SG11201601695WA - Automated screening of enzyme variants - Google Patents
Automated screening of enzyme variantsInfo
- Publication number
- SG11201601695WA SG11201601695WA SG11201601695WA SG11201601695WA SG11201601695WA SG 11201601695W A SG11201601695W A SG 11201601695WA SG 11201601695W A SG11201601695W A SG 11201601695WA SG 11201601695W A SG11201601695W A SG 11201601695WA SG 11201601695W A SG11201601695W A SG 11201601695WA
- Authority
- SG
- Singapore
- Prior art keywords
- enzyme variants
- automated screening
- screening
- automated
- variants
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C99/00—Subject matter not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
- G16B35/20—Screening of libraries
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/60—In silico combinatorial chemistry
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/60—In silico combinatorial chemistry
- G16C20/64—Screening of libraries
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Theoretical Computer Science (AREA)
- Library & Information Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Evolutionary Biology (AREA)
- Computing Systems (AREA)
- Analytical Chemistry (AREA)
- Ecology (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361883838P | 2013-09-27 | 2013-09-27 | |
| PCT/US2014/057899 WO2015048572A1 (en) | 2013-09-27 | 2014-09-26 | Automated screening of enzyme variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201601695WA true SG11201601695WA (en) | 2016-04-28 |
Family
ID=51662390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201601695WA SG11201601695WA (en) | 2013-09-27 | 2014-09-26 | Automated screening of enzyme variants |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10696964B2 (ru) |
| EP (2) | EP3049973B1 (ru) |
| JP (3) | JP6857029B2 (ru) |
| KR (1) | KR102342205B1 (ru) |
| CN (1) | CN105765592B (ru) |
| AU (1) | AU2014324669B2 (ru) |
| BR (1) | BR112016006285B1 (ru) |
| CA (1) | CA2923755C (ru) |
| DK (2) | DK3049973T3 (ru) |
| ES (2) | ES2693150T3 (ru) |
| HU (2) | HUE039618T2 (ru) |
| IL (1) | IL244457B (ru) |
| RU (2) | RU2016116253A (ru) |
| SG (1) | SG11201601695WA (ru) |
| WO (1) | WO2015048572A1 (ru) |
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| EP3049973B1 (en) | 2013-09-27 | 2018-08-08 | Codexis, Inc. | Automated screening of enzyme variants |
| NZ717647A (en) | 2013-09-27 | 2020-06-26 | Codexis Inc | Structure based predictive modeling |
| JP6667447B2 (ja) * | 2013-11-15 | 2020-03-18 | ヒンジ セラピューティクス，インコーポレイテッド | 治療設計のためのコンピュータ支援モデル化 |
| SG11201703258PA (en) | 2014-11-25 | 2017-05-30 | Codexis Inc | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
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| US10542961B2 (en) | 2015-06-15 | 2020-01-28 | The Research Foundation For The State University Of New York | System and method for infrasonic cardiac monitoring |
| WO2017155945A1 (en) * | 2016-03-09 | 2017-09-14 | President And Fellows Of Harvard College | Methods and systems of cell-free enzyme discovery and optimization |
| AU2018217495B2 (en) | 2017-02-13 | 2021-03-04 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
| JP6917050B2 (ja) * | 2017-03-06 | 2021-08-11 | 学校法人早稲田大学 | 最適特性を有する非天然型タンパク質の製造方法 |
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| NZ703347A (en) | 2012-06-29 | 2016-05-27 | Wisconsin Alumni Res Found | Use of 2-methylene-19-nor-(20s)-1α,25-dihydroxyvitamin d3 to treat secondary hyperparathyroidism |
| US20140303952A1 (en) | 2013-04-08 | 2014-10-09 | City University Of Hong Kong | Protein-ligand docking |
| CN103265635A (zh) * | 2013-04-28 | 2013-08-28 | 中山大学附属第一医院 | 一种通用的靶向蛋白嵌合型分子化合物的构建方法 |
| CN103324861B (zh) * | 2013-07-10 | 2016-07-20 | 南京大学 | 基于分子动力学模拟的核受体介导内分泌干扰物质的虚拟筛选方法 |
| NZ717647A (en) | 2013-09-27 | 2020-06-26 | Codexis Inc | Structure based predictive modeling |
| EP3049973B1 (en) | 2013-09-27 | 2018-08-08 | Codexis, Inc. | Automated screening of enzyme variants |
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