SG11201508186XA - Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids - Google Patents

Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids

Info

Publication number
SG11201508186XA
SG11201508186XA SG11201508186XA SG11201508186XA SG11201508186XA SG 11201508186X A SG11201508186X A SG 11201508186XA SG 11201508186X A SG11201508186X A SG 11201508186XA SG 11201508186X A SG11201508186X A SG 11201508186XA SG 11201508186X A SG11201508186X A SG 11201508186XA
Authority
SG
Singapore
Prior art keywords
phosphoketolases
isoprenoids
isoprene
improved production
acetyl coenzyme
Prior art date
Application number
SG11201508186XA
Other languages
English (en)
Inventor
Zachary Q Beck
Jeffrey W Munos
Derek H Wells
Jian Yao
Original Assignee
Danisco Us Inc
Goodyear Tire & Rubber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danisco Us Inc, Goodyear Tire & Rubber filed Critical Danisco Us Inc
Publication of SG11201508186XA publication Critical patent/SG11201508186XA/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/32Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y401/00Carbon-carbon lyases (4.1)
    • C12Y401/02Aldehyde-lyases (4.1.2)
    • C12Y401/02009Phosphoketolase (4.1.2.9)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11201508186XA 2013-04-10 2014-04-10 Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids SG11201508186XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361810696P 2013-04-10 2013-04-10
US201361834359P 2013-06-12 2013-06-12
PCT/US2014/033688 WO2014169144A2 (en) 2013-04-10 2014-04-10 Phosphoketolases foe improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precurosors, and isoprenoids

Publications (1)

Publication Number Publication Date
SG11201508186XA true SG11201508186XA (en) 2015-11-27

Family

ID=50877659

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201508186XA SG11201508186XA (en) 2013-04-10 2014-04-10 Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids

Country Status (8)

Country Link
US (3) US10246694B2 (zh)
EP (2) EP3425049A1 (zh)
JP (2) JP6530375B2 (zh)
CN (1) CN105555952A (zh)
BR (1) BR112015025489A2 (zh)
ES (1) ES2735331T3 (zh)
SG (1) SG11201508186XA (zh)
WO (1) WO2014169144A2 (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
ES2735331T3 (es) 2013-04-10 2019-12-18 Goodyear Tire & Rubber Fosfocetolasas para mejorar la producción de metabolitos derivados de acetil-coenzima A, isopreno, precursores de isoprenoides e isoprenoides
DK3194604T3 (da) * 2014-09-18 2020-05-25 Genomatica Inc Ikke-naturlig mikrobielle organismer med forbedret energisk effektivitet
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US20200377559A1 (en) * 2017-03-24 2020-12-03 Danisco Us Inc Reduction of acetate and glycerol in modified yeast having an exogenous ethanol-producing pathway
CN107841523A (zh) * 2017-10-19 2018-03-27 浙江大学 利用群体感应分子诱导从桦褐孔菌中提取三萜类物质方法
JP2021505154A (ja) 2017-12-07 2021-02-18 ザイマージェン インコーポレイテッド 発酵によって(6e)−8−ヒドロキシゲラニオールを生産するための設計された生合成経路
EP3728212A1 (en) 2017-12-21 2020-10-28 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
WO2019166647A1 (en) * 2018-03-01 2019-09-06 Total Raffinage Chimie Metabolic pathways with increased carbon yield
CN109929883A (zh) * 2019-04-02 2019-06-25 烟台华康荣赞生物科技有限公司 重组酵母、构建方法和其在制备酪醇及衍生物中的应用
WO2021063958A1 (en) * 2019-09-30 2021-04-08 Global Bioenergies Improved means and methods for increasing the yield of acetyl-coa from glucose

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR669447A (fr) 1929-02-09 1929-11-15 Dispositif pour arrêter automatiquement un moteur d'automobile après une période de temps prédéterminée
DE19629568C1 (de) 1996-07-15 1998-01-08 Fraunhofer Ges Forschung Verfahren zur Herstellung von Isopren
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
WO2003095651A1 (fr) 2002-05-10 2003-11-20 Kyowa Hakko Kogyo Co., Ltd. Procede de production d'acide mevalonique
KR101148255B1 (ko) 2002-10-04 2012-08-08 다니스코 유에스 인크. 고수율을 갖는 1,3-프로판디올의 생물학적 제조 방법
RU2004124226A (ru) * 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Использование фосфокетолазы для продукции полезных метаболитов
ES2341264T3 (es) * 2004-08-10 2010-06-17 Ajinomoto Co., Inc. El uso de fosfocetolasa para producir metabolitos utiles.
MY146612A (en) 2006-05-26 2012-09-14 Amyris Inc Production of isoprenoids
JP4986547B2 (ja) 2006-09-04 2012-07-25 株式会社Adeka 新規なアセトアセチルCoA合成酵素、それをコードするDNA配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法
WO2009005704A1 (en) * 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
SG162265A1 (en) 2007-12-13 2010-07-29 Danisco Us Inc Compositions and methods for producing isoprene
WO2009100231A2 (en) 2008-02-06 2009-08-13 The Regents Of The University Of California Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi
US8173410B2 (en) 2008-04-23 2012-05-08 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
US7632995B2 (en) 2008-05-09 2009-12-15 Monsanto Technology Llc Plants and seeds of hybrid corn variety CH852179
MY156256A (en) 2008-07-02 2016-01-29 Danisco Us Inc Compositions and methods for producing isoprene free of c5 hydrocarbons under decoupling conditions and/or safe operating ranges
HU3516U (en) 2008-07-31 2008-11-28 Zoltan Kuthi Anti-theft protection of draining for fuel tanks
SG169640A1 (en) 2008-09-15 2011-04-29 Danisco Us Inc Increased isoprene production using mevalonate kinase and isoprene synthase
WO2010031068A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
BRPI0918453A2 (pt) 2008-09-15 2019-12-17 Danisco Us Inc sistemas usando cultura de células para a produção de isopreno
WO2010031062A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
CA2737195A1 (en) 2008-09-15 2010-03-18 The Goodyear Tire & Rubber Company Conversion of prenyl derivatives to isoprene
CA2748887A1 (en) 2008-12-30 2010-07-08 Danisco Us Inc. Methods of producing isoprene and a co-product
US8324442B2 (en) 2009-03-03 2012-12-04 Amyris, Inc. Microbial derived isoprene and methods for making the same
US20100297749A1 (en) 2009-04-21 2010-11-25 Sapphire Energy, Inc. Methods and systems for biofuel production
WO2010124146A2 (en) 2009-04-23 2010-10-28 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
JP4760951B2 (ja) 2009-05-08 2011-08-31 トヨタ自動車株式会社 ブタノール生産能を有する組換え微生物及びブタノールの製造方法
TW201412988A (zh) 2009-06-17 2014-04-01 Danisco Us Inc 使用dxp及mva途徑之改良之異戊二烯製造
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
IN2012DN01694A (zh) 2009-09-15 2015-06-05 Sapphire Energy Inc
JP5643838B2 (ja) 2009-12-18 2014-12-17 ダニスコ・ユーエス・インク 再生可能資源からのイソプレンの精製
WO2011079314A2 (en) 2009-12-23 2011-06-30 Danisco Us Inc. Compositions and methods of pgl for the increased production of isoprene
US8871488B2 (en) 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
CN103443271A (zh) 2010-10-27 2013-12-11 丹尼斯科美国公司 用于增加异戊二烯产量的异戊二烯合酶变体
ES2699747T3 (es) * 2011-04-29 2019-02-12 Danisco Us Inc Microorganismos recombinantes para la producción potenciada de mevalonato, isopreno e isoprenoides
JP2014519811A (ja) * 2011-04-29 2014-08-21 ダニスコ・ユーエス・インク チオラーゼ、HMG−CoA合成酵素及びHMG−CoA還元酵素活性を有するポリペプチドをコードしている遺伝子を使用するメバロン酸、イソプレン、及びイソプレノイドの生産
RU2658770C2 (ru) 2011-07-12 2018-06-22 Сайентист Оф Фортчун С.А. Рекомбинантный микроорганизм для получения полезных метаболитов
DK2764084T4 (da) 2011-10-07 2021-12-06 Danisco Us Inc Anvendelse af phosphoketolase i fremstillingen af mevalonat, isoprenoid-udgangsstoffer, og isopren
US8415136B1 (en) * 2011-11-09 2013-04-09 Amyris, Inc. Production of acetyl-coenzyme a derived isoprenoids
JP2015516173A (ja) 2012-05-16 2015-06-11 グリコス バイオテクノロジーズ インコーポレイテッドGlycos Biotechnologies, Inc. イソプレン生産用微生物およびプロセス
ES2735331T3 (es) 2013-04-10 2019-12-18 Goodyear Tire & Rubber Fosfocetolasas para mejorar la producción de metabolitos derivados de acetil-coenzima A, isopreno, precursores de isoprenoides e isoprenoides

Also Published As

Publication number Publication date
EP2984105A2 (en) 2016-02-17
BR112015025489A2 (pt) 2017-10-10
EP2984105B1 (en) 2019-05-22
EP3425049A1 (en) 2019-01-09
WO2014169144A2 (en) 2014-10-16
JP2019162130A (ja) 2019-09-26
WO2014169144A3 (en) 2014-12-04
US10246694B2 (en) 2019-04-02
JP6530375B2 (ja) 2019-06-12
JP2016519577A (ja) 2016-07-07
US10988750B2 (en) 2021-04-27
ES2735331T3 (es) 2019-12-18
CN105555952A (zh) 2016-05-04
US20190367896A1 (en) 2019-12-05
US20160068831A1 (en) 2016-03-10
US11371035B2 (en) 2022-06-28
WO2014169144A8 (en) 2015-10-15
US20210139878A1 (en) 2021-05-13

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