SG11201507577RA - Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteins - Google Patents
Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteinsInfo
- Publication number
- SG11201507577RA SG11201507577RA SG11201507577RA SG11201507577RA SG11201507577RA SG 11201507577R A SG11201507577R A SG 11201507577RA SG 11201507577R A SG11201507577R A SG 11201507577RA SG 11201507577R A SG11201507577R A SG 11201507577RA SG 11201507577R A SG11201507577R A SG 11201507577RA
- Authority
- SG
- Singapore
- Prior art keywords
- galactose
- control
- acid content
- sialic acid
- manufacturing methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791094P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/021574 WO2014149935A1 (en) | 2013-03-15 | 2014-03-07 | Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201507577RA true SG11201507577RA (en) | 2015-10-29 |
Family
ID=51528780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507577RA SG11201507577RA (en) | 2013-03-15 | 2014-03-07 | Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteins |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20140273092A1 (pt) |
| EP (1) | EP2970980B2 (pt) |
| JP (1) | JP2016512029A (pt) |
| KR (1) | KR102216003B1 (pt) |
| CN (1) | CN105378086B (pt) |
| AR (2) | AR095660A1 (pt) |
| AU (2) | AU2014237635B2 (pt) |
| BR (1) | BR112015022971B1 (pt) |
| CA (1) | CA2907140A1 (pt) |
| CY (1) | CY1120980T1 (pt) |
| DK (1) | DK2970980T3 (pt) |
| EA (1) | EA201591807A1 (pt) |
| ES (1) | ES2690047T3 (pt) |
| HR (1) | HRP20181741T1 (pt) |
| IL (1) | IL240689B (pt) |
| LT (1) | LT2970980T (pt) |
| MX (1) | MX366910B (pt) |
| PH (1) | PH12015501837A1 (pt) |
| PL (1) | PL2970980T3 (pt) |
| PT (1) | PT2970980T (pt) |
| RS (1) | RS57791B1 (pt) |
| SG (1) | SG11201507577RA (pt) |
| SI (1) | SI2970980T1 (pt) |
| TW (1) | TWI630216B (pt) |
| WO (1) | WO2014149935A1 (pt) |
| ZA (1) | ZA201507671B (pt) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| SG11201507577RA (en) * | 2013-03-15 | 2015-10-29 | Janssen Biotech Inc | Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteins |
| CN105473614B (zh) | 2013-08-20 | 2019-11-01 | 斯洛文尼亚莱柯制药股份有限公司 | 用于控制多肽的α-酰胺化和/或C-末端氨基酸分裂的细胞培养基和方法 |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| KR20180069070A (ko) | 2015-11-03 | 2018-06-22 | 얀센 바이오테크 인코포레이티드 | Tim-3과 특이적으로 결합하는 항체 및 그의 용도 |
| WO2017083224A1 (en) * | 2015-11-09 | 2017-05-18 | Bristol-Myers Squibb Company | Methods to manipulate quality attributes of polypeptides produced in cho cells |
| BR112018012344A2 (pt) | 2015-12-17 | 2018-12-04 | Janssen Biotech Inc | anticorpos que se ligam especificamente a hla-dr e seus usos |
| CA3033661A1 (en) | 2016-08-12 | 2018-02-15 | Janssen Biotech, Inc. | Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions |
| KR102554331B1 (ko) | 2016-08-12 | 2023-07-10 | 얀센 바이오테크 인코포레이티드 | 향상된 효능적 활성을 갖는 Fc 조작된 항-TNFR 수퍼패밀리 구성원 항체 및 그의 사용 방법 |
| PE20200294A1 (es) | 2017-06-05 | 2020-02-05 | Janssen Biotech Inc | Anticuerpos que se unen especificamente a pd-1 y metodos de uso |
| CA3065171A1 (en) | 2017-06-05 | 2018-12-13 | Janssen Biotech, Inc. | Engineered multispecific antibodies and other multimeric proteins with asymmetrical ch2-ch3 region mutations |
| WO2019077628A1 (en) * | 2017-10-16 | 2019-04-25 | Council Of Scientific & Industrial Research | ZINC SUPPLEMENTATION TO DECREASE GALACTOSYLATION OF RECOMBINANT GLYCOPROTEINS |
| CN112703203A (zh) | 2018-05-24 | 2021-04-23 | 詹森生物科技公司 | 单特异性和多特异性抗-tmeff2抗体及其用途 |
| WO2020142275A1 (en) * | 2018-12-31 | 2020-07-09 | Momenta Pharmaceuticals, Inc. | Methods of producing ustekinumab |
| KR20220040483A (ko) | 2019-07-26 | 2022-03-30 | 얀센 바이오테크 인코포레이티드 | 칼리크레인 관련 펩티다제 2 항원 결합 도메인을 포함하는 단백질 및 이의 용도 |
| WO2021030657A1 (en) | 2019-08-15 | 2021-02-18 | Janssen Biotech, Inc. | Materials and methods for improved single chain variable fragments |
| EP4117715A1 (en) | 2020-03-13 | 2023-01-18 | Janssen Biotech, Inc. | Materials and methods for binding siglec-3/cd33 |
| EP4157459A1 (en) | 2020-05-27 | 2023-04-05 | Janssen Biotech, Inc. | Proteins comprising cd3 antigen binding domains and uses thereof |
| EP4188439A2 (en) | 2020-07-29 | 2023-06-07 | Janssen Biotech, Inc. | Proteins comprising hla-g antigen binding domains and their uses |
| EP4228693A1 (en) | 2020-10-13 | 2023-08-23 | Janssen Biotech, Inc. | Bioengineered t cell mediated immunity, materials and other methods for modulating cluster of differentiation iv &/or viii |
| TW202233672A (zh) | 2020-10-22 | 2022-09-01 | 美商健生生物科技公司 | 包括類δ配體３（ＤＬＬ３）抗原結合區之蛋白質及其用途 |
| KR20230137393A (ko) | 2021-01-28 | 2023-10-04 | 얀센 바이오테크 인코포레이티드 | Psma 결합 단백질 및 이의 용도 |
| WO2022201053A1 (en) | 2021-03-24 | 2022-09-29 | Janssen Biotech, Inc. | Proteins comprising cd3 antigen binding domains and uses thereof |
| AU2022244453A1 (en) | 2021-03-24 | 2023-11-09 | Janssen Biotech, Inc. | Antibody targeting cd22 and cd79b |
| CA3229822A1 (en) | 2021-09-13 | 2023-03-16 | Patrick John DOONAN | Cd33 x v?2 multispecific antibodies for the treatment of cancer |
| WO2023046322A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceutica Nv | Proteins comprising cd20 binding domains, and uses thereof |
| WO2023089587A1 (en) | 2021-11-22 | 2023-05-25 | Janssen Biotech, Inc. | Compositions comprising enhanced multispecific binding agents for an immune response |
| WO2024089551A1 (en) | 2022-10-25 | 2024-05-02 | Janssen Biotech, Inc. | Msln and cd3 binding agents and methods of use thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4870163A (en) | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
| DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
| EP0288088B1 (en) | 1987-04-24 | 1994-03-09 | Teijin Limited | Detection of tumor necrosis factor; monoclonal antibody and kit |
| WO1991002078A1 (en) | 1989-08-07 | 1991-02-21 | Peptide Technology Ltd | Tumour necrosis factor binding ligands |
| US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| US5919452A (en) | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| DK0610201T4 (da) | 1991-03-18 | 2008-02-04 | Centocor Inc | Monoklonale og kimære antistoffer, der er specifikke for human tumornekrosefaktor |
| FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| CA2450289A1 (en) | 2003-03-20 | 2005-05-19 | Imclone Systems Incorporated | Method of producing an antibody to epidermal growth factor receptor |
| US20040185047A1 (en) | 2003-03-21 | 2004-09-23 | Jill Giles-Komar | Anti- TNF antibodies, compositions, methods and uses |
| DE602005026548D1 (de) | 2004-11-02 | 2011-04-07 | Ares Trading Sa | Serumfreies kulturmedium für säugerzellen |
| WO2009126564A1 (en) * | 2008-04-07 | 2009-10-15 | Bayer Healthcare Llc | Methods of recombinant production of glycoproteins |
| PL2702164T3 (pl) * | 2011-04-29 | 2016-06-30 | Biocon Res Limited | Sposób obniżania heterogeniczności przeciwciał i sposób ich wytwarzania |
| US9475858B2 (en) | 2011-07-08 | 2016-10-25 | Momenta Pharmaceuticals, Inc. | Cell culture process |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| SG11201507577RA (en) * | 2013-03-15 | 2015-10-29 | Janssen Biotech Inc | Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteins |
-
2014
- 2014-03-07 SG SG11201507577RA patent/SG11201507577RA/en unknown
- 2014-03-07 ES ES14768761.0T patent/ES2690047T3/es active Active
- 2014-03-07 JP JP2016500790A patent/JP2016512029A/ja active Pending
- 2014-03-07 PL PL14768761T patent/PL2970980T3/pl unknown
- 2014-03-07 LT LTEP14768761.0T patent/LT2970980T/lt unknown
- 2014-03-07 MX MX2015012361A patent/MX366910B/es active IP Right Grant
- 2014-03-07 PT PT14768761T patent/PT2970980T/pt unknown
- 2014-03-07 EP EP14768761.0A patent/EP2970980B2/en active Active
- 2014-03-07 EA EA201591807A patent/EA201591807A1/ru unknown
- 2014-03-07 CN CN201480015815.5A patent/CN105378086B/zh not_active Expired - Fee Related
- 2014-03-07 WO PCT/US2014/021574 patent/WO2014149935A1/en active Application Filing
- 2014-03-07 BR BR112015022971-9A patent/BR112015022971B1/pt not_active IP Right Cessation
- 2014-03-07 RS RS20181228A patent/RS57791B1/sr unknown
- 2014-03-07 CA CA2907140A patent/CA2907140A1/en active Pending
- 2014-03-07 DK DK14768761.0T patent/DK2970980T3/en active
- 2014-03-07 AU AU2014237635A patent/AU2014237635B2/en not_active Ceased
- 2014-03-07 KR KR1020157029490A patent/KR102216003B1/ko active IP Right Grant
- 2014-03-07 SI SI201430848T patent/SI2970980T1/sl unknown
- 2014-03-13 TW TW103108900A patent/TWI630216B/zh not_active IP Right Cessation
- 2014-03-13 AR ARP140100976A patent/AR095660A1/es not_active Application Discontinuation
- 2014-03-13 US US14/207,915 patent/US20140273092A1/en not_active Abandoned
-
2015
- 2015-08-20 PH PH12015501837A patent/PH12015501837A1/en unknown
- 2015-08-20 IL IL240689A patent/IL240689B/en unknown
- 2015-10-14 ZA ZA2015/07671A patent/ZA201507671B/en unknown
- 2015-12-23 US US14/757,691 patent/US11149085B2/en active Active
-
2018
- 2018-10-23 HR HRP20181741TT patent/HRP20181741T1/hr unknown
- 2018-11-02 CY CY181101150T patent/CY1120980T1/el unknown
-
2020
- 2020-06-11 AU AU2020203864A patent/AU2020203864B2/en not_active Ceased
-
2021
- 2021-09-29 US US17/489,744 patent/US20220089712A1/en not_active Abandoned
-
2022
- 2022-02-14 AR ARP220100291A patent/AR124871A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20181741T1 (hr) | Postupci proizvodnje za kontrolu sadržaja c-terminalnog lizina, galaktoze i sijalinske kiseline u rekombiniranim proteinima | |
| WO2014151878A3 (en) | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides | |
| IL279676A (en) | Recombinant proteins and therapeutic uses | |
| HK1200489A1 (en) | Recombinant human naglu protein and uses thereof naglu | |
| SG11201505195TA (en) | Methods For Reducing Aggregate Content In Protein Preparations | |
| IN2014DN00161A (pt) | ||
| EP2947143A4 (en) | RECOMBINANT CELL, AND PROCESS FOR PRODUCING 1,4-BUTANEDIOL | |
| HK1220492A1 (zh) | 重組多肽生產 | |
| SG11201600682PA (en) | Expression vector for production of recombinant proteins in prokaryotic host cells | |
| HK1220991A1 (zh) | 用於增加的重組蛋白產生的製劑和方法 | |
| SG11201404180RA (en) | Cho-gmt recombinant protein expression | |
| EP3000890A4 (en) | Alphaviral vectors and cell lines for producing recombinant proteins | |
| GB201306114D0 (en) | Improvements in and relating to the production and control of ions | |
| GB201304973D0 (en) | Recombinant protein | |
| HK1221742A1 (zh) | 用於在原核細胞中重組生產多肽的方法 | |
| GB201308120D0 (en) | Recombinant protein and method for its production | |
| GB201320209D0 (en) | Improvements in or relating to protein Micro-nets | |
| GB201315578D0 (en) | Protein delivery to membranes |