SG11201509347UA - Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing - Google Patents

Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing

Info

Publication number
SG11201509347UA
SG11201509347UA SG11201509347UA SG11201509347UA SG11201509347UA SG 11201509347U A SG11201509347U A SG 11201509347UA SG 11201509347U A SG11201509347U A SG 11201509347UA SG 11201509347U A SG11201509347U A SG 11201509347UA SG 11201509347U A SG11201509347U A SG 11201509347UA
Authority
SG
Singapore
Prior art keywords
heparin
modulation
growth factor
epidermal growth
tympanic membrane
Prior art date
Application number
SG11201509347UA
Other languages
English (en)
Inventor
Maria Peter Luke Santa
Yunzhi Peter Yang
Sungwoo Kim
Chloe Domville-Lewis
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of SG11201509347UA publication Critical patent/SG11201509347UA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0076—Sprayable compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
    • A61F11/20—Ear surgery
    • A61F11/202—Surgical middle-ear ventilation or drainage, e.g. permanent; Implants therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/18—Internal ear or nose parts, e.g. ear-drums
    • A61F2002/183—Ear parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
SG11201509347UA 2013-05-15 2014-04-09 Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing SG11201509347UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361823749P 2013-05-15 2013-05-15
PCT/US2014/033536 WO2014186075A2 (en) 2013-05-15 2014-04-09 Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing

Publications (1)

Publication Number Publication Date
SG11201509347UA true SG11201509347UA (en) 2015-12-30

Family

ID=51898980

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201509347UA SG11201509347UA (en) 2013-05-15 2014-04-09 Modulation of heparin-binding epidermal growth factor activity for tympanic membrane healing

Country Status (27)

Country Link
US (3) US20160074476A1 (pt)
EP (2) EP2996709B1 (pt)
JP (1) JP6316943B2 (pt)
KR (1) KR102318748B1 (pt)
CN (2) CN113559242A (pt)
AU (2) AU2014265901B2 (pt)
BR (2) BR112015028367B1 (pt)
CA (1) CA2912411C (pt)
CY (1) CY1123464T1 (pt)
DK (1) DK2996709T3 (pt)
ES (1) ES2805002T3 (pt)
HK (1) HK1217166A1 (pt)
HR (1) HRP20200971T1 (pt)
HU (1) HUE049294T2 (pt)
IL (2) IL242454B (pt)
LT (1) LT2996709T (pt)
MX (2) MX2015015774A (pt)
PH (2) PH12015502577B1 (pt)
PL (1) PL2996709T3 (pt)
PT (1) PT2996709T (pt)
RS (1) RS60412B1 (pt)
RU (2) RU2676483C2 (pt)
SG (1) SG11201509347UA (pt)
SI (1) SI2996709T1 (pt)
UA (1) UA120037C2 (pt)
WO (1) WO2014186075A2 (pt)
ZA (1) ZA201508289B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102634748B1 (ko) 2018-06-15 2024-02-13 삼성전자주식회사 포토 마스크용 펠리클 및 이의 제조 방법
CN114222589A (zh) * 2019-07-31 2022-03-22 安斯泰来制药株式会社 耳内给药用药物组合物
CN116194147A (zh) 2020-09-25 2023-05-30 安斯泰来制药株式会社 耳内给药用药物组合物

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US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
EP0610441A4 (en) 1991-10-29 1996-01-10 Clover Cons Ltd CROSSLINKABLE POLYSACCHARIDES, POLYCATIONS AND LIPIDS CAN BE USED TO ENCODE AND DISPENSE MEDICINAL PRODUCTS.
US6514533B1 (en) * 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
US5827937A (en) 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
AU725654B2 (en) 1996-05-03 2000-10-19 Innogenetics N.V. New medicaments containing gelatin cross-linked with oxidized polysaccharides
WO1999017820A1 (en) 1997-10-03 1999-04-15 Texas Pharmaceuticals, Inc. Improved dual chamber syringe apparatus
US5971953A (en) 1998-01-09 1999-10-26 Bachynsky; Nicholas Dual chamber syringe apparatus
US6191109B1 (en) * 1997-10-31 2001-02-20 Children's Hospital, Inc. Methods of treating intestinal ischemia using heparin-binding epidermal growth factor
AU760664B2 (en) * 1998-04-17 2003-05-22 Angiogenix, Inc. Therapeutic angiogenic factors and methods for their use
AU2351601A (en) 1999-12-28 2001-07-09 Asger Lau Dalmose Dual chamber syringe with a dual function piston
US20030229113A1 (en) 2000-03-24 2003-12-11 Koji Hashimoto Keratinocyte growth inhibitors and hydroxamic acid derivatives
US7067492B2 (en) 2001-09-06 2006-06-27 Omnio Ab Method of promoting healing of a tympanic membrane perforation
US7220431B2 (en) 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
US20090148486A1 (en) * 2005-04-28 2009-06-11 Helen Lu Compositions and methods for treating pulp inflammations caused by infection or trauma
KR20080026198A (ko) * 2005-06-30 2008-03-24 안트로제네시스 코포레이션 태반 유도된 콜라겐 바이오패브릭을 사용한 고막의 복원
EP1949907B1 (en) 2005-09-28 2014-07-02 Kagoshima University Novel application of heparin-binding epidermal growth factor-like growth factor for medical purposes
US8093213B2 (en) 2007-04-30 2012-01-10 Nationwide Children's Hospital, Inc. Heparin binding epidermal growth factor (HB-EGF) for use in methods of treating and preventing intestinal injury related to hemorrhagic shock and resuscitation
US20090192079A1 (en) * 2007-10-09 2009-07-30 Genzyme Corporation Prolonged delivery of heparin-binding growth factors from heparin-derivatized collagen
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WO2009142719A2 (en) * 2008-05-19 2009-11-26 Massachusetts Institute Of Technology Tympanic membrane permeating ear drops and uses thereof
MX2010014077A (es) * 2008-06-26 2011-04-05 Kanemaru Shinichi Agente para la regeneracion de la membrana timpanica o el conducto auditivo externo.
WO2011021381A1 (ja) * 2009-08-17 2011-02-24 株式会社未来創薬研究所 抗hb-egf抗体を有効成分として含む医薬組成物
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WO2014169045A1 (en) 2013-04-09 2014-10-16 The Board Of Trustees Of The Leland Stanford Junior University Crosslinked chitosan-lactide hydrogels

Also Published As

Publication number Publication date
HUE049294T2 (hu) 2020-09-28
RS60412B1 (sr) 2020-07-31
EP3708181A1 (en) 2020-09-16
WO2014186075A3 (en) 2015-06-04
UA120037C2 (uk) 2019-09-25
BR112015028367A2 (pt) 2017-07-25
PH12020551126A1 (en) 2021-12-13
KR102318748B1 (ko) 2021-10-27
LT2996709T (lt) 2020-08-10
US20180256684A1 (en) 2018-09-13
CN105555296A (zh) 2016-05-04
AU2019200630B2 (en) 2020-08-27
US20220111006A1 (en) 2022-04-14
US11235027B2 (en) 2022-02-01
US20160074476A1 (en) 2016-03-17
PH12015502577A1 (en) 2016-02-29
BR122020011229B1 (pt) 2022-06-07
ZA201508289B (en) 2019-02-27
CY1123464T1 (el) 2022-03-24
AU2014265901B2 (en) 2018-11-08
MX2020001319A (es) 2020-03-20
JP2016520080A (ja) 2016-07-11
RU2676483C2 (ru) 2018-12-29
US11963998B2 (en) 2024-04-23
SI2996709T1 (sl) 2020-09-30
DK2996709T3 (da) 2020-06-02
RU2018146249A (ru) 2019-01-18
AU2014265901A1 (en) 2015-11-26
EP2996709A4 (en) 2016-11-16
PL2996709T3 (pl) 2021-02-08
AU2019200630A1 (en) 2019-02-21
IL273329A (en) 2020-04-30
HK1217166A1 (zh) 2016-12-30
EP2996709B1 (en) 2020-05-06
PH12015502577B1 (en) 2016-02-29
HRP20200971T1 (hr) 2020-10-02
ES2805002T3 (es) 2021-02-10
IL273329B (en) 2021-05-31
JP6316943B2 (ja) 2018-04-25
WO2014186075A2 (en) 2014-11-20
BR112015028367B1 (pt) 2020-12-01
EP2996709A2 (en) 2016-03-23
CN113559242A (zh) 2021-10-29
PT2996709T (pt) 2020-07-14
CA2912411A1 (en) 2014-11-20
KR20160013063A (ko) 2016-02-03
RU2015148636A (ru) 2017-06-20
MX2015015774A (es) 2016-07-26
IL242454B (en) 2020-05-31
CA2912411C (en) 2022-10-25

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