SG11201505875WA - Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (akr1 c3) - Google Patents
Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (akr1 c3)Info
- Publication number
- SG11201505875WA SG11201505875WA SG11201505875WA SG11201505875WA SG11201505875WA SG 11201505875W A SG11201505875W A SG 11201505875WA SG 11201505875W A SG11201505875W A SG 11201505875WA SG 11201505875W A SG11201505875W A SG 11201505875WA SG 11201505875W A SG11201505875W A SG 11201505875WA
- Authority
- SG
- Singapore
- Prior art keywords
- akr1
- estra
- tetraene
- carboxamides
- inhibition
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13156125 | 2013-02-21 | ||
PCT/EP2014/053094 WO2014128108A1 (de) | 2013-02-21 | 2014-02-18 | Estra-1,3,5(10),16-tetraen-3-carboxamide zur inhibierung von 17.beta.-hydroxysteroid dehdrogenase (akr1 c3) |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201505875WA true SG11201505875WA (en) | 2015-09-29 |
Family
ID=47748503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201505875WA SG11201505875WA (en) | 2013-02-21 | 2014-02-18 | Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (akr1 c3) |
Country Status (28)
Country | Link |
---|---|
US (1) | US9714266B2 (ko) |
EP (1) | EP2958928B1 (ko) |
JP (1) | JP6254195B2 (ko) |
KR (1) | KR20150118153A (ko) |
CN (1) | CN105008382B (ko) |
AP (1) | AP3826A (ko) |
AR (1) | AR094852A1 (ko) |
AU (1) | AU2014220800A1 (ko) |
BR (1) | BR112015018071A2 (ko) |
CA (1) | CA2901632C (ko) |
CL (1) | CL2015002346A1 (ko) |
CR (1) | CR20150432A (ko) |
CU (1) | CU20150091A7 (ko) |
EA (1) | EA201500851A1 (ko) |
ES (1) | ES2678993T3 (ko) |
GT (1) | GT201500235A (ko) |
HK (1) | HK1211592A1 (ko) |
IL (1) | IL240191A0 (ko) |
MA (1) | MA38349A1 (ko) |
MX (1) | MX2015010876A (ko) |
NI (1) | NI201500115A (ko) |
PE (1) | PE20151754A1 (ko) |
PH (1) | PH12015501819A1 (ko) |
SG (1) | SG11201505875WA (ko) |
TN (1) | TN2015000362A1 (ko) |
TW (1) | TWI523862B (ko) |
UY (1) | UY35344A (ko) |
WO (1) | WO2014128108A1 (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106687471B (zh) * | 2014-09-11 | 2018-10-30 | 拜耳医药股份公司 | 3-氮或者硫取代的雌甾-1,3,5(10),16-四烯akr1c3抑制剂 |
EP3401677A4 (en) * | 2016-01-05 | 2019-06-12 | Hamamatsu Photonics K.K. | LIVING BODY OBSERVATION PROCEDURE LIVING BODY OBSERVATION DEVICE |
US10167293B2 (en) | 2016-05-26 | 2019-01-01 | Bayer Pharma Aktiengesellschaft | [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones |
CZ307437B6 (cs) | 2016-06-07 | 2018-08-22 | Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. | 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz |
EP3269373A1 (en) | 2016-07-11 | 2018-01-17 | Bayer Pharma Aktiengesellschaft | Low-dosed oral dosage form of an akr1c3 inhibitor for treatment of diseases |
TW201825478A (zh) | 2016-12-19 | 2018-07-16 | 德商拜耳製藥公司 | [4-(苯基磺醯基)哌嗪-1--基](1h-1,2,3-三唑-4-基)甲酮 |
CA3047191A1 (en) | 2016-12-19 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | [4-(phenylsulfonyl)piperazin-1-yl](1h-1,2,3-triazol-4-yl)methanones |
WO2018114677A2 (en) | 2016-12-19 | 2018-06-28 | Bayer Pharma Aktiengesellschaft | [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones |
EP3421483A1 (en) | 2017-06-29 | 2019-01-02 | Bayer Pharma Aktiengesellschaft | Novel steroidal 17-beta heteroaryl compounds as inhibitors of akr1c3 |
CN108159056A (zh) * | 2018-02-09 | 2018-06-15 | 上海礼璞生物医药科技有限公司 | 孕激素在制备组蛋白去乙酰化酶抑制剂和气道周围胶原沉积抑制剂药物中的应用及抑制剂 |
CN110693892A (zh) * | 2018-07-09 | 2020-01-17 | 深圳艾欣达伟医药科技有限公司 | 化合物用于制备预防、治疗或改善疼痛的药物的用途 |
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US5604213A (en) | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
IL122740A (en) | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
DK0973790T3 (da) | 1997-04-07 | 2003-09-22 | Wyeth Corp | Estra-5(10),7-diener med østrogen aktivitet |
BR9908592A (pt) * | 1998-03-11 | 2001-04-24 | Endorech Inc | Processo para inibir a atividade de 17ß-hidroxiesteróide desidrogenase tipo 5, composição farmacêutica, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 5, processo para inibir 17ß-hidroxiesteróide desidrogenase tipo 3, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 3, processos para tratar, ou reduzir o risco de desenvolver, câncer da próstata, hiperplasia prostática benigna, acne, seborréia, hirsutismo ou alopécia androgênica, sìndrome de ovário policìstico, câncer de mama, endometriose ou leiomioma, para inibir as secreções hormonais testiculares, para tratar puberdade precoce, e, kit |
CN1322130A (zh) | 1998-08-07 | 2001-11-14 | 恩多研究公司 | 抑制3型3α-羟基类固醇脱氢酶 |
WO2005089256A2 (en) | 2004-03-12 | 2005-09-29 | Entremed, Inc. | Antiangiogenic agents |
JP5093096B2 (ja) | 2006-03-02 | 2012-12-05 | アステラス製薬株式会社 | 17βHSDtype5阻害剤 |
CA2671075A1 (en) | 2006-11-30 | 2008-06-05 | Solvay Pharmaceuticals Gmbh | Substituted estratrien derivatives as 17beta hsd inhibitors |
KR20090082502A (ko) | 2006-12-22 | 2009-07-30 | 에프. 호프만-라 로슈 아게 | 스피로-피페리딘 유도체 |
EP2172454A4 (en) | 2007-07-24 | 2010-12-08 | Astellas Pharma Inc | benzimidazole derivative |
WO2009120565A2 (en) | 2008-03-25 | 2009-10-01 | University Of Maryland, Baltimore | Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity |
AU2010210422A1 (en) | 2009-02-05 | 2011-08-18 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens |
AU2010295646B2 (en) | 2009-09-15 | 2016-02-11 | Ellipses Pharma Limited | Treatment of cancer |
CN104302958B (zh) | 2011-07-08 | 2017-04-05 | Fmc技术股份有限公司 | 具有多个铰接臂组件的管汇拖车 |
DE102011083725A1 (de) | 2011-09-29 | 2013-04-04 | Bayer Pharma AG | Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
PE20150353A1 (es) | 2012-07-10 | 2015-03-28 | Bayer Pharma AG | Derivados de estra-1,3,5(10),16-tetraeno 3-sustituidos, metodos para su preparacion, preparaciones farmaceuticas que los contienen, asi como su uso para la preparacion de medicamentos |
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2014
- 2014-02-18 KR KR1020157022300A patent/KR20150118153A/ko not_active Application Discontinuation
- 2014-02-18 MA MA38349A patent/MA38349A1/fr unknown
- 2014-02-18 MX MX2015010876A patent/MX2015010876A/es unknown
- 2014-02-18 SG SG11201505875WA patent/SG11201505875WA/en unknown
- 2014-02-18 US US14/770,444 patent/US9714266B2/en not_active Expired - Fee Related
- 2014-02-18 WO PCT/EP2014/053094 patent/WO2014128108A1/de active Application Filing
- 2014-02-18 PE PE2015001794A patent/PE20151754A1/es not_active Application Discontinuation
- 2014-02-18 JP JP2015558418A patent/JP6254195B2/ja not_active Expired - Fee Related
- 2014-02-18 ES ES14704817.7T patent/ES2678993T3/es active Active
- 2014-02-18 AP AP2015008658A patent/AP3826A/en active
- 2014-02-18 BR BR112015018071A patent/BR112015018071A2/pt not_active IP Right Cessation
- 2014-02-18 EA EA201500851A patent/EA201500851A1/ru unknown
- 2014-02-18 AU AU2014220800A patent/AU2014220800A1/en not_active Abandoned
- 2014-02-18 CA CA2901632A patent/CA2901632C/en not_active Expired - Fee Related
- 2014-02-18 CN CN201480009874.1A patent/CN105008382B/zh not_active Expired - Fee Related
- 2014-02-18 EP EP14704817.7A patent/EP2958928B1/de active Active
- 2014-02-21 AR ARP140100555A patent/AR094852A1/es unknown
- 2014-02-21 UY UY0001035344A patent/UY35344A/es not_active Application Discontinuation
- 2014-02-21 TW TW103105963A patent/TWI523862B/zh not_active IP Right Cessation
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2015
- 2015-07-28 IL IL240191A patent/IL240191A0/en unknown
- 2015-08-18 PH PH12015501819A patent/PH12015501819A1/en unknown
- 2015-08-20 CU CUP2015000091A patent/CU20150091A7/es unknown
- 2015-08-21 CL CL2015002346A patent/CL2015002346A1/es unknown
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- 2015-08-21 TN TN2015000362A patent/TN2015000362A1/en unknown
- 2015-12-11 HK HK15112236.2A patent/HK1211592A1/xx unknown
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