CA2604877A1 (fr) 2005-04-11 2006-10-19 J.P. Sercel Associates Inc. Purification des proteines
TWI391399B (zh) * 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法
WO2007081851A2 (fr) 2006-01-06 2007-07-19 Millipore Corporation Matrices de chromatographie d'affinite et procedes de fabrication et d'utilisation correspondants
WO2009017491A1 (fr) 2006-06-14 2009-02-05 Smithkline Beecham Corporation Procédés de purification d'anticorps à l'aide de céramique d'hydroxyapatite
JP5448825B2 (ja) 2006-10-19 2014-03-19 ヤンセン バイオテツク,インコーポレーテツド 非凝集抗体Fcドメインの製造方法
US20080167450A1 (en) 2007-01-05 2008-07-10 Hai Pan Methods of purifying proteins
US7999085B2 (en) 2007-01-09 2011-08-16 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US9433922B2 (en) 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
WO2009058769A1 (fr) 2007-10-30 2009-05-07 Schering Corporation Purification d'anticorps contenant des variants hydrophobes
CA2720615C (fr) 2008-04-08 2016-06-07 Bio-Rad Laboratories, Inc. Purification d'anticorps par chromatographie
EP2281000A2 (fr) * 2008-05-15 2011-02-09 Novo Nordisk A/S Procédé de purification d'anticorps
EP2321338A1 (fr) 2008-08-14 2011-05-18 Merck Sharp & Dohme Corp. Procédés de purification d'anticorps à l'aide d'une chromatographie d'affinité sur protéine a
CA2932207A1 (fr) 2008-10-20 2010-12-09 Abbvie Inc. Isolation et purification d'anticorps au moyen de chromatographie d'affinite de proteine a
JP2010133734A (ja) 2008-12-02 2010-06-17 Tosoh Corp アフィニティークロマトグラフィー用カルボキシル化担体、及びそれを用いたアフィニティークロマトグラフィー用分離剤
JP2010133733A (ja) 2008-12-02 2010-06-17 Tosoh Corp カチオン交換体、その製造方法及びその用途
WO2010071208A1 (fr) 2008-12-19 2010-06-24 武田薬品工業株式会社 Méthode de purification d'anticorps
US9676845B2 (en) * 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
CN107188960A (zh) * 2009-08-07 2017-09-22 Emd密理博公司 从样品的一或多种杂质中纯化靶蛋白的方法
US9527010B2 (en) * 2009-09-25 2016-12-27 Ge Healthcare Bio-Sciences Corp. Separation system and method
ES2813398T3 (es) 2009-10-20 2021-03-23 Abbvie Inc Aislamiento y purificación de anticuerpos anti-IL-13 usando cromatografía de afinidad a Proteína A
US8277649B2 (en) 2009-12-14 2012-10-02 General Electric Company Membranes and associated methods for purification of antibodies
SG184184A1 (en) 2010-03-24 2012-10-30 Kaneka Corp Protein capable of binding specifically to immunoglobulin, and immunoglobulin-binding affinity ligand
EP2649016B1 (fr) * 2010-12-06 2020-06-10 Pall Corporation Procédés de traitement continu pour produits biologiques
JP6335785B2 (ja) 2012-09-03 2018-05-30 株式会社カネカ ミックスモード抗体アフィニティー分離マトリックスとそれを用いた精製方法および標的分子
CN116003579A (zh) * 2013-05-06 2023-04-25 赛诺菲 用于纯化抗体的连续多步骤方法

Also Published As

Publication number Publication date
CN105555795A (zh) 2016-05-04
KR20160054597A (ko) 2016-05-16
US10519195B2 (en) 2019-12-31
JPWO2015041218A1 (ja) 2017-03-02
JP2019034963A (ja) 2019-03-07
US20160237113A1 (en) 2016-08-18
EP3048109A1 (fr) 2016-07-27
WO2015041218A1 (fr) 2015-03-26
EP3048109A4 (fr) 2017-04-19

Similar Documents

Publication Publication Date Title
HRP20190197T1 (hr) Postupci pročišćavanja rna
SG11201602061YA (en) Novel antibody purification method and antibody obtained therefrom, and novel antibody purification method using cation exchanger and antibody obtained therefrom
HK1221908A1 (zh) 多特異 試劑,其製備方法和用途
IL242408B (en) A continuous multistep step for antibody purification
PT3004163T (pt) Método para purificação de anticorpo
PL3603794T3 (pl) Ukształtowane według wzoru powierzchnie żelowe
EP3020688A4 (fr) Procédé de production de zéolite
EP3006415A4 (fr) Procédé de production de nanociment et nanociment
IL240753B (en) Antibody purification methods
SG11201505204VA (en) Protein purification process
SG11201505198WA (en) Protein purification methods
EP3031777A4 (fr) Zéolite et procédé de production et utilisation s'y rapportant
EP3060578A4 (fr) Purification d'anticorps
EP2987801A4 (fr) Procédé de purification d'une protéine d'anticorps
GB201315777D0 (en) Novel method
PL2985275T3 (pl) Sposób oczyszczania kwasu beta-hydroksy-beta-metylomasłowego
EP3009400A4 (fr) Zéolite de type lev et son procédé de fabrication
GB2530447B (en) Urea synthesis method
HUE045124T2 (hu) Szilánnal módosított kovasav, eljárás elõállítására és alkalmazása
EP2891626A4 (fr) Procédé de purification de difluorophosphate
IL241779A (en) Method for protein production
IL240161A0 (en) A human antibody specific for human meta-pneumonia virus, or a fragment thereof that binds an antigen
HK1226026A1 (zh) 轉送沖壓
EP2980582A4 (fr) Echangeur de cations pour chromatographie en phase liquide, procédé de fabrication de celui-ci, et utilisation de celui-ci
GB201301384D0 (en) Method for antibody production