SG11201506974XA - Methods for controlling t cell proliferation - Google Patents
Methods for controlling t cell proliferationInfo
- Publication number
- SG11201506974XA SG11201506974XA SG11201506974XA SG11201506974XA SG11201506974XA SG 11201506974X A SG11201506974X A SG 11201506974XA SG 11201506974X A SG11201506974X A SG 11201506974XA SG 11201506974X A SG11201506974X A SG 11201506974XA SG 11201506974X A SG11201506974X A SG 11201506974XA
- Authority
- SG
- Singapore
- Prior art keywords
- controlling
- methods
- cell proliferation
- proliferation
- cell
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/04—Amoebicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361783445P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/026734 WO2014151960A2 (fr) | 2013-03-14 | 2014-03-13 | Procédés de régulation de la prolifération cellulaire |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201506974XA true SG11201506974XA (en) | 2015-10-29 |
Family
ID=51569299
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201506974XA SG11201506974XA (en) | 2013-03-14 | 2014-03-13 | Methods for controlling t cell proliferation |
Country Status (10)
Country | Link |
---|---|
US (2) | US9944690B2 (fr) |
EP (1) | EP2968502B1 (fr) |
JP (3) | JP6541639B2 (fr) |
KR (1) | KR20150131218A (fr) |
CN (1) | CN105209065B (fr) |
AU (2) | AU2014236726A1 (fr) |
CA (1) | CA2905352A1 (fr) |
HK (1) | HK1217000A1 (fr) |
SG (1) | SG11201506974XA (fr) |
WO (1) | WO2014151960A2 (fr) |
Families Citing this family (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2543084T3 (es) | 2003-02-18 | 2015-08-14 | Baylor College Of Medicine | Activación inducida en células dendríticas |
EP2331680B1 (fr) | 2008-09-22 | 2017-05-03 | Baylor College Of Medicine | Procédés et compositions permettant la génération d'une réponse immunitaire par l'induction de cd40 et adaptateur de récepteurs de reconnaissance de motifs |
AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
JP6450690B2 (ja) | 2013-02-15 | 2019-01-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | キメラ抗原受容体及びその使用方法 |
JP6541639B2 (ja) | 2013-03-14 | 2019-07-10 | ベリカム ファーマシューティカルズ, インコーポレイテッド | T細胞増殖をコントロールするための方法 |
CA2907397C (fr) | 2013-03-15 | 2022-11-22 | Anthrogenesis Corporation | Lymphocytes t modifies |
CA2937750A1 (fr) | 2014-02-14 | 2015-08-20 | Bellicum Pharmaceuticals, Inc. | Methodes d'activation des lymphocytes t a l'aide d'un polypeptide chimere inductible |
KR20240042250A (ko) | 2014-04-07 | 2024-04-01 | 노파르티스 아게 | 항-cd19 키메라 항원 수용체를 사용한 암의 치료 |
EP3189148A4 (fr) * | 2014-09-02 | 2018-05-02 | Bellicum Pharmaceuticals, Inc. | Costimulation de récepteurs d'antigènes chimériques par des polypeptides dérivés de myd88 et cd40 |
JP6815992B2 (ja) | 2014-10-08 | 2021-01-20 | ノバルティス アーゲー | キメラ抗原受容体療法に対する治療応答性を予測するバイオマーカーおよびその使用 |
EP3215522B1 (fr) | 2014-11-03 | 2021-12-01 | Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum | Récepteurs de cellules t dirigées contre bob1 et leurs utilisations |
CA2966234A1 (fr) * | 2014-12-15 | 2016-06-23 | Bellicum Pharmaceuticals, Inc. | Procedes pour eliminer de maniere controlee des cellules therapeutiques |
AU2015362753A1 (en) * | 2014-12-15 | 2017-04-27 | Bellicum Pharmaceuticals, Inc. | Methods for controlled activation or elimination of therapeutic cells |
IL303247A (en) | 2014-12-29 | 2023-07-01 | Novartis Ag | Methods for preparing cells expressing a chimeric receptor antigen |
WO2016118857A1 (fr) * | 2015-01-23 | 2016-07-28 | Musc Foundation For Research Development | Gènes de récepteurs de cytokines et leur utilisation pour améliorer un traitement |
CN107683289B (zh) | 2015-01-26 | 2021-08-06 | 芝加哥大学 | IL13Rα2结合剂和其在癌症治疗中的用途 |
WO2016123143A1 (fr) * | 2015-01-26 | 2016-08-04 | The University Of Chicago | Lymphocytes t à récepteur d'antigène chimérique (car) reconnaissant le récepteur il 13rα2 spécifique au cancer |
EP3250606B1 (fr) | 2015-01-26 | 2020-11-25 | Cellectis | Recepteurs d'antigenes chimeriques monocatenaires specifiques anti-cll1 (sccar) pour une immunotherapie anticancereuse |
CN108064283B (zh) | 2015-02-24 | 2024-01-09 | 加利福尼亚大学董事会 | 结合触发的转录开关及其使用方法 |
WO2016149254A1 (fr) | 2015-03-17 | 2016-09-22 | Chimera Bioengineering, Inc. | Dispositifs smart-car, polypeptides de-car, side-car et leurs utilisations |
MX2017012939A (es) | 2015-04-08 | 2018-05-22 | Novartis Ag | Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19. |
US11896614B2 (en) | 2015-04-17 | 2024-02-13 | Novartis Ag | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
WO2017015427A1 (fr) | 2015-07-21 | 2017-01-26 | Novartis Ag | Méthodes pour améliorer l'efficacité et l'expansion de cellules immunitaires |
GB201513540D0 (en) | 2015-07-31 | 2015-09-16 | King S College London | Therapeutic agents |
EP3340995A4 (fr) | 2015-08-28 | 2019-04-03 | The Trustees Of The University Of Pennsylvania | Procédés et compositions pour des cellules exprimant une molécule de signalisation intracellulaire chimérique |
EP3340998B1 (fr) * | 2015-08-28 | 2023-01-11 | The Trustees of the University of Pennsylvania | Procédés et compositions pour cellules exprimant une molécule de signalisation intracellulaire chimérique |
JP6905163B2 (ja) | 2015-09-03 | 2021-07-21 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | サイトカイン放出症候群を予測するバイオマーカー |
EP3356524B1 (fr) * | 2015-09-30 | 2021-08-18 | Vycellix, Inc. | Administration améliorée de gènes dans des cellules tueuses naturelles, des cellules souches hématopoïétiques et des macrophages |
US10954500B2 (en) | 2015-10-23 | 2021-03-23 | Fred Hutchinson Cancer Research Center | Methods to create chemically-induced dimerizing protein systems for regulation of cellular events |
MA44314A (fr) * | 2015-11-05 | 2018-09-12 | Juno Therapeutics Inc | Récepteurs chimériques contenant des domaines induisant traf, et compositions et méthodes associées |
US11052111B2 (en) | 2015-12-08 | 2021-07-06 | Chimera Bioengineering, Inc. | Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses |
EP3390434A2 (fr) * | 2015-12-14 | 2018-10-24 | Bellicum Pharmaceuticals, Inc. | Doubles commandes pour l'activation ou l'élimination de cellules thérapeutiques |
SG11201804038VA (en) | 2016-01-08 | 2018-06-28 | Univ California | Conditionally active heterodimeric polypeptides and methods of use thereof |
US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
US11325948B2 (en) | 2016-03-19 | 2022-05-10 | Exuma Biotech Corp. | Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL |
CA3177398A1 (fr) | 2016-04-01 | 2017-10-05 | Kite Pharma, Inc. | Recepteurs chimeriques et leurs procedes d'utilisation |
AU2017240150C1 (en) | 2016-04-01 | 2022-10-27 | Kite Pharma, Inc. | BCMA binding molecules and methods of use thereof |
KR102584280B1 (ko) | 2016-04-01 | 2023-10-04 | 카이트 파마 인코포레이티드 | 키메라 항원 및 t 세포 수용체 및 사용 방법 |
MY201207A (en) | 2016-04-01 | 2024-02-09 | Amgen Inc | Chimeric receptors to flt3 and methods of use thereof |
US10222369B2 (en) | 2016-05-17 | 2019-03-05 | Chimera Bioengineering, Inc. | Methods for making novel antigen binding domains |
US20210177896A1 (en) | 2016-06-02 | 2021-06-17 | Novartis Ag | Therapeutic regimens for chimeric antigen receptor (car)- expressing cells |
EP3858365B1 (fr) | 2016-09-01 | 2024-01-31 | Chimera Bioengineering Inc. | Lymphocytes t car optimisés avec de l'or |
CN117866991A (zh) | 2016-10-07 | 2024-04-12 | 诺华股份有限公司 | 用于治疗癌症的嵌合抗原受体 |
US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
WO2018160622A1 (fr) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions et méthodes de thérapie par lymphocytes t car |
JOP20180027A1 (ar) * | 2017-03-28 | 2019-01-30 | Cell Design Labs Inc | بوليبيبتيدات مخلطة و طرق لتغيير موضع الغشاء فيها |
DK3391914T3 (da) * | 2017-04-21 | 2021-10-18 | Safe Implant Tech Aps | Guldpartikler til anvendelse i terapi til at forebygge eller mindske kapselkontraktur |
JOP20180042A1 (ar) | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
EP3621988A1 (fr) * | 2017-05-09 | 2020-03-18 | Bellicum Pharmaceuticals, Inc. | Procédés pour augmenter ou modifier la transduction de signal |
WO2018213848A1 (fr) | 2017-05-19 | 2018-11-22 | The Regents Of The University Of California | Dimériseur induit chimiquement par un anticorps (abcid) à titre de commutateurs moléculaires pour la régulation des thérapies cellulaires |
TWI731268B (zh) * | 2017-09-29 | 2021-06-21 | 財團法人國家衛生研究院 | 可增強抗腫瘤與抗病毒t細胞存活與其功能性之方法與組合物 |
KR20200069358A (ko) | 2017-10-25 | 2020-06-16 | 노파르티스 아게 | 키메라 항원 수용체 발현 세포의 제조 방법 |
US11390655B2 (en) | 2017-11-16 | 2022-07-19 | Kite Pharma, Inc. | Modified chimeric antigen receptors and methods of use |
US20200347148A1 (en) | 2017-12-08 | 2020-11-05 | Bellicum Pharmaceuticals, Inc. | Methods for enhancing and maintaining car-t cell efficacy |
US20200308144A1 (en) | 2017-12-20 | 2020-10-01 | Bellicum Pharmaceuticals, Inc. | Multimeric piperidine derivatives |
EP3684399A1 (fr) | 2017-12-29 | 2020-07-29 | Cellectis | Procédé d'amélioration de la production de lymphocytes t car |
CN112292138A (zh) | 2018-01-22 | 2021-01-29 | 西雅图儿童医院(Dba西雅图儿童研究所) | Car t细胞的使用方法 |
US11110125B2 (en) | 2018-02-13 | 2021-09-07 | Chimera Bioengineering, Inc. | Coordinating gene expression using RNA destabilizing elements |
WO2019200007A1 (fr) | 2018-04-10 | 2019-10-17 | Amgen Inc. | Récepteurs chimères pour dll3 et leurs procédés d'utilisation |
WO2019213282A1 (fr) | 2018-05-01 | 2019-11-07 | Novartis Ag | Biomarqueurs pour évaluer des cellules car-t pour prédire un résultat clinique |
EP3801769A1 (fr) | 2018-05-25 | 2021-04-14 | Novartis AG | Polythérapie comprenant des thérapies par récepteur antigénique chimérique (car) |
CN112771080A (zh) | 2018-07-18 | 2021-05-07 | 美国安进公司 | 针对steap1的嵌合受体及其使用方法 |
BR112021002390A2 (pt) | 2018-08-09 | 2021-05-11 | Juno Therapeutics Inc | processos para gerar células modificadas e suas composições |
EP3844265A2 (fr) | 2018-08-31 | 2021-07-07 | Novartis AG | Procédés de fabrication de cellules exprimant un récepteur d'antigène chimère |
WO2020047452A2 (fr) | 2018-08-31 | 2020-03-05 | Novartis Ag | Procédés de fabrication de cellules exprimant un récepteur d'antigène chimère |
WO2020069405A1 (fr) | 2018-09-28 | 2020-04-02 | Novartis Ag | Thérapies par récepteur antigénique chimérique (car) de cd22 |
US20210347851A1 (en) | 2018-09-28 | 2021-11-11 | Novartis Ag | Cd19 chimeric antigen receptor (car) and cd22 car combination therapies |
WO2020123691A2 (fr) | 2018-12-12 | 2020-06-18 | Kite Pharma, Inc | Récepteurs antigéniques chimériques et récepteurs de lymphocytes t et méthodes d'utilisation |
US11673953B2 (en) | 2019-03-01 | 2023-06-13 | Allogene Therapeutics, Inc. | DLL3 targeting chimeric antigen receptors and binding agents |
EP3931208A1 (fr) | 2019-03-01 | 2022-01-05 | Allogene Therapeutics, Inc. | Récepteurs de cytokine chimériques portant un ectodomaine de pd-1 |
WO2020210678A1 (fr) | 2019-04-12 | 2020-10-15 | Novartis Ag | Procédés de fabrication de cellules exprimant un récepteur antigénique chimérique |
FI3959235T3 (fi) | 2019-04-26 | 2023-09-27 | Allogene Therapeutics Inc | Rituksimabiresistenttejä kimeerisiä antigeenireseptoreja ja niiden käyttö |
WO2020219812A1 (fr) | 2019-04-26 | 2020-10-29 | Allogene Therapeutics, Inc. | Procédés de fabrication de cellules car-t allogéniques |
KR20220016475A (ko) | 2019-05-01 | 2022-02-09 | 주노 쎄러퓨티크스 인코퍼레이티드 | 변형된 tgfbr2 유전자 좌에서 재조합 수용체를 발현하는 세포, 관련 폴리뉴클레오티드 및 방법 |
WO2020223571A1 (fr) | 2019-05-01 | 2020-11-05 | Juno Therapeutics, Inc. | Cellules exprimant un récepteur chimérique à partir d'un locus cd247 modifié, polynucléotides et procédés associés |
JP2019170393A (ja) * | 2019-06-19 | 2019-10-10 | 国立大学法人九州大学 | iPS細胞の作製方法 |
AU2020334884A1 (en) | 2019-08-18 | 2022-02-17 | Chimera Bioengineering, Inc. | Combination therapy with gold controlled transgenes |
WO2021163618A1 (fr) | 2020-02-14 | 2021-08-19 | Novartis Ag | Procédé de prédiction de réponse à une thérapie de récepteur antigénique chimérique |
KR20220146530A (ko) | 2020-02-27 | 2022-11-01 | 노파르티스 아게 | 키메라 항원 수용체-발현 세포의 제조 방법 |
JP2023531531A (ja) | 2020-06-26 | 2023-07-24 | ジュノ セラピューティクス ゲーエムベーハー | 組換え受容体を条件付きで発現する操作されたt細胞、関連ポリヌクレオチド、および方法 |
EP4175650A1 (fr) | 2020-07-06 | 2023-05-10 | Kiromic BioPharma, Inc. | Molécules de liaison à l'isoforme de mésothéline et molécules de récepteur pd1 chimériques, cellules les contenant et leurs utilisations |
WO2022104061A1 (fr) | 2020-11-13 | 2022-05-19 | Novartis Ag | Polythérapies avec des cellules exprimant un récepteur antigénique chimérique (car) |
WO2022108627A1 (fr) | 2020-11-18 | 2022-05-27 | Kiromic Biopharma, Inc.Kiromic Biopharma, Inc. | Procédés de fabrication de lymphocytes t gamma-delta et molécules de récepteurs pd1 chimériques |
US20220227832A1 (en) | 2020-12-21 | 2022-07-21 | Allogene Therapeutics, Inc. | Protease-activating cd45-gate car |
US11945876B2 (en) | 2021-06-16 | 2024-04-02 | Instil Bio (Uk) Limited | Receptors providing targeted costimulation for adoptive cell therapy |
EP4370213A1 (fr) | 2021-07-16 | 2024-05-22 | Instil Bio (Uk) Limited | Molécules chimériques fournissant une co-stimulation ciblée pour une thérapie cellulaire adoptive |
US20230060292A1 (en) | 2021-07-26 | 2023-03-02 | Kite Pharma, Inc. | Split chimeric antigen receptors and methods of use |
CN114410689B (zh) * | 2022-03-29 | 2022-06-17 | 北京循生生物医学研究有限公司 | 一种增强肿瘤浸润淋巴细胞杀伤力的制备方法 |
WO2024056809A1 (fr) | 2022-09-15 | 2024-03-21 | Novartis Ag | Traitement de troubles auto-immuns à l'aide d'une thérapie par récepteur antigénique chimérique |
Family Cites Families (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4514506A (en) | 1982-02-23 | 1985-04-30 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Method for the identification and purification of human lung tumor-associated antigens (hLTAA) and clinical detection and determination of these antigens |
EP0273085A1 (fr) | 1986-12-29 | 1988-07-06 | IntraCel Corporation | Procédé pour faire entrer des acides nucléiques dans des cellules eucaryotes |
FR2610631B1 (fr) | 1987-02-09 | 1989-11-24 | Pasteur Institut | Molecules comportant au moins une sequence peptidique porteuse d'un ou plusieurs, epitope caracteristique d'une proteine produite par p. falciparum dans les hepatocytes, et leurs utilisations, notamment pour le diagnostic du paludisme ou dans des compositions de vaccins contre le paludisme |
US5869608A (en) | 1989-03-17 | 1999-02-09 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and amino acid sequences of the four variable domains of the major outer membrane proteins of Chlamydia trachomatis |
US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
GB9105383D0 (en) | 1991-03-14 | 1991-05-01 | Immunology Ltd | An immunotherapeutic for cervical cancer |
DE69233441T2 (de) | 1991-04-26 | 2005-10-13 | Osaka Bioscience Institute, Suita | Menschliches Zelloberflächen-Antigen codierende DNA |
US5780036A (en) | 1991-08-26 | 1998-07-14 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepattis B virus |
US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
DE4228457A1 (de) | 1992-08-27 | 1994-04-28 | Beiersdorf Ag | Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen |
GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
US5830462A (en) | 1993-02-12 | 1998-11-03 | President & Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
US5869337A (en) | 1993-02-12 | 1999-02-09 | President And Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
EP1978095A1 (fr) | 1993-02-12 | 2008-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Transcription régulée de gènes ciblés et autres évènements biologiques |
US5834266A (en) | 1993-02-12 | 1998-11-10 | President & Fellows Of Harvard College | Regulated apoptosis |
US5426027A (en) | 1993-05-20 | 1995-06-20 | The Government Of The United States Of America As Represented By The Secretary | Nucleic acid probes and methods for detecting Candida DNA cells in blood |
US5648226A (en) | 1993-07-22 | 1997-07-15 | Ludwig Institute For Cancer Research | Isolated peptides derived from tumor rejection antigens, and their use |
NZ271774A (en) | 1993-08-06 | 1998-02-26 | Cytel Corp | Immunogenic peptides from the c-terminus of the mage-1 (melanoma) antigen |
US5550214A (en) | 1994-02-10 | 1996-08-27 | Brigham And Women's Hospital | Isolated antigenic oncogene peptide fragments and uses |
US5709995A (en) | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
FR2722208B1 (fr) | 1994-07-05 | 1996-10-04 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique |
AU3968595A (en) | 1994-10-25 | 1996-05-15 | Board Of Trustees Of The Leland Stanford Junior University | Conditional transformation of genetically engineered cells |
US5741899A (en) | 1995-02-02 | 1998-04-21 | Cell Genesys, Inc. | Chimeric receptors comprising janus kinase for regulating cellular pro liferation |
US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
WO1998001538A1 (fr) | 1996-07-10 | 1998-01-15 | Immunex Corporation | Procede d'activation de cellules dendritiques |
US5955596A (en) | 1996-07-26 | 1999-09-21 | American Cyanamid Company | NucA protein of Haemophilus influenzae and the gene encoding that protein |
US6046158A (en) | 1996-12-20 | 2000-04-04 | Board Of Regents The University Of Texas Systems | Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof |
US5965242A (en) | 1997-02-19 | 1999-10-12 | Eastman Kodak Company | Glow-in-the-dark medium and method of making |
US6969609B1 (en) | 1998-12-09 | 2005-11-29 | The United States Of America As Represented By The Department Of Health And Human Serivces | Recombinant vector expressing multiple costimulatory molecules and uses thereof |
US6558951B1 (en) | 1999-02-11 | 2003-05-06 | 3M Innovative Properties Company | Maturation of dendritic cells with immune response modifying compounds |
GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
US20030108527A1 (en) | 1999-12-28 | 2003-06-12 | Tsukasa Seya | Maturation-promoting agent for immature dendrtic cells |
US7435585B2 (en) | 2000-01-03 | 2008-10-14 | University Of Pennsylvania | Auto-stimulating cells and methods for making and using the same |
SE0001642D0 (sv) | 2000-05-04 | 2000-05-04 | Sahltech Ab | Reagent for detection of biomolecules, and use thereof |
US20030232055A1 (en) | 2000-07-31 | 2003-12-18 | Ruslan Medzhitov | Innate immune system-directed vaccines |
AU2001281252A1 (en) | 2000-08-10 | 2002-02-18 | Board Of Regents, The University Of Texas System | The tumor suppressor car-1 |
US7666424B2 (en) * | 2001-10-17 | 2010-02-23 | Sloan-Kettering Institute For Cancer Research | Methods of preparing and using single chain anti-tumor antibodies |
WO2002036769A2 (fr) | 2000-10-31 | 2002-05-10 | F. Hoffmann-La Roche Ag | Acides nucleiques codant des polypeptides chimeriques cd40/cd40l, procedes de production et utilisations de ces acides nucleiques |
US6965023B2 (en) | 2000-11-17 | 2005-11-15 | The Burnham Institute | Death domain proteins |
AU2002354560A1 (en) | 2001-07-09 | 2003-01-29 | Oklahoma Medical Research Foundation | Targeted fusion proteins and methods for the characterization of cellular membrane domains |
US20040116333A1 (en) | 2001-08-03 | 2004-06-17 | Rong-Hwa Lin | Modulators of P-selectin glycoprotein ligand 1 |
JP4360906B2 (ja) | 2001-09-14 | 2009-11-11 | サイトス バイオテクノロジー アーゲー | ウィルス様粒子によって誘導される免疫応答を高めるための、抗原提示細胞のインビボでの活性化 |
US20050215472A1 (en) | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
US20030082163A1 (en) | 2001-10-26 | 2003-05-01 | Suyu Shu | Fused cells, methods of forming same, and therapies utilizing same |
GB0225279D0 (en) | 2002-10-30 | 2002-12-11 | Celltech R&D Ltd | Biological products |
ES2543084T3 (es) | 2003-02-18 | 2015-08-14 | Baylor College Of Medicine | Activación inducida en células dendríticas |
US20050113564A1 (en) * | 2003-11-05 | 2005-05-26 | St. Jude Children's Research Hospital | Chimeric receptors with 4-1BB stimulatory signaling domain |
WO2007050095A2 (fr) | 2004-11-19 | 2007-05-03 | The Trustees Of The University Of Pennsylvania | Vaccins améliorés et leurs procédés d'utilisation |
US8088908B2 (en) | 2005-05-10 | 2012-01-03 | City Of Hope | Humanized anti-prostate stem cell antigen monoclonal antibody |
KR100705981B1 (ko) | 2005-10-12 | 2007-04-10 | 주식회사 리제론 | 인간 성장호르몬을 포함하는 탈모방지 또는 발모촉진용조성물 |
US20100196336A1 (en) | 2006-05-23 | 2010-08-05 | Dongsu Park | Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods |
WO2008045437A2 (fr) * | 2006-10-09 | 2008-04-17 | The General Hospital Corporation | RÉCEPTEURS CHIMÉRIQUES DES CELLULES T ET CELLULES T CIBLANT LE EGFRvIII SUR DES TUMEURS |
CA2666667C (fr) * | 2006-10-19 | 2023-06-20 | Baylor College Of Medicine | Generation d'une reponse immunitaire par l'induction de recepteurs de cd40 et de reconnaissance de formes |
EP2224954B1 (fr) | 2007-11-07 | 2014-01-08 | Celldex Therapeutics, Inc. | Anticorps qui se lient à la cellule dendritique et épithéliale 205 (dec-205) humaine |
CA2717538A1 (fr) | 2008-03-03 | 2009-09-11 | Dyax Corp. | Proteines de liaison a metalloproteinase 12 |
ES2961498T3 (es) * | 2008-08-26 | 2024-03-12 | Hope City | Método y composiciones para el funcionamiento mejorado del efecto antitumoral de las células T |
EP2331680B1 (fr) | 2008-09-22 | 2017-05-03 | Baylor College Of Medicine | Procédés et compositions permettant la génération d'une réponse immunitaire par l'induction de cd40 et adaptateur de récepteurs de reconnaissance de motifs |
WO2011130566A2 (fr) * | 2010-04-16 | 2011-10-20 | Bellicum Pharmaceuticals, Inc. | Méthode de traitement de tumeurs solides |
US9089520B2 (en) | 2010-05-21 | 2015-07-28 | Baylor College Of Medicine | Methods for inducing selective apoptosis |
BR122021026169B1 (pt) | 2010-12-09 | 2023-12-12 | The Trustees Of The University Of Pennsylvania | Uso de uma célula |
ES2791716T3 (es) * | 2010-12-14 | 2020-11-05 | Univ Maryland | Células T que expresan al receptor de antígeno quimérico antietiqueta universal y métodos para el tratamiento del cáncer |
WO2012127464A2 (fr) | 2011-03-23 | 2012-09-27 | Gavish-Galilee Bio Applications Ltd | Lymphocytes t constitutivement activés pour l'utilisation dans une thérapie cellulaire adoptive |
US20130071414A1 (en) * | 2011-04-27 | 2013-03-21 | Gianpietro Dotti | Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies |
ES2795023T3 (es) * | 2011-09-16 | 2020-11-20 | Baylor College Medicine | Reconocimiento específico del microambiente tumoral mediante el uso de células NKT manipuladas |
ES2861435T3 (es) * | 2011-11-03 | 2021-10-06 | Univ Pennsylvania | Composiciones específicas de B7-H4 aisladas y métodos de uso de las mismas |
US8945876B2 (en) | 2011-11-23 | 2015-02-03 | University Of Hawaii | Auto-processing domains for polypeptide expression |
WO2013126720A2 (fr) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Compositions et procédés pour évaluer la résistance d'une cellule cancéreuse cible à la destruction par des lymphocytes t modifiés par car |
EP3689383A1 (fr) | 2012-04-11 | 2020-08-05 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Récepteurs antigéniques chimériques ciblant un antigène de maturation des lymphocytes b |
US20130280220A1 (en) * | 2012-04-20 | 2013-10-24 | Nabil Ahmed | Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes |
CN107746852B (zh) | 2012-05-04 | 2021-10-08 | 辉瑞公司 | 前列腺相关抗原及基于疫苗的免疫治疗疗法 |
WO2013176916A1 (fr) * | 2012-05-25 | 2013-11-28 | Roman Galetto | Utilisation de pré-t alpha ou d'un variant fonctionnel de celui-ci pour expanser des lymphocytes t déficients en tcr-alpha |
HUE050797T2 (hu) * | 2012-10-10 | 2021-01-28 | Sangamo Therapeutics Inc | T-sejt módosító vegyületek és alkalmazásaik |
JP6450690B2 (ja) | 2013-02-15 | 2019-01-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | キメラ抗原受容体及びその使用方法 |
US9434935B2 (en) | 2013-03-10 | 2016-09-06 | Bellicum Pharmaceuticals, Inc. | Modified caspase polypeptides and uses thereof |
JP6541639B2 (ja) | 2013-03-14 | 2019-07-10 | ベリカム ファーマシューティカルズ, インコーポレイテッド | T細胞増殖をコントロールするための方法 |
ES2791598T3 (es) | 2013-06-05 | 2020-11-05 | Bellicum Pharmaceuticals Inc | Métodos para inducir apoptosis parcial utilizando polipéptidos de caspasa |
US10144770B2 (en) | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
CA2937750A1 (fr) | 2014-02-14 | 2015-08-20 | Bellicum Pharmaceuticals, Inc. | Methodes d'activation des lymphocytes t a l'aide d'un polypeptide chimere inductible |
EP3114217A4 (fr) | 2014-03-07 | 2017-09-20 | Bellicum Pharmaceuticals, Inc. | Polypeptides de type caspase à activité modifiée et leurs utilisations |
EP3189148A4 (fr) | 2014-09-02 | 2018-05-02 | Bellicum Pharmaceuticals, Inc. | Costimulation de récepteurs d'antigènes chimériques par des polypeptides dérivés de myd88 et cd40 |
-
2014
- 2014-03-13 JP JP2016502228A patent/JP6541639B2/ja active Active
- 2014-03-13 CN CN201480028439.3A patent/CN105209065B/zh active Active
- 2014-03-13 SG SG11201506974XA patent/SG11201506974XA/en unknown
- 2014-03-13 US US14/210,034 patent/US9944690B2/en active Active
- 2014-03-13 EP EP14770399.5A patent/EP2968502B1/fr active Active
- 2014-03-13 AU AU2014236726A patent/AU2014236726A1/en not_active Abandoned
- 2014-03-13 KR KR1020157028844A patent/KR20150131218A/ko not_active Application Discontinuation
- 2014-03-13 WO PCT/US2014/026734 patent/WO2014151960A2/fr active Application Filing
- 2014-03-13 CA CA2905352A patent/CA2905352A1/fr not_active Abandoned
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2016
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- 2018-05-31 JP JP2018105044A patent/JP2018145194A/ja not_active Withdrawn
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2019
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- 2019-12-13 JP JP2019225565A patent/JP2020055863A/ja not_active Withdrawn
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JP2016519068A (ja) | 2016-06-30 |
JP6541639B2 (ja) | 2019-07-10 |
US9944690B2 (en) | 2018-04-17 |
WO2014151960A2 (fr) | 2014-09-25 |
JP2020055863A (ja) | 2020-04-09 |
CN105209065B (zh) | 2020-07-31 |
US20140286987A1 (en) | 2014-09-25 |
KR20150131218A (ko) | 2015-11-24 |
WO2014151960A3 (fr) | 2015-02-05 |
CN105209065A (zh) | 2015-12-30 |
CA2905352A1 (fr) | 2014-09-25 |
AU2014236726A1 (en) | 2015-09-17 |
JP2018145194A (ja) | 2018-09-20 |
AU2019201586A1 (en) | 2019-03-28 |
HK1217000A1 (zh) | 2016-12-16 |
EP2968502A4 (fr) | 2016-10-19 |
US20180265566A1 (en) | 2018-09-20 |
EP2968502A2 (fr) | 2016-01-20 |
EP2968502B1 (fr) | 2020-08-26 |
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