SG11201500881XA - Method for the production and selection of molecules comprising at least two different entities and uses thereof - Google Patents
Method for the production and selection of molecules comprising at least two different entities and uses thereofInfo
- Publication number
- SG11201500881XA SG11201500881XA SG11201500881XA SG11201500881XA SG11201500881XA SG 11201500881X A SG11201500881X A SG 11201500881XA SG 11201500881X A SG11201500881X A SG 11201500881XA SG 11201500881X A SG11201500881X A SG 11201500881XA SG 11201500881X A SG11201500881X A SG 11201500881XA
- Authority
- SG
- Singapore
- Prior art keywords
- molecules
- selection
- production
- different entities
- entities
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/22—Cysteine endopeptidases (3.4.22)
- C12Y304/2207—Sortase A (3.4.22.70)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12184473 | 2012-09-14 | ||
| PCT/EP2013/068910 WO2014041072A1 (en) | 2012-09-14 | 2013-09-12 | Method for the production and selection of molecules comprising at least two different entities and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201500881XA true SG11201500881XA (en) | 2015-03-30 |
Family
ID=46967992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201500881XA SG11201500881XA (en) | 2012-09-14 | 2013-09-12 | Method for the production and selection of molecules comprising at least two different entities and uses thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9862779B2 (es) |
| EP (1) | EP2895496B1 (es) |
| JP (1) | JP6405311B2 (es) |
| KR (1) | KR20150052085A (es) |
| CN (1) | CN104619715B (es) |
| BR (1) | BR112015003938A2 (es) |
| CA (1) | CA2879499A1 (es) |
| HK (1) | HK1210189A1 (es) |
| MX (1) | MX2015002407A (es) |
| RU (1) | RU2646159C2 (es) |
| SG (1) | SG11201500881XA (es) |
| WO (1) | WO2014041072A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2417156B1 (en) | 2009-04-07 | 2015-02-11 | Roche Glycart AG | Trivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| RU2015153109A (ru) | 2009-09-16 | 2019-01-15 | Дженентек, Инк. | Содержащие суперспираль и/или привязку белковые комплексы и их применения |
| TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
| WO2012025530A1 (en) | 2010-08-24 | 2012-03-01 | F. Hoffmann-La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
| SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| ES2549638T3 (es) | 2011-02-28 | 2015-10-30 | F. Hoffmann-La Roche Ag | Proteínas de unión a antígeno |
| CN103403025B (zh) | 2011-02-28 | 2016-10-12 | 弗·哈夫曼-拉罗切有限公司 | 单价抗原结合蛋白 |
| KR20140127854A (ko) | 2012-02-10 | 2014-11-04 | 제넨테크, 인크. | 단일-쇄 항체 및 다른 이종다량체 |
| RU2015100656A (ru) | 2012-06-27 | 2016-08-20 | Ф. Хоффманн-Ля Рош Аг | Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения |
| WO2014001324A1 (en) * | 2012-06-27 | 2014-01-03 | Hoffmann-La Roche Ag | Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof |
| WO2014041072A1 (en) * | 2012-09-14 | 2014-03-20 | F. Hoffmann-La Roche Ag | Method for the production and selection of molecules comprising at least two different entities and uses thereof |
| MX2016003593A (es) | 2013-10-11 | 2016-06-02 | Hoffmann La Roche | Anticuerpos de cadena ligera variable comun intercambiada de dominio multiespecifico. |
| EP3227332B1 (en) | 2014-12-03 | 2019-11-06 | F.Hoffmann-La Roche Ag | Multispecific antibodies |
| CN108026560A (zh) * | 2015-09-25 | 2018-05-11 | 豪夫迈·罗氏有限公司 | 在低共熔溶剂中使用分选酶的转酰胺反应 |
| JP6861702B2 (ja) | 2015-09-25 | 2021-04-21 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ソルターゼ・コンジュゲート化ループを含む組換え免疫グロブリン重鎖およびそのコンジュゲート |
| CN106191015B (zh) * | 2016-08-25 | 2019-09-13 | 北京大学 | 金黄色葡萄球菌分选酶a高效突变体 |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| SG11201908127WA (en) * | 2017-03-10 | 2019-10-30 | Hoffmann La Roche | Method for producing multispecific antibodies |
| WO2019004213A1 (ja) * | 2017-06-26 | 2019-01-03 | 国立研究開発法人理化学研究所 | 融合タンパク質 |
| EP3810186B1 (en) * | 2018-06-21 | 2022-09-28 | Novo Nordisk A/S | Novel compounds for treatment of obesity |
| WO2021185360A1 (en) * | 2020-03-20 | 2021-09-23 | Westlake Therapeutics (Hangzhou) Co., Limited | Novel truncated sortase variants |
| KR20230152035A (ko) * | 2021-02-01 | 2023-11-02 | 에쓰티 피에이치아이 테라퓨틱스 컴퍼니 리미티드 | 표적 단백질 분해 시스템 및 이의 응용 |
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| EP2403530B1 (en) | 2009-02-27 | 2016-05-11 | Massachusetts Institute of Technology | Engineered proteins with high affinity for dota chelates |
| CA2756244A1 (en) | 2009-04-02 | 2010-10-07 | Roche Glycart Ag | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
| EP2417156B1 (en) | 2009-04-07 | 2015-02-11 | Roche Glycart AG | Trivalent, bispecific antibodies |
| WO2010136172A1 (en) | 2009-05-27 | 2010-12-02 | F. Hoffmann-La Roche Ag | Tri- or tetraspecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| US8703132B2 (en) | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
| SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| CN103384831B (zh) | 2010-12-23 | 2016-02-10 | 霍夫曼-拉罗奇有限公司 | 通过二价结合剂来检测多肽二聚体 |
| CN103384681B (zh) | 2010-12-23 | 2018-05-18 | 霍夫曼-拉罗奇有限公司 | 结合剂 |
| CN103764665A (zh) * | 2011-06-28 | 2014-04-30 | 怀特黑德生物医学研究所 | 使用分选酶安装用于蛋白质连接的点击化学柄 |
| WO2014001324A1 (en) | 2012-06-27 | 2014-01-03 | Hoffmann-La Roche Ag | Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof |
| RU2015100656A (ru) | 2012-06-27 | 2016-08-20 | Ф. Хоффманн-Ля Рош Аг | Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения |
| BR112014029888A2 (pt) | 2012-06-27 | 2020-05-12 | Hoffmann La Roche | Métodos de produção de um anticorpo, de determinação de uma combinação de sítios de ligação e de tratamento de um indivíduo com câncer, formulação farmacêutica, anticorpo e uso de um anticorpo |
| WO2014041072A1 (en) * | 2012-09-14 | 2014-03-20 | F. Hoffmann-La Roche Ag | Method for the production and selection of molecules comprising at least two different entities and uses thereof |
-
2013
- 2013-09-12 WO PCT/EP2013/068910 patent/WO2014041072A1/en active Application Filing
- 2013-09-12 MX MX2015002407A patent/MX2015002407A/es unknown
- 2013-09-12 CN CN201380047702.9A patent/CN104619715B/zh active Active
- 2013-09-12 SG SG11201500881XA patent/SG11201500881XA/en unknown
- 2013-09-12 EP EP13759782.9A patent/EP2895496B1/en active Active
- 2013-09-12 RU RU2015111708A patent/RU2646159C2/ru not_active IP Right Cessation
- 2013-09-12 CA CA2879499A patent/CA2879499A1/en not_active Abandoned
- 2013-09-12 BR BR112015003938A patent/BR112015003938A2/pt active Search and Examination
- 2013-09-12 KR KR1020157006400A patent/KR20150052085A/ko not_active Application Discontinuation
- 2013-09-12 JP JP2015531559A patent/JP6405311B2/ja active Active
-
2015
- 2015-03-13 US US14/658,078 patent/US9862779B2/en active Active
- 2015-11-04 HK HK15110887.8A patent/HK1210189A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014041072A1 (en) | 2014-03-20 |
| CN104619715B (zh) | 2018-06-05 |
| KR20150052085A (ko) | 2015-05-13 |
| BR112015003938A8 (pt) | 2017-07-04 |
| EP2895496A1 (en) | 2015-07-22 |
| HK1210189A1 (en) | 2016-04-15 |
| MX2015002407A (es) | 2015-06-22 |
| JP6405311B2 (ja) | 2018-10-17 |
| RU2015111708A (ru) | 2016-11-10 |
| US20150291704A1 (en) | 2015-10-15 |
| BR112015003938A2 (pt) | 2018-09-04 |
| EP2895496B1 (en) | 2017-06-07 |
| CN104619715A (zh) | 2015-05-13 |
| JP2016500511A (ja) | 2016-01-14 |
| RU2646159C2 (ru) | 2018-03-01 |
| US9862779B2 (en) | 2018-01-09 |
| CA2879499A1 (en) | 2014-03-20 |
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